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Response of growth,metabolism and yield of Dendrocalamopsis oldhami to long-day photoperiod and fertilizer compensation

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Journal of Forestry Research 2023年第1期34卷 151-166页

作者： Zixu Yin shaohui Fan Wen Xia Yang Zhou Xiao Zhou xuan Zhang Chengji Li Fengying Guan International Center for Bamboo and Rattan Key Laboratory of National Forestry and Grassland AdministrationBeijing 100102People’s Republic of China National Location Observation and Research Station of the Bamboo Forest Ecosystem in Yixing National Forestry and Grassland AdministrationYixing 214200People’s Republic of China

The effects of long-day photoperiod on growth,photo synthetic fluorescence,carbon and nitrogen metabolism,and yield of Dendrocalamopsis oldhami and the compensation effects of fertilization were investigated.A completely randomized design was used with two light factors(bamboo culms cultivated in solar greenhouse under long-day[Ls]and short-day[Ln]treatments);two organic nitrogen fertilizer levels(application of organic fertilizer[OF]and no organic fertilizer[NF]);and three nitrogen fertilizer levels(Low[N0],medium[N1]and high nitrogen[N2]).Leaf chlorophyll and fluorescence parameters(φPo,PIABS,and ETo/CSm)decreased and DIo/CSmincreased in Ls compared to *** acetic acid(IAA)and gibberellic acid(GA3)levels decreased,whereas abscisic acid(ABA)*** area decreased and leaf dry mass *** contents of carbon and nitrogen metabolism-related enzymes(nitrate reductase,glutamine synthetase,amylase,and sucrose synthase)and products(total nitrogen,organic carbon,soluble sugar,and starch)*** bamboo shoot weight and diameter at breast height decreased,whereas shoot quantity and total yield *** application significantly affected physiological growth and yield in the two light treatments,thus promoting carbon and nitrogen ***φPo,PIABS,IAA,and GA3contents increased slightly,whereas ABA levels *** quantity,individual weight,and total yield *** A,soluble sugar,and total yield to organic manure and light were lower than those of nitrogen levels(FN>FL,FO).Other indicators showed lower responses to different fertilization treatments than the light factor(FL>FN,FO).The ability of *** to alter its morphological and physiobiochemical traits and yield in response to variations in light applications may translate into high phenotypic *** significantly improved photoplasticity of *** Ls,*** had high metabolic *** easily inhibited by light,and showed accelerate

关键词： Light Nitrogen Organic fertilizer Fluorescence parameters Carbon and nitrogen metabolism Yield

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Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1258-1268页

作者： Ying-Chih Wang xuan Yang Wen-Bin Wei Xiao-Lin Xu Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren HospitalCapital Medical University

AIM： To reveal the insight mechanism of liver metastasis in uveal melanoma, we investigated cell functions of microRNA-21 in three different uveal melanoma cell lines and analyze the relationship of target gene p53 and its downstream targets which been found significant expression in our previous ***： Quantitative real-time polymerase chain reaction （qRT-PCR） was used to detect microRNA-21 expression in normal uveal tissue and uveal melanoma cell lines. Lenti-virus expression system was used to construct OCM-1, MuM-2B and M619 cell line with stable overexpression and inhibition of microRNA-21. In vitro cell function tests such as cell proliferation, cell apoptosis, cell circle and abilities of migration and invasion were examined by MTT, Brdu assay, flow cytometry, transwell assay and Matrigel invasion assay respectively. The target gene was predicted by bioinformatics and confirmed by using a dual luciferase reporter assay. The expression of p53 and its suspected downstream targets LIM and sh3 protein 1 （LASP1） and Glutathione S Transferase pi （GST-Pi） were determined by qRT-PCR in mRNA level and western blotting analysis in protein level. Finally, the effect of microRNA-21 in a xenograft tumor model was assessed in four-week-old BALB/c nude mice. RESULTS： Compared to normal uveal melanoma, expressions of microRNA-21 were significantly higher in uveal melanoma cell lines. Overexpression of microRNA-21 promoted proliferation, migration, and invasion of OCM-1, M619 and MuM-2B cells, while inhibition of microRNA-21 reveal opposite effects. Wild type p53 was identified as a target gene of microRNA-21-3p, and proved by dual luciferase reporter assay. Up-regulated microRNA-21 inhibited the expression of wild type p53 gene, and the increased expression of LASP1 in mRNA level and protein level, while down-regulated microRNA-21 presented opposite way. However, GST-pi showed the potential pattern as expected, but relative mRNA level showed no statistically signific

关键词： uveal melanoma microRNA-21 p53 LIMand sh3 protein 1 Glutathione S Transferase pi

Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery

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World Journal of Diabetes 2024年第6期15卷 1234-1241页

作者： Jun-Ling Li Jin Zhao Zhen-Feng Guo Chang Xiao xuan Liu Department of Ophthalmology Tianjin Beichen HospitalThe Affiliated Hospital of Nankai UniversityTianjin 300400China Department of Ophthalmology Xianyang First People’s HospitalXianyang 712000Shaanxi ProvinceChina

BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of ***,effective alleviation of symptoms in patients with this disease has important clinical *** To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(sh)eye drops on DES after cataract surgery in patients with *** We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April *** were classified into an observation group(42 cases,rhEGF+sh eye drops)and a control group(40 cases,sh eye drops alone),depending on the different treatment *** therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two *** Therapeutic efficacy was higher in the observation group compared with the control *** groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation *** no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation *** rhEGF+sh eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety ***,this treatment should be promoted in clinical practice.

关键词： Recombinant human epidermal growth factor Sodium hyaluronate eye drops Diabetic patients Dry eye syndrome after cataract surgery Therapeutic efficacy

Deep profile soil moisture distribution characteristics for different microtopographies on the semi-arid Loess Plateau, China

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Journal of Mountain Science 2021年第10期18卷 2688-2697页

作者： GOU Qing-ping ZHU Qing-ke LI Yi-xuan TIAN Xiang-lei WANG Peng-xiang XIN Yun-ling LUO shu-yuan School of Soil and Water conservation Beijing Forestry UniversityBeijing 100083China Engineering Research Center of Forestry Ecological Engineering Ministry of EducationBeijing Forestry UniversityBeijing 100083China

Soil moisture is a limiting factor for vegetation restoration on the Loess Plateau, China. Micro-topography may cause heterogeneities in the distribution of soil moisture, but little is known about its effect on deep soil moisture. Our study aims to explore the distribution and impact of soil moisture within the upper 10 m of soil for different microtopographies. Taking undisturbed slope as the control, five micro-topographies were selected. Soil moisture over a depth of 0-10 m from 2017 to 2019 was investigated, and soil particle size and soil organic matter were measured. Variance analysis and multiple comparisons were used to analyze the difference in soil moisture for different microtopographies and multiple-linear regression was used to analyze the influence of micro-topography on soil moisture. There are significant differences in soil moisture within the different layers underlying the examined micro-topographies, while the inter-annual variation in soil water storage for the selected microtopographies increase with increased rainfall. The depth of influence of micro-topographic vegetation on soil moisture exceeded 1000 cm for a gully(GU), 740 cm for a sink hole(sh), 480 cm for a scarp(SC), 360 cm for an ephemeral gully(EG) and 220 cm for a platform(PL). Micro-topography will cause the heterogeneous distribution of soil moisture in the shallower layers, which changes the vegetation distribution differences between micro-topographies. This may be the survival strategy of herbaceous vegetation in response to climate change in the Loess Plateau. For future vegetation restoration efforts, we need to pay attention to the influence of microtopography on soil moisture.

关键词： Deep soil moisture Erosion degradation Micro-topography Semiarid loess region

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Love Is As Ethical Love Does

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Journal of Literature and Art Studies 2016年第4期6卷 356-368页

作者： shI xuan CHEN Xi Hunan University Changsha China

In their article ＂Love Is As Ethical Love Does＂, CHEN Xi and sh1 xuan discuss Toni Morrison＇s Love and assert that this novel is essentially an ethical tragedy of black women. From the perspective of ethical literary criticism, they analyze the dislocated ethical identity of the two main heroines and alignment of their ethical choices to illustrate that other than race and gender, Heed＇s and Christine＇s tragedies originate from their uncontrollable irrational willJ Moreover, this novel lays stress on love regarded from an ethical perspective, illuminating ＂we choose to love＂, that is, to love while bearing in mind the importance of ethical order and moral norms. Thus, this novel offers moral enlightenment for black women in the process of pursuing love, equality and of reconstructing their ethical identity.

关键词： Love Toni Morrison ethical identity ethical selection

Structure-based design,synthesis,and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

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Acta Pharmaceutica Sinica B 2018年第4期8卷 615-628页

作者： Xu-Nian Wu Ya-Dan Huang Jin-xuan Li Yan-Fa Yu Qian Zhou Chen Zhang Yinuo Wu Hai-Bin Luo School of Pharmaceutical Sciences Sun Yat-sen University Collaborative Innovation Center of High Performance Computing National University of Defense Technology

The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a series of PDE9 inhibitors combining the pharmacophore of rosiglitazone were discovered. All the compounds possessed remarkable affinities towards PDE9 and four of them have the IC_(50) values 5n mol/L. In addition, these four compounds showed low cell toxicity in human sh-SY5Y neuroblastoma *** 11a, the most effective one, gave the IC_(50) of 1.1 nmol/L towards PDE9, which is significantly better than the reference compounds PF-04447943 and BAY 73-6691. The analysis of putative binding patterns and binding free energy of the designed compounds with PDE9 may explain the structure–activity relationships and provide evidence for further structural modifications.

