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Unveiling the intricacies of irritable bowel syndrome

World Journal of Gastroenterology 2024年第44期30卷 4763-4767页

作者： Duygu Kirkik sevgi kalkanli tas Department of Immunology University of Health SciencesHamidiye Medicine FacultyIstanbul 34668Türkiye Department of Medical Biology University of Health SciencesHamidiye Medicine FacultyIstanbul 34668Türkiye

Irritable bowel syndrome(IBS)remains a challenging condition both for patients and clinicians,characterized by its chronic nature and the elusive complexity of its underlying *** multifaceted relationship between the neuroendocrine axis,gut microbiota,and inflammatory response has emerged as a focal point in recent research,offering new insights into the pathophysiology of *** neuroendocrine axis plays a crucial role in maintaining the delicate balance between the brain and the gut,often referred to as the“gut-brain axis”.This bidirectional communication is essential for regulating gastrointestinal function,stress responses,and overall *** of this axis,as highlighted by elevated cortisol and serotonin levels in IBS patients,suggests that neuroendocrine imbalances may significantly contribute to the severity of gastrointestinal *** findings underscore the need for a broader understanding of how stress and emotional factors influence IBS,potentially guiding more effective,personalized treatment *** important is the role of the gut microbiota,a diverse and dynamic ecosystem that directly impacts gut *** dysbiosis disrupts gut function and appears to exacerbate the neuroendocrine and inflammatory *** findings align with the growing recognition that gut microbiota is a critical player in IBS,influencing both the disease's onset and progression.

关键词： Gastrointestinal symptoms Inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis

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Atherosclerosis and the role of immune cells

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World Journal of Clinical Cases 2015年第4期3卷 345-352页

作者： Fulya Ilhan sevgi tas kalkanli Department of Immunology Faculty of Medicine University of Firat Department of Immunology Faculty of Medicine University of Dicle

Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon(IFN)-α and β are generated upon the activation of tolllike receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immunecells in the atherosclerosis.

关键词： Atherosclerosis Inflammatory cytokines Pro-inflammatory mediators Immune cells Adhesion molecules

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Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection

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World Journal of Gastroenterology 2013年第48期19卷 9377-9382页

作者： Mustafa Kemal Celen Duygu Mert Müzeyyen Ay Tuba Dal Safak Kaya Necmettin Yildirim Serda Gulsun Tunga Barcin sevgi kalkanli Mehmet Sinan Dal Celal Ayaz Department of Infectious Diseases Faculty of Medicine Dicle University 21280 YenisehirDiyarbakir Turkey State Hospital 72000 Merkez Batman Turkey State Hospital Kiziltepe 47500 Mardin Turkey Department of Medical Microbiology Faculty of Medicine Dicle University 21280 Yenisehir Diyarbakir Turkey Department of Infectious Disease Teaching and Research Hospital 21100 Diyarbakir Turkey Department of Infectious Diseases State Hospital 47000 Mardin Turkey Department of Infectious Diseases State Hospital 21100 Diyarbakir Turkey Department of Infectious Diseases Mardin Park Hospital 47000 Mardin Turkey Department of Immunology Faculty of Medicine Dicle University 21280 Yeni?ehir Diyarbakir Turkey Department of Internal Medicine Faculty of Medicine Dicle University 21280 Yenisehir Diyarbakir Turkey

AIM:To evaluate the effects of tenofovir disoproxil fumarate(TDF)use during late pregnancy to reduce hepatitis B virus(HBV)transmission in highly viremic ***:This retrospective study included 45 pregnant patients with hepatitis B e antigen(+)chronic hepatitis B and HBV DNA levels>107copies/mL who received TDF 300 mg/d from week 18 to 27 of gestation(n=21).Untreated pregnant patients served as controls(n =24).All infants received 200 IU of hepatitis B immune globulin(HBIG)within 24 h postpartum and 20μg of recombinant HBV vaccine at 4,8,and 24 *** transmission rate was determined by hepatitis B surface antigen and HBV DNA results in infants at week ***:At week 28,none of the infants of TDFtreated mothers had immunoprophylaxis failure,whereas2(8.3%)of the infants of control mothers had immunoprophylaxis failure(P=0.022).There were no differences between the groups in terms of adverse events in mothers or congenital deformities,gestational age,height,or weight in *** postpartum week 28,significantly more TDF-treated mothers had levels of HBV DNA<250 copies/mL and normalized alanine aminotransferase compared with controls(62%vs none,P<0.001;82%vs 61%,P=0.012,respectively).CONCLUSION:TDF therapy during the second or third trimester reduced perinatal transmission rates of HBV and no adverse events were observed in mothers or infants.

关键词： Hepatitis B Tenofovir Reverse transcriptase inhibitors Vertical transmission Chronic

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