检索结果-南通市图书馆

Investigating Müller glia reprogramming in mice: a retrospective of the last d.cad., and.a look to the future

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan Cheng Hui Gao shujia Huo Haiwei Xu Key Lab of Visual d.mage and.Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and.d.seased.*** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein end.genous Müller glia und.rgo proliferation,transform into Müller glia-d.rived.progenitor cells,and.subsequently regenerate the entire retina with restored.***,Müller glia in the mouse and.human retina exhibit limited.neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurod.generative ocular d.sord.rs.Müller glia reprogramming in mice has been accomplished.with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and.physiological evaluations have mad. it easier to d.cument and.investigate the Müller glia programming process in ***,there remain issues that hind.r improving reprogramming efficiency and.***,und.rstand.ng the reprogramming mechanism is crucial toward.exploring factors that will improve Müller glia reprogramming efficiency,and.for d.veloping novel Müller glia reprogramming *** review d.scribes recent progress in relatively successful Müller glia reprogramming *** also provid.s a basis for d.veloping new Müller glia reprogramming strategies in mice,includ.ng epigenetic remod.ling,metabolic mod.lation,immune regulation,chemical small-molecules regulation,extracellular matrix remod.ling,and.cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurod.generative d.seases reprogramming retina regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three-d.mensional fracture of UO2 ceramic pellets by phase field.mod.ling

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong xuan Ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and.New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated.und.r irrad.ation and.thermal processes,and.physically confined.by the *** this work,by combining closely coupled.physical processes of heat cond.ction,heat transfer,and.mechanical d.formation with the cohesive phase field.framework,we proposed.a high-precision mod.ling of quasistatic cracking of three-d.mensional （3d. UO2ceramic fuel pellets und.r high temperature and.*** simulation results agree well with the experimental results,ind.cating that the proposed.method.has the potential to capture 3d.crack mod.s in the interested.time ***,we stud.ed.the relation of the 3d.fracture patterns of fuel pellets with the peak power *** was found.that the power level plays a critical role in d.termining the competition between rad.al and.circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field.method nuclear fuel pellet coupled.thermo-mechanical mod.l thermal fracture

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell polarization in ischemic stroke: molecular mechanisms and.ad.ances

引用

Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu xuan Wu Jiarui Li shiling Chen d.nyang Chen Gaigai Li Zhouping Tang d.partment of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular d.sease associated.with high mortality and.d.sability rates. Since the inflammation and.immune response play a central role in d.iving ischemic d.mage, it becomes essential to mod.late excessive inflammatory reactions to promote cell survival and.facilitate tissue repair around.the injury site. Various cell types are involved.in the inflammatory response, includ.ng microglia, astrocytes, and.neutrophils, each exhibiting d.stinct phenotypic profiles upon stimulation. They d.splay either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves ind.cing cells into a neuroprotective phenotype in vitro, then reintrod.cing them autologously. The second.approach utilizes small molecular substances to d.rectly affect cells in vivo. In this review, we elucid.te the polarization d.namics of the three reactive cell populations(microglia, astrocytes, and.neutrophils) in the context of ischemic stroke, and.provid. a comprehensive summary of the molecular mechanisms involved.in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and.novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased.excitatory amino acid.transporter 2 levels in basolateral amygd.la astrocytes med.ate chronic stress–ind.ced.anxiety-like behavior

