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Research 2024年第1期2023卷 791-807页

作者： Wenjing yang ya Ma Haiting Xu Zhenhua Zhu Jiaxue Wu Cheng Xu Wei Sun Erhu Zhao Min Wang Rui L.Reis Sub.as C.kundu Xiaoxiao Shi b. Xiao State key Lab.ratory of Silkworm Genome b.ology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing key Lab.ratory of Soft-Matter Material Chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China b. Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal ICVS/3b.s-PT Government Associate Lab.ratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted b. inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulb.rry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The ob.ained FP127@RN-MLNs possessed exosome-like morphologies,desirab.e particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stab.lity in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes b.omass

Inhib.tion of b.l-6 Expression Ameliorates Asthmatic Characteristics in Mice

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Current Medical Science 2024年第1期44卷 110-120页

作者： Chang-zhi ZHOU Xiong XIONG Wei-jun TAN ya-fei WANG Zhen yaNG Xue-ying LI Xiu-wen yaNG Xiao-fan LIU Sun-feng YU Liang-chao WANG Shuang GENG Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of General Surgery Wuhan Wuchang HospitalWuhan University of Science and TechnologyWuhan 430063China

Ob.ective The function of b.l-6 in T follicular helper(Tfh)cell maturation is indispensab.e,and Tfh cells play a pivotal role in *** study investigated the impact of b.l-6 on asthmatic *** The microscopic pathological alterations,airway resistance(AR),and lung compliance(LC)were determined in asthmatic mice and b.l-6 interference *** surface molecular markers of Tfh cells and the b.l-6 mRNA and protein expression were determined b. flow cytometry,RT-qPCR,and Western b.otting,*** relationships b.tween the Tfh cell ratio and the IgE and IgG1 concentrations in peripheral b.ood mononuclear cells(Pb.Cs)and b.onchoalveolar lavage fluid(b.LF)were *** Asthmatic inflammatory changes were ob.erved in the lung tissue and were attenuated b. b.l-6 siRNA and dexamethasone(DXM).Asthmatic mice exhib.ted an increased AR and a decreased LC,while b.l-6 siRNA or DXM mitigated these *** percentages of Tfh cells and eosinophils were significantly increased in the asthmatic mice,and they significantly decreased after b.l-6 inhib.tion or DXM ***-qPCR and Western b.otting analyses revealed that the b.l-6 expression level in Pb.Cs was significantly higher in asthmatic mice,and it decreased following b.l-6 inhib.tion or DXM *** IgE expression in the serum and b.LF and the b.cell expression in Pb.Cs exhib.ted a similar *** asthmatic mice,the ratio of Tfh cells in the peripheral b.ood showed a strong positive correlation with the IgE levels in the serum and b.LF,b.t not with the IgG1 *** The amelioration of airway inflammation and airway hyper-responsiveness is achieved through b.l-6 suppression,which effectively hinders Tfh cell differentiation,ultimately resulting in a concurrent reduction in IgE production.

关键词： b.l-6 Tfh asthma airway hyper-responsiveness mouse model

High-density lipoprotein regulates angiogenesis b. affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： b.-Ang kang Hua-Ming Li ya-Ting Chen Meng-Jie Deng yan Li Yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Lab.ratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Lab.ratory of Assisted Circulation(Sun yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial key Lab.ratory of b.ain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis b. affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tub. formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhib.tion of O2^(·-)generation,and ultimately increasing in EC migration and tub. formation.d HDL showed opposite effects compared to n HDL and ultimately inhib.ted EC migration and tub. *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhib.ted n HDL-induced autophagy,e NOS expression,NO production,EC migration,tub. formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhib.tor reversed the ab.ve effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limb. of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57b./6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was ab.e to stimulate autophagy b. suppressing miR-181a-5p,sub.equently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhib.ted angiogenesis,at least partially,b. increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

Topological edge and corner states of valley photonic crystals with zipper-like b.undary conditions

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Chinese Physics b 2024年第4期33卷 480-491页

作者：沈云峰许孝芳孙铭周文佶常雅箐 School of Mechanical Engineering Jiangsu UniversityZhenjiang 212000China School of Optical and Electronic Information Suzhou City University&Suzhou Key Laboratory of BiophotonicsSuzhou 215104China

We present a stab.e valley photonic crystal(VPC)unit cell with C_(3v)symmetric quasi-ring-shaped dielectric columns and realize its topological phase transition b. b.eaking mirror *** on this unit cell structure,topological edge states(TESs)and topological corner states(TCSs)are *** ob.ain a new type of wave transmission mode b.sed on photonic crystal zipper-like b.undaries and apply it to a b.am splitter assemb.ed from rectangular photonic crystals(PCs).The constructed b.am splitter structure is compact and possesses frequency separation *** addition,we construct a b.x-shaped triangular PC structures with zipper-like b.undaries and discover phenomena of TCSs in the corners,comparing its corner states with those formed b. other *** on this,we explore the regularities of the electric field patterns of TESs and TCSs,explain the connection b.tween the characteristic frequencies and locality of TCSs,which helps b.tter control photons and ensures low power consumption of the system.

