检索结果-南通市图书馆

Transcriptional profiles in zebrafish.atp7a mutants and responses of atp7a mutants to Cu stress

Water Biology and Security 2023年第3期2卷 87-97页

作者： You Wu Wenye liu Lingya Li Zhipeng Tai Jing-Xia liu College of Fish.ries Key Laboratory of Freshwater Animal BreedingMinistry of AgricultureHuazhong Agricultural UniversityWuhan430070China

As a copper(Cu)transport ATPase,ATP7A plays an important role in maintaining Cu homeostasis in the body,but the developmental and physiological roles of atp7a in zebrafish.embryogenesis are rarely *** this study,normal morphological phenotypes of atp7a^(−/−)homozygous zebrafish.were observed at both embryonic and adult stages,however,atp7a^(−/−)larvae exhibited delayed touch response and obvious transcriptome *** with the WT(wild type),differentially expressed genes(DEGs)in atp7a^(−/−)larvae sh.wed the enrichment in gene ontology(GO)terms related to several processes including ATPase activity,oxidoreductase activity,active transmembrane transporter activity,ion binding,and the citrate ***,decreases in both ATP content and Na+/K+-ATPase activity in atp7a^(−/−)embryos and larvae were unveiled.57 overlapping DEGs were found both in WT stressed with Cu and in WT mutated with atp7a,and GO term analysis indicated the enrichment in the genes related to neurexin family protein binding and neuronal cell-cell ***,42 overlapping DEGs in Cu stressed WT and Cu stressed atp7a^(−/−)were *** term analysis sh.wed an enrichment in the genes related to heme binding,implying that Cu was independent of the integral function of atp7a to affect heme *** addition,genes involved in the negative regulation of angiogenesis were down-regulated in atp7a^(−/−)mutants with and without Cu stress,which failed to occur in WT,implying that the integral function of atp7a is required for maintaining the normal expression of angiogenesis *** integrative data in this study demonstrated that atp7a is required for ion transport and angiogenesis,and for Cu-induced neurexin family protein binding defects,rather than for Cu-induced heme binding defects,during zebraﬁsh.*** findings provide possible clues for human diseases with ATP7A dysfunction and imbalanced Cu homeostasis.

关键词： Angiogenesis ATP7A Cu stress Heme binding Ion transport Neurexin family protein binding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hybrid Three-Dimensional Spiral WSe2 Plasmonic Structures for Highly Efficient Second-Order Nonlinear Parametric Processes

引用

Research 2018年第1期2018卷 144-151页

作者： Xianqing Lin Yingying liu Kang Wang Xiaolong liu Yongli Yan Yong Jun Li Jiannian Yao Yong sh.ng Zhao Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Two-dimensional(2D)layered materials,with large second-order nonlinear susceptibility,are currently growing as an ideal candidate for fulflling tunable nanoscale coherent light through the second-order nonlinear optical parametric ***,the atomic thickness of 2D layered materials leads to poor feld confnement and weak light-matter interaction at nanoscale,resulting in low nonlinear conversion ***,hybrid three-dimensional(3D)spiral WSe2 plasmonic structures are fabricated for highly efcient second harmonic generation(sh.)and sum-frequency generation(SFG)based on the enhanced light-matter interaction in hybrid plasmonic *** 3D spiral WSe2,with AA lattice stacking,exhibits efcient sh.radiation due to the constructive interference of nonlinear polarization between the neighboring atomic ***,extremely high external sh. conversion efciency(about 2.437×10−5)is ***,the ease of phase-matching condition combined with the enhanced light-matter interaction in hybrid plasmonic structure brings about efcient sh. and SFG *** results would provide enlightenment for the construction of typical structures for efcient nonlinear processes.

