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Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer

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Cancer Communications 2024年第1期44卷 101-126页

作者： Monika Raab Izabela Kostova Samuel Peña-Llopis Daniela Fietz Monika Kressin seyed mohsen Aberoumandi Evelyn Ullrich Sven Becker Mourad Sanhaji Klaus Strebhardt Department of Gynecology Medical SchoolGoethe-UniversityFrankfurt am MainGermany Translational Genomics in Solid Tumors West German Cancer CenterUniversity HospitalEssenGermany German Cancer Consortium(DKTK) EssenGermany German Cancer Research Center(DKFZ) HeidelbergGermany Histology and Embryology Institute for Veterinary AnatomyGiessenGermany Franfurt Cancer Institute(FCI) Goethe UniversityFrankfurt am MainGermany German Cancer Consortium(DKTK) Partner site Frankfurt/Mainza partnership between DKFZ and University Hospital FrankfurtFrankfurt am MainGermany Experimental Immunology Department for Children and Adolescents MedicineUniversity Hospital FrankfurtGoethe UniversityFrankfurt am MainGermany

Background:The cellular tumor protein p53(TP53)is a tumor suppressor gene that is frequently mutated in human *** various cancer types,the very aggressive high-grade serous ovarian carcinoma(HGSOC)exhibits the high-est prevalence of TP53 mutations,present in>96%of *** intensive efforts to reactivate p53,no clinical drug has been approved to rescue p53 *** this study,our primary objective was to administer in vitro-transcribed(IVT)wild-type(WT)p53-mRNA to HGSOC cell lines,primary cells,and ortho-topic mouse models,with the aim of exploring its impact on inhibiting tumor growth and dissemination,both in vitro and in ***:To restore the activity of p53,WT p53 was exogenously expressed in HGSOC cell lines using a mammalian vector ***,IVT WT p53 mRNA was delivered into different HGSOC model systems(primary cells and patient-derived organoids)using liposomes and studied for proliferation,cell cycle progression,apoptosis,colony formation,and chromosomal *** alterations induced by p53 mRNA were analyzed using RNA sequencing in OVCAR-8 and primary HGSOC cells,followed by ingenuity path-way *** vivo effects on tumor growth and metastasis were studied using orthotopic xenografts and metastatic intraperitoneal mouse ***:Reactivation of the TP53 tumor suppressor gene was explored in differ-ent HGSOC model systems using newly designed IVT mRNA-based *** introduction of WT p53 mRNA triggered dose-dependent apoptosis,cell cycle arrest,and potent long-lasting inhibition of HGSOC cell *** analysis of OVCAR-8 cells upon mRNA-based p53 reactivation revealed significant alterations in gene expression related to p53 signaling,such as apoptosis,cell cycle regulation,and DNA *** p53 function concurrently reduces chromosomal instability within the HGSOC cells,under-scoring its crucial contribution in safeguarding genomic integrity by moderating the baselin

关键词： apoptosis cell cycle chromosomal instability HGSOC metastatic intraperitoneal mouse model HGSOC orthotopic Xenograft model high-grade serous ovarian cancer in vitro-transcribed p53-mRNA liposomal IVT mRNA delivery system patient-derived organoid patient-derived primary cancer cell

A comparative study of physicochemical and photocatalytic properties of visible light responsive Fe,Gd and P single and tri-doped TiO_2 nanomaterials

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Journal of Rare Earths 2018年第1期36卷 72-85页

作者： seyed mohsen adyani mohammad ghorbani department of materials science and engineering sharif university of technologyPO．Box 11155-9466Tehran，lran institute for nanoscience and nanotechnology(inst) sharif university of technologyP0．Box 11155-8639，Tehran1ran

