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Geology and geochemical evaluation of Taftan Volcano, Sistan and Baluchestan Province, southeast of Iran

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Chinese Journal Of Geochemistry 2008年第4期27卷 356-369页

作者： Biabangard h. Moradian A. Department of Geology Shahid Bahonar University of Kerman Iran

在它的 stratighraphy 的一瞥， Taftan 火山能作为三个组被分类：pre- ， syn -- 并且 volcanic 以后沉积物。pre 暴烈的存款主要由复理层外形和有颜色的 m é lange 建筑群组成。syn 暴烈的存款主要是主要从这座火山的主要身体由碎屑... 详细信息

在它的 stratighraphy 的一瞥， Taftan 火山能作为三个组被分类：pre- ， syn -- 并且 volcanic 以后沉积物。pre 暴烈的存款主要由复理层外形和有颜色的 m é lange 建筑群组成。syn 暴烈的存款主要是主要从这座火山的主要身体由碎屑状的焦性没食子酸和熔岩流组成的 Taftan 火山的产品。volcanic 以后存款主要是从 Taftan 火山的 epiclastic 和重做的材料由于它的侵蚀并且捱过。专业和痕量元素，和从 Taftan 火山在整个岩石的样品上决定的 Sr/rb 同位素组成证明火山在大陆人边缘被形成。Taftan 火山的整个岩石的同位素组成与 87Sr/86 Sr=0.705326 0.705921。Taftan 火山的 Geochronological 样品由 40K/40 Ar 方法把 6.95 ± 0 .72 的一个年龄范围给了 0.71 ± 0 .03 妈。稀土元素的元素模式被高 LrEE 和将近强烈线性的模式为 MrEE 描绘到 hrEE，建议象橄榄石和辉石那样的特殊矿物质在早 magmatic 阶段结晶然后涉及在下地壳和残余岩浆之间的反应。在 Taftan 火山下面的综合同位素和痕量元素分类学和构造结构由主要岩浆建议了降低外壳的吸收。主要岩浆从异构的披风来源和一个第二等的 petrogenetical 过程产生了。这岩浆能被阿曼海的俯冲在大陆人欧亚大陆板下面影响了。

关键词：地球化学地质火山年代学同化作用

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水面下物体作任意运动的兴波阻力

上海交通大学学报 1963年第1期 35-41页

作者：何友声

本文应用流体动力学的經典理論研究了軸对称細长体在水面下作任意运动及出水时的兴波阻力,并根据小波理論和源汇法推导出流場扰动势和兴波阻力的計算公式。研究結果表明所受阻力与整个运动的过程有关。

关键词：兴波阻力速度势

Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain

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Frontiers in Biology 2014年第1期9卷 66-74页

作者： Junjie U. GUO Keith E. SZULWACh Yijing SU Yujing LI Bing YAO Zihui XU Joo heon sh1N Bing XIE Yuan GAO Guo-li MING Peng JIN hongjun SONG Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA The Solomon h. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of human Genetics Emory University School of Medicine 615 Michael Street Atlanta GA 30322 USA Lieber Institute for Brain Development Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Mounting evidence points to critical roles for DNA modifications, including 5-methylcytosine （5mC） and its oxidized forms, in the development, plasticity and disorders of the mammalian nervous system. The novel DNA base 5- hydroxymethylcytosine （5hmC） is known to be capable of initiating passive or active DNA demethylation, but whether and how extensively 5hmC functions in shaping the post-mitotic neuronal DNA methylome is unclear. here we report the genome-wide distribution of 5hmC in dentate granule neurons from adult mouse hippocampus in vivo. 5hmC in the neuronal genome is highly enriched in gene bodies, especially in exons, and correlates with gene expression. Direct genome-wide comparison of 5hmC distribution between embryonic stem cells and neurons reveals extensive differences, reflecting the functional disparity between these two cell types. Importantly, integrative analysis of 5hmC, overall DNA methylation and gene expression profiles of dentate granule neurons in vivo reveals the genome-wide antagonism between these two states of cytosine modifications, supporting a role for 5hmC in shaping the neuronal DNA methylome by promoting active DNA demethylation.

