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Adjuvant activity of Pasteurella multocida A strain,Pasteurella multocida B strain and Salmonella typhimurium bacterial DNA on cellular and humoral immunity responses against Pasteurella multocida specific strain infections in Balb/c mice

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 336-341页

作者： Maryam Homayoon Yahya Tahamtan mohammad Kargar seyed mohammad hossein hosseini Abbas Akhavan Sepahy Department of Biology Science and Research BranchIslamic Azad University Department of Microbiology Shiraz BranchRazi Vaccine and Serum Research InstituteAgriculture ResearchEducation and Extension Organization Department of Microbiology Jahrom Branch Islamic Azad University Department of Microbiology Tehran North BranchIslamic Azad University

Objective: To evaluate the effects of Pasteurella multocida(P. multocida) vaccines on the expression and release of antibodies, interleukin(IL)-6 and IL-12 by serum. Methods: Balb/c mice were immunized with two formalin and iron inactivated vaccine doses within 2 weeks. The vaccines were adjuvant with P. multocida A strain, P. multocida B strain and Salmonella typhimurium bacterial DNA(AbDNA, BbDNA and SbDNA for short, respectively). The animals were challenged 4 weeks after immunization. Blood of mice was collected to detect the change of specific antibody, IL-6, and IL-12 using ELISA. Results: The specific antibody and interleukins in the immunized group increased significantly compared to the control mice after vaccination and challenge(P<0.05). The highest release of these cytokines was obtained by P.multocida inactivated with iron and adjuvant with AbDNA at a concentration of 25 μg/mL. The antibody titer peak was 0.447 in mice vaccinated with iron-killed whole-cell antigen adjunct with AbDNA. The time-courses of release showed that bacterial DNA was able to stimulate IL-6 and IL-12 production more than alum(P<0.05). Conclusions: Our findings introduce that bacterial DNA is capable of releasing an immunological response with several cytokines.These indicate that bacterial DNA entrapped with killed P. multocida antigen is a new and effective adjuvant to enhance specific immunity and resistance of animal against the infectious pathogen, which could simplify the development of highly promising strong adjuvant.

关键词： Pasteurella multocida Bacterial DNA Adjuvant activity Vaccine Immunity Balb/c mice

Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

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World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： Amir Human Hoveidaei Reza Niakan seyed hossein hosseini-Asl Abijith Annasamudram Janet D Conway International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all ages.LLRS membership characteristics,however,are poorly reported.This study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United States.AIM To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching field.METHODS This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical attributes.After reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled data.Sex and ethnicity were evaluated visually utilizing retrieved images.The Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were categorized.LLRS members per state and capita determined geographic distribution.The Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice facilities.RESULTS The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)female.Surgeons with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(P=0.002).Most orthopedic surgeons(88.12%,)practiced in academic centers.Of those professionals who occupied leadership positions,14%were women,while 86%were men.Additionally,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic surgeon.Total per capita rate across the United States was 0.30 LLRS orthopedic surgeons per 1 million people.CONCLUSION Over 21

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships

Er_(2)TiO_(5)@Ag nanocomposites:Enhanced photocatalysis and bacteria inactivation,and cytotoxicity

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Journal of Rare Earths 2024年第5期42卷 851-858,I0002页

作者： Mehdi Nazeri hossein Sedaghat Reza Rafiei mohammad Amin Farzin seyed Mostafa hosseinpour Mashkani Department of Parasitology and Mycology Kashan University of Medical SciencesKashanIran Department of Microbiology Kashan University of Medical SciencesKashanIran General Medicine Student School of MedicineKashan University of Medical SciencesKashanIran Student Research Committee Kashan University of Medical SciencesKashanIran Institute for Biomedical Materials and Devices School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyNSW2007Australia

