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Circulating levels of advanced glycation end products in females with polycystic ovary syndrome:a meta-analysis

Reproductive and Developmental Medicine 2024年第2期8卷 93-100页

作者： seyed Sobhan Bahreiny Akram Ahangarpour Mojtaba Aghaei Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences Research Institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Polycystic ovary syndrome(PCOS)is a common endocrine disorder characterized by a hormonal imbalance that affects females of reproductive *** association between advanced glycation end products(AGEs)and PCOS has attracted considerable attention in recent years,highlighting the potential of AGEs as biomarkers for this *** the present systematic review and meta-analysis,we aimed to examine the association between AGEs and PCOS,evaluate their potential as biomarkers,and improve our understanding of the pathophysiology of PCOS and its associated metabolic complications.A literature search was performed using various databases from January 2000 to March 2023 to identify relevant studies investigating the association between AGEs and *** effect estimates were calculated using standardized mean differences(SMD)with 95%confidence intervals(CIs).Sub-group and meta-regression analyses were performed to examine potential sources of *** meta-analysis included six studies with a total of 623 *** results revealed a significant increase in circulating AGE levels in females with PCOS compared to healthy females(SMD=2.35;95%CI:1.10-3.60;P<0.001).Significant heterogeneity was observed between the studies(I2=96.37%;P<0.001),indicating the presence of several factors influencing the ***-group analyses based on body mass index,age,and homeostatic model assessment for insulin resistance indicated differential effects of AGEs on specific *** systematic review and meta-analysis support the association between elevated AGE levels and PCOS,thereby suggesting the potential role of AGEs as biomarkers in PCOS.

关键词： Polycystic ovary syndrome PCOS Advanced glycation end products AGEs Biomarker Meta-analysis

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Effects of L-carnitine on treatment outcomes of COVID-19 patients hospitalized in intensive care units:A double-blind randomized clinical trial

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Journal of Acute Disease 2024年第3期13卷 100-105页

作者： Hesameddin Modir Behnam Mahmoudieh seyed Yousef Shahtaheri Fariba Farokhi Department of Anesthesiology and Critical Care Arak University of Medical SciencesArakIran Clinical Research Development Valiasr HospitalArak University of Medical SciencesArakIran

Objective:To assess the effects of L-carnitine on the outcomes of patients with moderate to severe coronavirus disease 2019(COVID-19)in intensive care unit(ICU).Methods:This double-blind clinical trial was carried out in 2022-2023.64 Patients with COVID-19 were selected from Amiralmomenin and Khansari hospitals in Arak,*** were randomly assigned to the control and the L-carnitine treatment group via block *** blood gases,disease severity,and levels of D-dimer,lactate dehydrogenase,ferritin,and C-reactive protein were daily assessed during the seven days of the intervention,and the length of ICU stay,the need for endotracheal intubation,and mortality rate were ***:There were significant differences in length of ICU stay,the need for endotracheal intubation,and levels of D-dimer,lactate dehydrogenase,ferritin,APACHE栻score,and C-reactive protein between the two groups(P0.05).Conclusions:L-carnitine can improve outcomes of patients with ***,it can be used as an adjuvant therapy for these patients.

关键词： L-carnitine COVID-19 ICU Critically ill Mortality Clinical outcome

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Evaluation of enhancing CO_(2) sequestration by post-brine injection under different scenarios using the E300 compositional simulator

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Petroleum Research 2019年第4期4卷 314-333页

作者： mahdi Mohajeri seyed Shariatipour School of Energy Construction and EnvironmentCoventry UniversityUnited Kingdom

To accelerate the CO_(2) trapping in geological storage sites,several injection strategies have been proposed by researchers so ***,the question remains unanswered as to which one of these injection strategies is the most efficient in terms of immobilising CO_(2) and more importantly,how these strategies might be *** this paper,we attempt to simulate a typical geological CO_(2) storage scheme in an aquifer using the E300 compositional reservoir simulator and subsequently investigate and compare the impact of various injection strategies on CO_(2) immobilising ***,the impact of adding a short period of post-brine injection on various strategies is newly *** results reveal that using a relatively short period of post-brine injection can significantly improve total CO_(2) trapping efficiency in all the *** general,by using post injection of brine,more CO_(2) is spread out through the aquifer and,as a consequence,by increasing the interfacial area of the CO_(2) plume,the amount of dissolution as a result of mass transfer increases ***,the effect of convection can become stronger in the case of post-brine injection creating a stronger density instability and thus a more rapid initiation of ***,when brine is injected into the system,CO_(2) is displaced away from the well resulting in a forced imbibition process and thereby enhancing the capillary trapping *** post-injection of brine has also one more particular effect in strategies of horizontal injection and simultaneous CO_(2)/brine injection in different *** this regard,postbrine injection creates a stronger downward pressure gradient that counters the tendency of the CO_(2) plume to rise and therefore retards the CO_(2) in reaching the top of the *** increases the time that the CO_(2) can be in contact with the fresh formation brine and so enhances the trapping *** envisage that the post-

