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黄河三角洲海岸线提取及其近期时空变化格局

中国农村水利水电 2024年第10期 81-85,95页

作者：韩沙沙谈广鸣赵连军王静雯王现春黄河水利委员会黄河水利科学研究院水利部黄河下游河道与河口治理重点实验室河南郑州450003 武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 开封黄河河务局第一黄河河务局河南开封475002

新入海水沙情势下,黄河三角洲海岸线变迁也相应呈现出新的特征。考虑不同潮位、水体计算指数、涨落潮阶段对海岸线提取效果的影响,利用ArcGIS、ENVI提取了黄河三角洲海岸线,并借助DSAS数字化海岸线分析系统,定量分析了1976-2020年黄河... 详细信息

新入海水沙情势下,黄河三角洲海岸线变迁也相应呈现出新的特征。考虑不同潮位、水体计算指数、涨落潮阶段对海岸线提取效果的影响,利用ArcGIS、ENVI提取了黄河三角洲海岸线,并借助DSAS数字化海岸线分析系统,定量分析了1976-2020年黄河口海岸线变迁特征。研究发现,选择潮位相近、同处落潮阶段且成像质量较好的遥感图,并采用改进的归一化差异水体指数MNDWI计算,黄河三角洲海岸线的提取效果较好。黄河三角洲海岸线变化表现出明显的时空性,神仙沟-刁口河叶瓣1976年以来海岸线基本处于蚀退状态;东营港至孤东油田海岸线自1990年在人工海堤的防护下维持稳定;入海口附近海岸线的蚀退和淤进与陆向来沙量直接相关,陆向来沙充足时呈淤进趋势,反之则冲蚀后退,同时其也受河口改道、海洋动力等其他因素影响。研究可为未来黄河口综合治理规划提供一定参考。

关键词：黄河三角洲海岸线提取海岸线变迁来沙量

Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer

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World Journal of Clinical Oncology 2024年第4期15卷 531-539页

作者： De-Yi Geng Qing-shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-sha han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Department of Plastic and Burns Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina Plastic Surgery Research Institute Ear Deformities Treatment Center and Cleft Lip and Palate Treatment Center of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina

Metastasis remains a major challenge in the successful management of malignant *** liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon,stomach,and pancreatic cancers,as well as melanoma,breast cancer,and *** an important factor that influences the development of metastatic liver cancer,alternative splicing drives the diversity of RNA transcripts and protein subtypes,which may provide potential to broaden the target *** particular,the dysfunction of splicing factors and abnormal expression of splicing variants are associated with the occurrence,progression,aggressiveness,and drug resistance of cancers caused by the selective splicing of specific *** review is the first to provide a detailed summary of the normal splicing process and alterations that occur during metastatic liver *** will cover the role of alternative splicing in the mechanisms of metastatic liver cancer by examining splicing factor changes,abnormal splicing,and the contribution of hypoxia to these changes during metastasis.

关键词： Alternative splicing Carcinoma Hepatocellular Metastasic Liver neoplasms Prognosis

亚硝酸盐氮急性胁迫对刺参“鲁海2号”非特异性免疫的影响

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海洋渔业 2024年第3期46卷 353-360页

作者：王琦胡炜李成林韩莎姚琳琳赵斌山东省海洋科学研究院山东省智慧海洋牧场重点实验室(筹)山东青岛266104

为探索刺参(Apostichopus japonicus)“鲁海2号”对亚硝酸盐氮的适应性,在实验室条件下,开展了不同浓度亚硝酸盐氮(0、4.0、15.8、63.0、251.0和1000.0 mg·L^(-1))对刺参“鲁海2号”的急性胁迫实验,在胁迫后1、3、6、9、12、24、48、72... 详细信息

为探索刺参(Apostichopus japonicus)“鲁海2号”对亚硝酸盐氮的适应性,在实验室条件下,开展了不同浓度亚硝酸盐氮(0、4.0、15.8、63.0、251.0和1000.0 mg·L^(-1))对刺参“鲁海2号”的急性胁迫实验,在胁迫后1、3、6、9、12、24、48、72、96 h测定各浓度组刺参体腔液中酸性磷酸酶(ACP)、碱性磷酸酶(AKP)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性以及丙二醛(MDA)含量变化。结果显示,仅亚硝酸盐氮浓度1000.0 mg·L^(-1)处理组刺参有死亡,死亡率随胁迫时间延长而升高;在亚硝酸盐氮胁迫下,刺参“鲁海2号”体腔液中ACP、AKP、SOD、CAT活性总体呈现先升高后降低的趋势,MDA含量随胁迫时间延长而升高。研究表明,在低于4.0 mg·L^(-1)亚硝酸盐氮胁迫下,刺参“鲁海2号”体内非特异性免疫酶可以维持正常生理功能;但在高浓度亚硝酸盐氮胁迫下,其非特异性免疫能力显著下降。在刺参“鲁海2号”养殖生产中,建议水体亚硝酸盐氮浓度应控制在4.0 mg·L^(-1)以下,为新品种创造良好的养殖环境,更好地体现出良种增产的优势。

