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Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran

World Journal of Gastroenterology 2006年第36期12卷 5890-5892页

作者： mahmood Haghighat seyed Mohsen Dehghani Abdolvahab Alborzi Mohammad Hadi Imanieh Bahman Pourabbas Mehdi Kalani Department of Pediatric Gastroenterology Shiraz University of Medical Science Shiraz Iran Department of Professor Alborzi Clinical Microbiology Research Center Shiraz University of Medical Science Shiraz Iran

AIM： To determine the causative agents of spontaneous bacterial peritonitis （SBP） in children with liver disease and ascites in our center. METHODS： During a 2.5 year period, from September 2003 to March 2006, 12 patients with 13 episodes of SBP were studied. In all cases at the time of admission serum albumin and glucose, urinalysis and urine culture was performed. Analysis [white blood cell （WBC） count with differential, albumin, glucose], gram stain, culture by BACTEC method and antibiogram was done on ascitic fluids. Abdominal paracentesis was repeated after 48 h of antibiotic therapy for bacteriologic assay. The patients were followed for at least three months in a gastroenterology clinic. RESULTS： There were 7 girls （58%） and 5 boys （42%） with a median age of 5.2 years （range, 6 mo to 16 years）. All cases had positive ascitic fluid culture. Gram stain was positive in 5 （38.5%） of them. The isolated organisms were S. pneumoniae in 5 （38.5%）, E. coli in 2 （15.3%）, S. viridans in 2 （15.3%）, and K. pneumoniae, H. influenza, Enterococci, and nontypable Streptococcus each in one （7.7%）. All of them except Enterococci were sensitive to ciprofloxacin and ceftriaxone. All ascitic fluid cultures were negative after 48 h of antibiotic therapy. CONCLUSION： S. pneumoniae is the most common cause of SBP in the pediatric age group and we recommend a third generation cephalosporine （e.g., Ceftriaxlone or Cefotaxime） for empirical therapy in children with SBP.

关键词： Spontaneous bacterial peritonitis Children Cirrhosis Causes Empirical therapy

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The comparison of insulin and uric acid levels in adolescents with and without metabolic syndrome

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Frontiers in Biology 2018年第6期13卷 452-457页

作者： Homeira Rashidi Hajieh Shahbazian Forogh Nokhostin seyed mahmood Latifi Mehrian Jafarizade Diabetes Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of internal medicine Ahvaz Jundishapur University of Medical SciencesAhvazIran

The prevalence of metabolic syndrome (MS) increased in recent years in both adolescents and children groups. The aim of the study is evaluating the relationship between insulin and uric acid (UA) level in MS in adolescents we studied 120 adolescence aged 10 to 19 in two groups: control group without metabolic syndrome and case group with metabolic syndrome. The Criteria of ATP III was considered as a diagnosis factor for metabolic syndrome. Various studies have been conducted in various populations to evaluate the relationship between UA level and MS in adolescents. Abdominal obesity, low HDL, hypertriglyceridemia and hypertension are associated with high UA level. In their analysis, the MS OR in UA level⩽4.9, 4.9-5.8 and ⩾5.8 mg/dl was 1, 2.53 and 9.03, respectively, which were higher than our findings in current study. Hyperinsulinemia caused by insulin resistance is one of the complications associated with MS, which puts individuals at risk of diabetes and cardiovascular events. Uric acid level in the Case group was significantly higher than the control group (p = 0.0001, 43.8±1.4 vs. 4.1±1 mg/dl, respectively). Insulin level was significantly higher in the case group in compare to the control group (p = 0.008, 9.8± 5.3 vs. 12.2±6 μU/ml, respectively). The findings of this case-control study showed that adolescents with metabolic syndrome have a higher uric acid and insulin level in compare to normal subjects. We hypothesis that increase in serum insulin and uric acid level can be a risk factor in the development of metabolic syndrome.

