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Bioactive Materials:A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response

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Journal of Bionic Engineering 2019年第4期16卷 563-581页

作者： Shirin Nour Nafiseh Baheiraei Rana Imam Navid Rabiee mohammad Khodaei Akram Alizadeh seyed mohammad moazzeni Tissue Engineering Group Biomedical Engineering DepartmentAmirkabir University of Technology(Tehran Polytechnic)TehranIran Tissue Engineering and Applied Cell Sciences Division Department of HematologyFaculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Chemistry Shahid Beheshti UniversityTehranIran Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayeganIran Department of Tissue Engineering and Applied Cell Sciences Faculty of MedicineSemnan University of Medical SciencesSemnanIran Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon ***,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the *** this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent *** the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory ***,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface *** better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed.

关键词： implant bioactive materials cell-biomaterial interactions immune response surface engineering

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<i>In vitro</i>analysis of T cell responses induced by breast tumor cell lysate pulsed with autologous dendritic cells

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Advances in Bioscience and Biotechnology 2012年第2期3卷 126-136页

作者： Nowruz Delirezh seyed mohammad moazzeni Fazel Shokri mohammad Ali Shokrgozar Morteza Morteza Atri Hamid Karbassian Cancer Institute Imam Hospital Tehran University of Medical Science Tehran Iran Department of Cellular and Molecular Institute of Biotechnology Urmia University Urmia Iran Department of Immunology School of Health Tehran University of Medical Science Tehran Iran Department of Immunology School of Medical Science Trabiat Modares University Tehran Iran Department of Surgery Athieh Hospital Tehran Iran National Cell Bank of Iran Pasteur Institute of Iran Tehran Iran

In this In vitro study, T cell responses induced by breast tumor cell lysate pulsed monocyte-derived DCs were analyzed in terms of proliferation, specific cytotoxicity and cytokine-release in order to use in immunotherapeutic settings. Nylon wool enriched T lymphocytes from 5 patients with breast cancer stimulated In vitro with tumor cell lysate pulsed monocyte-derived DCs and their proliferation response were analyzed by [3H] thymidine uptake test. Specific cytotoxic activity of tumor antigen primed T cells after three rounds weekly stimulation was evaluated by flow cytometry, and interferon-γ (IFN-γ) and interleukin-4 (IL-4) cytokines release assay was carried out 24 hours after last stimulation in the supernatant of primed T cells using commercially available ELI-SA kits. T cell proliferation assay revealed that tumor cell lysate pulsed DCs could stimulate autologous T cell proliferation response with stimulation indices 4.9 - 30. T cell mediated cytotoxicity assay demonstrated that tumor antigen primed T cells could significantly kill autologous tumor cells more than normal cells (P γ and IL-4 in response to restimulation by antigen pulsed DCs which were dominated by IFN-γ production in 2 and IL-4 production in 3 out of 5 patients. Our result suggested that breast tumor antigen pulsed DCs could elicit effective specific antitumor T cell responses In vitro, therefore, tumor antigen pulsed DC vaccination may be considered as a novel strategy for immunotherapy of patients with breast cancer refractory to standard modalities.

关键词： Breast Lysate Dendritic Cells T Cell

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Role of cytomegalovirus on the maturation and function of monocyte derived dendritic cells of liver transplant patients

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World Journal of Transplantation 2016年第2期6卷 336-346页

作者： mohammad Hossein Karimi Afsoon Shariat Ramin Yaghobi Talat Mokhtariazad seyed mohammad moazzeni Shiraz Trans-plant Research Center Shiraz University of Medical Sciences Department of Microbiology Faculty of Basic SciencesKazerun BranchIslamic Azad University College of Basic Sciences Tehran Science and Research BranchIslamic Azad University Department of Virology School of Public HealthTehran University of Medical Sciences Department of Immunology Faculty of Medical SciencesTarbiat Modarres University

AIM: To study the impact of association between cytomegalovirus(CMV) pathogenesis with dendritic cell(DC) maturation and function was evaluated in CMV reactivated liver transplanted patients in comparing with non-reactivated ones, and healthy controls. METHODS: Monocyte derived dendritic cells(Mo DCs) was generated from collected ethylenediaminetetraacetic acid-treated blood samples from patient groups and controls. In these groups, expression rates and mean fluorescent intensity of DC markers were evaluated using flowcytometry technique. Secretion of cytokines including: interleukin(IL)-6, IL-12 and IL-23 were determined using enzyme-linked immunosorbent assay methods. The gene expression of toll-like receptor 2(TLR2), TLR4 and IL-23 were analyzed using in-house real-time polymerase chain reaction ***: Results have been shown significant decreases in: Expression rates of Mo DC markers including CD83, CD1 a and human leukocyte antigen DR(HLA-DR), the mean fluorescence intensitys for CD1 a and HLA-DR, and secretion of IL-12 in CMV reactivated comparedwith non-reactivated liver transplanted patients. On the other hand, significant increases have been shown in the secretions of IL-6 and IL-23 and gene expression levels of TLR2, TLR4 and IL-23 from Mo DCs in CMV reactivated compared with non-reactivated liver transplanted recipients. CONCLUSION: DC functional defects in CMV reactivated recipients, such as decrease in expression of DC maturation markers, increase in secretion of proinflammatory cytokines, and TLRs can emphasize on the importance of CMV infectivity in development of liver rejection in transplanted patients.

关键词： Cytomegalovirus Dendritic cells Liver transplantation

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