High performance Fe-Gd-P tri-doped TiO2 nanoparticles （1 at% for each dopant） were successfully synthesized by a modified sol-gel method. Various analytical and spectroscopic techniques were carried out to determine the physicochemical properties of the prepared samples, including XRD, EDX, FESEM, BET, FFIR, XPS, PL, EIS and UV-Vis diffuse reflectance spectroscopy. The photocatalytic activities of prepared samples were evaluated by photo degradation of methyl orange （MO） and 4-chlorophenol （4- CP） as model pollutants under visible light irradiation. Effects of each dopant on different properties of TiO2 nanoparticles were investigated. Results show that Gd and P doping enhances Ti02 surface textural properties by forming Ti O Gd and Ti-O-P bonds. It is found that Gd plays a superior role in increasing oxygen vacancies and organic species on TiO2 surface. Gd doping also facilitates transferring of the photo-induced charge carriers to the surface adsorbed species. The enhanced electronic band structure and visible light response, as well as high electron lifetime of Fe-Gd-P tri-doped sample is mainly attributed to Fe and Gd doping. The tri-doped TiO2 with rate constant ofkapp - 1.28 ~ 10-2 min-1 for MO and kapp ~ 0.94 ~ 10-2 min-1 for 4-CP, shows the highest photodegradation rate among all samples including undoped and single doped samples. The improved photocatalytic performance of Fe-Gd-P tri- doped Ti02 is due to the synergistic effect of enhanced surface chemistry and textural properties, increased number of surface adsorbed hydroxyl groups and organic species, improved visible light ab- sorption, increased lifetime of the photo-induced electron/hole pairs and boosted interfacial charge transfer.

关键词： Fe-Gd-P tri-doped TiO2Sol-gel synthesisPhotodegradationVisible light responseSynergistic effectRare earths

Visible light-induced synthesis of biomass-derived quinoxaline by using Co phthalocyanine immobilized on pyridine-doped g-C_(3)N_(4)

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Journal of Energy Chemistry 2023年第7期82卷 638-652,I0013页

作者： Mingren Jin seyed mohsen Sadeghzadeh Jinzhu Chen College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 511443GuangdongChina New Materials Technology and Processing Research Center Department of ChemistryNeyshabur BranchIslamic Azad UniversityNeyshaburIran

Visible light-driven valorization of biomass has recently been a pioneering field for nitrogen-containing heterocyclics syntheses due to its sustainable ***,various aromatic ring-doped g-C_(3)N_(4) nanosheets(Ar-g-C_(3)N_(4);Ar=Py,Pm,Ph)were precisely designed to modulate their intrinsic electronic and band structure,which involves pyridine(Py),pyrimidine(Pm),and benzene(Ph)-doped g-C_(3)N_(4).Photocatalysts(CoPc/Ar-g-C_(3)N_(4)) of cobalt(II)phthalocyanine(CoPc)-fabricated Ar-g-C_(3)N_(4) were then developed for oxidative cyclization of furoin with 1,2-phenylenediamines for syntheses of various biomass-derived quinoxalines under visible-light *** catalytic activity(in terms of TOFs)of serial CoPc/Ar-g-C_(3)N_(4) samples increased with their transient photocurrents with CoPc/Py-g-C_(3)N_(4) as the most active *** CoPc/Py-g-C_(3)N_(4),CoPc species functioned as both sensitizer and catalytic sites;while,doped Py led to a narrowed bandgap *** research further demonstrated that O_(2) was activated to superoxide radical(·O_(2)^(-)) by photoexcited high-level-energy electron(HLEE)transfer from Py-g-C_(3)N_(4) to CoPc for the subsequent aerobic oxidation.

