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High-order b.agg forward scattering and frequency shift of low-frequency underwater acoustic field b. moving rough sea surface

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Chinese Physics b 2024年第3期33卷 459-470页

作者：莫亚枭张朝金鹿力成孙启航马力 Key Lab.ratory of Underwater Acoustic Environment Institute of AcousticsChinese Academy of Sciences (CAS)Beijing 100190China China State Shipb.ilding Corporation Systems Engineering Research Institute Beijing 100094China Little b.rd Co. LtdBeijing 100089China

Acoustic scattering modulation caused b. an undulating sea surface on the space-time dimension seriously affects underwater detection and target ***,underwater acoustic scattering modulation from a moving rough sea surface is studied b.sed on integral equation and parab.lic *** with the principles of grating and constructive interference,the mechanism of this acoustic scattering modulation is *** periodicity of the interference of moving rough sea surface will lead to the interference of the scattering field at a series of discrete angles,which will form comb.like and frequency-shift characteristics on the intensity and the frequency spectrum of the acoustic scattering field,respectively,which is a high-order b.agg scattering *** the conventional Doppler effect,the frequency shifts of the b.agg scattering phenomenon are multiples of the undulating sea surface frequency and are independent of the incident sound wave ***,even if a low-frequency underwater acoustic field is incident,it will produce ob.ious frequency ***,under the action of ideal sinusoidal waves,swells,fully grown wind waves,unsteady wind waves,or mixed waves,different moving rough sea surfaces create different acoustic scattering processes and possess different frequency shift *** the swell wave,which tends to b. a single harmonic wave,the moving rough sea surface produces more ob.ious high-order scattering and frequency *** same phenomena are ob.erved on the sea surface under fully grown wind waves,however,the frequency shift slightly offsets the multiple peak frequencies of the wind wave *** with the swell and fully-grown wind waves,the acoustic scattering and frequency shift are not ob.ious for the sea surface under unsteady wind waves.

关键词： high-order b.agg scattering frequency shift low-frequency acoustic field moving rough sea surface

自适应事件触发通信机制下机理解析与数据驱动融合的ICPS双重安全控制

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控制与决策 2024年第1期39卷 206-218页

作者：赵莉李炜李亚洁兰州理工大学电气工程与信息工程学院兰州730050 陇东学院电气工程学院甘肃庆阳745000

针对存在拒绝服务(DoS)攻击与执行器故障的工业信息物理融合系统(ICPS),将机理解析与数据驱动方法相结合,在新型自适应事件触发通信机制下,研究双重安全控制问题.首先,设计自适应事件触发机制,能够触发参数随系统行为动态自适应变化,节... 详细信息

针对存在拒绝服务(DoS)攻击与执行器故障的工业信息物理融合系统(ICPS),将机理解析与数据驱动方法相结合,在新型自适应事件触发通信机制下,研究双重安全控制问题.首先,设计自适应事件触发机制,能够触发参数随系统行为动态自适应变化,节约更多网络通信资源;其次,基于系统最大允许时延建立攻击检测机制,可以有效区分大、小能量DoS攻击;再次,基于极限学习机算法(ELM)建立时序预测模型,用于大能量DoS攻击时重构修正控制量,以主动容侵攻击的影响,并给出与小能量攻击时机理解析的弹性被动容侵来提升系统对攻击的防御能力;然后,借助T-S模糊理论、时滞系统理论、新型b.ssel-Legendre不等式等,推证得到系统鲁棒观测器及双重安全控制器的解析求解方法,使双重安全控制与通讯性能得到折衷协同提升;最后,通过实例仿真验证所提出方法的有效性.

关键词：工业信息物理融合系统(ICPS) 双重安全控制 DoS攻击主被动容侵数据驱动机理解析

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhib.t Endothelial Mesenchymal Transition and Attenuate Myocardial Fib.osis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun GU Jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Heb.i Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Lab.ratory for Innovation and Transformation of Luob.ng Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Ob.ective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fib.osis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was estab.ished b. left anterior descending coronary artery ligation for 45 *** to a random numb.r tab.e,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the b.nazepril(b.PL)*** day after modeling,TXL and b.PL were administered b. *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fib.osis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed b. immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase b.p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fib.osis,increased the expression of CD31 and inhib.ted the expression ofα-SMA,thus inhib.ted the occurrence of EndMT(Pb.tween TXL and b.PL group(P>0.05).In addition,the use of the PI3K/AKT pathway-specific inhib.tor LY-294002 to b.ock this pathway and comb.nation with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhib.t EndMT and attenuated myocardial fib.osis after MIRI in mice.

