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Evaluation of miR-21 and miR-150 expression in immune thrombocytopenic purpura pathogenesis： a case-control study

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Frontiers in Biology 2017年第5期12卷 361-369页

作者： Elahe Khodadi Ali Amin Asnafi Javad Mohammadi-Asl seyed ahmad hosseini Amal Saki Malehi Najmaldin Saki Thalassemia & Hemoglobinopathy Research center research institute of health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Immune thrombocytopenic purpnra （ITP） is a common autoimmune disorder diagnosed with thrombocytopenia and bleeding symptoms due to production of autoantibodies （Abs） against platelets. Nowadays, microRNAs are known as novel biomarkers for diagnosis of diseases. The aim of this study was to investigate the expression levels of miR-21 and miR-150 in ITP patients and determine the role of these miRNAs in ITP pathogenesis. MATERIALS and METHODS： Thirty newly diagnosed patients with acute ITP and 30 healthy subjects（ age and sex matched） as controls were enrolled in this study. The expression level ofmiR-21 and miR- 150 was investigated using Real-time-PCR. Comparison of demographic characteristics of the cases was done using independent t-test and chi-square test. Comparison of the expression level of miR-21 and miR-150 with the related parameters was done using independent t-test or Mann-Whitney and Kruskal-Wallis test, Spearman rho correlation coefficient was used to investigate the relationship between the expression of miR-21 and miR-150 with demographic characteristics. RESULTS： The expression of miR-21, 150 in the patients was not different compared with the control group in general. A significant relationship between the expression of miR-21 with hemoglobin, hematocrit and red blood cell hemoglobin concentration was observed. DISCUSSION： Expression of miR-21 and miR-150 is not associated with pathogenesis of acute ITP and can involve the synergistic role of other miRNAs. Investigation of miR-21 and miR-150 expression along with other miRNAs and cytokines can be helpful in diagnosis and pathogenesis of ITP.

关键词： immune thrombocytopenic purpura miR-21 miR- 15 0

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1699-1700页

作者： seyed Mojtaba hosseini Soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CentreRady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada Manitoba Multiple Sclerosis Research Center WinnipegMBCanada Children Hospital Research Institute of Manitoba WinnipegMBCanada

Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).

关键词： peroxidation Fischer injury

Complete Moment Convergence for the Dependent Linear Processes with Random Coefficients

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Acta Mathematica Sinica,English Series 2019年第8期35卷 1321-1333页

作者： seyed Mohammad hosseini ahmad NEZAKATI Faculty of Mathematical Sciences Shahrood University of Technology

In this paper, we investigate the complete moment convergence for dependent linear processes with random coefficients to form Xt =∑j^∞=∞ Aj∈t-j,where {∈n, n ∈ Z} is a sequence of END stochastically dominated random variables and {An,n ∈ Z} is a sequence of random varibles. As applications, the convergence rate, Marcinkiewicz-Zvgmund strong law and strong law of large numbers for this linear process are established.

关键词： Complete moment convergence ext ended negatively dependen t random variables linear processes random coefficients

Linking morphological and ecophysiological leaf traits to canopy dieback in Persian oak trees from central Zagros

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Journal of Forestry Research 2019年第5期30卷 1755-1764页

作者： ahmad hosseini seyed Mohsen hosseini Juan Carlos Linares Department of Natural Resources AREEOIlam Agricultural and Natural Research and Education CenterIlam 69317-73835Iran Faculty of Natural Resources&Marine Sciences Tarbiat Modares UniversityNoorMazandaran 46417-76489Iran Department of Physical Chemical and Natural SystemsUniversity Pablo de OlavideCarretera de Utrera Km 141013 SevilleSpain

