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Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease

World Journal of Gastroenterology 2016年第8期22卷 2592-2600页

作者： Myong Ki Baeg Seung Kew Yoon Sun-Hye Ko Yong-Sun noh In-Seok Lee Myung-Gyu Choi Department of Internal Medicine The Catholic University of Korea College of Medicine

AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to 13C urea breath tests. NAFLD was defined using the hepatic steatosis index (HSI) and NAFLD liver fat score (NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS > -0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for ***: Three thousand six hundred and sixty-three people were analyzed and 1636 (44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects (median 33.2, interquartile range (IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median -1.7, IQR -2.4 - -0.7 vs median -1.8, IQR -2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differ between infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for ***: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Hepatic steatosis index Nonalcoholic fatty liver disease liver fat score Urea breath test

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Upgrading and upstaging of low-risk prostate cancer among Korean patients： a multicenter study

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Asian Journal of Andrology 2015年第5期17卷 811-814,I0009页

作者： Insang Hwang Donghoon Lim Young Beom Jeong Seung Chol Park Jun Hwa noh Dong Deuk Kwon Taek Won Kang Department of Urology Chonnam National University Medical School Gwangju Korea Department of Urology Chosun University Medical School Gwangju Korea Department of Urology Chonbuk National University Medical School Jeonju Korea Department of Urology Wonkwang University School of Medicine Iksan Korea Department of Urology Kwangju Christian Hospital Gwangju Korea

Only 54% of prostate cancer cases in Korea are localized compared with 82% of cases in the US. Furthermore, half of Korean patients are upgraded after radical prostatectomy （41.6%-50.6%）. We investigated the risk factors for upgrading and/or upstaging of low-risk prostate cancer after radical prostatectomy. We retrospectively reviewed the medical records of 1159 patients who underwent radical prostatectomy at five hospitals in Honam Province. Preoperative data on standard clinicopathological parameters were collected. The radical prostatectomy specimens were graded and staged and we defined a ＂worsening prognosis＂ as a Gleason score ≥ 7 or upstaging to ≥ pT3. Multivariate logistic regression models were used to assess factors associated with postoperative pathological upstaging. Among the 1159 patients, 324 were classified into the clinically low-risk group, and 154 （47.5%） patients were either upgraded or upstaged. The multivariable analysis revealed that the preoperative serum prostate-specific antigen level （odds ratio [OR], 1.131; 95% confidence interval [CI], 1.007-1.271; P = 0.037）, percent positive biopsy core （OR： 1.018; 95% CI： 1.002-1.035; P = 0.032）, and small prostate volume （≤30 ml）（OR： 2.280; 95% CI： 1.351-3.848; P = 0.002） were predictive of a worsening prognosis. Overall, 47.5% of patients with low-risk disease were upstaged postoperatively. The current risk stratification criteria may be too relaxed for our study cohort.

关键词： prostate cancer prostatectomy risk factors

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Retrieval of the Single Scattering Albedo of Asian Dust Mixed with Pollutants Using Lidar Observations

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Advances in Atmospheric Sciences 2014年第6期31卷 1417-1426页

作者： Sungkyun SHIN Young Min noh Kwonho LEE Hanlim LEE Detlef MLLER Y.J.KIM Kwanchul KIM Dongho SHIN School of Environmental Science and Engineering Gwangju Institute of Science and TechnologyKorea Department of Geoinformatics Engineering Kyungil UniversityKorea Department of Spatial Information Engineering Pukyong National UniversityKorea Science System and Applications Inc. NASA Langley Research CenterUSA University of Hertfordshire United Kingdom

The vertical distribution of single scattering albedos （SSAs） of Asian dust mixed with pollutants was derived using the multi-wavelength Raman lidar observation system at Gwangju （35.10°N,126.53°E）.Vertical profiles of both backscatter and extinction coefficients for dust and non-dust aerosols were extracted from a mixed Asian dust plume using the depolarization ratio from lidar *** profiles of backscatter and extinction coefficients of non-dust particles were input into an inversion algorithm to retrieve the SSAs of non-dust *** aerosol layers at different heights had different light-absorbing *** SSAs of non-dust particles at each height varied with aerosol type,which was either urban/industrial pollutants from China transported over long distances at high altitude,or regional/local pollutants from the Korean *** advantage of independent profiles of SSAs of non-dust particles,vertical profiles of SSAs of Asian dust mixed with pollutants were estimated for the first time,with a new approach suggested in this study using an empirical determination of the SSA of pure *** SSAs of the Asian dust-pollutants mixture within the planetary boundary layer （PBL） were in the range 0.88-0.91,while the values above the PBL were in the range 0.76-0.87,with a very low mean value of 0.76 ± *** total mixed dust plume SSAs in each aerosol layer were integrated over height for comparison with results from the Aerosol Robotics Network （AERONET） *** of SSA retrieved from lidar observations of 0.92 ± 0.01 were in good agreement with the results from AERONET measurements.

