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Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer

World Journal of Gastroenterology 2011年第44期17卷 4905-4910页

作者： sevgi a ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun Clinic of Radiation Oncology Dr.Lütfi K|rdar Kartal Education and Research Hospital Clinic of Radiation Oncology Medical Park Department of Biophysics Marmara University School of Medicine Clinic of Surgery Dr.Lütfi K|rdar Kartal Education and Research Hospital Department of Pathology Dr. Lütfi K|rdar Kartal Education and Research Hospital Telomere Aging Group Center for IRSSouthern Denmark University Faculty of Medicine Near East University Department of Biophysics Ac badem University School of Medicine

AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after *** specimens were excised from the rectal tumor preceding ***:SAG,Bcl-X L and Bak proteins showed significant correlations with each *** multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to *** overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),***:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals.

关键词： Sensitive-to-apoptosis gene Sensitive-toapoptosis Rectal cancer B-cell lymphoma-extra large Bcl-2 homologous antagonist/killer Apoptosis

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Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants

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World Journal of Gastroenterology 2015年第4期21卷 1222-1233页

作者： sevgi ozden Zerrin Ozgen Hazan Ozyurt Cengiz Gemici Gokhan Yaprak Huseyin Tepetam Alpaslan Mayadagli Radiation Oncology Dr. Lutfi Kirdar Kartal Training and Research Hospital34890IstanbulTurkey Faculty of Medicine Bezmialem Vakif University34093 IstanbulTurkey

AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF surviv

关键词： Gastric carcinoma Local recurrence free survival D

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