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Protective role of metalloproteinase inhibitor(AE-941) on ulcerative colitis in rats

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World Journal of Gastroenterology 2012年第47期18卷 7063-7069页

作者： Jing-Wei mao Xiao-Mei He Hai-Ying Tang Ying-de Wang department of Gastroenterology the First Affiliated Hospital of Dalian Medical University department of Respiratory Medicine the First Affiliated Hospital of Dalian Medical University

AIM:To evaluate the protective role of AE-941,a matrix metalloproteinase(MMP) inhibitor,on ulcerative colitis(UC) in ***:Sprague Dawley(SD) rats were randomly divided into three groups:a control group,an AE-941 treatment group,and an UC model *** were sacrificed on days 7,21,or 56 following administration of treatment by enema and the disease activity index(DAI),colonic mucosa damage index(CMDI) and colonic expression of MMP-2 and MMP-9 were ***:DAI and CDMI scores in the UC model group increased significantly compared to the control group at all timepoints(P del group increased significantly compared to the control group(P < 0.001),and also increased compared to the AE-941-treated group on the 21-and 56-d timepoints(MMP-2:21-and 56-d = 0.6048 ± 0.0522,0.4163 ± 0.0330vs 0.3983 ± 0.0218,0.1093 ± 0.0072,respectively,P = 0.010;MMP-9:21-and 56-d = 0.6873 ± 0.0472,0.4328 ± 0.0257vs 0.5179 ± 0.0305,0.2673 ± 0.0210,respectively,P = 0.010 and 0.040).CONCLUSION:Expression of MMP-2 and MMP-9 increased significantly in rats with ***-941 can reduce colonic mucosal damage by downregulating the expression of MMP-2 and MMP-9.

关键词： AE-941 Extracellular matrix Matrix metalloproteinase-2 Matrix metalloproteinase-9 Ulcerative colitis

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基于MPC的智能网联卡车队列最优能耗控制

计算机仿真 2024年第3期41卷 128-133页

作者：闫茂德金鑫杨盼盼刘军浩长安大学电子与控制工程学院陕西西安710064

针对高速公路智能网联卡车队列的能耗优化问题,提出了一种基于模型预测控制的双层控制算法。算法由速度规划层和跟踪控制层两部分构成,其中速度规划层结合道路坡度及车辆状态,通过线性能量守恒模型来消除动力学模型中的非线性项,并以发... 详细信息

针对高速公路智能网联卡车队列的能耗优化问题,提出了一种基于模型预测控制的双层控制算法。算法由速度规划层和跟踪控制层两部分构成,其中速度规划层结合道路坡度及车辆状态,通过线性能量守恒模型来消除动力学模型中的非线性项,并以发动机输出功率作为油耗优化指标,采用线性模型预测控制方法获得车队的规划速度;为减少简化车队模型引起的不确定性,跟踪控制层采用基于线性矩阵不等式的分布式鲁棒模型预测控制算法,设计状态反馈控制器对上层规划的最优速度进行跟踪。仿真结果验证了上述双层控制算法的可行性和有效性,可以在保证最优能耗控制的前提下实现车队安全稳定行驶。

关键词：卡车队列控制最优能耗速度规划轨迹跟踪模型预测控制

三维超声心动图评估左心室收缩失同步在射血分数保留心衰中的应用研究

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中国超声医学杂志 2024年第3期40卷 293-296页

作者：冒惠崔磊周仲胤如皋市中医院超声科南通市第一人民医院影像科南通市第一人民医院心超室

目的探讨实时三维超声心动图(RT-3de)对射血分数保留心衰(HFpEF)患者左心室收缩失同步(ISD)的评估价值。方法选取133例慢性心衰患者，根据2016年欧洲心脏病学会的定义分为射血分数保留心衰(HFpEF)组(75例)和射血分数减低心衰(HFrEF)组... 详细信息

目的探讨实时三维超声心动图(RT-3de)对射血分数保留心衰(HFpEF)患者左心室收缩失同步(ISD)的评估价值。方法选取133例慢性心衰患者，根据2016年欧洲心脏病学会的定义分为射血分数保留心衰(HFpEF)组(75例)和射血分数减低心衰(HFrEF)组(58例),选取61例健康体检者为对照组。在患者入院或诊断后收集常规超声心动图及RT-3de参数。结果各组间左心室大小、LVEF、左心室壁厚度、E/e′、三维左心室收缩不同步指数(3D-SDI)差异均有统计学意义(Pde对HFpEF患者ISD的评估具有独特的优势，可以为HFpEF患者的诊断提供更加全面和准确的信息，有望成为HFpEF中重要的辅助检查手段。