关键词： metabolic syndrome uric acid insulin adolescents

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Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran

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Asian Pacific Journal of Tropical Medicine 2021年第1期14卷 10-16页

作者： seyed Abbas Mousavi Hamed Rouhanizadeh Majid Saeedi mahmood Moosazadeh Abolqasem Ajami AfsanehFendereski Jamshid Yazdani-Charati seyed Mohsen Soleimani Nader Ahangar seyed Hossein seyedpour Zahra Bandalizaeh Psychiatry and Behavioral Sciences Research Center Institute of AddictionDepartment of PsychiatryMazandaran University of Medical SciencesSariIran Department of Pediatrics School of MedicineMazandaran University of Medical SciencesSariIran Department of Pharmaceutics Faculty of PharmacyMazandaran University of Medical SciencesSariIran Health Sciences Research Center Institute of AddictionMazandaran University of Medical SciencesSariIran Deptartment of Immunology Faculty of MedicineMazandaran University of Medical SciencesSariIran Department of Biostatistics Mazandaran University of Medical SciencesSariIran Department of Biostatistics Health Sciences Research CenterInstitute of AddictionMazandaran University of Medical SciencesSariIran General Physician Deputy of HealthMazandaran University of Medical SciencesSariIran Deputy of Health Mazandaran University of Medical SciencesSariIran

Objective:To determine the seroprevalance of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)antibodies in the general population of Mazandaran province in Iran and to estimate the percentage of asymptomatic,mild,and severe ***:We chose 1588 inhabitants of Mazandaran province with cluster *** measured their SARS-Co V-2 immunoglobulin M(Ig M)and immunoglobulin G(Ig G)serum ***,risk factors,and symptoms were *** seroprevalence of SARS-Co V-2 was calculated by age and city and the World Health Organization(WHO)protocol and further stratified by demographic variables and risk ***,we identified the symptoms and factors related to COVID-19 with logistic ***:Two hundred subjects(12.59%)were tested positive for either Ig G or Ig *** May 23,2020,the prevalence of COVID-19 was 15.26%(95%CI:12.97%-17.79%)based on direct standardization and WHO’s standardized age *** on multivariate logistic regression,the incidence of getting an infection increased by an average of 11.6%for every 10-year increase in age(OR=1.116,95%CI:1.008-1.236,P=0.035).Furthermore,those in contact with COVID-19 patients had a 66.1%higher risk of developing the disease(OR=1.661,95%CI:1.104-2.497,P=0.015).In addition,the chance of getting SARS-Co V-2 infection was almost four times higher in people who had consulted a doctor during the pandemic than those who had not(OR=3.942,95%CI:2.813-5.524,P<0.001).Conclusions:The prevalence of COVID-19 in Mazandaran province could be higher than the officially reported statistics based on diagnostic tests and clinical *** seems to be more asymptomatic or mild symptom cases than what was previously reported.

关键词： SARS-CoV-2 COVID-19 Prevalance Iran Serology IgM IgG

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Excellent photocatalytic performance under visible-light irradiation of ZnS/rGO nanocomposites synthesized by a green method

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Frontiers of Materials Science 2016年第4期10卷 385-393页

作者： Hassan Rayat AZIMI mahmood GHORANNEVISS seyed Mohammad ELAHI Mohammad Reza MAHMOUDIAN Farid JAMALI-SHEINI Ramin YOUSEFI Plasma Physics Research Center Science and Research Branch Islamic Azad University Tehran Iran Department of Chemistry Shahid Sherafat University of Farhangian 15916 Tehran Iran Advanced Surface Engineering and Nano Materials Research Center Department of Physics Ahvaz Branch Islamic Azad University Ahvaz Iran Department of Physics Masjed-Soleiman Branch isiamic Azad University Masjed-Soleiman Iran

ZnS/graphene nanocomposites with different graphene concentrations （5, 10 and 15 wt.%） were synthesized using L-cysteine as surfactant and graphene oxide （GO） powders as graphene source. Excellent performance for nanocomposites to remove methylene blue （MB） dye and hexavalent chromium （Cr（VI）） under visible-light illumina- tion was revealed. TEM images showed that ZnS NPs were decorated on GO sheets and the GO caused a significant decrease in the ZnS diameter size. XRD patterns, XPS and FTIR spectroscopy results indicated that GO sheets changed into reduced graphene oxide （rGO） during the synthesis process. Photocurrent measurements under a visible- light source indicated a good chemical reaction between ZnS NPs and rGO sheets.

