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Neural Regeneration Research 2019年第8期14卷 1372-1373页

作者： Burak Yulug seyda can.aya Department of Neurology Faculty of Medicine Alanya Alaaddin Keykubat University

Cinnamon, is an exotic spice and a major constituent of our food which is commonly used in different areas of the world for the treatment of various diseases (Kawatra et al., 2015). Besides 让s anti-inflammatory, anti-diabetic and anti-cancer properties, cinnamon also exerts strong brain protective and pro-cogrdtive effects in various models of neurodegeneration (Kawatra et al., 2015;Kelestemur et al., 2016)(Figure 1).

关键词： Translational perspective suitable agent brain trauma

A different view on the pathophysiology of Parkinson’s disease:a descendent neurochemical hypothesis?

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Neural Regeneration Research 2019年第10期14卷 1717-1718页

作者： Burak Yulug Mehmet Ozansoy seyda can.aya Department of Neurology Alanya Alaaddin Keykubat UniversityAntalya/AlanyaTurkey Istanbul Medipol University Restorative and Regenerative Medicine CenterIstanbulTurkey Department of Physiology International School of MedicineIstanbul Medipol UniversityIstanbulTurkey

It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN) neurons. Growing evidence suggests that there is a latent period of PD associated with slight non-motor findings such as olfactory dysfunction (Dickson et al., 2018). However, the potential biomarker role of olfactory dysfunction in PD has been a topic of great interest in the last years (Raskin et al., 1990;Dickson et al., 2018). The classical hypothesis of Braak suggests that PD begins as a synucleinopathy in the lower brainstem or in the olfactory bulb (OB) that progresses rostrally to the SN and amygdala to cause parkinsonism at a later stage of the disease (Burke et al., 2008).

关键词： Parkinson period cause has neu PD is

Tribological behavior of CrN-coated Cr–Mo–V steels used as die materials

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International Journal of Minerals,Metallurgy and Materials 2017年第12期24卷 1394-1402页

作者： Gulsah Aktas Celik seyda Polat S.Hakan Atapek Kocaeli University Faculty of EngineeringDepartment of Metallurgical and Materials EngineeringUmuttepe Campus41380 KocaeliTurkey

DIN 1.2343 and 1.2367 steels are commonly used as die materials in aluminum extrusion, and single/duplex/multi-coatings enhance their surface properties. The design of an appropriate substrate/coating system is important for improving the tribological performance of these steels under service conditions because the load-carrying capacity of the system can be increased by decreasing the plastic deformation of the substrate. In this study, the tribological behavior of CrN-coated Cr–Mo–V steels(DIN 1.2343, 1.2367, and 1.2999 grades) was investigated using different setups and tribological pairs at room and elevated temperatures. The aim of this study was to reveal the wear resistance of a suggested system(1.2999/CrN) not yet studied and to understand both the wear and the failure characteristics of coated systems. The results showed that(i) among the steels studied, the DIN 1.2999 grade steel exhibited the lowest friction coefficient because it had the highest load-carrying capacity as a result of secondary hardening at elevated temperatures;(ii) at room temperature, both abrasive tracks and adhesive layers were observed on the worn surfaces; and(iii) a combination of chemical reactions and progressive oxidation caused aluminum adhesion on the worn surface, and the detachment of droplets and microcracking were the characteristic damage mechanisms at high temperatures.

关键词： Cr–Mo–V steels CrN coating aluminum extrusion tribological behavior

Removal of astrazon golden yellow 7GL from colored wastewater using chemically modified clay

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Journal of Central South University 2017年第4期24卷 743-753页

作者： Meltem CAKMAK seyda TASAR Veyis SELEN Dursun OZER Ahmet OZER Department of Chemical Engineering Firat University23279 ElazigTurkey

Chemically modified clay(CMC) was used as an adsorbent for the removal of Astrazon Golden Yellow 7GL(AGY-7GL), which is a basic dye from wastewater. For this purpose, the chemically modified clay was first characterized by determining zero point of charge(p Hzpc), and using BET, SEM and FTIR. Then effects of operational parameters on adsorption of AGY-7GL were studied in a batch system. The effect of various parameters such as contact time(0-180 min), pH(2-8), temperature(293-323 K), CMC concentration(0.075-0.5 mg/L) and initial AGY-7GL concentration(75-250 mg/L) were investigated on the adsorption efficiency and capacity adsorption of CMC for the removal of AGY-7GL. Thermodynamic and kinetic parameters were calculated from the results of the adsorption experiment. The evaluation of kinetic models shows that this data best fits the pseudo-second-order model. It is determined that the adsorption equilibrium data works very well with the nonlinear Freundlich isotherm model. Thermodynamic parameters such as ?H^0(19.0 k J/mol), ?G^0(-28.8 k J/mol) and ?S^0(0.148 k J/mol) were also determined. According to the experimental results, it is concluded that CMC could be used as an alternative low cost potential adsorbent for the removal of AGY-7GL from wastewater.