In this study,we successfully synthesized Er_(2)TiO_(5)@Ag nanocomposites(NCPs) using the ultrasonicmediated sol-gel technique to create a multifunctional material with enhanced photocatalytic and antibacterial properties.The visible light photocatalytic activities of Er_(2)TiO_(5) nanoparticles(NPs) and Er_(2)TiO_(5)@Ag NCPs were systematically evaluated under various conditions,including different concentrations of Basic Blue 41(BB 41) dye and photocatalyst.The results reveal a remarkable improvement in the photocatalytic degradation efficiency of Er_(2)TiO_(5)@Ag NCPs(95%) compared to Er_(2)TiO_(5) NPs(80%).Furthermore,the antibacterial efficacy of Er_(2)TiO_(5) NPs and Er2TiO_5@Ag NCPs were extensively examined against Gram-positive and Gram-negative bacteria.Notably,Er_(2)TiO_(5)@Ag NCPs exhibit significantly higher minimum bactericidal concentration(MBC) values compared to Er_(2)TiO_(5) NPs.The antibacterial effect of Er_(2)TiO_(5)@Ag NCPs is particularly pronounced against S.aureus and Pseudomonas aeruginosa,while demonstrating moderate effects on Escherichia coli and Enterococcus faecalis.To assess the biocompatibility of the synthesized materials,we investigated their internalization by MCF-7 cells.Encouragingly,both Er_(2)TiO_(5) NPs and Er_(2)TiO_(5)@Ag NCPs are found to be effectively internalized by the cells,suggesting their potential application in biomedical fields.Intriguingly,our study unveils the exceptional potential of Er_(2)TiO_(5)@Ag NCPs as a dual-action solution,simultaneously possessing enhanced photocatalytic efficiency and potent antibacterial properties.This multifunctional nanocomposite not only outperforms Er_(2)TiO_(5) and Ag but also paves the way for innovative applications in sustainable environmental remediation and advanced biomedical technologies,promising a brighter and cleaner future.

关键词： Rare earth catalysis Nanocomposite Er_(2)TiO_(5)@Ag Antibacterial activity Photocatalysis Cytotoxicity

Theoretical framework of the Isfahani style: Inspiring sustainable aspects of a vernacular urban development

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Frontiers of Architectural Research 2024年第2期13卷 349-369页

作者： Hatef Jafari Sharami seyed Jamalaldin hosseini Department of Architecture and Urbanism University of EyvanekeyEyvanekey 99888-35918Iran Faculty of Civil and Architecture University of EyvanekeyEyvanekey 99888-35918Iran

The Isfahani style represents a method of traditional Iranian architecture and urban development that existed in the early 20th century and is regarded as a leading model in most traditional Iranian cities. It exhibits several vigorous features contributing to its recognition as a traditional approach to sustainable architecture and urban development. This research endeavors to reveal a theoretical framework beneath these inspiring aspects using the typology of sustainable modern forms, including the hierarchy, passive design strategies, compactness, density, diversity, mixed land use, pluralism, balance, good composition, and integration over time. To this end, the study employs qualitative research methods, drawing from traditional samples, to identify innovative, energy and socially efficient, and low-impact strategies implemented in this vernacular architecture of Iran's semi-arid and hot climates. The findings revealed that the neighborhood concept as a local and plural community (Mahalla) was a vital phenomenon in Iran's urban development. Apparently, the demise of this paradigm effectively played an important role in the numerous challenges regarding the social, energy, and economic viability of modern Iranian cities. Hence, this study presented theoretical frameworks—aligned with sustainable concepts—from the Isfahani style through its analysis, classification, and interpretation, which can contribute to modern urban development.