关键词： ZnS/rGO nanocomposites graphene photocatalytic performance watertreatment green nanotechnology

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Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level

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World Journal of Gastroenterology 2017年第7期23卷 1224-1232页

作者： Ahad Eshraghian Mohammad Hadi Imanieh seyed Mohsen Dehghani Saman Nikeghbalian Alireza Shamsaeefar Frouzan Barshans Kourosh Kazemi Bita Geramizadeh seyed Ali Malek-hosseini Transplant Research Center Shiraz University of Medical Sciences Gastroenterohepatology Research Center Namazi Hospital

To investigate incidence and survival of post-transplant lymphoproliferative disorder (PTLD) patients after liver *** cross-sectional survey was conducted among patients who underwent liver transplantation at Shiraz Transplant Center (Shiraz, Iran) between August 2004 and March 2015. Clinical and laboratory data of patients were collected using a data gathering *** were 40 cases of PTLD in the pediatric age group and 13 cases in the adult group. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The post-PTLD survival of patients at 6 mo was 75.1% ± 6%, at 1 year was 68.9% ± 6.5% and at 5 years was 39.2% ± 14.2%. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients (OR = 1.07, 95%CI: 1.006-1.15, P = 0.032). A serum tacrolimus level over 11.1 ng/mL was predictive of post PTLD survival (sensitivity = 90%, specificity = 52%, area under the curve = 0.738, P = 0.035).CONCLUSIONIncidence of PTLD in our liver transplant patients is comparable to other centers. Transplant physicians may consider adjustment of tacrolimus dose to maintain its serum level below this cutoff point.

关键词： Post-transplant lymphoproliferative disorder Liver transplantation Survival Tacrolimus Epstein-Barr virus

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Assessment of the anterior chamber parameters after laser iridotomy in primary angle close suspect using Pentacam and gonioscopy

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 680-684页

作者： Alireza Esmaeili Behzad Barazandeh Sina Ahmadi Alireza Haghi seyed Mahdi Ahmadi hosseini Fereshteh Abolbashari Department of Ophthalmology Razavi Hospital Refractive Error Research Center School of Paramedical SciencesMashhad University of Medical Sciences

AIM:To evaluate the changes in the anterior segment parameters of the subjects with primary angle closure suspect(PACS) before and after laser iridotomy(LI) using the Pentacam and gonioscopy. METHODS:Forty-eight eyes of 48 PACS were *** chamber angle(ACA),central anterior chamber depth(ACD),anterior chamber volume(ACV) and central corneal thickness(CCT) were recorded from the Pentacam before and one month after *** was graded according to Shaffer classification using Goldmann ***:ACA increased significantly from 25.59±4.41 to 26.46±4.33 degrees(P=0.009) and ACV changed from 85.97±16.07mm3to 99.25±15.83mm3(P=0.000).The changes in ACD,CCT and intraocular pressure were non-significant(P>0.05).Gonioscopy showed significant widening of the Shaffer angle in 4 quadrants(P<0.001).CONCLUSION:Pentacam can serve as the objective instrument in assessing the efficacy of LI.

关键词： glaucoma laser iridotomy Pentacam angle closure gonioscopy

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Assessment of dietary chaste tree (Vitex agnus-castus) fruit extract on growth performance, hemato-biochemical parameters, and mRNA levels of growth and appetite-related genes in goldfish (Carassius auratus)

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Aquaculture and Fisheries 2022年第3期7卷 296-303页

作者： Maedeh Rashmeei seyed Pezhman hosseini Shekarabi Mehdi Shamsaie Mehrgan Hamed Paknejad Department of Fisheries Science and Research BranchIslamic Azad UniversityTehran***Iran Department of Fisheries Faculty of Fisheries and Environmental SciencesGorgan University of Agricultural Sciences and Natural ResourcesGorgan***Iran

In this study,the effect of oral administration of chaste tree fruit(CTF)extract was evaluated on growth performance,hematological indices,serum biochemical parameters,and the expression of growth and appetite-related genes in goldfish(Carassius auratus).The fry(N=300;2.40±0.12 g)were randomly dispersed into 12 aquaria and fed with different levels of CTF extract(0(control),0.5%,1.0%,and 1.5%)for 56 *** the end of the trial,the highest body weight gain and the lowest feed conversion ratio were observed in the fish fed with 1.5%CTF extract(P0.05).The levels of aspartate transaminase and lactate dehydrogenase were decreased by increasing the supplementation levels of CTF extract and the lowest values were obtained in 1.5%CTF extract diet(P<0.05).The expression of growth hormone,insulin-like growth factor 1,and ghrelin genes was significantly up-regulated in the fish fed with 1.5%CTF extract compared to other treatments(P<0.05).Overall,the enrichment of goldfish diet with 1.5%CTF extract could interfere positively in the growth-related traits and hematological parameters.