关键词： adsorption astrazon golden yellow 7GL(AGY-7GL) chemically modified clay(CMC) thermodynamic and kinetic parameters

Artificial intelligence and kidney transplantation

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World Journal of Transplantation 2021年第7期11卷 277-289页

作者： Nurhan Seyahi seyda Gul Ozcan Department of Nephrology Istanbul University-CerrahpaşaCerrahpaşa Medical FacultyIstanbul 34098FatihTurkey Department of Internal Medicine Istanbul University-CerrahpaşaCerrahpaşa Medical FacultyIstanbul 34098FatihTurkey

Artificial intelligence and its primary subfield,machine learning,have started to gain widespread use in medicine,including the field of kidney *** made a review of the literature that used artificial intelligence techniques in kidney *** located six main areas of kidney transplantation that artificial intelligence studies are focused on:Radiological evaluation of the allograft,pathological evaluation including molecular evaluation of the tissue,prediction of graft survival,optimizing the dose of immunosuppression,diagnosis of rejection,and prediction of early graft *** learning techniques provide increased automation leading to faster evaluation and standardization,and show better performance compared to traditional statistical *** intelligence leads to improved computer-aided diagnostics and quantifiable personalized predictions that will improve personalized patient care.

关键词： Artificial intelligence Kidney transplantation Machine learning,Neuronal networks Deep learning Support vector machines

Geological and Morphological Features of the Karap?nar Sinkholes(Konya,Central Anatolia,Türkiye)

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Journal of Earth Science 2024年第5期35卷 1654-1668页

作者： Yasar Eren seyda Parlar Berkant Coskuner Sükrü Arslan Department of Geological Engineering Faculty of Engineering and Natural SciencesKonya Technical UniversityKonya 42250Turkiye Prime Ministry Disaster and Emergency Management Authority Konya Provincial Directorate of Disaster and EmergencySelcuklu/Konya42100Turkiye

Karapınar region(Konya,Türkiye)is one of the important regions of the world in terms of sinkhole *** research aimed to map the sinkholes in detail,to determine their spatial distribution and geometrical *** this purpose,the long axes,short axes,depths and the proximity to settlements of the sinkholes were measured and their circumferences and areas were *** the studies,the relationship of the sinkholes with lithology,their cross sections,shapes and the related structures were determined and the sinkholes were divided into five main groups as following:Basement rock sinkholes,Obruk Plateau sinkholes,Seyithacı sinkholes,Siyeklik sinkholes and Basin *** d/l ratios of each sinkhole group were separately determined and ***,most of the d/l ratios are smaller than ***,the long axes are higher than the depth and it indicates that the shallow and wide sinkholes are common in the *** has been determined that the fracture systems in the region,as well as the lithology and groundwater factors,are quite effective in the formation and distribution of the sinkholes in the Karapınar *** the distance of the sinkholes to the settlements,Seyithac?sinkholes are the most risky group in the region because they are deep and close to the settlements.

关键词： Karapinar Sinkhole Turkiye Central Anatolia Obruk Plateau hydrogeology

Sertraline-induced reproductive toxicity in male rats： evaluation of possible underlying mechanisms

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Asian Journal of Andrology 2017年第6期19卷 672-679页

作者： Ozlem Atli Merve Baysal Gozde Aydogan-Kilic Volkan Kilic seyda Ucarcan Burak Karaduman Sinem Ilgin Department of Pharmaceutical Toxicology Faculty of Pharmacy Anadolu University Eskisehir 26470 Turkey Department of Biology Faculty of Science Anadolu University Eskisehir 26470 Turkey

This study was conducted to clarify the toxic effects of sertraline （SRT） on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg-1 for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted. Serum testosterone, follicle-stimulating hormone （FSH）, and luteinizing hormone （LH） levels were measured to determine the effects of SRT on the spermatogenesis process. One-way ANOVA, post-hoc Dunnett＇s T3 test for the sperm comet assay, and post-hoc Tukey＇s test for the others were performed for statistical analysis. The results showed that SRT caused an increase in sperm DNA damage and induced histopathological lesions in all groups treated with SRT. There was abnormal sperm morphology and increased malondialdehyde （MDA） in the 10 mg kg-1 treatment group. More dramatic changes were observed in the 20 mg kg-1 treatment group. Decreased sperm count was accompanied by a significant increase in abnormal sperm morphology, DNA damage, and degeneration in cellular-tubular structures. Serum LH and testosterone levels were elevated in the 20 mg kg-~ treatment group. Decreased glutathione （GSH） and increased MDA were signs of enhanced oxidative stress （OS）. In conclusion, SRT induced testicular toxicity in a dose-dependent manner and OS is suggested as a crucial mechanism.