关键词： dentate granule neuron active DNA demethylation TET methylome

The 13th and 14th Workshops on Antarctic Meteorology and Climate

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Advances in Atmospheric Sciences 2020年第5期37卷 423-430页

作者： Matthew A.LAZZArA Sophie A.OrENDOrF Taylor P.NOrTON Jordan G.POWErS David h.BrOMWICh Scott CArPENTIEr John J.CASSANO Steven r.COLWELL Arthur M.CAYETTE Kirstin WErNEr Antarctic Meteorological research Center Space Science and Engineering CenterUniversity of Wisconsin-MadisonMadisonWI 53706USA Department of Physical Sciences School of Arts and SciencesMadison Area Technical CollegeMadison WI 53704USA Department of Atmospheric Sciences University of Wisconsin-MadisonMadisonWI 53706USA National Center for Atmospheric research Boulder CO 53706USA Polar Meteorology Group Byrd Polar&Climate Research CenterThe Ohio State UniversityColumbus OH 43210USA Bureau of Meteorology HobartTasmania 7001Australia Cooperative Institute for research in Environmental Sciences and Department of Atmospheric and Oceanic Sciences University of ColoradoBoulderCO 80309USA British Antarctic Survey Cambridge CB30ETUnited Kingdom Naval Information Warfare Center CharlestonSC 29406USA Year of Polar Prediction(YOPP)International Coordination Office Alfred Wegener InstituteHelmholtz Centre for Polar and Marine ResearchBremerhaven 27570Germany

*** In July 2018,the Antarctic community came together to meet at the 13th Workshop on Antarctic Meteorology and Climate(WAMC)in Madison,Wisconsin,USA(Fig.1);and in the following year in June 2019,the 14th WAMC was held in Charleston,South Carolina,USA(Fig.2).With a growing history,the WAMC addresses the topics of Antarctic meteorology and climate(Kameda et al.,2008;Colwell et al.,2016;Lazzara et al.,2018)as well as weather-related issues of scientific and operational *** workshops bring together researchers,operational forecasters,numerical modelers,observational specialists,and *** themes of both workshops included Antarctic meteorological observations,Antarctic atmospheric numerical modeling,Antarctic meteorological and climate research,and Antarctic weather forecasting and operational *** 2018 and 2019 WAMC were both followed by a one-day focus on the Year of Polar Prediction-Southern hemisphere(YOPP-sh),when preparations and follow-up discussions were made with regard to the YOPP Special Observing Period from 16 November 2018 to 15 February 2019.

关键词： Antarctic weather meteorological

外源性肾上腺髓质素对肾脏创伤大鼠Th1/Th2的调节作用

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中国组织工程研究与临床康复 2007年第16期11卷 3078-3081页

作者：张希炯孙少华兰州大学基础医学院法医学研究室甘肃省兰州市730000

目的:观察外源性肾上腺髓质素(adrenomedullin,ADM)对大鼠肾脏创伤后外周血Th1/Th2的调节作用,并了解给药时间对此作用的影响。方法:实验于2005年在兰州大学实验中心进行。将104只Wistar大鼠随机分为4大组:①正常对照组(8只);不打击。... 详细信息

目的:观察外源性肾上腺髓质素(adrenomedullin,ADM)对大鼠肾脏创伤后外周血Th1/Th2的调节作用,并了解给药时间对此作用的影响。方法:实验于2005年在兰州大学实验中心进行。将104只Wistar大鼠随机分为4大组:①正常对照组(8只);不打击。②创伤组(32只);自由落体生物撞击仪撞击大鼠脊肋区,间接打击双侧肾脏造成肾脏Ⅰ级损伤。③创伤前注射ADM组(32只);打击同创伤组,打击前10min腹腔注射肾上腺髓质素0.1nmol/kg(终体积0.5mL)。④创伤后注射ADM组(32只):打击同创伤组,打击后10min腹腔注射肾上腺髓质素0.1nmol/kg(终体积0.5mL)。后3组分别在打击后1,6,12,24h各处死8只。采用酶联免疫斑点法测定Th1与Th2阳性率。结果:82只大鼠进入结果分析。①创伤组:Th1细胞在创伤后6h显著增加并达峰值,高于创伤后1h及正常对照组[(0.32±0.07)%,(0.13±0.06)%,(0.16±0.07)%,Ph2各时间点比较均无差异;Th1/Th2在创伤后6h达高峰,创伤后24h降至正常对照组水平。②创伤前注射ADM组:Th1在创伤后6h低应答,在创伤后12h增高并达峰值,高于创伤后6h及正常对照组[(0.32±0.08)%,(0.08±0.06)%,(0.16±0.07)%,Ph2在创伤后6-12h的变化趋势与Th1相同;Th1/Th2创伤后6h达最低,低于该时点创伤组(4.58±3.81,23.44±6.19,Ph达高峰。③创伤后注射ADM组:Th1自创伤后1h逐渐上升,至24h达高峰,高于创伤后1,6h[(0.32±0.10)%,(0.10±0.04)%,(0.17±0.07)%,Ph2细胞各时间点比较均无差异;Th1/Th2于创伤后1,6h接近正常对照组,然后逐渐上升,至创伤后24h达最高,高于正常对照组及该时点创伤组(22.49±12.64,5.33±4.55,4.78±3.15,Ph为著),外源性肾上腺髓质素通过抑制Th1优势应答,具有校正Th1/Th2比例失衡的免疫调节作用。②急性创伤后最初6h内,创伤后给予肾上腺髓质素调节Th1/Th2平衡作用明显优于创伤前给药。