关键词：实时三维超声心动图射血分数保留型心力衰竭同步性

群智能算法在月径流预测支持向量机建模中的适应性研究

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水电能源科学 2024年第5期42卷 34-38页

作者：毛建刚王庆杰新疆水利水电科学研究院新疆乌鲁木齐830000 四川水发勘测设计研究有限公司四川成都610065

变化环境下,径流的精准预测愈加困难,集成稳健的优化算法是近年来机器学习发展的动力,也是提高径流预测精度的有效途径。为规避支持向量机(SVM)建模时适应度函数选取的不足,提出基于群智能算法的SVM参数优化范式,并以新疆克孜尔水库月... 详细信息

变化环境下,径流的精准预测愈加困难,集成稳健的优化算法是近年来机器学习发展的动力,也是提高径流预测精度的有效途径。为规避支持向量机(SVM)建模时适应度函数选取的不足,提出基于群智能算法的SVM参数优化范式,并以新疆克孜尔水库月平均径流量预测为例,对粒子群算法(PSO)、差分算法(de)、灰狼算法(GWO)、鲸鱼算法(WOA)和麻雀算法(SSA)5个典型算法进行仿真验证。结果表明,PSO建立SVM模型合格率(QR)小于60%,预测精度不达标,其余4类算法的平均绝对相对误差和纳什系数分别介于10%~20%和0.75~1之间,预测效果良好;20次独立运算结果中,PSO、WOA、SSA和de存在预测结果较差的情况,其中PSO的稳定性最差。综合而言,GWO优化的SVM(SVMGWO)在月径流预测中精度、稳定性和可靠性更佳。

关键词：径流预测支持向量机群智能算法交叉验证参数优化

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恒流径向柱塞泵输出特性分析与试验

液压与气动 2024年第1期48卷 131-140页

作者：王德海杨凌王二毛杨帅刘宝玉安高成内蒙古第一机械集团股份有限公司科研所内蒙古包头014010 太原科技大学机械工程学院山西太原030024

基于特种装备车辆转向系统恒流量需求的背景,以优化某型恒流量径向柱塞泵输出动特性为目的,进行了恒流量机理解析及流量脉动分析优化。针对流量输出特性搭建了数学及仿真模型,并对比仿真、试验结果,以验证原理、模型的有效性。并以恒流... 详细信息

基于特种装备车辆转向系统恒流量需求的背景,以优化某型恒流量径向柱塞泵输出动特性为目的,进行了恒流量机理解析及流量脉动分析优化。针对流量输出特性搭建了数学及仿真模型,并对比仿真、试验结果,以验证原理、模型的有效性。并以恒流量值、恒流量临界转速为约束条件,对流量脉动率进行了优化分析研究。结果表明:可通过该型结构实现柱塞泵恒流量功能;在输入转速大于恒流量临界转速后,随转速升高,平均流量将趋于稳定,而流量脉动将随转速升高而升高;通过优化柱塞直径、偏心距和节流口开口量,可有效降低流量脉动率5%以上。

关键词：柱塞泵优化分析恒流量流量脉动

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Effects of Cr content on corrosion behaviour and corrosion products of spring steels

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Journal of Iron and Steel Research International 2019年第9期26卷 1000-1010页

作者： mao-fang Zuo Yin-li Chen Zhen-li Mi Yi-de Wang Hai-tao Jiang Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

Neutral salt spray corrosion experiments of spring steels with different Cr contents were carried out for different corrosion periods. The optical microscope was used to observe the macroscopic corrosion morphology of the steel surface. The corrosion pit morphology of steel surface was observed by laser scanning confocal microscopy and scanning electron microscopy, and three-dimensional simulation was carried out. At the same time, the corrosion products (rust layer) were qualitatively and quantitatively analysed by X-ray diffraction. As the results show, Cr is beneficial to improving corrosion resistance of the experimental steel matrix, and the higher the content of Cr, the stronger the corrosion resistance will be. With increase in Cr content in steel, the development of corrosion process will be more effectively suppressed. With the increase in Cr content, the denser the corrosion products, the stronger the bond with the metal matrix is. The corrosion products have obvious stratification;the outer layer is mainly composed of c-FeOOH, which is relatively loose and not firmly integrated with the matrix, while the inner layer contains a-FeOOH and Fe3O4, which are relatively dense and closely integrated with the matrix. The types of corrosion are constantly changing during different phases of corrosion.