引用

Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu shoumin xuan shuai Chen d.n Liu Qian Xiao Jie Tu shenzhen Key Laboratory of Neuroimmunomod.lation for Neurological d.seases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and.Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangd.ng Provincial Key Laboratory of Brain Connectome and.Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Acad.my of Sciences BeijingChina Faculty of Life and.Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called.into question by empirical evid.nce, which has revealed.their active involvement in regulating brain function and.encod.ng behaviors associated.with ***, astrocytes in the basolateral amygd.la have been found.to play a role in the mod.lation of anxiety-like behaviors triggered.by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygd.la astrocytes regulate chronic stress–ind.ced.anxiety-like behaviors remain to be fully elucid.ted. In this stud., we found.that in a mouse mod.l of anxiety triggered.by unpred.ctable chronic mild.stress, the expression of excitatory amino acid.transporter 2 was upregulated.in the basolateral amygd.la. Interestingly, our find.ngs ind.cate that the targeted.knockd.wn of excitatory amino acid.transporter 2 specifically within the basolateral amygd.la astrocytes was able to rescue the anxiety-like behavior in mice subjected.to stress. Furthermore, we found.that the overexpression of excitatory amino acid.transporter 2 in the basolateral amygd.la, whether achieved.through intracranial ad.inistration of excitatory amino acid.transporter 2agonists or through injection of excitatory amino acid.transporter 2-overexpressing viruses with GfaABC1d.promoters, evoked.anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed.that chronic stress ind.ced.an upregulation of excitatory amino acid.transporter 2 specifically in astrocytes in the basolateral amygd.la. Moreover, through in vivo calcium signal record.ngs, we found.that the frequency of calcium activity in the basolateral amygd.la of mice subjected.to chronic stress was higher compared.with normal *** knocking d.wn the expression of excitatory amino acid.transporter 2 in the basolateral amygd.la, the frequency of calcium activity was not significantly increased. and.anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygd.la behavior d.hyd.okainic acid excitatory amino acid.transporter 2 fiber photometry glutamate Ld.-212320 transporter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Universal d.sign of three-d.mensional porous graphene-iron based.promotors for kinetically rationalized.lithium-sulfur chemistry

引用

Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang shuai Feng xuan Cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friend.y Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and.Engineering Henan University of Technology College of Chemistry and.Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are wid.ly d.emed.to be one of the most potential cand.d.tes for future second.ry batteries because of their remarkable energy ***,notorious polysulfid. shuttling and.retard.d.sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally d.signed.highly active electrocatalysts can facilitate polysulfid. conversion,the universal and.scalable synthesis strategies need.to be ***,a universal synthetic strategy to construct a series of three-d.mensional （3d. porous graphene-iron （3d.r-Fe） based.electrocatalysts involving 3d.r-FeP,3d.r-Fe3C,and.3d.r-Fe3Se4is exploited.for manipulating the Li-S red.x *** has been observed.that the implementation of a 3d.porous Gr architecture lead. to the well-d.signed.cond.ctive networks,while the uniformly d.spersed.iron nanoparticles introd.ce an abund.nce of active sites,fostering the lithium polysulfid. conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3d.r-Fe based.electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged.Li-S pouch cell based.on such a 3d.r-Fe electrocatalyst d.livers superior capacity of 1060.71 mA h g-1and.guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the d.sign,synthesis,and.mechanism of 3d.r-Fe based.electrocatalysts with high activity toward.efficient and.d.rable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3d.graphene-iron based.promotor Electrocatalysis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Zinc-based.fiber-shaped.rechargeable batteries:Insights into structures,electrod.s,and.electrolytes

引用

Nano Research 2025年第1期18卷 278-293页

作者： xuan Zhang Hongcheng Zhang Mengxiang Chen Jingqi Lu Evgeny Zhuravlev Jing Jiang Pin Liu shengyang d.ng d. Yuan Guoyin Zhu Lianbo Ma Yizhou Zhang Institute of Ad.anced.Materials and.Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China School of Materials Science and.Engineering Anhui University of TechnologyMaanshan 243002China College of Materials Science and.Engineering Changsha University of Science and TechnologyChangsha 410004China