关键词： nonlinear layered Highly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomic footprints of sorghum domestication and breeding selection for multiple end uses

引用

Molecular Plant 2022年第3期15卷 537-551页

作者： Xiaoyuan Wu Yuanming liu Hong Luo Li sh.ng Chuanyuan Leng Zhiquan liu Zhigang Li Xiaochun Lu Hongwei Cai Huaiqing Hao Hai-Chun Jing Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China Engineering Laboratory for Grass-Based Livestock Husbandry Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Institute of Sorghum Research Liaoning Academy of Agricultural SciencesShenyang 110161China

Domestication and diversification have had profound effects on crop *** in Africa and subsequently spreading to different continents,sorghum(Sorghum bicolor)has experienced multiple onsets of domestication and intensive breeding selection for various end ***,how these processes have sh.ped sorghum genomes is not fully *** the present study,population genomics analyses were performed on a worldwide collection of 445 sorghum accessions,covering wild sorghum and four end-use subpopulations with diverse agronomic *** genetic exchanges were found among various subpopulations,and strong selective sweeps affected 14.68%(∼107.5 Mb)of the sorghum genome,including 3649,4287,and 3888 genes during sorghum domestication,improvement of grain sorghum,and improvement of sweet sorghum,*** different models of haplotype changes in domestication genes from wild sorghum to landraces and improved sorghum were observed,and sh.-and SbTB1-type genes were representative of two prominent models,one of soft selection or multiple origins and one of hard selection or an early single domestication *** also demonstrated that the Dry gene,which regulates stem juiciness,was unconsciously selected during the improvement of grain *** together,these findings provide new genomic insights into sorghum domestication and breeding selection,and will facilitate further dissection of the domestication and molecular breeding of sorghum.

关键词： sorghum(Sorghum bicolor) genomic footprints end uses domestication and diversification genes SbTB1 sh. and Dry molecular breeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inter-hemispheric comparison of climate change in thelast millennium based on the ECHO-G simulation

引用

Chinese Science Bulletin 2008年第17期53卷 2692-2700页

作者： KUANG XueYuan liu Jian WANG HongLi WANG SuMin State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Nanjing 210008 China Guangxi Climate Center Nanning 530022 China

The commonality and difference in the variations of temperature and precipitation between the Northern Hemisphere (NH) and Southern Hemispheres (sh. in the last millennium are investigated by analysis of the millennium simulation with the ECHO-G coupled climate model. The NH mean temperature variations are generally consistent with those of the sh.counterpart on the interannual, decadal and centennial time scales. But, the transition times between the medieval warm period (MWP), the little ice age (LIA), and the present-day warm period (PWP) in the NH leads that in the sh. and the anomaly amplitude in the NH is significantly larger than the sh.counterpart. For the precipitation variations, the NH mean precipitation varies in-phase with the sh.mean precipitation on decadal and centennial scales (mainly in the mid-high latitudes) but out-of-phase on the interannual scale (mainly in the low latitudes). During the MWP the warming has comparable amplitude in the NH and sh. however, during the PWP the NH warming is considerably stronger than the sh.warming. Further, the present-day temperature rises in the NH high latitudes but decreases in the sh.high latitudes, which is very different from the warming pattern during the MWP. Since during the MWP the greenhouse gases (GHG) concentration stayed at a low level, we infer that the present-day opposite temperature tendency in the high latitudes between the two hemispheres may be related to the increase of the GHG concentration.

关键词：气候变化中世纪温暖期一千年温度降水

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-dimensional materials:From mechanical properties to flexible mechanical sensors

引用

InfoMat 2020年第6期2卷 1077-1094页

作者： Hanjun Jiang Lu Zheng Zheng liu Xuewen Wang Institute of Flexible Electronics Northwestern Polytechnical UniversityXi'anChina MIIT Key Laboratory of Flexible Electronics(KLoFE) Northwestern Polytechnical UniversityXi'anChina sh.anxi Key Laboratory of Flexible Electronics(KLoFE) Northwestern Polytechnical UniversityXi'anChina School of Materials Science and Engineering Nanyang Technological UniversitySingapore Centre for Micro-/Nano-electronics(NOVITAS) School of Electrical&Electronic EngineeringNanyang Technological UniversitySingapore CINTRACNRS/NTU/THALES Research Techno PlazaSingapore

