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Intravenous immune globulin suppresses angiogenesis in mice and humans

Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati sevim barbasso helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

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Modeling Cadmium Transport in Neutral and Alkaline Soil Columns at Various Depths

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Pedosphere 2012年第3期22卷 273-282页

作者： QI Zhi-Ming FENG Shao-Yuan M.J.helmers USDA-ARS Agricultural Systems Research Unit Fort CollinsCO 80526(USA) College of Hydraulic Science and Engineering Yangzhou UniversityYangzhou 225009(China) Department of Agricultural and Biosystems Engineering Iowa State UniversityAmesIA 50011(USA)

Human health has been potentially threatened by cadmium (Cd) contained in sewage irrigation *** studies of Cd transport in soils were mainly conducted using small soil cores with pH values less than *** objectives of this study were to determine the parameters of the convection-dispersion equation (CDE) for Cd transport in relatively larger columns with neutral and alkaline soils,and to investigate the parameters' variability with *** soil columns were 50 cm in length and 12.5 cm in *** suction lysimeters were buried at depths of 2.5,7.5,17.5,27.5,and 37.5 cm to abstract soil *** concentration in the soil solution samples were subsequently analyzed to obtain breakthrough curves (BTCs).Equilibrium and nonequilibrium models in CXTFIT program were used to estimate parameters of the *** results suggested that both equilibrium and non-equilibrium models performed well in modeling Cd *** hydrodynamic dispersion coefficient (D) ranged from 0.18 to 10.70 cm 2 h 1,showing large differences among different *** retardation factor (R d) ranged from 25.4 to 54.7 and the standard deviation of R d value was lower than 30% of the mean *** coefficient (R p) decreased consistently with increasing depth,varying from 1.000 × 10 10 to 0.661 h *** tests showed that D was less sensitive than R *** results would be helpful in understanding the transport and retention of Cd in non-acidic soils.

关键词： convection-dispersion equation (CDE) CXTFIT dispersion retardation sewage effluent irrigation

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DRAINMOD-NⅡ模拟冬季长期覆盖黑麦对地下排水及NO_3^--N流失的影响

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农业工程学报 2017年第12期33卷 153-161页

作者：杜璇冯浩 Matthew J.helmers 齐志明西北农林科技大学水利与建筑工程学院杨凌712100 西北农林科技大学中国旱区节水农业研究院杨凌712100 Department of Agricultural and Biosystems Engineering Iowa State University 中国科学院水利部水土保持研究所杨凌712100 Department of Bioresource Engineering McGill University

在玉米-大豆轮作系统中种植冬季覆盖作物黑麦有助于减小地下排水量和硝态氮(NO_3^--N)的流失量。该研究利用美国爱荷华州的试验数据校正和验证了DRAINMOD-N II模型在美国寒冷地区的适用性,并模拟长期(20 a)种植冬季覆盖作物黑麦对地下... 详细信息

在玉米-大豆轮作系统中种植冬季覆盖作物黑麦有助于减小地下排水量和硝态氮(NO_3^--N)的流失量。该研究利用美国爱荷华州的试验数据校正和验证了DRAINMOD-N II模型在美国寒冷地区的适用性,并模拟长期(20 a)种植冬季覆盖作物黑麦对地下排水量和氮素运移的影响。结果表明,模型模拟地下排水量和NO_3^--N流失量时,Nash-Sutcliffe模型效率系数(Nash-Sutcliffe efficiency,NSE)>0.65、百分比偏差(percent bias,PBIAS)在±25%之间、均方根误差与标准差比值(ratio of root mean square error to standard deviation,RSR)≤0.7均在误差范围内;模拟地下排水中NO_3^--N浓度时,NSE>0.50、PBIAS在±15%之间、RSR≤0.5均在误差范围内,说明模型模拟的效果好。长期种植冬季覆盖作物黑麦可降低排水量8.1%(2.5 cm),减小NO_3^--N流失量16.6%(6 kg/hm^2),NO_3^--N流量加权平均浓度下降了8.6%(1 mg/L,以N计),增加蒸散值5.9%,模型模拟值与实测值拟合效果好,表明模型具有良好的水文和氮素运移模拟功能,可以模拟不同农田管理措施对地下水和氮素运移的长期影响,为优化农田管理措施提供参考。

