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new measurements and reanalysis of^14n elastic scattering on^10B target

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Chinese Physics C 2020年第10期44卷 115-123页

作者： Marzh.n nassurlla n.Burtebayev T.Kh.Sadykov I.Boztosun n.Amangeldi D.Alimov zh.Kerimkulov J.Burtebayeva Maulen nassurlla A.Kurakhmedov S.B.Sakuta Mesut Karakoc Awad A.Ibraheem K.W.Kemper sh.Hamada Institute of nuclear Physics AlmatyKazakhstan Satbayev University Institute of physics and technology050032AlmatyKazakhstan Al-Farabi Kazakh national University AlmatyKazakhstan Department of Physics Akdeniz UniversityAntalyaTurkey L.n.Gumilyov Eurasian national University AstanaKazakhstan national Research Center“Kurchatov Institute” MoscowRussia Physics Department King Khalid UniversityAbhaSaudi Arabia Physics Department Al-Azhar UniversityAssiut BranchAssiut 71524Egypt Department of Physics Florida State UniversityTallahasseeFlorida 32306USA Faculty of Science Tanta UniversityTantaEgypt

The angular distributions of elastic scattering of^14n ions on^10B targets have been measured at incident beam energies of 21.0 and 24.5 *** distributions at higher energies 38–94.0 MeV(previously measured)were also included in the *** data were analyzed within the framework of the optical model and the distorted waves Born approximation *** observed rise in cross sections at large angles was interpreted as a possible contribution of theα-cluster exchange *** amplitudes SA2 and SA4 for the configuration^14n→^10B+αwere *** average values are 0.58±0.10 and 0.81±0.12 for SA2 and SA4,respectively,suggesting that the exchange mechanism is a major component of the elastic scattering for this *** energy dependence of the depths for the real and imaginary potentials was found.

关键词： elastic scattering optical model potential DWBA method spectroscopic amplitudes

Polymorphisms at GSTM 1, GSTP 1, GSTT 1 Detoxification Genes Loci and Risk of Breast Cancer in Kazakhstan Population

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Advances in Breast Cancer Research 2013年第4期2卷 114-118页

作者： T. S. Balmukhanov A. K. Khanseitova V. G. nigmatova E. E. Ash.rbekov sh. zh. Talaeva n. A. Aitkhozh.na Institute of Molecular Biology & Biochemistry Almaty Kazakhstan

Associations of null polymorphism (copy number variation) of detoxification genes GSTM1, GSTT1 and GSTP1 (at rs2495636, 105 Ile/Val) with the breast cancer (BC) were assessed in two main ethnic groups of the Republic of Kazakhstan (Kazakhs and Russians). Total number of patients was 181, and of controls 397. Statistically significant difference was observed between BC patients and healthy individuals in alleles frequency (χ2 = 4.89, р = 0.007) of GSTP1 gene at rs2495636 (105 Ile/Val) among the Kazakhs ethnic group. Difference in genotypes distribution (χ2 =5.26, р = 0.076) at this site is approximating to be statistically significant. In the Russian group, no differences were found in genotypes and alleles atrs 2495636 of GSTP1 gene between cases and controls. There was no significant difference between null polymorphism (copy number variation) of GSTM1 and GSTT1 genes among cases and controls in both ethnic groups.

关键词： Breast Cancer Gene Polymorphism GSTM 1 GSTP 1 GSTT 1 Genes Kazakhstan

Associations of Polymorphisms of the CYP1A1 and CYP1B1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan

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Advances in Breast Cancer Research 2013年第3期2卷 51-55页

作者： T. S. Balmukhanov A. K. Khanseitova V. G. nigmatova S. P. Varchenko sh. zh. Talaeva n. A. Aitkhozh.na Structural and Functional Genomics Laboratory Institute of Molecular Biology and Biochemistry Almaty Kazakhstan

Associations of polymorphisms in rs4646903 site of CYP1A1 and rs1056836 site of CYP1B1 genes with the breast cancer (BC) were studied in two main ethnic groups of Kazakhstan Republic (Kazakhs and Russians). Total number of BC patients was 181, controls—397. The statistically significant differences were revealed in allele frequencies (χ2 = 5.93, р = 0.004) and in genotypes distribution (χ2 = 8.71, р = 0.015) in rs4646903 site of CYP1A1 gene in Kazakh but not in Russian group. The study of CYP1В1 rs1056836 site demonstrated differences in genotype distributions (χ2 = 7.48, р = 0.023) between BC patients and controls in Russian but not in Kazakh ethnic group.