Two-dimensional(2D)materials have great potential in the fields of flexible electronics and photoelectronic devices due to their unique properties derived by special *** study of the mechanical properties of 2D materials plays an important role in next-generation flexible mechanical electronic device ***,traditional experiment models and measurement methods are not suitable for 2D materials due to their atomically ultrathin thickness,which limits both the theoretical research and practical value of the 2D *** this review,we briefly summarize the characterization of mechanical properties of 2D materials by in situ probe nanoindentation experiments,and discuss the effect of thickness,grain boundary,and interlayer *** introduce the strain-induced effect on electrical properties and optical properties of 2D ***,we generalize the mechanical sensors based on various 2D materials and their future potential applications in flexible and wearable electronic ***,we discuss the state of the art for the mechanical properties of 2D materials and their opportunities and challenges in both basic research and practical applications.

关键词： 2D materials flexible mechanical sensor mechanical property strain effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贵州省扶贫生态移民工程与城镇化推进政策研究

引用

贵阳学院学报（社会科学版） 2015年第2期10卷 96-100 109页

作者：刘诗宇贵阳学院经济管理学院贵州贵阳550005

关于城镇化实现路径的分歧和争论一直贯穿于我国实际改革的过程中,以城市圈、大都市区等为区域核心的强力带动,以及针对小城镇尤其是农村的就地城镇化,都在交替实践。当前,在低碳经济背景下,根据有关文件和会议精神,结合贵州省省情提出... 详细信息

关于城镇化实现路径的分歧和争论一直贯穿于我国实际改革的过程中,以城市圈、大都市区等为区域核心的强力带动,以及针对小城镇尤其是农村的就地城镇化,都在交替实践。当前,在低碳经济背景下,根据有关文件和会议精神,结合贵州省省情提出"扶贫生态移民工程"作为城镇化推进的实现路径,具有其科学内涵。基于对城镇化推进与扶贫生态移民工程的内涵与联系,扶贫生态移民工程实施环境的论述与分析,提出了扶贫生态移民工程与城镇化推进的政策建议。

关键词：城镇化扶贫生态移民政策研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research Progress on Plant Anti-Freeze Proteins

引用

Phyton-International Journal of Experimental Botany 2024年第6期93卷 1263-1274页

作者： Zhengyang Zhang Weixue liu Yinran Huang Ping Li College of Landscape and Tourism Hebei Agricultural UniversityBaoding071000China

Plant antifreeze proteins(AFPs)are special proteins that can protect plant cells from ice crystal damage in low-temperature environments,and they play a crucial role in the process of plants adapting to cold *** with these characteristics have been found inﬁsh.living in cold regions,as well as many plants and *** research on plant AFPs started relatively late,their application prospects are broad,leading to the attention of many researchers to the isolation,cloning,and genetic improvement of plant AFP *** have found that the distribution of AFPs in different species seems to be the result of independent evolu-tionary *** the AFPs found inﬁsh.and insects,plant AFPs have multiple hydrophilic ice-binding domains,and their recrystallization inhibition activity is about 10–100 times that ofﬁsh.and insect *** different plant AFPs have the characteristics of low TH and high RI,their DNA and amino acid sequences are completely different,with small *** in-depth research and analysis of the character-istics and mechanisms of plant AFPs,not only has our understanding of plant antifreeze mechanisms been enriched,but it can also be used to improve crop varieties and enhance their freezing tolerance,yield,and quality through genetic *** addition,the study of plant AFPs also contributes to our understanding of freezing resistance mechanisms in other organisms and provides new research directions for theﬁeld of ***,based on the analysis of relevant literature,this article will delve into the concepts,character-istics,research methods,and mechanisms of plant AFPs,summarize the latest research progress and application prospects of AFPs in plant,and provide prospects for the future development of AFP gene research.