关键词：肾脏创伤肾上腺髓质素 Th1细胞 Th2细胞

Toll样受体3介导呼吸道合胞病毒感染人肺上皮细胞的炎性反应及其信号转导通路

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中国组织工程研究与临床康复 2007年第21期11卷 4119-4122页

作者：云云黄升海安徽医科大学基础医学院安徽省合肥市230032

目的:观察呼吸道合胞病毒感染肺上皮细胞A549后Toll样受体3表达的变化,探讨Toll样受体3介导呼吸道合胞病毒感染肺上皮细胞的炎性反应及其介导的信号转导通路。方法:实验于2006-05/12在安徽医科大学基础医学院分子生物学实验室完成。用... 详细信息

目的:观察呼吸道合胞病毒感染肺上皮细胞A549后Toll样受体3表达的变化,探讨Toll样受体3介导呼吸道合胞病毒感染肺上皮细胞的炎性反应及其介导的信号转导通路。方法:实验于2006-05/12在安徽医科大学基础医学院分子生物学实验室完成。用呼吸道合胞病毒感染体外培养的A549细胞,于感染后4,8,16,24h收集细胞和细胞培养上清。用Trizol提取细胞总rNA,rT-PCr法检测TOLL样受体3mrNA、肿瘤坏死因子αmrNA表达的变化;提取细胞总蛋白和核蛋白,免疫印迹法分别检测TOLL样受体3蛋白、核内活性核因子κB的变化;用ELISA检测细胞培养上清肿瘤坏死因子α的表达。以未感染病毒的细胞为正常对照组。结果:①呼吸道合胞病毒感染A549细胞后,Toll样受体3和肿瘤坏死因子α的mrNA和蛋白的表达量均升高且有时间依赖性,Toll样受体3mrNA24h表达量是基础表达量的5倍多,肿瘤坏死因子αmrNA24h表达量是基础表达量的3倍多。②A549细胞中核内活性核因子κB有基础表达,经由呼吸道合胞病毒感染,核内活性核因子κB随感染时间的延长升高;同时呼吸道合胞病毒感染能促进Toll样受体3蛋白的表达,高于正常对照组(Ph分泌达到高峰。结论:呼吸道合胞病毒感染A549细胞后上调Toll样受体3表达,其诱导的炎性反应与Toll样受体3介导的信号转导途径有关。

关键词： Toll样受体呼吸道合胞病毒肿瘤坏死因子α 核因子κB

Laparoscopic pancreaticoduodenectomy: a descriptive and comparative review

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Chinese Journal of Cancer research 2015年第4期27卷 368-375页

作者： Justin Merkow Alessandro Paniccia Barish h.Edil Department of Surgery University Of Colorado

Laparoscopic pancreaticoduodenectomy（LPD） is an extremely challenging surgery. First described in 1994, it has been slow to gain in popularity. recently, however, we have seen an increase in the number of centers performing this operation, including our own institution, as well as an increase in the quantity of published data. The purpose of this review is to describe the current status of LPD as described in the literature. We performed a literature search in the Pub Med database using Me sh terms ＂laparoscopy＂ and ＂pancreaticoduodenectomy＂. We then identified articles in the English language with over 20 patients that focused on LPD only. review articles were excluded and only one article per institution was used for descriptive analysis in order to avoid overlap. There were a total of eight articles meeting review criteria, consisting of 492 patients. On descriptive analysis we found that percent of LPD due to high-grade malignancy averaged 47% over all articles. Average operative time was 452 minutes, blood loss 369 cc＇s, pancreatic leak rate 15%, delayed gastric emptying 8.6%, length of hospital stay 9.4 days, and short term mortality 2.3%. Comparison studies between open pancreaticoduodenectomy（OPD） and LPD suggested decreased blood loss, longer operative time, similar post-operative complication rate, decreased pain, and shorter hospital length of stay for LPD. There was also increased number of lymph nodes harvested and similar margin free resections with LPD in the majority of studies. LPD is a safe surgery, providing many of the advantages typically associated with laparoscopic procedures. We expect this operation to continue to gain in popularity as well as be offered in increasingly more complex cases. In future studies, it will be beneficial to look further at the oncologic outcome data of LPD including survival.

