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Journal of Computer Science & Technology 2020年第2期35卷 475-489页

作者： Shu-Quan Wang Lei Wang Yu Deng Zhi-Jie Yang sha-sha guo Zi-Yang Kang Yu-Feng guo Wei-Xia Xu College of Computer Science and Technology National University of Defense TechnologyChangsha 430041China

Neuromorphic computing is considered to be the future of machine learning,and it provides a new way of cognitive *** by the excellent performance of spiking neural networks(SNNs)on the fields of low-power consumption and parallel computing,many groups tried to simulate the SNN with the hardware ***,the efficiency of training SNNs with neuromorphic algorithms is not ideal *** this,Michael et *** a method which can solve the problem with the help of DNN(deep neural network).With this method,we can easily convert a well-trained DNN into an SCNN(spiking convolutional neural network).So far,there is a little of work focusing on the hardware accelerating of *** motivation of this paper is to design an SNN processor to accelerate SNN inference for SNNs obtained by this DNN-to-SNN *** propose SIES(Spiking Neural Network Inference Engine for SCNN Accelerating).It uses a systolic array to accomplish the task of membrane potential increments *** integrates an optional hardware module of max-pooling to reduce additional data moving between the host and the *** also design a hardware data setup mechanism for the convolutional layer on the SIES with which we can minimize the time of input spikes *** implement the SIES on FPGA *** number of neurons it supports is up to 4000 while the synapses are *** SIES can run with the working frequency of 200 MHz,and its peak performance is 1.5625 TOPS.

关键词： spiking neural network(SNN) field-programmable gate array(FPGA) neuromorphic systolic array spiking convolutional neural network(SCNN) integrete and fire(I&F)model hardware accelerator

Role of ADAM10 and ADAM17 in CD16b Shedding Mediated by Different Stimulators

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Chinese Medical Sciences Journal 2012年第2期27卷 73-79页

作者： sha guo Min Peng Qing Zhao Wei Zhang Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Objective To investigate the main proteinases responsible for CD16b shedding under different stimulators. Methods HEK293 cell line stably expressing CD16b was constructed by lentivirus system. The cell line was then overexpressed with a disintegrin and metalloproteinase 10 （ADAM10） or ADAM17, sup- pressed with short hairpin RNA of ADAM10 or ADAM I 7, and reconstituted with ADAM 10 or ADAM17, respectively. After each treatment, the cell line was stimulated with ionomycin or phorbol 12-myristate- 13-acetate （PMA） for 12 hours. The soluble CD 16b released from cell membrane was detected by immuno- precipition and immunoblot. Quantitation was then implemented to compare the amount of soluble CD 16b in cell supernatant after stimulation. Results HEK293 cell line stably expressing CD16b was successfully established. When CDI6b ex- pressing cell line was overexpressed with ADAM 10, shedding of CD 16b was increased after stimulation with ionomycin but not PMA; when the cell line overexpressed with ADAM I7, shedding of CDI6b was increased after stimulation with PMA but not ionomycin. Similarly, when ADAM10 was suppressed by short hairpin RNA, CD 16b shedding was decreased after stimulation with ionomycin; when ADAM 17 was suppressed by short hairpin RNA, CD16b shedding was decreased after stimulation with PMA. The shedding of CD16b was increased again when CD16b expressing cell line was reconstituted with ADAM10 and stimulated by ionomycin or reconstituted with ADAM 17 and stimulated by PMA. Conclusions Both ADAM10 and ADAM17 could shed CD16b, but they possess differed prefer- ences. ADAM10 is the main sheddase under stimulation of ionomycin, while ADAM17 is the main sheddase under stimulation of PMA.