关键词： Biomass Functionalized carbon nitride Nitrogen-containing heterocyclics Photocatalysis Quinoxaline

Hydrodynamic and heat transfer properties of magnetic fluid in porous medium considering nanoparticle shapes and magnetic field-dependent viscosity

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Chinese Journal of Chemical Engineering 2020年第2期28卷 329-339页

作者： mohsen Izadi Masoud Javanahram seyed mohsen Hashem Zadeh Dengwei Jing Mechanical Engineering Department Lorestan UniversityKhorramabadIran Mechanical Engineering Department Islamic Azad UniversityBushehrIran Department of Mechanical Engineering Shahid Chamran University of AhvazIran School of Energy and Power Engineering State Key Lab of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an 710049China

The purpose of this paper is to study the characteristics of the combined convection heat transfer and a micropolar nanofluid flow passing through an impermeable stretching sheet in a porous *** nanofluid flow field is affected by a magnetic field perpendicular to the *** dynamic viscosity of the micropolar nanofluid changes under the influence of the magnetic *** continuity,linear momentum,angular momentum,and energy equations are first simplified using the order of magnitude technique that,along with the applied boundary conditions and the definition of the appropriate parameters,are transferred to the similarity space using the similarity *** the resulting equations are solved using the Runge–Kutta *** distinction of the macroscale and microscale flow fields and temperature fields resulting from different nanoparticle shapes was *** the Hartmann number,the vortex viscosity parameter,the magnetic parameter,the nanoparticle volume fraction,and the permeability parameter of the porous media increased the surface friction on the *** the vortex viscosity parameter,the magnetic parameter,and the volume fraction of the nanoparticles increases the Nusselt number.

关键词： MHD-combined convection Porous media Magnetic micropolar nanofluid

Classification of Special Anosov Endomorphisms of Nil-manifolds

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Acta Mathematica Sinica,English Series 2019年第12期35卷 1871-1890页

作者： seyed mohsen MOOSAVI Khosro TAJBAKHSH Department of Mathematics Faculty of Mathematical Sciences Tarbiat Modares University

In this paper we give a classification of special endomorphisms of nil-manifolds:Let f:N/Γ→N/Γbe a covering map of a nil-manifold and denote by A:N/Γ→N/Γthe nil-endomorphism which is homotopic to *** f is a spec... 详细信息

关键词： Hyperbolicity Anosov endomorphisms special Anosov endomorphisms TA maps nilmanifolds

Variation of XCO_(2) anomaly patterns in the Middle East from OCO-2 satellite data

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International Journal of Digital Earth 2022年第1期15卷 1219-1235页

作者： Foroogh Golkar seyed mohsen Mousavi Department of Water Engineering&Oceanic and Atmospheric Research Centre College of AgricultureShiraz UniversityShirazIran Department of Environmental Planning and Design Shahid Beheshti UniversityTehranIran

The anthropogenic CO_(2) emission is contributed to the rapid increase in CO_(2) *** the current study the anthropogenic CO_(2) emission in the Middle East(ME)is investigated using 6 years columnaveraged CO_(2) dry air mole fraction(XCO_(2))observation from Orbiting Carbon Observatory-2(OCO-2)*** this way,the XCO_(2) anomaly(DXCO_(2))as the detrended and deseasonalized term of OCO-2XCO_(2) product,was computed and compared to provide the direct spacebased anthropogenic CO_(2) emission *** a result,the high positive and negative DXCO_(2) values have corresponded to the major sources such as oil and gas industries,and growing seasons over ME,***,the Open-source Data Inventory for Anthropogenic CO_(2)(ODIAC)emission and the gross primary productivity(GPP)were utilized in exploring the DXCO_(2) relation with human and natural driving *** results showed the capability of DXCO_(2) maps in detecting CO_(2) emission fluctuations in defined periods were detectible in daily to annual *** simplicity and accuracy of the method in detecting the man-made and natural driving factors including the main industrial areas,megacities,or local changes due to COVID-19 pandemic or geopolitical situations as well as the vegetation absorption and biomass burning is the key point that provides the environmental managers and policymakers with valuable and accessible information to control and ultimately reduce the CO_(2) emission over critical regions.