关键词： Spring steel Cr content Corrosion behaviour Corrosion product Rust layer

Review:Anticancer effects of Chinese herbal medicine,science or myth?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第12期7卷 1006-1014页

作者： RUAN Wen-jing LAI mao-de ZHOU Jian-guang department of Pathology School of MedicineZhejiang Universitv Hangzhou 310006 China department of dermatology the Second Affiliated Hospital School of Medieine Zhejiang University. Hangzhou 310009 China

Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (CHM). In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of CHM due to the lack of scientific evidence from their perspective. Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of CHM. Experiments showed that CHM played its anticancer role by inducing apoptosis and differentiation, enhancing the immune system, inhibiting angiogenesis, reversing multidrug resistance (MDR), etc. Clinical trials demonstrated that CHM could improve survival, increase tumor response, improve quality of life, or reduce chemotherapy toxicity, although much remained to be determined regarding the objective effects of CHM in human in the context of clinical trials. Interestingly, both laboratory experiments and clinical trials have demonstrated that when combined with chemotherapy, CHM could raise the efficacy level and lower toxic reactions. These facts raised the feasibility of the combination of herbal medicines and chemotherapy, although much remained to be investigated in this area.

关键词： Chinese herbal medicine Anticancer

Characteristic Analysis of Solidified Crust for Basic Tundish Flux With Al-Killed Steel Casting

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Journal of Iron and Steel Research International 2011年第1期18卷 16-19页

作者： WANG de-yong ZHANG Zhi-xiang WANG Hui-hua JIANG mao-fa School of Materials and Metallurgy Northeastern University Shenyang 110004 Liaoning China College of Materials Science and Engineering Shenyang University of Chemical Technology Shenyang 110142 I.iaoning China

The solidified crust was harmful to Al-killed steel casting using a basic tundish flux. After sampling from an actual tundish, XRD, SEM and EDX examinations were carried out to analyze the microstructure of solidified crusts. The conclusions were obtained as follows： main crystallization phases existing in tundish crust were Ca12 A14 O23, Ca2SiO4 and a little spinel; spinel and Ca2SiO4 distributed between the grain boundaries of Ca12 A14 Oa3, which increased the connection strength of crystallization phases by pinning grain boundary, density or hardness of solidified crust maybe also significantly increases; when initial composition of tundish flux was located in spinel region of CaO-SiO2-Al2 O3-10 % MgO phase diagram, it was easier to precipitate spinel from molten slag; three approaches of spinel formation in flux were summarized. When flux was saturated with magnesia on the metal/flux interface, MgO in flux was reduced by dissolved aluminum and then formed spinel. On the interface of steel/refractory, with feasible aluminum content, it was also easy to form spinel, and spinel inclusions will be floated and captured by tundish flux.

关键词： tundish flux solidified crust spinel formation approach

Tuning energy output of PTFE/Al composite materials through gradient structure

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defence Technology（防务技术） 2023年第8期26卷 134-142页

作者： Yao-feng mao Qian-qian He Jian Wang Chuan-hao Xu Jun Wang Fu-de Nie China Academy of Engineering Physics Institute of Chemical Materials China

As a typical energetic composite,polytetrafluoroethylene(PTFE)/aluminum(Al)has been widely applied in explosives,pyrotechnics,and propellants due to its ultra-high energy density and intense exothermic *** this work,the radial gradient(RG)structure of PTFE/Al cylinders with three different PTFE morphologies(200 nm and 5μm particles and 5μm fiber)and content changes are prepared by 3D printing *** effect of radial gradient structure on the pressure output of PTFE/Al has been *** with the morphology change of PTFE,the change of component content in the gradient structure has an obvious effect on the pressure output of the PTFE/Al ***,the relationships of the morphology,content of PTFE and the combustion reaction of the PTFE/Al cylinder reveal that the cylinder shows a more complex flame propagation process than *** results could provide a strategy to improve the combustion and pressure output of PTFE/Al.

关键词： PTFE/Al composite Gradient structure Radial gradient Pressure output