关键词： lidar Asian dust depolarization ratio microphysical properties single scattering albedo

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Carbon and nitrogen dynamics in a Pinus densiflora forest with low and high stand densities

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Journal of Plant Ecology 2013年第5期6卷 368-379页

作者： Nam Jin noh Choonsig Kim Sang Won Bae Woo Kyun Lee Tae Kyung Yoon Hiroyuki Muraoka Yowhan Son Division of Environmental Science and Ecological Engineering Korea UniversitySeoul 136-713Republic of Korea River Basin Research Center Gifu UniversityGifu 501-1193Japan Department of Forest Resources Gyeongnam National University of Science and TechnologyJinju 660-758Republic of Korea Department of Forest Conservation Korea Forest Research InstituteSeoul 130-712Republic of Korea

Aims Understanding carbon(C)and nitrogen(N)dynamics and their dependence on the stand density of an even-aged,mature forest provides knowledge that is important for forest *** study investigated the differences in ecosystem total C and N storage and flux between a low-density stand(LD)and a high-density stand(HD)and examined the effects of stand density on aboveground net primary productivity(ANPP),total belowground C allocation(TBCA)and net ecosystem production(NEP)in a naturally regenerated,65-to 75-year-old Pinus densiflora *** *** LD(450 trees ha^(−1))and HD(842 trees ha^(−1))were established in an even-aged,mature *** forest in September *** forest had been naturally regenerated following harvesting,and the stand density was naturally maintained without any artificial management such as *** diameter at breast height(DBH≥5.0cm)of all live stems within the stands was measured yearly from 2007 to *** compare C and N storage and fluxes in LD and HD,C and N pools in aboveground and belowground biomass,the forest floor,coarse woody debris(CWD)and soil;soil CO_(2) efflux(R_(S));autotrophic respiration(R_(A));litter production;and soil N availability were ***,ANPP,TBCA and NEP were estimated from plot-based measurement *** Findings Ecosystem C(Mg C ha^(−1))and N(Mg N ha^(−1))storage was,respectively,173.0±7.3(mean±SE)and 4.69±0.30 for LD and 162±11.8 and 4.08±0.18 for *** were no significant differences in C and N storage in the ecosystem components,except for soils,between the two *** contrast,there were significant differences in aboveground ANPP and TBCA between the two stands(P<0.05).Litterfall,biomass increment and R_(S) were major C flux components with values of,respectively,3.89,3.74 and 9.07 Mg C ha^(−1) year^(−1) in LD and 3.15,2.94 and 7.06 Mg C ha^(−1) year^(−1) in ***-based NEP(Mg C ha^(−1) year^(−1))was 4.18 in LD and 5.50 in *** the even-aged,mature P

关键词： aboveground net primary productivity net ecosystem production Japanese red pine stand density total belowground carbon allocation

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Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells

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Science Bulletin 2015年第8期60卷 773-784,M0003页

作者： Sungeun Ahn Muhammad Hanif Siddiqi Hae-Yong noh Yu-Jin Kim Yeon-Ju Kim Chi-Gyu Jin Deok-Chun Yang Ginseng Genetic Bank Graduate School of BiotechnologyCollege of Life Science Kyung Hee University