关键词： Greenhouse gas remote sensing CO_(2)emission ODIAC GPP

A novel control strategy based on a look-up table for optimal operation of MTDC systems in post-contingency conditions

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Protection and Control of Modern Power Systems 2022年第1期7卷 40-50页

作者： seyed mohsen Alavi Reza Ghazi Department of Electrical Engineering Ferdowsi University of MashhadMashhadIran

Multi terminal VSC-HVDC systems are a promising solution to the problem of connecting offshore wind farms to AC *** power sharing and appropriate control of DC-link voltages are essential and must be maintained dur-ing the operation of VSC-MTDC systems,particularly in post-contingency *** traditional droop control methods cannot satisfy these requirements,and accordingly,this paper proposes a novel centralized control strategy based on a look-up table to ensure optimal power sharing and minimum DC voltage deviation immediately during post-contingency conditions by considering converter *** also reduces destructive effects(e.g.,frequency devia-tion)on onshore AC grids and guarantees the stable operation of the entire MTDC *** proposed look-up table is an array of data that relates operating conditions to optimal droop coefficients and is determined according to N-1 contingency analysis and a linearized system *** constraints and contingencies such as wind power changes,converter outage,and DC line disconnection are considered in its formation *** performed on a 4-terminal VSC-MTDC system in the MATLAB-Simulink environment validate the effectiveness and superiority of the proposed control strategy.

关键词： Optimal power sharing DC voltage deviation Adaptive droop control Multi-terminal HVDC(MTDC) Voltage source converter(VSC)

Success criteria analysis in support of probabilistic risk assessment for nuclear power plants: application on SGTR accident

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Nuclear Science and Techniques 2017年第3期28卷 42-58页

作者： seyed mohsen Hoseyni Kaveh Karimi seyed Mojtaba Hoseyni Meisam Mohammadnia East Tehran Branch Islamic Azad University Tehran Iran

Success criteria analysis(SCA) bridges the gap between deterministic and probabilistic approaches for risk assessment of complex systems. To develop a risk model,SCA evaluates systems behaviour in response to postulated accidents using deterministic approach to provide required information for the probabilistic model. A systematic framework is proposed in this article for extracting the front line systems success criteria. In this regard, available approaches are critically reviewed and technical challenges are discussed. Application of the proposed methodology is demonstrated on a typical Westinghouse-type nuclear power plant. Steam generator tube rupture is selected as the postulated accident. The methodology is comprehensive and general; therefore, it can be implemented on the other types of plants and complex systems.

关键词： Success criteria analysis Probabilistic safety assessment (PSA) Deterministic safety assessment (DSA) Thermo-hydraulics SGTR

Creep rupture assessment for Level-2 PSA of a 2-loop PWR： accounting for phenomenological uncertainties

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Nuclear Science and Techniques 2017年第8期28卷 117-125页

作者： Faramarz Yousefpour seyed mohsen Hoseyni seyed Mojtaba Hoseyni seyed Ali Hashemi Olia Kaveh Karimi Nuclear Science and Technology Research Institute TehranIran Young Researchers and Elite Club East Tehran BranchIslamic Azad University Tehran Iran

The Level-2 probabilistic safety assessment(PSA) of pressurized water reactors studies the possibility of creep rupture for major reactor coolant system components during the course of high pressure severe accident sequences. The present paper covers this technical issue and tries to quantify its associated phenomenological uncertainties for the development of Level-2 PSA. A framework is proposed for the formal quantification of uncertainties in the Level-2 PSA model of a PWR type nuclear power plant using an integrated deterministic and PSA approach. This is demonstrated for estimation of creep rupture failure probability in station blackout severe accident of a 2-loop PWR, which is the representative case for high pressure sequences. MELCOR 1.8.6 code is employed here as the deterministic tool for the assessment of physical phenomena in the course of accident. In addition, a MATLAB code is developed for quantification of the probabilistic part by treating the uncertainties through separation of aleatory and epistemic sources of *** probability for steam generator tube creep rupture is estimated at 0.17.

关键词：模型不确定性蠕变断裂 PSA 压水堆断裂评价二级现象学反应堆冷却剂系统