关键词： a disintegrin and metalloproteinase 10 a disintegrin and metalloproteinase 17 CD 16b shedding

Foliar application of strigolactones improves the desiccation tolerance,grain yield and water use efficiency in dryland wheat through modulation of non-hydraulic root signals and antioxidant defense

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Stress Biology 2023年第1期3卷 583-597页

作者： sha guo Xiaofei Wei Baoluo Ma Yongqing Ma Zihan Yu Pufang Li College of Forestry Northwest A&F UniversityShaanxi 712000YanglingChina College of Soil and Water Conservation Science and Engineering Northwest A&F UniversityShaanxi 712000YanglingChina Ottawa Research and Development Centre(ORDC) Agriculture and Agri-Food CanadaOttawaON K1A0C6Canada College of Natural Resources and Environment Northwest A&F UniversityShaanxi 712000YanglingChina

Non-hydraulic root signals(nHRS)are affirmed as a unique positive response to soil drying,and play a crucial role in regulating water use efficiency and yield formation in dryland wheat ***(SLs)can enhance plant drought ***,the question of whether strigolactones enhance grain yield and water use efficiency by regulating nHRS and antioxidant defense systems in dryland wheat remains *** this study,pot experiments were conducted to investigate the effects of strigolactones on nHRS,antioxidant defense system,and grain yield and water use efficiency in dryland *** results showed that external application of SLs increased drought-induced abscisic acid(ABA)accumulation and activated an earlier trigger of nHRS at 73.4% field capacity(FC),compared to 68.5%FC in the control group(CK).This phenomenon was mechanically associated with the physiological mediation of *** application of SLs significantly enhanced the activities of leaf antioxidant enzymes,reduced ROS production,and mitigated oxidative damage to lipid ***,root biomass,root length density,and root to shoot ratio were increased under strigolactone ***,exogenous application of SLs significantly increased grain yield by 34.9%under moderate drought *** use efficiency was also increased by 21.5% and 33.3% under moderate and severe drought conditions respectively,compared to the control group(CK).The results suggested that the application of strigolactones triggered earlier drought-sensing mechanism and improved the antioxidant defense ability,thus enhancing grain yield and water use efficiency in dryland wheat production.

关键词： Strigolactones Non-hydraulic root signals Antioxidant defense system Grain yield Water use efficiency

M-LSM:An Improved Multi-Liquid State Machine for Event-Based Vision Recognition

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Journal of Computer Science & Technology 2023年第6期38卷 1288-1299页

作者：王蕾郭莎莎曲连华田烁徐炜遐 College of Computer Science and Technology National University of Defense TechnologyChangsha 410073China

Event-based computation has recently gained increasing research interest for applications of vision recogni-tion due to its intrinsic advantages on efficiency and ***,the existing event-based models for vision recogni-tion are faced with several issues,such as large network complexity and expensive training *** this paper,we propose an improved multi-liquid state machine(M-LSM)method for high-performance vision ***,we intro-duce two methods,namely multi-state fusion and multi-liquid search,to optimize the liquid state machine(LSM).Multi-state fusion by sampling the liquid state at multiple timesteps could reserve richer spatiotemporal *** adapt network architecture search(NAS)to find the potential optimal architecture of the multi-liquid state *** also train the M-LSM through an unsupervised learning rule spike-timing dependent plasticity(STDP).Our M-LSM is evalu-ated on two event-based datasets and demonstrates state-of-the-art recognition performance with superior advantages on network complexity and training cost.

关键词： liquid state machine bio-inspired learning classification event-based vision

Electric Acupuncture Treated Mainly 100 Cases of Prolapsed Lumbar Intravertebral Disc

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Journal of Acupuncture and Tuina Science 2003年第1期1卷 44-45页

作者： XU sha-sha HUANG guo-qi Department of Acupuncture Nantong No. 1 People's Hospital Jiangsu 226001 China

In the treatment of 100 cases of prolapsed lumbar intravertebral disc mainly by electric acupuncture on Jiaji (Ex-B 2) plus traction, the total effective rate was 91%. Key Words Electroacupuncture - Cupping Therapy - Intervertebral Disk Displacement, Lumbar Vertebrae - Traction Author: Xu sha-sha(1954-), female, attending physicianTranslator: Huang guo-qi

关键词： Electroacupuncture Cupping Therapy Intervertebral Disk Displacement, Lumbar Vertebrae Traction

A Delayed-interval Delivery of An in vitro-fertilized Twin Pregnancy with Premature Rupture of Membranes

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Journal of Reproduction and Contraception 2013年第2期24卷 126-130页

作者： Hui-ling QIU Jian-zhi REN Ping LI Ai-guo sha Assisted Reproductive Center Chenggong Hospital Xiamen University