Ginsenosides, the main active constituents of Panax ginseng Meyer （P. ginseng）, have potential therapeutic effects. All tested ginsenosides except gin- senoside F1 have previously been reported in inflammation studies using the RAW 264.7 macrophage cell line. We ex- amined the anti-inflammatory effects of single sugar moiety ginsenosides such as compound K （CK）, Rh2, Rhl, and F1 that were isolated from P. ginseng through in silico docking studies. We investigated their biological activity predictions, including absorption, distribution, metabolism, excretion, and toxicity and PASS properties, on the suppression of NF- κB, followed by in vitro validation in lipopolysaccharide （LPS）-stimulated RAW 264.7 macrophage cells. The molecular docking results of our study showed that all treated ginsenosides are non-toxic and may be drug-like molecules. The molecular binding interactions of these ginsenosides with the active residues of NF-κB noticeably support their anti-inflammatory activity. CK and Rhl sig- nificantly reduced the production of nitric oxide, cyclooxy- genase-2 （COX-2）, and pro-inflammatory cytokines such as prostaglandin E2 and tumor necrosis factor alpha （TNF-α） in a dose-dependent manner. Real-time PCR and Western blot analyses further confirmed that protopanaxadiols （PPDs） and protopanaxatriols （PPTs） inhibitory effects may have been due to the down-regulation of TNF-α, inducible nitric oxide synthase, COX2, nuclear factor kappa B （NF-κB）, and I kappa B kinase. The expression of co-stimulatory molecules such as ROS was also inhibited by CK and Rhl in a dose- dependent manner. Furthermore, activation of NF-κB in LPS-stimulated RAW 264.7 macrophages was significantly suppressed by CK and Rhl. Taken together, these results provide evidence that PPD- and PPT-type ginsenosides in- cluding CK and Rhl may exhibit strong anti-inflammatory effects by inhibiting pro-inflammatory mediators through down-regulation of NF-κB.

关键词： Ginsenosides Protopanaxadiol Protopanaxatriol Inflammation NF-κB/IKK RAW 264.7

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Change in renal function after sodium phosphate preparation for screening colonoscopy

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World Journal of Gastroenterology 2010年第16期16卷 2010-2016页

作者： Dong Choon Seol Sung noh Hong Jeong Hwan Kim In Kyung Sung Hyung Seok Park Jung Hyun Lee Chan Sup Shim Department of Internal Medicine Konkuk University School of Medicine Department of Health Promotion Healthcare CenterKonkuk University Medical Center Healthcare Center Konkuk University Medical CenterDepartment of Internal MedicineKonkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology Department of Internal Medicine Konkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology

AIM:To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate(NaP) preparation for screening ***:We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 *** to screening colonoscopy,224 patients underwent bowel cleansing with NaP(NaP group) and 113 patients with polyethylene glycol(PEG group).The control group comprised 672 age-matched *** compared the changes in the creatinine levels and the glomerular filtration rates(GFRs) from baseline to 12-24 mo between the NaP,PEG,and control groups using two-way repeated measured analysis of *** addition,multivariate linear regression analysis was performed to assess the risk factors for a decreased ***:The baseline mean serum creatinine level in the NaP,PEG,and control groups was 1.12 ± 0.15,1.12 ± 0.16,and 1.12 ± 0.15 mg/dL,which increased to 1.15 ± 0.15,1.15 ± 0.18,and 1.15 ± 0.15 mg/dL,respectively,after 12-24 *** baseline mean GFR in the NaP,PEG,and control groups was 69.0 ± 7.7,68.9 ± 8.0,and 69.6 ± 6.7 mL/min per 1.73 m2,which decreased to 66.5 ± 7.8,66.5 ± 8.3,and 67.4 ± 6.4 mL/min per 1.73 m2,respectively,after 12-24 *** changes in serum creatinine levels and GFRs were not significantly between the NaP,PEG,and control groups(P = 0.992 and P = 0.233,respectively).Using multivariate linear regression analysis,only the baseline GFR was associated with the change in GFR(P < 0.001).Indeed,the bowel preparations were not associated with the change in GFR(P = 0.297).CONCLUSION:NaP bowel preparation in subjects with normal renal function was not associated with renal injury,and NaP can thus be used safely for screening colonoscopy.

关键词： Sodium phosphate Polyethylene glycol Purgatives Colonoscopy Creatinine Glomerular filtration rate

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Fiber-based quantum-dot pulse oximetry for wearable health monitoring with high wavelength selectivity and photoplethysmogram sensitivity

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npj Flexible Electronics 2023年第1期7卷 413-424页

作者： Ho Seung Lee Byeongju noh Seong Uk Kong Yong Ha Hwang Ha-Eun Cho Yongmin Jeon Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Biomedical Engineering Gachon UniversitySeongnamRepublic of Korea

Increasing demand for real-time healthcare monitoring is leading to advances in thin and flexible optoelectronic device-based wearable pulse *** previous studies have used OLEDs for this purpose,but did not consider the side effects of broad full-width half-maximum(FWHM)characteristics and single *** this study,we performed SpO_(2)measurement using a fiber-based quantum-dot pulse oximetry(FQPO)system capable of mass production with a transferable encapsulation technique,and a narrow FWHM of about 30 *** on analyses we determined that uniform angular narrow FWHM-based light sources are important for accurate SpO_(2)measurements through multi-layer structures and human skin *** FQPO was shown to have improved photoplethysmogram(PPG)signal sensitivity with no waveguide-mode noise signal,as is typically generated when using a single substrate(30–50%).We successfully demonstrate improved SpO_(2)measurement accuracy as well as all-in-one clothing-type pulse oximetry with FQPO.