关键词： Isfahani style Vernacular urban development Sustainable urban development Iranian cities Vernacular architecture

3D打印和电沉积多层超轻夹层板的力学性能和能量吸收性能

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Transactions of Nonferrous Metals Society of China 2024年第1期34卷 255-264页

作者： Mehrnoosh hosseinPOUR Salar ROHANI NEJAD seyed mohammad hossein MIRBAGHERI Department of Materials and Metallurgical Engineering Amirkabir University of TechnologyHafez St.Tehran15875-4413Iran

研究由开孔聚合物和金属/聚合物泡沫芯制成的轻质夹层板的力学性能和能量吸收性能。通过结合聚合物树脂的增材制造和三层金属(Ni/Ni-Cu/Ni)的电沉积制备多层夹层板,每英寸孔数(PPI)为4、5和6。测试样品在单轴压缩变形过程中的屈服强度,... 详细信息

研究由开孔聚合物和金属/聚合物泡沫芯制成的轻质夹层板的力学性能和能量吸收性能。通过结合聚合物树脂的增材制造和三层金属(Ni/Ni-Cu/Ni)的电沉积制备多层夹层板,每英寸孔数(PPI)为4、5和6。测试样品在单轴压缩变形过程中的屈服强度,计算其能量吸收密度、互补能和比吸收能(SEA)。结果表明,与相同厚度的纯Ni和Cu夹层板相比,复合夹层板的性能有明显改善。增加PPI和金属层可提高力学性能和能量吸收性能,当PPI为6时,屈服强度(能量吸收密度)由聚合物夹层板的0.12 MPa(0.12MJ/m^(3))提高到三层金属夹层板的1.83MPa(0.67 MJ/m^(3))。对夹层板结构归一化能量的研究表明,夹层板具有可预测的塑性变形行为,多金属层改善了新型夹层板的力学性能。其能量吸收性能的显著增强可保证材料在不同行业的独特应用。

关键词：夹层板能量吸收金属泡沫 Voronoi结构增材制造金属电层级

Applications of SMILE-extracted lenticules in ophthalmology

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 173-187页

作者： hossein Aghamollaei Hassan Hashemi Mahsa Fallahtafti seyed-Hashem Daryabari Mehdi Khabazkhoob Khosrow Jadidi Chemical Injuries Research Center Systems Biology and Poisonings InstituteBaqiyatallah University of Medical SciencesTehran ***Iran Noor Research Center for Ophthalmic Epidemiology Noor Eye HospitalTehran ***Iran Vision Health Research Center Semnan University of Medical SciencesSemnan ***Iran Department of Basic Sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To review recent innovations,challenges,and applications of small incision lenticule extraction(SMILE)extracted lenticule for treating ocular disorders.METHODS:A literature review was performed in the PubMed database,which was last updated on 30 December 2021.There was no limit regarding language.The authors evaluated the reference lists of the collected papers to find any relevant research.RESULTS:Due to the simplicity and accuracy of modern femtosecond lasers and the extensive development of SMILE surgery,many healthy human corneal stromal lenticules were extracted during surgery,motivating some professionals to investigate the SMILE lenticule reusability in different ocular disorders.In addition,new approaches had been developed to preserve,modify,and bioengineer the corneal stroma,leading to the optimal use of discarded byproducts such as lenticules from SMILE surgery.The lenticules can be effectively re-implanted into the autologous or allogenic corneas of human subjects to treat refractive errors,corneal ectasia,and corneal perforation and serve as a patch graft for glaucoma drainage devices with better cosmetic outcomes.CONCLUSION:SMILE-extracted lenticules could be a viable alternative to human donor corneal tissue.

关键词： small incision lenticule extraction corneal lenticule implantation keratoconus corneal perforation femtosecond laser stromal keratophakia

Numerical study of convective heat transfer in static arrangements of particles with arbitrary shapes:A monolithic hybrid lattice Boltzmann-finite difference-phase field solver

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Particuology 2024年第2期85卷 186-197页