关键词： Laparoscopic laparoscopy pancreaticoduodenectomy whipple review laparoscopic vs.open

Impact of coupling geometry on thermoelectric properties of oligophenyl-base transistor

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Chinese Physics B 2017年第2期26卷 420-427页

作者： S ramezani Akbarabadi h rahimpour Soleimani M Bagheri Tagani Z Golsanamlou Computational Nanophysics Laboratory (CNL) Department of Physics University of Guilan Rasht P. O. Box 41335-1914 Iran

Thermal and electron transport through organic molecules attached to three-dimensional gold electrodes in two different configurations, namely para and meta with thiol-terminated junctions is studied theoretically in the linear response regime using Green＇s function formalism. We used thiol-terminated（–sh bond） benzene units and found a positive thermopower because the highest occupied molecular orbital（hOMO） is near the Fermi energy level. We investigated the influence of molecular length and molecular junction geometry on the thermoelectric properties. Our results show that the thermoelectric properties are highly sensitive to the coupling geometry and the molecular length. In addition, we observed that the interference effects and increasing molecular length can increase the thermoelectric efficiency of device in a specific configuration.

关键词： coupling geometry figure of merit Green's function oligophenyl thermopower

构建适合骨髓衍生肝干细胞移植的小鼠酒精性肝纤维化模型

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中国组织工程研究与临床康复 2007年第4期11卷 649-652页

作者：苏俊廖彩仙周杰唐浩张守华张春兴南方医科大学南方医院肝胆血管外科广东省广州市510515

目的:建立适合骨髓衍生肝干细胞移植的小鼠酒精性肝纤维化模型,为移植骨髓衍生肝干细胞对酒精性肝损伤修复的研究提供进一步探讨的价值。方法:实验于2006-02/06在南方医科大学实验动物中心完成。取Balb/c雌性小鼠100只,SPF级,5～6周龄,... 详细信息

目的:建立适合骨髓衍生肝干细胞移植的小鼠酒精性肝纤维化模型,为移植骨髓衍生肝干细胞对酒精性肝损伤修复的研究提供进一步探讨的价值。方法:实验于2006-02/06在南方医科大学实验动物中心完成。取Balb/c雌性小鼠100只,SPF级,5～6周龄,体质量15～18g,随机区组法分为造模组92只,对照组8只。用白酒灌胃法建立小鼠酒精性肝纤维化模型。造模组于灌胃的第4,8,12,16周末分别随机选取6只小鼠,眼球采血后,颈椎脱臼处死,取出肝脏,以100g/L的甲醛固定,石蜡包埋切片,苏木精-伊红染色和苦味酸-酸性复红染色,光镜观察病理变化。血标本用于测定生化及肝纤维化指标。对照组以等量的蒸馏水灌胃,于实验的第16周末处死,处理同造模组。组间比较采用单因素方差分析。结果:纳入Balb/c雌性小鼠100只,实验中造模组共23只小鼠死亡,多为急性和亚急性死亡。对照组全部成活。①灌胃初期,造模组小鼠出现精神萎靡等现象,实验开始4周后上述症状减轻,对照组小鼠则食欲正常,无嗜睡现象。②在实验刚开始1周时小鼠体质量(15.67±0.98)g,与实验开始时(16.38±0.58)g相比呈明显负增长(P<0.05)。第4,8,12,16周称质量时,造模组小鼠体质量[(16.17±0.91),(17.23±1.39),(18.27±0.85),(19.31±0.95)g]均明显低于对照组[(18.31±0.57),(19.52±0.85),(20.56±0.86),(21.41±0.95)g],(P<0.05)。③对照组小鼠肝脏表面光滑细润、色红等。造模组小鼠肝脏色泽较正常肝脏暗淡,表面充血,肝脏呈增大趋势。造模组小鼠的肝重比(肝脏湿重/小鼠体质量×100%)均大于对照组。④造模组4周时可见轻度酒精性脂肪肝病理改变,12周时酒精性肝炎改变加重并出现了纤维组织增生,16周时肝纤维化已明显形成。⑤不同时间点与对照组相比,血清中天冬氨酸氨基转氨酶、丙氨酸氨基转氨酶、天冬氨酸氨基转氨酶/丙氨酸氨基转氨酶、三酰甘油均呈升高的趋势:造模第8周后,天冬氨酸氨基转氨酶和三酰甘油的水平均逐步增高,尤其以天冬氨酸氨基转氨酶升高明显。⑥小鼠血清肝纤维化指标的变化:造模第8周后血清中透明质酸和层粘连蛋白的水平均逐步增高,与对照组相比,差异均有显著性意义。结论:应用酒精灌胃法可成功建立小鼠酒精性肝纤维化模型,为骨髓衍生肝干细胞的移植提供了前期的实验研究。

关键词：肝疾病/酒精性肝纤维化病理学动态观察