关键词： pulse waveguide quantum

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Improvement of Flow Duration Curves in Downstream Reach Followed by Operations of Bakgog and Miho Irrigation Reservoirs to be Heightened

Improvement of Flow Duration Curves in Downstream Reach Foll...

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民生水利——理念与行动：中国水利学会2010学术年会

作者： noh Jaekyoung Dept. of Agricultural and Rural Engineering Chungnam National UniversityDaejeonKorea

Bakgog reservoir with watershed area of 84.8 km and Miho reservoir with watershed area of 133.3 km are located in Jincheon County,Chungbuk Province within the watershed of Miho stream with its area of 1,856.08 *** by heightening 2 m of Bakgog reservoir with total water storage capacity increased from 21.75 mm to 26.62 mm and 1 m of Miho reservoir with total water storage capacity increased from 13.87 mm to 16.49 mm,streamflows at Miho A station with watershed area of 579.6 km,at Miho B station with watershed area of 1,625.1 km,and at Miho C station with watershed area of 1,856.1 km downstream were simulated on a daily basis and flow duration curves were drawn and compared between before and after heightening upstream reservoirs. Improvement of flow duration curves could be not visible at any *** a little some streamflow increase could be visible in low flows from 275th flow to 355th flow at Miho A *** of reservoir water storage capacity were 4.87 mm in Bakgog reservoir and 2.62 mm in Miho reservoir. Amounts of annual mean streamflows were decreased from 295.2 mrn to 294.9 mm at Miho A station,from 1,050.2 mm to 1,049.9 mm at Miho B station,and from 1,182.2 mm to 1,180.8 mm at Miho C *** decreases of annual streamflows were considered as the storage effect of *** the above study it was concluded that any effect of increasing downstream streamflows by heightening upstream irrigation reservoirs would be very negligible *** the possibility of improving low flows in a short reach downsream of irrigation reservoirs would be remained.

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Nutritional risk index as a predictor of postoperative wound complications after gastrectomy

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World Journal of Gastroenterology 2012年第7期18卷 673-678页

作者： Cheong Ah Oh Dae Hoon Kim Seung Jong Oh Min Gew Choi Jae Hyung noh Tae Sung Sohn Jae Moon Bae Sung Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine50 Irwon-dongGangnamguSeoul 135-710South Korea

AIM： To investigate the correlation between the nutri- tional risk index （NRI） and postoperative wound com- plications.

关键词： Nutritional risk index Wound complication Gastric cancer

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An improvement of snow/cloud discrimination from machine learning using geostationary satellite data

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International Journal of Digital Earth 2022年第1期15卷 2355-2375页

作者： Donghyun Jin Kyeong-Sang Lee Sungwon Choi noh-Hun Seong Daeseong Jung Suyoung Sim Jongho Woo Uujin Jeon Yugyeong Byeon Kyung-Soo Han Division of Earth Environmental System Science (Major of Spatial Information System Engineering) Pukyong National UniversityBusanKorea Korea Institute of Ocean Science and Technology Korea Ocean Satellite CenterBusanKorea BK21 FOUR Project of the School of Integrated Science for Sustainable Earth Environmental Disaster Pukyong National UniversityBusanKorea

Snow and cloud discrimination is a main factor contributing to errors in satellite-based snow *** address the error,satellite-based snow cover performs snow reclassification tests on the cloud pixels of the cloud mask,but the error still *** Learning(ML)has recently been applied to remote sensing to calculate satellite-based meteorological data,and its utility has been *** this study,snow and cloud discrimination errors were analyzed for GK-2A/AMI snow cover,and ML models(Random Forest and Deep Neural Network)were applied to accurately distinguish snow and *** ML-based snow reclassified was integrated with the GK-2A/AMI snow cover through *** used the S-NPP/VIIRS snow cover and ASOS in situ snow observation data,which are satellite-based snow cover and ground truth data,as validation data to evaluate whether the snow/cloud discrimination is *** ML-based integrated snow cover detected 33–53%more snow compared to the GK-2A/AMI snow *** terms of performance,the F1-score and overall accuracy of the GK-2A/AMI snow cover was 73.06%and 89.99%,respectively,and those of the integrated snow cover were 76.78–78.28%and 90.93–91.26%,respectively.

关键词： Geostationary satellite GK-2A/AMI snow cover product snow/cloud discrimination machine learning remote sensing

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