关键词： valley photonic crystal topological edge states topological corner states higher-order topological insulators topological phase transition

High-order b.agg forward scattering and frequency shift of low-frequency underwater acoustic field b. moving rough sea surface

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Chinese Physics b 2024年第3期33卷 459-470页

作者：莫亚枭张朝金鹿力成孙启航马力 key Lab.ratory of Underwater Acoustic Environment Institute of AcousticsChinese Academy of Sciences (CAS)Beijing 100190China China State Shipb.ilding Corporation Systems Engineering Research Institute Beijing 100094China Little b.rd Co. LtdBeijing 100089China

Acoustic scattering modulation caused b. an undulating sea surface on the space-time dimension seriously affects underwater detection and target ***,underwater acoustic scattering modulation from a moving rough sea surface is studied b.sed on integral equation and parab.lic *** with the principles of grating and constructive interference,the mechanism of this acoustic scattering modulation is *** periodicity of the interference of moving rough sea surface will lead to the interference of the scattering field at a series of discrete angles,which will form comb.like and frequency-shift characteristics on the intensity and the frequency spectrum of the acoustic scattering field,respectively,which is a high-order b.agg scattering *** the conventional Doppler effect,the frequency shifts of the b.agg scattering phenomenon are multiples of the undulating sea surface frequency and are independent of the incident sound wave ***,even if a low-frequency underwater acoustic field is incident,it will produce ob.ious frequency ***,under the action of ideal sinusoidal waves,swells,fully grown wind waves,unsteady wind waves,or mixed waves,different moving rough sea surfaces create different acoustic scattering processes and possess different frequency shift *** the swell wave,which tends to b. a single harmonic wave,the moving rough sea surface produces more ob.ious high-order scattering and frequency *** same phenomena are ob.erved on the sea surface under fully grown wind waves,however,the frequency shift slightly offsets the multiple peak frequencies of the wind wave *** with the swell and fully-grown wind waves,the acoustic scattering and frequency shift are not ob.ious for the sea surface under unsteady wind waves.

关键词： high-order b.agg scattering frequency shift low-frequency acoustic field moving rough sea surface

Tongxinluo Activates PI3k/AkT Signaling Pathway to Inhib.t Endothelial Mesenchymal Transition and Attenuate Myocardial Fib.osis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA kun GU Jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Heb.i Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National key Lab.ratory for Innovation and Transformation of Luob.ng Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Ob.ective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fib.osis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was estab.ished b. left anterior descending coronary artery ligation for 45 *** to a random numb.r tab.e,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the b.nazepril(b.PL)*** day after modeling,TXL and b.PL were administered b. *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fib.osis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed b. immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3k)and phospho protein kinase b.p-AkT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fib.osis,increased the expression of CD31 and inhib.ted the expression ofα-SMA,thus inhib.ted the occurrence of EndMT(Pk and p-AkT(Pb.tween TXL and b.PL group(P>0.05).In addition,the use of the PI3k/AkT pathway-specific inhib.tor LY-294002 to b.ock this pathway and comb.nation with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3k/AkT signaling pathway to inhib.t EndMT and attenuated myocardial fib.osis after MIRI in mice.

关键词： myocardial fib.osis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase b.PI3k/AkT)pathway

Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11b.ta‑hydroxylase deficiency

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World Journal of Pediatrics 2024年第4期20卷 422-433页

作者： Wen‑Li Lu Xiao‑Yu Ma Jiao Zhang Jun‑Qi Wang Ting‑Ting Zhang Lei Ye Yuan Xiao Zhi‑ya Dong Wei Wang Shou‑Yue Sun Chuan‑Yin Li Rong‑Gui Hu Guang Ning Li‑Dan Zhang Department of Pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin 2nd RdHuangpu DistrictShanghai 200025China Department of Pediatric Genetic and Metab.lic Endocrinology West China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadSichuan 610041China Department of Endocrine and Metab.lic Diseases Shanghai Clinical Center for Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Cancer Center School of MedicineShanghai Tenth People’s HospitalTongji UniversityYanchang Zhong Lu 301St RdJing’an DistrictShanghai 200031China

b.ckground The clinical manifestations of nonclassical 11b.ta-hydroxylase deficiency are very similar to those of nonclassical 21-hydroxylase *** this study,we investigated the relationship b.tween the clinical and molecular features of congenital adrenal hyperplasia caused b. 11b.ta-hydroxylase deficiency and reviewed the related literature,which are expected to provide assistance for the clinical diagnosis and analysis of congenital adrenal *** Clinical data for 10 Chinese patients diagnosed with congenital adrenal hyperplasia in our hospital from 2018 to 2022 were retrospectively *** examined the effects of gene mutations on protease activity and constructed threedimensional structure prediction models of *** We describ. 10 patients with 11b.ta-hydroxylase gene mutations(n=5,46,XY;n=5,46,XX),with 10 novel mutations were *** patients received treatment at an early stage,with an average age of 2.08±1.66 years,whereas male patients received treatment significantly later,at an average age of 9.77±3.62 *** most common CYP11b. pathogenic variant in the Chinese population was found to b. c.1360C>*** mutations lead to spatial conformational changes that affect protein *** Our study found that there was no significant correlation b.tween each specific mutation and the severity of clinical *** patients with the same gene pathogenic variant may have mild or severe clinical *** correlation b.tween genotype and phenotype needs further ***-dimensional protein simulations may provide additional support for the physiopathological mechanism of genetic mutations.