关键词： PDE9 inhibitors Alzheimer’s disease Type 2 diabetes mellitus Rosiglitazone Molecular docking Dynamics simulation

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BaTi_2As_2O电子结构的第一性原理研究

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计算物理 2012年第5期29卷 786-790页

作者：轩书科山东工艺美术学院公共课教学部山东济南250014

利用基于密度泛函理论的平面波赝势方法,研究BaTi2As2O的能带结构、费米面和态密度.发现:BaTi2As2O是一种非磁性金属,费米能级处的态密度主要来自Ti原子的3d电子,Ti 3d轨道和As 4p轨道有较强的杂化.没有发现其磁性基态,说明Ti原子上没... 详细信息

利用基于密度泛函理论的平面波赝势方法,研究BaTi2As2O的能带结构、费米面和态密度.发现:BaTi2As2O是一种非磁性金属,费米能级处的态密度主要来自Ti原子的3d电子,Ti 3d轨道和As 4p轨道有较强的杂化.没有发现其磁性基态,说明Ti原子上没有局域磁矩,与Pickett对Na2Ti2Sb2O的研究结论相吻合.

关键词：第一性原理电子结构磁序 BaTi2As2O

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Hereditary severe insulin resistance syndrome:Pathogenesis,pathophysiology,and clinical management

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Genes & Diseases 2023年第5期10卷 1846-1856页

作者： Junaid Iqbal Hong-Li Jiang Hui-xuan Wu Long Li Ying-Hui Zhou Nan Hu Fen Xiao Ting Wang shi-Na Xu Hou-De Zhou National Clinical Research Center for Metabolic Diseases Hunan Provincial Key Laboratory for Metabolic Bone Diseasesand Department of Endocrinology and MetabolismThe Second XiangYa Hospital of Central South UniversityChangshaHunan 410011China

Severe insulin resistance has been linked to some of the most globally prevalent disorders,such as diabetes mellitus,nonalcoholic fatty liver disease,polycystic ovarian syndrome,and *** severe insulin resistance syndrome(H-SIRS)is a rare disorder classified into four principal categories:primary insulin receptor defects,lipodystrophies,complex syndromes,and obesity-related *** such as INSR,AKT2,TBC1D4,AGPAT2,BSCL2,CAV1,PTRF,LMNA,PPARG,PLIN1,CIDEC,LIPE,PCYT1A,MC4R,LEP,POMC,sh2B1,RECQL2,RECQL3,ALMS1,PCNT,ZMPSTE24,PIK3R1,and POLD1 have been linked to *** clinical features include insulin resistance,hyperglycemia,hyperandrogenism,severe dyslipidemia,fatty liver,abnormal topography of adipose tissue,and low serum leptin and adiponectin *** of H-SIRS is based on the presence of typical clinical features associated with the various H-SIRS forms and the identification of mutations in H-SIRS-linked genes by genetic *** therapy,insulin sensitization,exogenous insulin therapy,and leptin replacement therapy have widely been adopted to manage *** rarity of H-SIRS,its highly variable clinical presentation,refusal to be tested for genetic mutations by patients’family members who are not severely sick,unavailability of genetic testing,and testing expenses contribute to the delayed or underdiagnoses of *** diagnosis facilitates early management of the condition,which results in improved glycemic control and delayed onset of diabetes and other complications related to severe insulin *** use of updated genetic sequencing technologies is recommended,and long-term studies are required for genotype–phenotype differentiation and formulation of diagnostic and treatment protocols.

关键词： Diabetes Genetics Insulin resistance Lipodystrophy Pathophysiology Therapy

Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

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Bioactive Materials 2024年第11期41卷 440-454页

作者： Xiaoting Zhang Boguang Yang Lu Feng Xiayi Xu Chenmin Wang Yuk-wai Lee Ming Wang xuan Lu Ling Qin Sien Lin Liming Bian Gang Li Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China sh Ho Scoliosis Research Laboratory Department of Orthopaedics and TraumatologyThe Chinese University of Hong KongHong KongChina Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University The Chinese University of Hong KongHong KongChina Li Ka shing Institute of Health Sciences The Chinese University of Hong KongChina School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442PR China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina

Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing *** address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect *** hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-*** of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell *** results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion *** of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone *** findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone *** findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.

关键词： Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment Secretome Focal adhesion pathway