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Enhanced two-loop model predictive control design for linear uncertain systems

Journal of Systems Engineering and Electronics 2021年第1期32卷 220-227页

作者： Mohammad-Ghassem FARAJZADEH-DEVIN seyed kamal hosseini sani Department of Electrical Engineering Ferdowsi University of MashhadMashhad 1696700Iran

Model predictive controllers(MPC)with the two-loop scheme are successful approaches practically and can be classified into two main categories,tube-based MPC and MPCbased reference governors(RG).In this paper,an enhanced twoloop MPC design is proposed for a pre-stabilized system with the bounded uncertainty subject to the input and state *** proposed method offers less conservatism than the tube-based MPC methods by enlarging the restricted input *** to the MPC-based RGs,the investigated method improves tracking performance of the pre-stabilized system while satisfying the ***,the robust global asymptotic stability of the closed-loop system is guaranteed in a novel procedure with terminal constraint *** of the proposed method on a servo system shows its effectiveness in comparison to the others.

关键词： model predictive control(MPC) robust control cascade control constraint satisfaction

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A Novel Distributed Optimal Adaptive Control Algorithm for Nonlinear Multi-Agent Differential Graphical Games

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 331-341页

作者： Majid Mazouchi Mohammad Bagher Naghibi-Sistani seyed kamal hosseini sani Department of Electrical Engineering Ferdowsi University of Mashhad

In this paper, an online optimal distributed learning algorithm is proposed to solve leader-synchronization problem of nonlinear multi-agent differential graphical games. Each player approximates its optimal control policy using a single-network approximate dynamic programming(ADP) where only one critic neural network(NN) is employed instead of typical actorcritic structure composed of two NNs. The proposed distributed weight tuning laws for critic NNs guarantee stability in the sense of uniform ultimate boundedness(UUB) and convergence of control policies to the Nash equilibrium. In this paper, by introducing novel distributed local operators in weight tuning laws, there is no more requirement for initial stabilizing control policies. Furthermore, the overall closed-loop system stability is guaranteed by Lyapunov stability analysis. Finally, Simulation results show the effectiveness of the proposed algorithm.

关键词： Approximate dynamic programming(ADP) distributed control neural networks(NNs) nonlinear differentia graphical games optimal control

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Nicorandil potentiates sodium butyrate induced preconditioning of neurons and enhances their survival upon subsequent treatment with H_(2)O_(2)

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Translational Neurodegeneration 2017年第1期6卷 291-299页

作者： Parisa Tabeshmehr Haider Kh Husnain Mahin Salmannejad Mahsa sani seyed Mojtaba hosseini Mohammad Hossein Khorraminejad Shirazi Student Research Committee Shiraz University of Medical SciencesShirazIran Cell&Molecular Medicine Student Research Group Medical FacultyShiraz University of Medical SciencesShirazIran Department of Basic Sciences SRURiyadhSaudi Arabia Stem Cell Laboratory Department of AnatomyShiraz University of Medical SciencesShirazIran

Background:Extensive loss of donor neural stem cell(NSCs)due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation *** that histone deacetylases(HDACs)modulate various cellular processes by deacetylating histones and non-histone proteins,we hypothesized that combined treatment with small molecules,sodium butyrate(NaB;a known HDAC inhibitor)and nicorandil,will enhance the rate neuronal differentiation of NSCs besides their preconditioning to resist oxidative ***:NSCs derived from 14-day old Sprague Dawley rat ganglion eminence were characterized for tri-lineage *** with 1 mM NaB significantly changed their culture characteristics while continuous treatment for 10 days enhanced their neural *** treatment also preconditioned the cells for their resistance to oxidative ***:The highest rate of neural differentiation and preconditioning effect was achieved when the NSCs were treated concomitantly with NaB and *** proliferation assay showed that concomitant treatment with NaB and nicorandil retarded their rate of ***:These data conclude that preconditioning of NSCs with NaB and nicorandil effectively enhances their differentiation capacity besides preconditioning the cells to support their survival under ischemic conditions.

关键词： Apoptosis Neural stem cells Oxidative stress Preconditioning

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Differentiation of Menstrual Blood Derived Stem Cell (MensSCs) to Hepatocyte-Liked Cell on Three Dimensional Nanofiberscaffold: Poly Caprolacton (PCL)

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Journal of Biomedical Science and Engineering 2016年第4期9卷 216-225页

作者： Farnaz sani Giti Borzooeian Somayeh Kazemnejad Sepideh Ebrahimi Masoomeh Mohamadpour Sayeh Khanjani Mona Latifi seyed Mojtaba hosseini Mahin Salmannejad Fatemeh Aleahmad Hossein Mehraban Jahromi Mahsa sani Laboratory for Stem Cell Research Anatomy Department Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran Departments of Embryology and Stem Cells Reproductive Biotechnology Research Center Avicenna Research Institute ACECR Tehran Iran Department of Biochemistry Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran Anatomy Histomorphometry and Stereology Research Center Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran

Menstrual blood stem cells (MensSCs) have enormous potential as a source for cell replacement therapies. Since there is a major concern in utilization of nanofibers in tissue engineering of stem cells, we examined the potential of MensSCs to differentiate into hepatocytes, using different protocols and compare cells, with two-dimensional (2D) and three-dimensional (3D) culture systems. Cell characterization experiments of MensSCs have demonstrated that they are multipotent stem cells similar to mesenchymal stem cells, which can successfully differentiate into osteogenic and adipogenic lineages. The efficiency of the cells on the scaffold was appraised by scanning electron microscopy (SEM), MTT assay, and hematoxylin and eosin (H&E) staining. Thereafter, the differentiation protocols were developed by hepatocyte growth factor (HGF) and oncostatin M (OSM) with serum-supplemented or serum-free culture media up to 30 days. Immunofluorescence analysis and ELISA assay revealed the expression of albumin (ALB) in differentiated cells. Hepatocyte-like cells expressed liver-specific gene such as albumin(ALB), α-fetoprotein (AFP), tyrosine aminotransferase (TAT) and cytochrome P450 subunit 7a1 (Cyp7a1) at mRNA levels. In conclusion, the evidences presented in this study show that the nanofiber scaffold and MensSCs may provide a source of differentiated cells for treatment of liver diseases.

关键词： Differentiation Hepatocyte Menstrual Blood Stem Cell 3D Cultures

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