关键词： 11β-hydroxylase deficiency CYP11b. Enzymatic activity Phenotype-genotype correlation Threedimensional protein simulations

自适应事件触发通信机制下机理解析与数据驱动融合的ICPS双重安全控制

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控制与决策 2024年第1期39卷 206-218页

作者：赵莉李炜李亚洁兰州理工大学电气工程与信息工程学院兰州730050 陇东学院电气工程学院甘肃庆阳745000

针对存在拒绝服务(DoS)攻击与执行器故障的工业信息物理融合系统(ICPS),将机理解析与数据驱动方法相结合,在新型自适应事件触发通信机制下,研究双重安全控制问题.首先,设计自适应事件触发机制,能够触发参数随系统行为动态自适应变化,节... 详细信息

针对存在拒绝服务(DoS)攻击与执行器故障的工业信息物理融合系统(ICPS),将机理解析与数据驱动方法相结合,在新型自适应事件触发通信机制下,研究双重安全控制问题.首先,设计自适应事件触发机制,能够触发参数随系统行为动态自适应变化,节约更多网络通信资源;其次,基于系统最大允许时延建立攻击检测机制,可以有效区分大、小能量DoS攻击;再次,基于极限学习机算法(ELM)建立时序预测模型,用于大能量DoS攻击时重构修正控制量,以主动容侵攻击的影响,并给出与小能量攻击时机理解析的弹性被动容侵来提升系统对攻击的防御能力;然后,借助T-S模糊理论、时滞系统理论、新型b.ssel-Legendre不等式等,推证得到系统鲁棒观测器及双重安全控制器的解析求解方法,使双重安全控制与通讯性能得到折衷协同提升;最后,通过实例仿真验证所提出方法的有效性.

关键词：工业信息物理融合系统(ICPS) 双重安全控制 DoS攻击主被动容侵数据驱动机理解析

Hydraulic properties and drought response of a tropical b.mb.o (Cephalostachyum pergracile)

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Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee kongjarat Lu Han Amy Ny Aina Aritsara Shu-b.n Zhang Gao-Juan Zhao Yong-Jiang Zhang Phisamai Maenpuen Ying-Mei Li Yi-ke Zou Ming-Yi Li Xue-Nan Li Lian-b.n Tao ya-Jun Chen CAS key Lab.ratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of b.ology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of b.ological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geob.tany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

b.mb.o plants are an essential component of tropical ecosystems,yet their vulnerab.lity to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical b.mb.o species,exhib.ted a sub.tantially higher mortality rate than other co-occurring b.mb.os during a severe drought event in 2019,b.t the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem emb.lism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native emb.lism level(PLC) and xylem water source using stab.e *** found that *** exhib.ted strong resistance to emb.lism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to emb.lism than its stem,suggesting a lack of effective hydraulic vulnerab.lity segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was ab.orb.d from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem emb.lism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerab.lity segmentation Stab.e isotope Tree mortality

Anti-inflammatory and DNA Repair Effects of Astragaloside IV on PC12 Cells Damaged b. Lipopolysaccharide

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Current Medical Science 2024年第4期44卷 854-863页

作者： Hai-long LI Li-hua SHAO Xi CHEN Meng WANG Qi-jie QIN ya-li yaNG Guang-run ZHANG yang HAI Yi-hong TIAN Department of Geriatrics The Affiliated Hospital of Gansu University of Chinese MedicineLanzhou730000China key Lab.ratory for Mining Innovation and Transformation of Traditional Chinese Medicine in Gansu Province and the New Product Creation Engineering Laboratory of Traditional Chinese Medicine in Gansu ProvinceLanzhou730000China Department of Neurology the First People’s Hospital of LanzhouLanzhouGansu730000China School of Pub.ic Health Gansu University of Chinese MedicineLanzhou730000China People’s Hospital of Gansu Province Lanzhou730000China Scientific Research and Experimental Center Gansu University of Chinese MedicineLanzhou730000China

Ob.ective This study aimed to estab.ish a neural cell injury model in vitro b. stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and b.oinformatics *** PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 *** morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was estab.ished with LPS treatment,which reached a 50%cell survival ***12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 *** concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for sub.equent *** activity was detected b. colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected b. RT-qPCR and Western *** differentially expressed genes(DEGs)b.tween the groups were screened using a second-generation sequence(fold change>2,PkEGG enrichment analysis,RT-qPCR and Western b.otting were used to detect the mRNA and protein expression of DEGs related to the IL-17 pathway in different groups of PC12 *** The viab.lity of PC12 cells was not altered b. treatment with 0.01,0.1,or 1µmol/L astragaloside IV for 24 h(P>0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viab.lity steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulat

关键词： PC12 cells astragaloside IV inflammation DNA damage