关键词： Breast Cancer Gene Polymorphism CYP1A1 CYP1B1 Kazakhstan

Mathematical modeling of the aerodynamic coefficients of a sail blade

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Advances in Aerodynamics 2023年第1期5卷 267-281页

作者： Akmaral zh.Tleubergenova nazgul K.Tanash.va Kulzh.n M.sh.imerdenova Serik S.Kassymov Asem R.Bakhtybekova nurgul n.sh.yush.ayeva Saule zh.Uzbergenova Gulden A.Ranova Department of Engineering Thermophysics named after Professor zh.S.Akylbayev E.A.Buketov Karaganda UniversityKaraganda 100028Kazakhstan Scientific Research Center“Alternative Energy” E.A.Buketov Karaganda UniversityKaraganda 100028Kazakhstan Department of Science E.A.Buketov Karaganda UniversityKaraganda 100028Kazakhstan Department of Mathematics and Physics Sh.Ualikhanov Kokshetau UniversityKokshetau 020000Kazakhstan Department of Engineering Technologies and Transport Sh.Ualikhanov Kokshetau UniversityKokshetau 020000Kazakhstan

The authors of the work numerically studied the aerodynamic coefficients of the sail blade,during which the patterns of three-dimensional flow around airflow and the pressure distribution field were *** triangular sail blade is used as the power element of wind *** sail blade modeling was based on the Reynolds-averaged navier-Stokes equations(RAnS)using the AnSYS FLUEnT computer program.A flow pattern is obtained,which gives a physical explanation of the nature of the airflow around the sail blade and the pressure distribution *** analyses of theory and experiment are *** the range of Reynolds numbers from 0.5×10^(4) to 2.5×10^(4),the change in the drag force coefficient is from 1.04 to 0.54,and the difference in the lift force coefficient is from 0.52 to 0.33.

关键词： Sail blade Wind turbine Modeling AnSYS FLUEnT Aerodynamic coefficients

Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP

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Journal of Molecular Cell Biology 2023年第2期15卷 3-16页

作者： Weicheng Luo yi Li yi Zeng yining Li Minzh.ng Cheng Cheng zh.ng Fei Li yiqing Wu Chunhong Huang Xiaolong Yang Joachim Kremerskothen Jianmin zh.ng Chunbo zh.ng sh.o Tu zhihua Li zhĳun Luo zh.nghong Lin Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330031China Department of Rheumatology and Clinical Immunology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Pathology and Molecular Medicine Queen’s UniversityKingstonON K7L 3N6Canada Department of nephrology Hypertension and RheumatologyUniversity Hospital MünsterMünster 48149Germany Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNY 14203USA School of Pharmacy Nanchang University Jiangxi Medical CollegeNanchang 330008China Key Laboratory of Breast Diseases of Jiangxi Province Nanchang People’s HospitalNanchang 330025China Department of Pathology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330006China School of Life Sciences Chongqing UniversityChongqing 405200China

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRnAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little ***, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner.

关键词： TGF-β TEAD4 p300 signaling regulation transcriptional activity hepatocellular carcinoma

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广东农村居民消费结构变化的实证分析

消费经济 2005年第6期21卷 54-57页

作者：丁元周树高暨南大学广东广州510632 广东技术师范学院广东广州510665

本文从各类支出比重、消费结构变动度等方面分析了广东农村居民消费结构的变化。同时,又运用ELES对广东农村居民的消费倾向和需求弹性进行了实证研究,结果表明可根据消费倾向变化、降价和提高居民收入来有效促进消费需求。

关键词：广东农村居民消费结构实证分析

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鞑靼滨藜挥发性化学成分分析

天然产物研究与开发 2010年第6期22卷 1040-1044页

作者： Janar Jenis G.sh.Burash.va 阿吉艾克拜尔.艾萨巴杭 zh.A Abilov 哈萨克斯坦国立大学化学系阿拉木图050012 中科院新疆理化技术研究所乌鲁木齐830011