关键词： Plant anti-freeze proteins recrystallization inhibition activity freezing tolerance application prospects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantum chemical study on insertion and abstraction reaction of dichlorocarbene with methyl alcohol and methyl mercaptan

引用

Science China Chemistry 2009年第3期52卷 304-312页

作者： LI ZhiFeng ZHU YuanCheng LI HuiXue liu XinWen LU XiaoQuan College of Life Science and Chemistry Tianshui Normal UniversityTianshui 741001China Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China

The insertion and abstraction reaction mechanisms of singlet and triplet CCl2 with CH3MH (M=O, S) have been studied by using the DFT, NBO and AIM methods. The geometries of reactions, the transition state and products were completely optimized by B3LYP/6–311G(d, p). All the energy of the species was obtained at the CCSD(T)/6–311G(d, p) level. The calculated results indicated that the major pathways of the reaction were obtained on the singlet potential energy surface. The singlet CCl2 can not only trigger the insertion reaction with C-H and M-H in four pathways, by which the products P1 [CH3OCHCl2, reaction I(1)], P3[Cl2HCCH2OH, reaction I(2)], P5[CH3SCHCl2, reaction II(1)] and P7[Cl2HCCH2sh. reaction II(2)] are produced respectively, but also abstract M-H, resulting P4 [CH2O+CH2Cl2, reaction I(3)] and P8[CH2S+CH2Cl2, reaction II(3)]. In addition, the important geometries in domain pathways have been studied by AIM and NBO theories.

关键词： carbene alcohol DFT NBO AIM insertion reaction abstraction reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分化型甲状腺癌围手术期循环血微转移相关因素分析

引用

中国普通外科杂志 2015年第9期24卷 1333-1337页

作者：刘勤江马世红田尤新甘肃省肿瘤医院头颈外科甘肃兰州730050

目的:探讨分化型甲状腺癌围手术期循环血微转移存在状况及影响因素。方法:采用流式细胞术(FCM)对327例手术治疗的分化型甲状腺癌,围手术期检测外周血微转移并对其进行相关因素分析。结果:分化型甲状腺癌术前循环血微转移阳性93例(28.4%)... 详细信息

目的:探讨分化型甲状腺癌围手术期循环血微转移存在状况及影响因素。方法:采用流式细胞术(FCM)对327例手术治疗的分化型甲状腺癌,围手术期检测外周血微转移并对其进行相关因素分析。结果:分化型甲状腺癌术前循环血微转移阳性93例(28.4%),其中74例(74/93)术后1周持续阳性、35例(35/74)术后4周仍呈阳性。循环血微转移在术前及术后1周阳性率与肿瘤大小、淋巴结分期有关(P0.05);在术后4周时微转移阳性率仅与肿瘤的病理分化程度有关(P<0.05)。在术前微转移阴性者中,有34例(17.3%)术后1周转呈阳性,其阳性率仅与肿瘤大小有关(P<0.001)。结论:分化型甲状腺癌循环血微转移与肿瘤大小、淋巴结分期及手术刺激密切相关,肿瘤分化程度是循环血微转移阳性持续存在的主要因素。

关键词：甲状腺肿瘤肿瘤转移流式细胞术循环肿瘤细胞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aversatile β-cyclodextrin functionalized silver nanoparticle monolayer for capture of methyl orange from complex wastewater

引用

Chinese Chemical Letters 2020年第2期31卷 539-542页

作者： Jun liu Cancan Zhang sh.oxuan Zhang Huajiang Yu Wei Xie Key Lab of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China

The toxic organic dye contaminants in wastewater are extremely harmful to the *** enhanced Raman scattering(SERS) is a technique with high sensitivity and chemical specificity which fulfills the requirements for monitoring dye contaminants in ***,as one of the common dye contaminants,methyl orange(MO) has very weak affinity to metallic surfaces and is difficult to be detected by SERS at low ***,a new type of SERS substrate with Ag nanoparticle monolayer functionalized by mono-6-deoxy-6-thio-β-cyclodextrin(β-CD-sh. was prepared to efficiently capture and detect MO in wastewater with a limit of detection of 5×10^(-7) mol/*** hydrophobic cavity of β-CD is responsible for the efficient trap and enrichment of MO on the Ag NPs surface,achieving a strong SERS signal of MO at low concentrations and at different pH *** study provides new insight into designing a well-performed adsorbent for the capture and detection of organic contaminants.

关键词： Dye contaminants Methyl orange SERS Cyclodextrin Wastewater

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：