Intraspecific variability in morphological and ecophysiological leaf traits might be theorized to be present in declining populations,since they seem to be exposed to stress and plasticity could be *** we focused on declining Persian oaks(Quercus brantii ***(Jaub and Spach)Zohary)in the Zagros Mountains of western Iran,representing the most important tree species of this *** selected trees with contrasting crown dieback,from healthy to severely defoliated,to investigate the relationships between canopy dieback and leaf morphology,water content and *** also measured esterase and peroxidase,as enzymatic antioxidants and indicators of contrasting *** showing moderate to severe defoliation showed higher leaf mass area(LMA),reduced relative water content(RWC),and lower stomatal density(SD).Increasing LMA indicates a more sclerophyllic structure,according to drier *** did not find significant differences in leaf pigments(chlorophyll a and b,and carotenoids)among crown dieback classes,suggesting that Persian oak trees are able to maintain accurate photochemical efficiency,while reduced RWC and SD suggest hydraulic *** results do not provide a consistent pattern as regards enzymatic antioxidant defense in Persian *** leaf traits would be important drivers of future adaptive evolution in Persian oak,leading to smaller and thicker leaves,which have fitness benefits in dry ***,drought responses may be critically affecting carbon uptake,as photosynthetic compounds are less effectively used in leaves with higher sclerophylly.

关键词： Crown dieback Drought Leaf mass area Oak decline Quercus brantii Stomatal density Sclerophylly

Two-dimensional MOF-based materials:Preparations and applications as electrodes in Li-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 388-418,I0008页

作者： Narges Nobakht Seyyed ahmad Etghani Mohammad hosseini seyed Hamed Aboutalebi Condensed Matter National Laboratory Institute for Research in Fundamental SciencesTehran 19395-5531Iran School of Biological Sciences Institute for Research in Fundamental SciencesTehran 19395-5746Iran BattScout Company London RoadBishopdownSalisbury SP13EnglandUnited Kingdom

Two-dimensional(2D)metal-organic frameworks(MOFs)are rapidly emerging as a unique class of mushrooming family of 2D materials offering distinctive features,such as hierarchical porosity,extensive surface area,easily available active sites,and versatile,adaptable *** promising characteristics have positioned them as highly appealing alternatives for a wide range of applications in energy storage technologies,including lithium ***,the poor conductivity and limited stability of 2D MOFs have limited their real applications in electrochemical energy *** limitations have therefore warranted ongoing research to enhance the performance of 2D *** the significance of 2D MOF-based materials as an emerging class of advanced materials,a multitude of strategy has been devised to address these challenges such as synthesizing 2D conductive MOFs and derivatives along with 2D MOF *** promising approach involves the use of 2D MOF derivatives,including transition metal oxides,which due to their abundant unsatu rated active metal sites and shorter diffusion paths,offer superior electrochemical ***,by combining pristine 2D MOFs with other materials,hybrid 2D MOF materials can be *** hybrids,with their enhanced stability and conductivity,can be directly utilized as active materials in lithium *** the present review,we categorize 2D MOF-based materials into three distinct groups:pristine 2D MOFs,2D MOFderived materials,and 2D MOF hybrid *** synthesis methods for each group,along with their specific applications as electrode materials in lithium-ion batteries,are discussed in *** comprehensive review provides insights into the potential of 2D MOFs while highlighting the opportunities and challenges that are present in this evolving field.

关键词： Li-ion batteries 2D materials 2D metal-organic frameworks Energy storage Synthesis

Prediction of bed load sediments using different artificial neural network models

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Frontiers of Structural and Civil Engineering 2020年第2期14卷 374-386页

作者： Reza ASHEGHI seyed Abbas hosseini Department of Civil Engineering Science and Research BranchIslamic Azad UniversityTehranIran

Modeling and prediction of bed loads is an important but difficult issue in river *** introduced empirical equations due to restricted applicability even in similar conditions provide different accuracies with each other and measured *** this paper,three different artificial neural networks(ANNs)including multilayer percepterons,radial based function(RBF),and generalized feed forward neural network using five dominant parameters of bed load transport formulas for the Main Fork Red River in Idaho-USA were *** optimum models were found through 102 data sets of flow discharge,flow velocity,water surface slopes,flow depth,and mean grain *** deficiency of empirical equations for this river by conducted comparison between measured and predicted values was approved where the ANN models presented more consistence and closer estimation to observed *** coefficient of determination between measured and predicted values for empirical equations varied from 0.10 to 0.21 against the 0.93 to 0.98 in ANN *** accuracy performance of all models was evaluated and interpreted using different statistical error criteria,analytical graphs and confusion *** the ANN models predicted compatible outputs but the RBF with 79%correct classification rate corresponding to 0.191 nctwork error was outperform than others.