关键词： Goldfish Hepatic enzymes Hematology Growth promoter Herbal medicine

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An Innovative Finite Element Geometric Modeling of Single-Layer Multi-Bead WAAMed Part

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2383-2401页

作者： Xiangman Zhou Jingping Qin Zichuan Fu Min Wang Youlu Yuan Junjian Fu Haiou Zhang seyed Reza Elmi hosseini College of Mechanical and Power Engineering China Three Gorges UniversityYichang443002China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China School of Metallurgy and Materials Engineering Iran University of Science and TechnologyNarmakIran

Finite element (FE) coupled thermal-mechanical analysis is widely used to predict the deformation and residualstress of wire arc additive manufacturing (WAAM) parts. In this study, an innovative single-layermulti-bead profilegeometric modeling method through the isosceles trapezoid function is proposed to build the FE model of theWAAMprocess. Firstly, a straight-line model for overlapping beads based on the parabola function was establishedto calculate the optimal center distance. Then, the isosceles trapezoid-based profile was employed to replace theparabola profiles of the parabola-based overlapping model to establish an innovative isosceles trapezoid-basedmulti-bead overlapping geometric model. The rationality of the isosceles trapezoid-based overlapping model wasconfirmed by comparing the geometric deviation and the heat dissipation performance index of the two overlappingmodels. In addition, the FE-coupled thermal-mechanical analysis, as well as a comparative experiment of thesingle-layer eight-bead deposition process show that the simulation results of the above two models agree with theexperimental results. At the same time, the proposed isosceles trapezoid-based overlappingmodels are all straightlineprofiles, which can be divided into high-quality FE elements. It can improve the modeling efficiency andshorten the simulation calculation time. The innovative modeling method proposed in this study can provide anefficient and high-precision geometricmodelingmethod forWAAMpart FE coupled thermal-mechanical analysis.

关键词： WAAM FE coupled thermal-mechanical analysis the isosceles trapezoid-based model residual stress

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Nicorandil potentiates sodium butyrate induced preconditioning of neurons and enhances their survival upon subsequent treatment with H_(2)O_(2)

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Translational Neurodegeneration 2017年第1期6卷 291-299页

作者： Parisa Tabeshmehr Haider Kh Husnain Mahin Salmannejad Mahsa Sani seyed Mojtaba hosseini Mohammad Hossein Khorraminejad Shirazi Student Research Committee Shiraz University of Medical SciencesShirazIran Cell&Molecular Medicine Student Research Group Medical FacultyShiraz University of Medical SciencesShirazIran Department of Basic Sciences SRURiyadhSaudi Arabia Stem Cell Laboratory Department of AnatomyShiraz University of Medical SciencesShirazIran

Background:Extensive loss of donor neural stem cell(NSCs)due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation *** that histone deacetylases(HDACs)modulate various cellular processes by deacetylating histones and non-histone proteins,we hypothesized that combined treatment with small molecules,sodium butyrate(NaB;a known HDAC inhibitor)and nicorandil,will enhance the rate neuronal differentiation of NSCs besides their preconditioning to resist oxidative ***:NSCs derived from 14-day old Sprague Dawley rat ganglion eminence were characterized for tri-lineage *** with 1 mM NaB significantly changed their culture characteristics while continuous treatment for 10 days enhanced their neural *** treatment also preconditioned the cells for their resistance to oxidative ***:The highest rate of neural differentiation and preconditioning effect was achieved when the NSCs were treated concomitantly with NaB and *** proliferation assay showed that concomitant treatment with NaB and nicorandil retarded their rate of ***:These data conclude that preconditioning of NSCs with NaB and nicorandil effectively enhances their differentiation capacity besides preconditioning the cells to support their survival under ischemic conditions.

关键词： Apoptosis Neural stem cells Oxidative stress Preconditioning

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Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens

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World Journal of Gastroenterology 2006年第33期12卷 5368-5374页

作者： Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi seyed Mohammad Jazayeri William F Carman mahmood Chamankhah Manley Rashedan Fazel Shokri Department of Immunology School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran Division of Virology Institute of Biomedical and Life Science University of Glasgow Glasgow United Kingdom Monoclonal Antibody Research Center Avesina Research Center Tehran Iran

AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” ***: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these ***: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants.

关键词： Hepatitis B surface antigen Hepatitis B virus Mutant Epitope mapping Vaccination Monoclonal antibody

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