关键词：氮排水蒸散玉米-大豆轮作系统 DRAINMON-N II 冬季覆盖作物黑麦

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波激振动的理论预报及与实船试验结果的比较(英文)

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船舶力学 2003年第6期7卷 100-115页

作者：顾学康 GauteStorhaug Jelena Vidic-Perunovic Gabriel Holtsmark Jens Block helmers 中国船舶科学研究中心无锡214082 挪威科技大学丹麦技术大学挪威船级社

本文研究一艘大型海船的波激振动问题。该船在运行过程中发生了频繁的波激振动,导致严重的结构裂纹。文中对四种预报船体波激振动响应的理论及其计算机程序进行了描述。这些理论在计算水动力载荷和结构振动时具有各自的特点,如:线性、... 详细信息

本文研究一艘大型海船的波激振动问题。该船在运行过程中发生了频繁的波激振动,导致严重的结构裂纹。文中对四种预报船体波激振动响应的理论及其计算机程序进行了描述。这些理论在计算水动力载荷和结构振动时具有各自的特点,如:线性、二阶、非线性、频域、时域、二维和三维等。相应的程序(WASIM,SOST,SINO和VERES)对低频波浪诱导响应预报已有较多的验证。文中对各程序在波激振动预报中的前提条件作了说明。计算中进行了参数敏感性分析并给出了主要结果。在与实船试验结果的比较过程中选择了十个不同的工况,对其海况、航向和试验现象给出了简要描述。对低频波浪诱导和高频波激振动响应分别进行了比较,得出了一些有意义的结论。

关键词：大型海船波激振动理论预报实船试验

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Water cycling under contrasting annual-perennial plant systems in agricultural landscapes in the Midwestern U.S.

Water cycling under contrasting annual-perennial plant syste...

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第三世界生态高峰会

作者： M.J.helmers H.Asbiomsen R.Kolka M.Tomer Iowa State University Ames IA Iowa State University Ames IA USDA Forest Service.Grand Rapids.MN ARS National Soil Tilth Lab Ames.IA

Over a century of agricultural expansion and intensification in the Midwest region of the United States has transformed landscapes that were historically dominated by prairies,woodlands,savanna,and wetlands into landscapes that are dominated by annual crops of primarily corn and *** research assesses the potential to achieve significant improvements in water quality and flow regulation through strategic integration of small amounts of perennial vegetation embedded in agriculturally dominated *** ecohydrological functioning of annual(corn,soybeans)and perennial(prairie,savanna,

关键词： Water cycling under contrasting annual-perennial plant systems in agricultural landscapes in the Midwestern U.S

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老龄癫痫

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世界医学杂志 2004年第3期8卷 4-6,10页

作者： SuzetteM.LaRoch~ SandraL.helmers 魏微张微微 EmoryClinic BuildingA1365CliftonRoadAtlantaGA30322 不详

背景：癫痫是老年人群常见的一种神经系统疾病。由于特殊的因素其病因诊断及治疗与年轻人不同。综述总结：老年人发生癫痫的危险性与该年龄组人群常见病如中风、痴呆、代谢障碍等有关，死亡率也较高。如何判断癫痫发作是一个难题。在年... 详细信息

背景：癫痫是老年人群常见的一种神经系统疾病。由于特殊的因素其病因诊断及治疗与年轻人不同。综述总结：老年人发生癫痫的危险性与该年龄组人群常见病如中风、痴呆、代谢障碍等有关，死亡率也较高。如何判断癫痫发作是一个难题。在年轻人群中，EEG、MRI是诊断癫痫病因的重要方法，老年人由于年龄增加而引起的脑的非特异性病理改变为我们的诊断带来了困难。治疗老年人的癫痫是一种挑战，幸运的是我们可以采取多种治疗方案，包括非药物性治疗。结论：了解老年人癫痫的特点制定相应的治疗措施对于提高生活质量非常重要，我们还需要加强这方面的研究以便制定最佳的治疗方案。

关键词：老龄癫痫老年人神经系统治疗诊断代谢障碍

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