关键词： bed load prediction artificial neural network modeling empirical equations

Enhanced microstructural and mechanical properties of Stellite/WC nanocomposite on Inconel 718 deposited through vibration-assisted laser cladding

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International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 327-334页

作者： Hossein hosseini-Tayeb seyed Mahdi Rafiaei Daneshpajoohan Pishro Higher Education Institute IsfahanIran Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayeganIsfahanIran

Stellite-21/WC nanopowders were deposited on Inconel through vibration-assisted laser cladding with different laser *** and scanning electron microscopy,hardness measurements,and wear characterizations were employed to understand the microstructural and mechanical behaviors of the *** showed that varying the cooling rate exerted remarkable effects on the microstructure of the as-cladded ***,increasing the laser power from 150 W to 250 W increased the heat input and the *** was affected by the scanning rate and powder feeding rate at a high laser power of 250 *** WC nanoparticles were added as reinforcement,the dilution magnitude intensified while the hardness value increased from HV 350 to HV *** wear characterizations indicated that the composites containing 3 wt%WC nanoparticles possessed the highest wear resistance.

关键词： Stellite WC nanoparticles mechanical properties laser cladding

Simultaneous Employment of Generation Rescheduling and Incentive-based Demand Response Programs for Congestion Management in Case of Contingency

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 902-912页

作者： seyed Erfan hosseini Alimorad Khajehzadeh Mahdiyeh Eslami Department of Electrical Engineering Kerman branchIslamic Azad UniversityKermanIran

Relieving congestion significantly influences the operation and security of the transmission ***,the congestion alleviation of transmission network in all power systems is ***,it could prevent price spikes and/or involuntary load shedding and impose high expenses on the transimission network,especially in case of ***,the increasing or decreasing generation rescheduling has been used as one of the most imperative approaches for correctional congestion management when a contingency ***,demand response programs(DRPs)could also be a vital tool for managing the ***,the simultaneous employment of generation rescheduling and DRPs is proposed for congestion management in case of *** objective is to reschedule the generation of power plants and to employ DRPs in such a way so as to lessen the cost of *** crow search algorithm is employed to determine the *** accuracy and efficiency of the proposed approach are assessed through the tests conducted on IEEE 30-bus and 57-bus test *** results of various case studies indicate the better performance of the proposed approach in comparison with different approaches presented in the literature.

关键词： Congestion management demand response generation rescheduling transmission economy transmission lines

Multidisciplinary design optimization of a dual-spin guided vehicle

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Defence Technology（防务技术） 2024年第7期37卷 133-148页

作者： Jalal Karimi Mohammad Reza Rajabi seyed Hossein Sadati seyed Mahid hosseini Department of Aerospace Engineering Malek Ashtar University of TechnologyTehranIran

In this research,a Multidisciplinary Design Optimization approach is proposed for the dual-spin guided flying projectile design considering external and internal parts of the body as design *** this way,a parametric formulation is *** related disciplines,including structure,aerodynamics,guidance,and control are *** total mass,maximum aerodynamic control effectiveness,minimum miss distance,maximum yield stress in all subsystems,controllability and gyroscopic stability constraints are some of objectives/constraints taken into *** problem is formulated in All-At-Ones Multidisciplinary Design Optimization approach structure and solved by Simulated Annealing and minimax *** optimal configurations are evaluated in various *** resulted optimal configurations have met all design objectives and constraints.

关键词： Flying projectile optimal design All-at-ones multidisciplinary optimization Structure discipline Guidance and control discipline Aerodynamic discipline