作者： Reza Namdar mohammadhassan Khodsiani Hesameddin Safari Tanya Neeraj seyed Ali hosseini Frank Beyrau Benoit Fond Dominique Thevenin Fathollah Varnik Interdisciplinary Centre for Advanced Materials Simulation(ICAMS) Ruhr-University BochumBochum44801Germany Laboratory of Technical Thermodynamics University of Magdeburg"Otto von Guericke"Magdeburg39106Germany Laboratory of Fluid Dynamics and Technical Flows University of Magdeburg"Otto von Guericke"MagdeburgD-39106Germany Department of Mechanical and Process Engineering ETH ZurichZurich8092Switzerland ONERA The French Aerospace Lab Department of AerodynamicsAeroelasticity and Acoustics(DAAA)Paris-Saclay UniversityMeudon92190France

A compressible lattice Boltzmann-finite difference method is extended by the phase-field approach into a monolithic scheme to study fluid flow and heat transfer through regular arrangements of solid bodies of circular,elliptical and irregular shapes.The advantage of using the phase-field method is demon-strated both in its simplicity of accounting for flow and thermal boundary conditions at solid surfaces with irregular shapes and in the capability of generating such complex-shaped objects.For an array of discs,numerical results for the overall solid-to-gas heat transfer rate are validated via experiments on flow through arrays of hot cylinders.The thus validated compressible LB-FD-PF hybrid scheme is used to study the dependence of heat transfer on flow and thermal boundary conditions(Reynolds number,temperature difference between the hot solid bodies and the inlet gas),porosity as well as on the shape of solid objects.Results are rationalized in terms of the residence time of the gas close to the solid body and downstream variations of gas velocity and temperature.Perspective for further applications of the proposed methodology are also discussed.

关键词： Lattice Boltzmann method Finite difference scheme Convective heat transfer Diffuse interface Thermal compressible flow

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1699-1700页

作者： seyed Mojtaba hosseini Soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CentreRady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada Manitoba Multiple Sclerosis Research Center WinnipegMBCanada Children Hospital Research Institute of Manitoba WinnipegMBCanada

Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).

关键词： peroxidation Fischer injury

Assessment of rehabilitation strategies for lakes affected by anthropogenic and climatic changes: A case study of the Urmia Lake, Iran

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Journal of Arid Land 2024年第6期16卷 752-767页

作者： seyed Morteza MOUSAVI hossein BABAZADEH Mahdi SARAI-TABRIZI Amir KHOSROJERDI Department of Water Science and Engineering Science and Research BranchIslamic Azad UniversityTehran 147789-3855Iran

Over the last three decades,more than half of the world's large lakes and wetlands have experienced significant shrinkage,primarily due to climate change and extensive water consumption for agriculture and other human needs.The desiccation of lakes leads to severe environmental,economic,and social repercussions.Urmia Lake,located in northwestern Iran and representing a vital natural ecosystem,has experienced a volume reduction of over 90.0%.Our research evaluated diverse water management strategies within the Urmia Lake basin and prospects of inter-basin water transfers.This study focused on strategies to safeguard the environmental water rights of the Urmia Lake by utilizing the modeling and simulating(MODSIM)model.The model simulated changes in the lake's water volume under various scenarios.These included diverting water from incoming rivers,cutting agricultural water use by 40.0%,releasing dam water in non-agricultural seasons,treated wastewater utilization,and inter-basin transfers.Analytical hierarchy process(AHP)was utilized to analyze the simulation results.Expert opinions with AHP analysis,acted as a multi-criteria decision-making tool to evaluate the simulation and determine the optimal water supply source priority for the Urmia Lake.Our findings underscore the critical importance of reducing agricultural water consumption as the foremost step in preserving the lake.Following this,inter-basin water transfers are suggested,with a detailed consideration of the inherent challenges and limitations faced by the source watersheds.It is imperative to conduct assessments on the impacts of these transfers on the downstream users and the potential environmental risks,advocating for a diplomatic and cooperative approach with adjacent country.This study also aims to forecast the volumes of water that can be transferred under different climatic conditions—drought,normal,and wet years—to inform strategic water management planning for the Urmia Lake.According to our projection,implementing the strategic scenarios outl

关键词： climate change drought lake ecological level agricultural water demand inter-basin water transfer