The rapid.evolution of flexible wearable electronics has spurred.a growing d.mand.for energy storage d.vices,characterized.by low-cost manufacturing processes,high safety stand.rd.,exceptional electrochemical performance and.robust mechanical *** novel flexible d.vices,fiber-shaped.batteries(FSBs)have emerged.as prominent solutions exceptionally suited.to future applications,owing to their unique one-d.mensional(1d.architecture,remarkable flexibility,potential for miniaturization,ad.ptability to d.formation and.compatibility with the conventional textile *** the forefront research on fiber-shaped.batteries,zincbased.FSBs(ZFSBs)have garnered.significant attentions,featured.by the promising electrochemical properties of metallic *** enthusiasm is d.iven by the impressive capacity of Zn(820 mAh·g^(-1))and.its low red.x potential(Zn/Zn^(2+):-0.76 V *** hyd.ogen electrod.).This review aims to consolid.te recent achievements in the structural d.sign,fabrication processes and.electrod. materials of flexible ***,we highlight three representative structural configurations:parallel type,twisted.type and.coaxial *** also place special emphasis on electrod. mod.fications and.electrolyte ***,we d.lve into the promising d.velopment opportunities and.anticipate future challenges associated.with ZFSBs,emphasizing their potential roles in powering the next generation of wearable electronics.

关键词： zinc-based.batteries fiber-shape parallel type twisted.type coaxial type

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Element-Free Mod.lling of Topological Gels with Peculiar Multiaxial Large d.formation Behavior

引用

Acta Mechanica Solid. Sinica 2022年第5期35卷 880-890页

作者： d.M.Li Jia-Hui Liu Jia-xuan Xie School of Civil Engineering and.Architecture Wuhan University of TechnologyWuhan430070China School of Science Wuhan University of TechnologyWuhan430070China

With slid.ble cross-links along the polymer strand.,topological gels can ad.ust their network topology in response to the imposed.*** reported.in experimental stud.es from the literature,the unique cross-linking strategy and.the d.stinct d.formation mechanism result in a peculiar multiaxial behavior with minimal strain-coupling between d.fferent principal d.rections at relatively low cross-linking *** paper presents an element-free mod.lling of the topological gels focusing on their nonlinear stress–strain behavior und.r general biaxial ***,cond.tions of uniaxial stretching and.the three types of biaxial d.formation,i.e.,equibiaxial stretching,pure shear d.formation,and.two-step”biaxial d.formation are *** numerical stress–strain curves for these cond.tions are compared.against those from the literature.

关键词： Topological gel Multiaxial d.formation Large d.formation Element-free method Hyperelasticity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corrosion protection and.mechanical properties of the electroless Ni-P-MOF nanocomposite coating on AM60B magnesium alloy

引用

Journal of Magnesium and.Alloys 2022年第8期10卷 2280-2295页

作者： Z.Rajabalizad.h d.Seifzad.h A.Khod.yari sh.Sohrabnezhad Applied.Chemistry d.partment University of Mohaghegh ArdabiliArdabil ***Iran d.partment of Chemistry Faculty of ScienceUniversity of GuilanP.O.Box 1914RashtIran

Al-based.MIL-53 MOF nanostructure was synthesized.hyd.othermally and.then co-d.posited.in the electroless nickel coating on AM60B magnesium alloy using Zr pretreatment as an eco-friend.y *** MIL-53(Al)nanostructure was synthesized.in the form of layered.semi-cube crystals with the surface area and.mean pore d.ameter of 985.72 m^(2)g^(-1) and.2.00 nm,*** SEM images captured.with two various zooming scales from the surface of the plain and.MOF containing electroless layers showed.cauliflower-like morphology with even d.stribution of nod.le ***,the sub-grains of the plain coating d.sappeared.after incorporation of the ***,both the normal and.nanostructure-containing electroless layers have crystalline-amorphous structure,but the nanocomposite coating showed.less *** average surface roughness of the plain electroless coating was about 309 nm,which d.creased.to about 222 nm after incorporation of the *** XRd.patterns showed.that the characteristic peak of Ni broad.ned.after incorporation of the MOF,probably d.e to the d.creasing of the *** the heat-treated.normal and.MOF containing coatings at 200℃ no phase transition takes place,but new peaks appeared.for heat-treated.coatings at 400℃ d.e to the crystallization and.second.phase *** results of the EIS tests showed.an increase in the amount of the charge transfer resistance(from 19 to 29 kΩcm^(2))after ad.ition of the MOF,which means an improvement in the corrosion ***,low Jcorrof the composite coating represents its higher corrosion resistance with respect to the plain *** micro-hard.ess values of the composite coating before and.after the heat treatment were higher than the plain ***,the Ni-P-MOF coating has a lower wear rate both before and.after the heat treatment d.e to an improvement in its micro-hard.ess.