关键词： CO_(2)storage Brine injection Injection strategies Capillary trapping Dissolution trapping CO_(2)trapping CO_(2)sequestration

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基于深度神经网络模拟复杂多孔介质中两相驱替过程

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石油勘探与开发 2024年第5期51卷 1126-1140页

作者： ASADOLAHPOUR seyed Reza JIANG Zeyun LEWIS Helen 闵超赫瑞瓦特大学能源、地球科学、基础设施与社会学院地球能源工程研究所爱丁堡EH144AS英国西南石油大学理学院成都610500 油气藏地质及开发工程全国重点实验室西南石油大学成都610500

为了预测复杂孔隙结构中毛管压力主导下两相流排驱过程中的流体分布,从仿真多孔介质和岩石CT图像中抽取子样本,并采用孔隙形态模拟器(PMS)生成流体分布,以创建多样化的数据集,将距离图及像素大小、界面张力、接触角、压力作为输入参数,... 详细信息

为了预测复杂孔隙结构中毛管压力主导下两相流排驱过程中的流体分布,从仿真多孔介质和岩石CT图像中抽取子样本,并采用孔隙形态模拟器(PMS)生成流体分布,以创建多样化的数据集,将距离图及像素大小、界面张力、接触角、压力作为输入参数,通过改造、训练、评估卷积神经网络(CNN)、递归神经网络(RNN)和视觉转换器(ViT),优选用于预测流体分布的模型。模拟分析表明,常用的卷积和递归神经网络在捕捉流体连通性方面存在不足。基于ViT构建了一个高维视觉转换器(HD-ViT),该转换器先忽略孔隙的空间位置仅根据其大小进行排驱,再在后处理步骤中追加流体连通要求,这种方法允许在任何坐标方向预设出入口,并使用不同尺寸和不同分辨率的图像进行渗流状态推断。通过在砂岩和碳酸盐岩大图像上验证,并与微流控驱替测试的实验结果比较,证实了HD-ViT模型的有效性、精确性和速度优势,且在捕捉孔隙尺度三维流动方面存在较大的潜力。

关键词：两相驱替流体分布深度神经网络视觉转换器孔隙形态模拟器大数据集

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On the Nonorientable Genus of the Generalized Unit and Unitary Cayley Graphs of a Commutative Ring

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Algebra Colloquium 2022年第1期29卷 167-180页

作者： mahdi Reza Khorsandi seyed Reza Musawi Faculty of Mathematical Sciences Shahrood University of Technology P.O.Box 36199-95161ShahroodIran

Let R be a commutative ring and U(R)the multiplicative group of unit elements of *** 2012,Khashyarmanesh et *** the generalized unit and unitary Cayley graph,T(R,G,S),corresponding to a multiplicative subgroup G of U(R)and a nonempty subset S of G with S^(-1)={s^(-1)|s∈S}■S,asthegraphwithvertexsetR and two distinct vertices x and y being adjacent if and only if there exists s∈S such that x+sy∈*** this paper,we characterize all Artinian rings R for which T(R,U(R),S)is *** leads us to determine all Artinian rings whose unit graphs,unitary Cayley graphs and co-maximal graphs are *** addition,we prove that for an Artinian ring R for which T(R,U(R),S)has finite nonorientable genus,R must be a finite ***,it is proved that for a given positive integer k,the number of finite rings R for which T(R,U(R),S)has nonorientable genus k is finite.

关键词： unit graph unitary Cayley graph co-maximal graph projective graph nonorientable genus

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Progressive failure analysis of notched composite plate by utilizing macro mechanics approach

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 623-642页

作者： seyed M.N.GHOREISHI mahdi FAKOOR Ahmad AZIZI Faculty of New Sciences and Technologies University of TehranTehran***Iran Department of Mechanical Engineering Science and Research BranchIslamic Azad UniversityTehran***Iran

In this study,gradual and sudden reduction methods were combined to simulate a progressive failure in notched composite plates using a macro mechanics *** the presented method,a progressive failure is simulated based on a linear softening law prior to a catastrophic failure,and thereafter,sudden reduction methods are employed for modeling a progressive *** combination method significantly reduces the computational cost and is also capable of simultaneously predicting the first and last ply failures(LPFs)in composite *** proposed method is intended to predict the first ply failure(FPF),LPF,and dominant failure modes of carbon/epoxy and glass/epoxy notched composite *** addition,the effects of mechanical properties and different stacking sequences on the propagation of damage in notched composite plates were *** results of the presented method were compared with experimental data previously reported in the *** comparing the numerical and experimental data,it is revealed that the proposed method can accurately simulate the failure propagation in notched composite plates at a low computational cost.