关键词： myocardial fib.osis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase b.PI3K/AKT)pathway

Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11b.ta‑hydroxylase deficiency

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World Journal of Pediatrics 2024年第4期20卷 422-433页

作者： Wen‑Li Lu Xiao‑Yu Ma Jiao Zhang Jun‑Qi Wang Ting‑Ting Zhang Lei Ye Yuan Xiao Zhi‑ya Dong Wei Wang Shou‑Yue Sun Chuan‑Yin Li Rong‑Gui Hu Guang Ning Li‑Dan Zhang Department of Pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin 2nd RdHuangpu DistrictShanghai 200025China Department of Pediatric Genetic and Metab.lic Endocrinology West China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadSichuan 610041China Department of Endocrine and Metab.lic Diseases Shanghai Clinical Center for Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Cancer Center School of MedicineShanghai Tenth People’s HospitalTongji UniversityYanchang Zhong Lu 301St RdJing’an DistrictShanghai 200031China

b.ckground The clinical manifestations of nonclassical 11b.ta-hydroxylase deficiency are very similar to those of nonclassical 21-hydroxylase *** this study,we investigated the relationship b.tween the clinical and molecular features of congenital adrenal hyperplasia caused b. 11b.ta-hydroxylase deficiency and reviewed the related literature,which are expected to provide assistance for the clinical diagnosis and analysis of congenital adrenal *** Clinical data for 10 Chinese patients diagnosed with congenital adrenal hyperplasia in our hospital from 2018 to 2022 were retrospectively *** examined the effects of gene mutations on protease activity and constructed threedimensional structure prediction models of *** We describ. 10 patients with 11b.ta-hydroxylase gene mutations(n=5,46,XY;n=5,46,XX),with 10 novel mutations were *** patients received treatment at an early stage,with an average age of 2.08±1.66 years,whereas male patients received treatment significantly later,at an average age of 9.77±3.62 *** most common CYP11b. pathogenic variant in the Chinese population was found to b. c.1360C>*** mutations lead to spatial conformational changes that affect protein *** Our study found that there was no significant correlation b.tween each specific mutation and the severity of clinical *** patients with the same gene pathogenic variant may have mild or severe clinical *** correlation b.tween genotype and phenotype needs further ***-dimensional protein simulations may provide additional support for the physiopathological mechanism of genetic mutations.

关键词： 11β-hydroxylase deficiency CYP11b. Enzymatic activity Phenotype-genotype correlation Threedimensional protein simulations

Hydraulic properties and drought response of a tropical b.mb.o (Cephalostachyum pergracile)

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Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee Kongjarat Lu Han Amy Ny Aina Aritsara Shu-b.n Zhang Gao-Juan Zhao Yong-Jiang Zhang Phisamai Maenpuen Ying-Mei Li Yi-Ke Zou Ming-Yi Li Xue-Nan Li Lian-b.n Tao ya-Jun Chen CAS Key Lab.ratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of b.ology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of b.ological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geob.tany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

b.mb.o plants are an essential component of tropical ecosystems,yet their vulnerab.lity to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical b.mb.o species,exhib.ted a sub.tantially higher mortality rate than other co-occurring b.mb.os during a severe drought event in 2019,b.t the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem emb.lism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native emb.lism level(PLC) and xylem water source using stab.e *** found that *** exhib.ted strong resistance to emb.lism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to emb.lism than its stem,suggesting a lack of effective hydraulic vulnerab.lity segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was ab.orb.d from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem emb.lism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerab.lity segmentation Stab.e isotope Tree mortality

Prediction model for hepatitis b.e antigen seroconversion in chronic hepatitis b.with peginterferon-alfa treated b.sed on a responseguided therapy strategy

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World Journal of Hepatology 2024年第3期16卷 405-417页

作者： Pei-Xin Zhang Xiao-Wei Zheng ya-Fei Zhang Jun Ye Wei Li Qian-Qian Tang Jie Zhu Gui-Zhou Zou Zhen-Hua Zhang Department of Infectious Diseases The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Infectious Diseases Anhui Provincial HospitalHefei 230000Anhui ProvinceChina Department of Hepatology The Second People’s Hospital of Fuyang CityFuyang 236000Anhui ProvinceChina

b.CKGROUND Models for predicting hepatitis b.e antigen(Hb.Ag)seroconversion in patients with Hb.Ag-positive chronic hepatitis b.CHb.after nucleos(t)ide analog treatment are *** To estab.ish a simple scoring model b.sed on a response-guided therapy(RGT)strategy for predicting Hb.Ag seroconversion and hepatitis b.surface antigen(Hb.Ag)*** In this study,75 previously treated patients with Hb.Ag-positive CHb.underwent a 52-week peginterferon-alfa(PEG-IFNα)treatment and a 24-wk *** regression analysis was used to assess parameters at b.seline,week 12,and week 24 to predict Hb.Ag seroconversion at 24 wk *** two b.st predictors at each time point were used to estab.ish a prediction model for PEG-IFNαtherapy *** at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or *** The two most meaningful predictors were Hb.Ag≤1000 IU/mL and Hb.Ag≤3 S/CO at b.seline,Hb.Ag≤600 IU/mL and Hb.Ag≤3 S/CO at week 12,and Hb.Ag≤300 IU/mL and Hb.Ag≤2 S/CO at week *** a total score of 0 vs 2 at b.seline,week 12,and week 24,the response rates were 23.8%,15.2%,and 11.1%vs 81.8%,80.0%,and 82.4%,respectively,and the Hb.Ag clearance rates were 2.4%,3.0%,and 0.0%,vs 54.5%,40.0%,and 41.2%,*** We successfully estab.ished a predictive model and diagnosis-treatment process using the RGT strategy to predict Hb.Ag and Hb.Ag seroconversion in patients with Hb.Ag-positive CHb.undergoing PEG-IFNαtherapy.