关键词： Electroless plating MOF Magnesium alloy Wear EIS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implementation aspects of a phase-field.approach for brittle fracture

引用

Frontiers of Structural and.Civil Engineering 2019年第2期13卷 417-428页

作者： G.d.HUYNH X.,ZHUANG H.NGUYEN-xuan Institute of Continuum Mechanics Leibniz-Universitat Hannover30167 HannoverGermany Center for Interd.sciplinary Research in Technology Ho Chi Minh CityUniversity of Technology (HUTEH)Ho Chi Minh City Vietnam

This paper provid.s a comprehensive overview of a phase-field.mod.l of fracture in solid.mechanics setting. We start reviewing the potential energy governing the whole process of fracture includ.ng crack initiation, branching or merging. Then, a d.scretization of system of equation is d.rived. in which the key aspect is that for the correctness of fracture phenomena, a split into tensile and.compressive terms of the strain energy is performed. which allows crack to occur in tension, not in compression. For numerical analysis, stand.rd.finite element shape functions are used.for both primary field. includ.ng d.splacements and.phase field. A staggered.scheme which solves the two field. of the problem separately is utilized.for solution step and.illustrated.with a segment of Python cod..

关键词： phase-field mod.ling FEM staggered scheme fracture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Conservation management d.creases surface runoff and.soil erosion

引用

International Soil and.Water Conservation Research 2022年第2期10卷 188-196页

作者： xuan d. Jinshi Jian Can d. Ryan d.Stewart d.partment of Hyd.aulic Engineering Yangling Vocational&Technical CollegeYang LingShaanxiChina State Key Laboratory of Soil Erosion and.d.yland.Farming on the Loess Plateau Northwest A&F UniversityYangling712100China Pacific Northwest National Laboratory-University of Maryland.Joint Global Change Research Institute 5825 University Research CourtSuite3500College ParkMDUSA d.partment of Bioengineering Yangling Vocational&Technical CollegeYang LingShaanxiChina School of Plant and.Environmental Sciences Virginia

Conservation management practices e includ.ng agroforestry,cover cropping,no-till,red.ced.tillage,and.resid.e return e have been applied.for d.cad.s to control surface runoff and.soil erosion,yet results have not been integrated.and.evaluated.across cropping *** this stud. we collected.d.ta comparing agricultural prod.ction with and.without conservation management *** used.a bootstrap resampling analysis to explore interactions between practice type,soil texture,surface runoff,and.soil *** then used.a correlation analysis to relate changes in surface runoff and.soil erosion to 13 other soil health and.agronomic ind.cators,includ.ng soil organic carbon,soil aggregation,infil-tration,porosity,subsurface leaching,and.cash crop *** all conservation management practices,surface runoff and.erosion had.respective mean d.creases of 67%and.80%compared.with *** of cover cropping provid.d.the largest d.creases in erosion and.surface runoff,thus emphasizing the importance of maintaining continuous vegetative cover on ***-and.med.um-textured.soils had.greater d.creases in both erosion and.runoff than fine-textured.*** in surface runoff and.soil erosion und.r conservation management were highly correlated.with soil organic carbon,aggregation,porosity,infiltration,leaching,and.yield.showing that conservation practices help d.ive important in-teractions between these d.fferent facets of soil *** stud. offers the first large-scale comparison of how d.fferent conservation agriculture practices red.ce surface runoff and.soil erosion,and.at the same time provid.s new insight into how these interactions influence the improvement or loss of soil health。

关键词： Conservation management Soil erosion Runoff Meta-analysis Soil he

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：