关键词：刺参“鲁海2号” 亚硝酸盐氮急性胁迫非特异性免疫

Preparation and Electrochemical Properties of Pb-0.3wt%Ag/Pb-WC Composite Inert Anodes

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Journal of Wuhan University of Technology(Materials Science) 2016年第4期31卷 811-817页

作者：何世伟徐瑞东 WANG Jiong han sha CHEN Buming Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology School of Metallurgical Engineering Anhui University of Technology State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization

We prepared Pb-0.3wt%Ag/Pb-WC（WC stands for tungsten carbide,the same below） composite inert anodes by double-pulse electrodeposition on the surface of Pb-0.3wt%Ag substrates,and investigated the electrochemical properties of the composite inert anodes,which were obtained under different forward pulse average current densities from 2 A/dm2 to 5 A/dm2 and WC concentrations from 0 g/L to 40 g/L in *** kinetic parameters of oxygen evolution,corrosion potential and corrosion current of the composite inert anodes were obtained in a synthetic zinc electrowinning electrolyte of 50 g/L Zn2＋ and 150 g/L H2SO4 at 35 ℃,by measuring the anodic polarization curves,Tafel polarization curves and cyclic voltammetry *** results show that Pb-0.3wt% Ag/Pb-WC composite inert anodes obtained under forward pulse average current density of 3 A/dm2 and WC concentration of 30 g/L in an original acid plating bath,possess higher electrocatalytic activity of oxygen evolution,lower overpotential of oxygen evolution,better reversibility of electrode reaction and corrosion resistance in [ZnSO4＋H2SO4] *** overpotential of oxygen evolution of the composite inert anode is 0.926 V under 500 A/m2 in [ZnSO4＋H2SO4] solution,and 245 mV lower than that of Pb-1% Ag alloy;the corrosion current of the composite inert anode is 0.95×10-4A which is distinctly lower than that of Pb-1%Ag alloy,showing the excellent corrosion resistance.

关键词： inert electrolyte anodic anode tungsten plating voltammetry carbide cathodic dispersed

黄河下游高村-孙口段冲淤变化及影响因素定量分析

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水电能源科学 2024年第9期42卷 75-79页

作者：全李宇李铭牛超杰李东阳刘尚彬李想赵连军韩沙沙胡彩虹郑州大学水利与交通学院河南郑州450001 河南黄河勘测规划设计研究院有限公司河南郑州450003 黄河水利委员会黄河水利科学研究院河南郑州450003 清华大学水沙科学与水利水电工程国家重点实验室北京100084

为探究黄河过渡段河道滩槽演变规律,采用实测水沙和大断面数据,分析近年来高孙段河床冲淤、水沙条件和河床形态的演变,以年和汛期为时间尺度,用灰色关联度分析河槽冲淤量与水沙条件及河床形态的关联程度。结果表明,近年来高孙段以冲刷为... 详细信息

为探究黄河过渡段河道滩槽演变规律,采用实测水沙和大断面数据,分析近年来高孙段河床冲淤、水沙条件和河床形态的演变,以年和汛期为时间尺度,用灰色关联度分析河槽冲淤量与水沙条件及河床形态的关联程度。结果表明,近年来高孙段以冲刷为主,汛期是年内输沙的主要时期;高村断面来沙系数可以分为波动减小(2002~2017年)和快速增加(2018~2019年)两大阶段,而河床形态中水力半径和宽深比变化趋势完全相反,糙率存在增大趋势;高村断面的水沙条件及河床形态与高孙段河道冲淤具有较高的关联程度,河床形态比水沙条件具有更高的相关性。

关键词：冲淤量水沙条件河床形态河槽演变黄河下游

In situ cornea harvesting through the Red Cross Organization:a new approach to relieving severe cornea donor shortage in Chinese eye banks

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1611-1613页

作者： Su-Xia Li Fu-Hua Wang Ting Wang sha-sha han Wei-Yun Shi shandong Eye Hospital Shandong Eye InstituteShandong Academy of Medical Sciences The People Hospital of Dongying

Corneal diseases are currently the second main cause of blindness in *** most of the corneal blindness could be treated by corneal transplantation,only about 10 000 operations were carried out each year owing to the severe shortage of corneal donors and limited eye bank programs.A feasible cornea donation program was established through the organization of the Red Cross,and in situ corneal removal techniques were developed to avoid conflicts with Chinese traditions of keeping the deceased *** number of donated corneas,which had a safe and secure quality,increased significantly year by year.