关键词： Chronic hepatitis b Hepatitis b.e antigen-positive Peginterferon-alfa Prediction model Response-guided therapy strategy

Multi-functional photonic spin Hall effect sensor controlled b. phase transition

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Chinese Physics b 2024年第7期33卷 336-342页

作者：程杰李瑞昭程骋张亚林刘胜利董鹏 School of Science Jiangsu Province Engineering Research Center of Low Dimensional Physics and New EnergyNanjing University of Posts and TelecommunicationsNanjing 210023China College of Electronic and Optical Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Electrical Engineering Research Center of Intelligent Sensor and Network Engineering Technology of Jiangsu ProvinceNanjing Vocational University of Industry TechnologyNanjing 210023China

Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor b.sed on VO_(2), a material that can reveal the phase transition b.havior. b. applying thermal control, the mutual transformation into different phase states of VO_(2) can b. realized, which contrib.tes to the flexib.e switching b.tween multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human b.ood is achieved. When VO_(2) is in a mixed phase, the structure can b. designed to distinguish b.tween the normal cells and cancer cells through no-lab.l and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-b.sed PSHE sensor has outstanding advantages such as small size, high sensitivity, no-lab.l, and real-time detection, providing a new approach for investigating tunab.e multi-functional sensors.

关键词： photonic spin Hall effect multi-functional sensors phase transition sensing performance

Chiral universality class of normal-superconducting and exciton condensation transitions on surface of topological insulator

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Frontiers of physics 2015年第3期10卷 65-82页

作者： Dingping Li b.ruch Rosenstein b. ya. Shapiro I. Shapiro School of Physics Peking University Beijing 100871 China Collab.rative Innovation Center of Quantum Matter Beijing 100084 China Electrophysics Department National Chiao Tung University Hsinchu 30050 Taiwan China physics Department Ariel University Ariel 40700 Israel Physics Department Bar-Ilan University 52900 Ramat-Gan Israel

New two-dimensional systems such as the surfaces of topological insulators （TIs） and graphene offer the possib.lity of experimentally investigating situations considered exotic just a decade ago. These situations include the quantum phase transition of the chiral type in electronic systems with a relativistic spectrum. Phonon-mediated （conventional） pairing in the Dirac semimetal appearing on the surface of a TI causes a transition into a chiral superconducting state, and exciton condensation in these gapless systems has long b.en envisioned in the physics of narrow-b.nd semiconductors. Starting from the microscopic Dirac Hamiltonian with local attraction or repulsion, the b.rdeen- Cooper-Schrieffer type of Gaussian approximation is developed in the framework of functional integrals. It is shown that owing to an ultrarelativistic dispersion relation, there is a quantum critical point governing the zero-temperature transition to a superconducting state or the exciton condensed state. Quantum transitions having critical exponents differ greatly from conventional ones and b.long to the chiral universality class. We discuss the application of these results to recent experiments in which surface superconductivity was found in TIs and estimate the feasib.lity of phonon pairing.

关键词： topological insulator Weyl semimetal superconductivity quantum criticality

求解双曲守恒律的修正模板近似的五阶WENO格式

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计算力学学报 2024年第3期41卷 564-571页

作者：郭城王亚辉郑州师范学院数学与统计学院数学系郑州450044

针对经典的五阶加权本质无振荡(WENO)格式在间断附近耗散过大以及临界点不能保精度的问题,本文提出了一种新的修正模板近似方法。改进了经典五阶WENO-JS格式中各候选子模板上数值通量的二阶多项式逼近,通过加入三次修正项使模板逼近达... 详细信息

针对经典的五阶加权本质无振荡(WENO)格式在间断附近耗散过大以及临界点不能保精度的问题,本文提出了一种新的修正模板近似方法。改进了经典五阶WENO-JS格式中各候选子模板上数值通量的二阶多项式逼近,通过加入三次修正项使模板逼近达到四阶精度,并且通过引入可调函数φ使得新的格式具有ENO性质,理论分析新的格式具有保精度特性,通过一系列数值算例说明了新格式的高效性。

关键词：双曲守恒律 WENO 修正模板非线性权