This article presents a case of conservative managements of an in vitro-fertilized twin pregnancy with early loss of the first fetus. A 37-year-old woman in the 21st week of a twin pregnancy delivered her one of the fetuses with unfortunate outcome after the premature rupture of membranes. The umbilical cord of the first fetus was ligated at the cervical level and the second surviving fetus was left in utero. In order to save the surviving fetus, conservative managements including combination of steroids, tocolytics, antibiotics and cervical cerclage were performed. The second fetus was delivered vaginally in the 27th week of pregnancy, 4 h after premature rupture of membranes of the remaining amniotic sac, 41 d after the first fetus was born. The child and the mother have been followed up for 4 years and they are healthy. Conservative managements including steroids, tocolytics, antibiotics and cervical cerclage in a closely monitored environment would be given following the delivery of the first fetus. Delayed-interval pregnancy appears to be safe for the mother and the remaining fetuses.

关键词： in vitro fertilization (IVF) multiple pregnancies delayed-interval delivery

The beauty of multi-active sites

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cMat 2024年第1期1卷 20-21页

作者： Yu-Qing Wang sha-sha guo Zheng Liu School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore Department of Chemistry and Chemical Biology Cornell UniversityIthacaNew YorkUSA CINTRA CNRS/NTU/THALES UMI 3288Research Techno PlazaSingaporeSingapore Institute for Functional Intelligent Materials National University of SingaporeSingaporeSingapore

The Sabatier principle—which states that the best catalyst should be at the peak of the volcano plot,with neither too strong nor too weak intermediate binding strength—plays the golden rule in designing highly active *** instance,Pt with a“just right”hydrogen adsorption free energy(ΔG_(H^(*))=~0 eV)is the most efficient catalyst for hydrogen evolution reaction(HER).^(1)Nevertheless,the pressing demand for renewable energy has sparked a quest beyond the top of the volcano plot,driving the innovation towards more effective,economical.

关键词： catalyst instance adsorption

Amyloid β3-10 DNA vaccination suggests a potential new treatment for Alzheimer＇s disease in BALB/c mice

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Chinese Medical Journal 2011年第17期124卷 2636-2641页

作者： XING Xiao-na ZHANG Wei-ge sha sha LI Yu guo Rong WANG Cai CAO Yun-peng Department of Neurology First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China

Background Amyloid β1-42 （Aβ42） peptide vaccination has been proved to be effective in reducing amyloid burden in brain and improving cognitive function in Alzheimer＇s disease （AD） mouse models. But the phase II trial of Aβ42 peptide vaccine was halted because of T cell-mediated meningoencephalitis. In this study, a DNA vaccine, p（Aβ3-10）10-CpG, was constructed to test whether it would induce predominant TH2 immune response upon immunization of BALB/c mice. Methods BALB/c mice were vaccinated intramuscularly with p（Aβ3-10）10-CpG plasmids. Aβ42 peptide, pcDNA3.1（＋） empty vector and PBS were injected to the control groups. Expression of interesting gene in injected muscle was identified by immunohistochemistry. Anti-Aβ antibody titers, isotype profiles as well as cytokines in ex vivo splenocytes culture supernatants were analyzed by enzyme-linked immunosorbent assay （ELISA）. Results P（Aβ3-10）lo-CpG plasmid was expressed in muscle after injection detected by immunohistochemistry. The p（Aβ3-10）10-CpG vaccine induced high titers of anti-Aβ antibodies in BALB/c mice. And isotype of the antibodies was mainly IgG1, the IgG1/IgG2a ratio for the p（Aβ3-10）10-CpG group was approximately 5 times greater than that for the Aβ42 peptide group. Ex vivo cultured splenocytes isolated from mice immunized with p（Aβ3-10）10-CpG exhibited high interleukin-4 response and low interleukin-y （IFN-γ） response. Conclusions Immunization with p（Aβ3-10）10-CpG vaccine primarily induces a TH2 type of response, thus reduces the probability of inflammation. This （Aβ3-10）10-CpG vaccine possesses the basic factors required for a safe and effective AD vaccine.

关键词： Alzheimer's disease vaccine DNA

New Progresses of LIS at IMP

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 273-274页

作者： sha shan guo Xiaohong Zhao Hongwei

Theoretical Studies on the Mechanisms and Kinetics of the Reaction between CH3CH2O and OH Radicals

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Theoretical Studies on the Mechanisms and Kinetics of the Re...