关键词： cornea donor transplantation eye bank

Establishment of a three-dimensional particle library for graded crushed stone based on a new aggregate morphology characterization method

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 117-130页

作者： Haitao Ge Aimin sha Zhenqiang han School of Future Transportation Chang'an UniversityXi'an 710064China University of Strasbourg INSA StrasbourgCNRSICubeUMR 7357Strasbourg F-67000France School of Highway Chang'an UniversityXi'an 710064China Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China

The morphology of graded crushed stone(GCS)particles has an essential influence on the performance of aggregate *** impact of particle shape is a comprehensive effect that cannot be considered separately,leading to difficulties in establishing the relationship between the mixture properties and the aggregate morphology by using laboratory *** discrete element method(DEM)is an effective way widely adopted to reconstruct the morphology of particles and simulate performance tests of granular ***,selecting limited particles characterizing a real particle-assembly for simulation is still a challenge in current research due to the inherent rich variability of particle *** this study,based on the acquisition of three-dimensional(3D)aggregate shapes by using laser scanning,ellipsoid index(EDI)translating the particle shape as a function of surface area,volume,and contour length is proposed to comprehensively evaluate aggregate ***,a particle library capable of characterizing aggregate morphology distribution is established based on the statistics of the corresponding morphological characteristics of particle *** model reliability is validated by carrying out a series of experimental and numerical penetration tests with nine different *** established particle library can be used to model aggregate mixtures and the proposed simulation framework is promising for optimizing the mixture gradation design numerically.

关键词： Particle library Discrete element method 3D laser scanning Coarse aggregate Morphology characterization Gradation design

白鹤灵芝化学成分及其体外抗肿瘤与降脂活性研究

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中成药 2024年第8期46卷 2630-2637页

作者：龚志强肖阳韩沙刘颖齐晋霍宇黄艳红杨立芳广西中医药大学赛恩斯新医药学院瑶医药学院广西壮瑶药重点实验室广西南宁530200 广西民族大学化学化工学院广西林产化学与工程重点实验室广西南宁530008

目的研究白鹤灵芝的化学成分及其体外抗肿瘤与降脂活性。方法白鹤灵芝乙酸乙酯部位采用正相、反相硅胶柱和半制备HPLC分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。采用MTT法测定体外抗肿瘤活性,采用油酸诱导的HepG2高脂细胞... 详细信息

目的研究白鹤灵芝的化学成分及其体外抗肿瘤与降脂活性。方法白鹤灵芝乙酸乙酯部位采用正相、反相硅胶柱和半制备HPLC分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。采用MTT法测定体外抗肿瘤活性,采用油酸诱导的HepG2高脂细胞模型评价体外降脂活性。结果从中分离得到20个化合物,分别鉴定为rhinacanthin A(1)、rhinacanthin B(2)、rhinacanthin C(3)、rhinacanthin D(4)、rhinacanthin E(5)、rhinacanthin M(6)、rhinacanthin N(7)、rhinacanthin Q(8)、rhinacanthin T(9)、rhinacanthone(10)、β-谷甾醇(11)、没食子酸(12)、香草酸(13)、丁香酸(14)、拉帕醇(15)、伞形花内酯(16)、sambucunlin A(17)、17α,21-dihydroxy-1,4-pregnadiene-3,11,20-trione,21-acetate(18)、1,8-二羟基蒽醌(19)、2,6-二甲氧基-1,4-苯醌(20)。化合物3、7抑制HepG2、Hela、A549、H22肿瘤细胞增殖的IC_(50)值为(0.66±0.17)~(3.22±0.49)μmol/L,且呈时间和浓度依赖性;化合物3、7、9对油酸诱导的HepG2高脂细胞脂质的清除率高达50%以上。结论化合物16~20为首次从该植物中分离得到。化合物3、7具有良好的体外抗肿瘤活性,3、7、9具有较好的体外降脂活性。

关键词：白鹤灵芝化学成分分离鉴定抗肿瘤降脂

Effects of different levels of sweet potato in feeds on body composition and digestive enzymes activities of A postichopus japonicas Selenka

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Journal of Oceanology and Limnology 2018年第5期36卷 1835-1842页

作者： ZHAO Bin HU Wei LI Chenglin han sha XU Tao Marine Biology Institute of shandong Province Qingdao 266104China shandong Province Fisheries Technology Extension Station Jinan 250013China Homey Foods Co.Ltd. Weihai 264305China

The aim of this study was to test the ef fects of including sweet potato tuber and stem powder in feed on the body composition and digestive enzyme activities of the sea cucumber A postichopus japonicas Selenka. Dif ferent proportions of sweet potato tuber and stem powders(from 10% to 50%) were added into compound feeds, which were supplied to A. japonicas during a 60-day experiment. The results showed that the two sweet potato ingredients had different eff ects on the nutrient contents of the sea cucumber body wall. The group supplied with feed containing 20% sweet potato tuber powder(T2) had the highest level of crude protein in body walls(P 0.05). In all the groups fed with powdered sweet potato tubers(T groups), the proportions of glutamic acid and lysine in body walls were higher than those in the control, whereas the proportion of methionine decreased slightly. Diff erent proportions of sweet potato ingredients in compound feeds also af fected digestive enzyme activities in the sea cucumbers. The activities of protease and lipase first increased and then gradually decreased with increasing proportions of sweet potato materials in the feed. The highest protease activity was in the T2 and the group and the highest lipase activity was in the 10% sweet potato stem(S1) group. These results show that feed components can stimulate digestive enzyme activities in sea cucumber, and that the proportions of tubers and stems of sweet potato in feed can be adjusted to improve the digestion and growth of A. japonicas in marine farms.

关键词： Apostichopus japonicas Selenka sweet potato body composition digestive enzymes