关键词： progressive failure notched composite plate Hashin failure criterion macro mechanics approach finite element method

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Post-discharge follow-up of patients with spine trauma in the National Spinal Cord Injury Registry of Iran during the COVID-19 pandemic:Challenges and lessons learned

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Chinese Journal of Traumatology 2024年第3期27卷 173-179页

作者： Zahra Azadmanjir Moein Khormali Mohsen Sadeghi-Naini Vali Baigi Habibollah Pirnejad Mohammad Dashtkoohi Zahra Ghodsi seyed Behnam Jazayeri Aidin Shakeri mahdi Mohammadzadeh Laleh Bagheri Mohammad-Sajad Lotfi Salman Daliri Amir Azarhomayoun Homayoun Sadeghi-Bazargani Gerard O'reilly Vafa Rahimi-Movaghai Health Information Management Department School of Allied Medical SciencesTehran University of Medical SciencesTehranIran Sina Trauma and Surgery Research Center Tehran University of Medical SciencesTehranIran Department of Neurosurgery Lorestan University of Medical SciencesKhoram-AbadIran Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehranIran Patient Safety Research Center Clinical Rsearch Institute Urma Universty of Medical SciencesUrmaIran Erasmus School of Health Policy&Management(ESHPM) Erasmus University RotterdamRoterdamthe Netherlands Brain and Spinal Cord Injury Research Center Neuroscience InstituteTehran University of Medical SciencesTehranIran Students Scientifc Research Center(SSRC) Tehran University of Medical SciencesTehranIran Department of Neurosurgery Arak University of Medical SciencesArakIran Trauma Research Center Kashan University of Medical SciencesKashanIran Shahid Rahnemoun Hospital Shahid Sadoughi University of Medical SciencesYazdIran Trauma Nuring Rearch entre Faculty of Nursing and Midwifry Kahan Universty of Medical Sciences Kahan Iran Clinical Research Development Unit Imam Hossein HospitalShahroud University of Medical SciencesShahroudIran Research Center for Evidence Based Medicine Faculty of MedicineTabriz University of Medical SciencesTabrizIran Road Trafic Injury Research Center Tabriz University of Medical SciencesTabrizIran School of Public Health and Preventive Medicine Monash UniversityMelbourneAustralia National Trauma Research Institute The AlfredMelbourneAustralia Department of Neurosurgery Shariati HospitalTehran University of Medical SciencesTehranIran Universal Scientific Education and Research Network(USERN) TehranIran Institute of Biochemistry and Biophysics University of TehranTehranIran

Purpose:The purpose of the National Spinal Cord Injury Registry of Iran(NSCIR-IR)is to create an infrastructure to assess the quality of care for spine trauma and in this study,we aim to investigate whether the NSCIR-IR successfully provides necessary post-discharge follow-up data for these ***:An observational prospective study was conducted from April 11,2021 to April 22,2022 in 8 centers enrolled in NSCIR-IR,respectively Arak,Rasht,Urmia,Shahroud,Yazd,Kashan,Tabriz,and *** were classified into 3 groups based on their need for care resources,respectively:(1)non-spinal cord injury(SCI)patients without surgery(group 1),(2)non-SCI patients with surgery(group 2),and(3)SCI patients(group 3).The assessment tool was a self-designed questionnaire to evaluate the care quality in 3 phases:pre-hospital,in-hospital,and *** data from the first 2 phases were collected through the *** post-hospital data were collected by conducting follow-up *** follow-ups were conducted for groups 1 and 2(non-SCI patients),while group 3(SCI patients)had a face-to-face *** study took place during the COVID-19 *** on age and time interval from injury to follow-up were expressed as mean±standard deviation(SD)and response rate and follow-up loss as a ***:Altogether 1538 telephone follow-up records related to 1292 patients were registered in the *** the total calls,918(71.05%)were related to successful follow-ups,but 38 cases died and thus were excluded from data *** the end,post-hospital data from 880 patients alive were *** success rate of follow-ups by telephone for groups 1 and 2 was 73.38%and 67.05%respectively,compared to 66.67%by face-to-face visits for group 3,which was very hard during the COVID-19 *** data completion rate after discharge ranged from 48%-100%,22%-100%and 29%-100%for groups ***:To improve patient accessibility,NSCIR-IR should take me

关键词： Follow-up studies Spinal injuries Spinal cord injuries COVID-19 NSCIR-IR

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Probiotic microorganisms affect the reproductive and nervous systems of male rats treated with acrylamide

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Asian pacific Journal of Reproduction 2024年第4期13卷 178-186页

