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Effect of Gold Nanoparticle on Percentage Depth Dose of 18 MV X-Ray in MAGICA Polymer Gel Dosimeter

Open Journal of Microphysics 2013年第2期3卷 28-33页

作者： Mohammad mahdavi Mahbobeh Khadem-Abolfazli seyed rabee mahdi mahdavi Gholamreza Ataei Medical Physics Department Tehran University of Medical Sciences Tehran Iran Para Medical Department Babol University of Medical Sciences Babol Iran Physics Department Mazandaran University Babolsar Iran

Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like phantom developed to date. This study is an investigating of percentage depth dose enhancement within the gel medium with the use of conformal distribution gold nanoparticle as contrast agents by high atomic number material. In this work, the normoxic polymer gel dosimeter MAGICA tissue-equivalence was first theoretically verified using MCNPX Monte Carlo code and experimentally by percentage depth dose curves within the gel medium. Then gold nanoparticles (GNPs) of 50 nm diameter with different concentrations of 0.1 mM, 0.2 mM, and 0.4 mM were embedded in MAGICA gel and irradiated by 18 MV photon beam. Experimental results have shown dose increase of 10%, 2% and 4% in 0.1 mM, 0.2 mM and 0.4 mM concentrations, respectively. Simulation results had good agreement in the optimum concentration of 0.1 mM. The largest error between experimental and simulation results was equal to 9.28% stood for 0.4 mM concentration. The results showed that the optimum concentration of gold nanoparticles to achieve maximum absorbed dose in both experimental and simulation was 0.1 mM and so it can be used for clinical studies.

关键词： Percentage Depth Dose Polymer Gel Dosimeter Gold Nanoparticles

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Estimation of overall heat transfer coefficient of cooling system in RF capacitive hyperthermia

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Journal of Biomedical Science and Engineering 2013年第5期6卷 509-517页

作者： seyed Ali Aghayan Dariush Sardari seyed Rabii mahdi mahdavi Mohammad Hasan Zahmatkesh Department of Engineering Science and Research Branch Islamic Azad University Tehran Iran Department of Medical Physics Shahid Beheshti University Tehran Iran Department of Medical Physics Tehran University of Medical Science Tehran Iran

The study presented in this article involves the estimation of the overall heat transfer coefficient of cooling system in RF capacitive hyperthermia treatment using inverse problem based on the conjugate gradient method to provide improved distribution of temperature. The temperature data computed numerically from the direct problem using the finite difference time domain method are used to simulate the temperature measurements. The effects of the errors and sensor positions upon the precision of the estimated results are also considered. The results show that a reasonable estimation of the unknown can be obtained. Finally, measurements in a tissue-equivalent phantom are employed to appraise the reliability of the presented method. The comparison of computed data with measurements shows a good agreement between numerical and experimental results.

关键词： Estimation Hyperthermia Inverse Problem Phantom Overall Heat Transfer Coefficient

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