关键词： DNA damage oxidative stress reproductive toxicity sertraline

Thermal and microstructural characterization of a novel ductile cast iron modified by aluminum addition

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International Journal of Minerals,Metallurgy and Materials 2020年第2期27卷 190-199页

作者： Gülsah Aktas Celik Maria-Ioanna TTzini seyda Polat SHakan Atapek Gregory NHaidemenopoulos Department of Metallurgical and Materials Engineering Kocaeli UniversityKocaeli 41001Turkey Laboratory of Materials Department of Mechanical EngineeringUniversity of ThessalyVolos 38334Greece Department of Mechanical Engineering Khalifa University of Science and TechnologyAbu Dhabi 127788UAE

In high-temperature applications,like exhaust manifolds,cast irons with a ferritic matrix are mostly ***,the increasing demand for higher-temperature applications has led manufacturers to use additional expensive materials such as stainless steels and Ni-resist austenitic ductile cast ***,in order to meet the demand while using low-cost materials,new alloys with improved high-temperature strength and oxidation resistance must be *** this study,thermodynamic calculations with Thermo-Calc software were applied to study a novel ductile cast iron with a composition of 3.5wt%C,4wt%Si,1wt%Nb,0‒4wt%*** designed compositions were cast,and thermal analysis and microstructural characterization were performed to validate the *** lowest critical temperature of austenite to pearlite eutectoid transformation,i.e.,A1,was calculated,and the solidification sequence was *** calculations and experimental data revealed the importance of aluminum addition,as the A1 increased by increasing the aluminum content in the alloys,indicating the possibility of utilizing the alloys at higher *** experimental data validated the transformation temperature during solidification and at the solid state and confirmed the equilibrium phases at room temperature as ferrite,graphite,and MC-type carbides.

关键词： ductile cast iron alloy design Thermo-Calc high-temperature material

辊弯成形下塑性应变对挤压态6063T66铝合金型材疲劳性能的影响

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Transactions of Nonferrous Metals Society of China 2023年第11期33卷 3282-3294页

作者： Tomasz TOMASZEWSKI Michał STOPEL Andrzej SKIBICKI Jan seyda Tomasz PIĄTKOWSKI Faculty of Mechanical Engineering Bydgoszcz University of Science and TechnologyBydgoszczPoland

分析从辊弯成形型材区和预应变材料取样的材料的拉伸塑性应变。利用概率Weibull累积分布(P-S-N曲线)近似高周疲劳的实验数据。利用LS-Dyna程序和实验数据对辊弯成形进行数值模拟,建立疲劳寿命预测模型。材料的循环行为表明,随着静态失... 详细信息

分析从辊弯成形型材区和预应变材料取样的材料的拉伸塑性应变。利用概率Weibull累积分布(P-S-N曲线)近似高周疲劳的实验数据。利用LS-Dyna程序和实验数据对辊弯成形进行数值模拟,建立疲劳寿命预测模型。材料的循环行为表明,随着静态失效水平的增加,疲劳寿命分布减小。断裂表面的断口形貌分析表明,由于晶界附近的位错积累,拉伸预应变的晶间裂纹水平增加。所提模型预测结果与概率散射带具有良好的相关性(误差低于10%)。

关键词： 6063铝合金预应变高周疲劳 P-S-N曲线 Weibull分布

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Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters

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World Journal of Gastroenterology 2007年第3期13卷 426-431页

作者： Derya Gumurdulu seyda Erdogan Fazilet Kayaselcuk Gulsah seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer Department of Pathology of Affiliated Hospital Faculty of Medicine Cukurova University Adana 01330 Turkey Department of Pathology of Affiliated Hospital Baskent University Adana Resarch and Practice Center Adana 01330 Turkey Department of Biostatistics of Affiliated Hospital Faculty of Medicine Cukurova University Adana 01330 Turkey Department of Surgery of Affiliated Hospital Faculty of Medicine Cukurova University Adana 01330 Turkey

AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time.

关键词： Gastrointestinal stromal tumor Cyclooxygenase-2 Proliferating cell nuclear antigen Ki-67 p53 Immunohistochemistw