对鞑靼滨藜全草的挥发性化学成分进行分析。采用水蒸气蒸馏法及索氏提取法提取鞑靼滨藜全草中的挥发性化学成分,用GC-MS联用技术分析其化学组成,计算其相对百分含量,并对两种提取方法进行比较研究。结果表明:水蒸气蒸馏法提取物的成分... 详细信息

对鞑靼滨藜全草的挥发性化学成分进行分析。采用水蒸气蒸馏法及索氏提取法提取鞑靼滨藜全草中的挥发性化学成分,用GC-MS联用技术分析其化学组成,计算其相对百分含量,并对两种提取方法进行比较研究。结果表明:水蒸气蒸馏法提取物的成分比索氏提取法较多。从水蒸气蒸馏法分离出的53个色谱峰中鉴定了51种成分,含量最高的是茴香脑(45.84%),其次为正二十七烷(9.28%),羟基吲哚(6.81%),α-羟基-2-甲基丙基苯乙酸酯(4.03%)。从索氏提取法分离出的26个色谱峰中鉴定了22种成分,含量最高的是正二十九烷(22.63%),其次为硬酯酸(16.69%),十六醛(6.89%),棕榈酸(5.43%)。

关键词：鞑靼滨藜挥发性化学成分水蒸气蒸馏法索氏提取法

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捷联式速率陀螺仪漂移误差的分析和估算

国防科技大学学报 1980年第1期 185-200页

作者：冯振声

本文从比较平台式与捷联式惯导系统的陀螺仪角度出发,叙述了飞行器捷联惯导系统对陀螺仪性能的要求;推导了动态环境下捷联速率陀螺仪的数学模型及其漂移误差的数学模型;对漂移误差进行了分析,并给出了漂移误差的表达式;最后,用平稳随机... 详细信息

本文从比较平台式与捷联式惯导系统的陀螺仪角度出发,叙述了飞行器捷联惯导系统对陀螺仪性能的要求;推导了动态环境下捷联速率陀螺仪的数学模型及其漂移误差的数学模型;对漂移误差进行了分析,并给出了漂移误差的表达式;最后,用平稳随机过程理论估算了动态环境下捷联速率陀螺的动态误差。

关键词：陀螺仪漂移数学模型动态环境试验模型漂移误差捷联式惯导系统

Enhanced removal of bisphenol A by cyclodextrin in photocatalytic systems:Degradation intermediates and toxicity evaluation

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Chinese Chemical Letters 2020年第10期31卷 2623-2626页

作者： yi zhou Jie He Jian Lu Yongdi Liu Yanbo zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China national Engineering Laboratory for Industrial Wastewater Treatment East China University of Science and TechnologyShanghai 200237China

At present,the assessment of photooxidation system mainly focuses on the photodegradation efficie ncy of target pollutant,lacking of the toxicity assessment in the photocatalysis ***,photodecomposition of bisphenol A(BPA)was used to investigate the performance of several cyclodextrin modified ***,the comprehensive toxicity changes of BPA under different photocatalytic oxidation conditions were ***β-cyclodextrin(β-CD)modified photocatalyst,including titanium dioxide(CM-β-CD-TiO_(2)),carbon nitride(CM-β-CD-C_(3)n_(4))and cadmium sulfide(sh.β-CD-AM/CdS)exhibit high degradation rate and mineralization efficiency of *** highest total organic carbon(TOC)removal of BPA observed in the oxidation system of sh.β-CD-AM/CdS nano reactor(73.4%).The main oxidation intermediates in these systems were detected,and the comprehension toxicity of BPA and its oxidation intermediates in different system were compared by toxicity estimation software tool(T.E.S.T.)based on quantitative structure-activity relationsh.p(QSAR)*** results sh.w thatβ-CD can facilitate the photodecomposition of the target *** r,many oxidation intermediates with high compre hensive toxicity,eve n in the oxidation system with high B PA removal,can still be *** re,not only decomposition of target contaminant but also the comprehensive toxicity of oxidation intermediates sh.uld be regarded as index to evaluate a photocatalysis technology.

关键词： Cyclodextrin Bisphenol A Photocatalysis Toxicity Carbon nitride