作者： seyedhossein Hekmatimoghaddam Maryam Yadegari Fateme Zare Fatemeh Zakizadeh seyed Mohammad Seifati Hematology and Oncology Research Center Shahid Sadoughi University of Medical SciencesYazdIran Department of Laboratory Sciences School of ParamedicineShahid Sadoughi University of Medical SciencesYazdIran Neuroendocrine Research Center Shahid Sadoughi University of Medical SciencesYazdIran Department of Anatomy and Cell Biology Faculty of MedicineShahid Sadoughi University of Medical SciencesYazdIran Reproductive Immunology Research Center Shahid Sadoughi University of Medical SciencesYazdIran

Objective:To evaluate the protective effects of probiotic microorganisms on the reproductive and nervous systems of male rats treated with ***:Thirty-two rats were randomly divided into 4 groups and received normal saline through gavage(control),acrylamide 20 mg/kg body weight,acrylamide plus probiotic microorganisms(Lactobacillus acidophilus,Lactobacillus casei,Lactobacillus bulgaricus,Lactobacillus rhamnosus,Bifidobacterium breve,Bifidobacterium infantis,Streptococcus thermophilus and fructooligosaccharides,all mixed in sachets)20 or 200 mg/kg body weight,*** 30 days,the testis,prostate,seminal vesicle and cerebellum were removed,fixed and stained with hematoxylin-eosin(H&E).The Johnsen score was used to classify ***'s principle method was used to evaluate the total volume(in mm3)of the *** number of each intratubular cell type as well as intertubular Leydig cells in whole samples was measured using the physical dissector counting *** analysis and the grids were used to determine the volume of cerebellar layers as well as the Purkinje cell ***:The testis weight decreased significantly in the acrylamide-treated group compared to the other groups(P<0.001).The number of spermatogonia,spermatocytes,spermatids and Leydig cells in the acrylamide-treated group were significantly less compared to the control group(P<0.05),while they were increased significantly in the acrylamide+200 mg/kg probiotic group(P<0.05;P<0.01).The mean Johnsen score in the acrylamide-treated group was lower than in the control group(P<0.001).Acrylamide-induced changes including congestion,vacuolization in the secretory epithelial cells,and epithelial rupture were observed in the prostate and seminal *** volumes of cerebellar layers were decreased in the acrylamide group compared to the control group while recovered in both probiotic treated ***:Probiotic microorganisms alleviate acryl

关键词： Acrylamide Cerebellum Microorganisms Probiotics Prostate Rats Testis

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Synthesis of phenanthrimidazole from 9,10-phenanthraquinone and aldehydes by molecular iodine as catalyst

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Chinese Chemical Letters 2009年第1期20卷 5-8页

作者： Hossein Behmadi Mina Roshani seyed mahdi Saadati Department of Chemistry Faculty of Basic SciencesIslamic Azad UniversityMashhad Branch Department of Chemistry Faculty of Basic SciencesIslamic Azad University

A new,convenient,efficient,and cost-effective one-pot synthesis of 1H-phenanthro[9,10]imidazol-2-yl from phenantherenquinone and aldehydes,using molecular iodine as catalyst is *** present methodology offers several a... 详细信息

关键词： 1H-Phenanthroimidazol-2-yl Phenantherenquinone Molecular iodine

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An Efficient Lightweight Authentication and Key Agreement Protocol for Patient Privacy

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Computers, Materials & Continua 2021年第12期69卷 3495-3512页

作者： seyed Amin Hosseini Seno mahdi Nikooghadam Rahmat Budiarto Department of Computer Engineering Ferdowsi University of MashhadMashhad***Iran Department of Informatics Faculty of Science and TechnologyUniversitas Alazhar IndonesiaJakarta12110Indonesia

Tele-medical information system provides an efficient and convenient way to connect patients at home with medical personnel in clinical *** this system,service providers consider user authentication as a critical *** address this crucial requirement,various types of validation and key agreement protocols have been *** main problem with the two-way authentication of patients and medical servers is not built with thorough and comprehensive analysis that makes the protocol design yet has *** paper analyzes carefully all aspects of security requirements including the perfect forward secrecy in order to develop an efficient and robust lightweight authentication and key agreement *** secureness of the proposed protocol undergoes an informal analysis,whose findings show that different security features are provided,including perfect forward secrecy and a resistance to DoS ***,it is simulated and formally analyzed using Scyther *** results indicate the protocol’s robustness,both in perfect forward security and against various *** addition,the proposed protocol was compared with those of other related protocols in term of time complexity and communication *** time complexity of the proposed protocol only involves time of performing a hash function Th,i.e.,:O(12Th).Average time required for executing the authentication is 0.006 seconds;with number of bit exchange is 704,both values are the lowest among the other *** results of the comparison point to a superior performance by the proposed protocol.

关键词： Authentication key agreement protocol tele-medical Scyther perfect forward secrecy

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