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Arterial stiffness expressed as brachial–ankle pulse wave velocity and gait assessment independent of lower extremity strength:a cross-sectional study in the older men population

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Journal of Geriatric Cardiology 2023年第2期20卷 91-99页

作者： Tae Kyung Yoo seunghee lee Sae-Jong Park Jong-Young lee Department of Medicine MetroWest Medical CenterFraminghamUSA Department of Physical Education Korea UniversitySeoulSouth Korea Division of Sports Science Korea Institute of Sport ScienceSeoulSouth Korea Division of Cardiology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea

BACKGROUND Older men are more vulnerable to fatal falls than women,and gait disturbances contribute to the risk of *** have assessed the association between arterial stiffness and gait dysfunction,but the results have been *** study aimed to conduct a cross-sectional analysis to evaluate the association between brachial–ankle pulse wave velocity(baPWV)and gait assessment in older *** Data from the 2014–2015 Korea Institute of Sport Science Fitness Standards project were used for the *** inclusion criteria were men aged>65 years with gait assessment[the 30-s chair stand test(30s-CST),the timed up and go(TUG)test,the figure-of-8 walk(F8W)test,the 2-min step test(2MST),and the 6-min walk test(6MWT)]and baPWV measurement *** linear regression analysis was conducted with multiple confounding factor adjustments,including lower extremity isometric *** A total of 291 participants were included in the *** mean age was 71.38±4.40 *** mean values were as follows:(1)30s-CST,17.48±5.00;(2)TUG test,6.01±1.10 s;(3)F8W test,25.65±4.71 s;(4)2MST,102.40±18.83 per 2 min;and(5)6MWT,500.02±85.65 *** multivariable adjustment,baPWV was associated with the 6MWT(β=−0.037,95%CI:−0.072–−0.002),TUG test(β=0,95%CI:0.000–0.001),and F8W test(β=0.002,95%CI:0.000–0.004).baPWV was not associated with the 30s-CST and *** The current study showed a statistically significant association between gait assessments and arterial stiffness,independent of lower extremity ***,this association was *** prospective studies are needed to elucidate the complex relationship between arterial stiffness and gait dysfunction.

关键词： stiffness sectional pulse

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Expansive Homoclinic Classes of Generic C^1-Vector Fields

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Acta Mathematica Sinica,English Series 2016年第12期32卷 1451-1458页

作者： seunghee lee Junmi PARK Department of Mathematics Chungnam National University

Let γ be a hyperbolic closed orbit of a C1 vector field X on a compact C∞ manifold M of dimension n ≥ 3, and let Hx（γ） be the homoclinic class of X containing γ. In this paper, we provethat Cl-generically, if ... 详细信息

关键词： C1-genericity hyperbolicity homoclinic class expansive flow

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Optimal Control of a Mackerel-Mimicking Robot for Energy Efficient Trajectory Tracking

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Journal of Bionic Engineering 2007年第4期4卷 209-215页

作者： seunghee lee Jounghyun Park Cheolheui Han Department of Mechanical Engineering Hanyang University Seoul 133-791 Korea Department of Aeronautical and Mechanical Design Engineering Chungju National University Chungju 380-702 Korea

A robotic fish, BASEMACK1, is designed and fabricated by mimicking the shape of a live mackerel. Three DC servo-motors are serially linked together and actuated to mimic the mackerel＇s Carangiform motion. Hydrodynamic characteristics of a fish-mimetic test model are experimentally identified and utilized in order to numerically simulate fish swimming. The discrete set of kinematic and dynamic parameters are obtained by considering required horizontal and lateral forces and minimum energy consumption. Using the optimized parameter set, optimal control of the robot is studied.

关键词： mackerel-mimicking robot optimal control trajectory tracking

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Two gap-free reference genomes and a global view of the centromere architecture in rice

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Molecular Plant 2021年第10期14卷 1757-1767页

作者： Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long seunghee lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Guangxi UniversityNanning 530004China Wheat Genetics Resource Center Department of Plant PathologyKansas State UniversityManhattanKSUSA Arizona Genomics Institute School of Plant SciencesUniversity of ArizonaTucsonAZ 85721USA Center for Desert Agriculture Biological and Environmental Sciences&Engineering Division(BESE)King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Plant and Wildlife Science Department Brigham Young UniversityProvoUT 84602USA International Rice Research Institute(IRRI) Strategic InnovationLos Baños4031 LagunaPhilippines Crop Germplasm Research Unit USDA-ARS2881 F&B RoadCollege StationTX 77845USA

Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ***,reference genomes for all higher organisms to date contain gaps and missing ***,we report the assembly and analysis of gap-free reference genome sequences for two elite *** xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and ***-free reference genomes provide the opportunity for a global view of the structure and function of *** show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and *** addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and *** genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively *** large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two *** availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties.

关键词： rice genome ZS97 MH63 hybrid rice centromere architecture

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相区成像——电磁波场中的等效地震偏移算法

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石油物探译丛 1989年第1期 40-55页

作者： seunghee lee George A. McMechan Carlos L. V. Aiken 曹辉

电磁资料的另一种解释方法是将观测数据下延,以构制产生这些数据的地下二维电阻率介质模型。将电磁波波动方程与声波动方程类比可知,下延可以用一直接法进行。运用适当的近似算法,取等效方程式中相同的主要项,並将初值问题化为边值问题... 详细信息

电磁资料的另一种解释方法是将观测数据下延,以构制产生这些数据的地下二维电阻率介质模型。将电磁波波动方程与声波动方程类比可知,下延可以用一直接法进行。运用适当的近似算法,取等效方程式中相同的主要项,並将初值问题化为边值问题,则电磁资料的成像可用由地震资料偏移技术导出的任何方法去完成。我们这里选用的是Claerbout单程有限差分波动方程偏移技术。计算是在频率域中进行的。分别处理电场和磁场视剖面,以获得这两个关联反射的像。实际反射位置的最佳估计是这两个像相吻合的地方。反过来,可用同样的方法去模拟二维电阻率分布的响应。方法中的主要假设与现代地震资料处理中的假设基本类似:即数据波场中所含的电磁反射的细节可与背景电导率(波场在背景电导率分布中进行下延)分布相分离,且无多次反射。由此可知,其主要约束为电阻率的变化足够小。成像结果表明,电阻率(是位置的函数)成像的想法是切实可行的,而且可直接模仿地震偏移技术。

关键词：电磁波场相区成像法地震偏移

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Creutzfeldt-Jakob disease presenting with bilateral hearing loss:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6333-6337页

作者： seunghee Na Se A lee Jong Dae lee Eek-Sung lee Tae-Kyeong lee Department of Neurology Incheon St.Mary’s HospitalThe Catholic University of KoreaIncheon 21431South Korea Department of Otorhinolaryngology-Head and Neck Surgery Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Neurology Soonchunhyang University Bucheon HospitalBucheon 14584South Korea

BACKGROUND Sporadic Creutzfeldt-Jakob disease(s CJD)is a prion disease characterized as a fatal transmissible neurodegenerative *** is often the first presenting symptom of s CJD,but hearing loss as an early manifestation is very *** SUMMARY A 76-year-old man presented with bilateral sudden hearing impairment and dizziness for 10 *** was taking medications for hypertension and *** denied any difficulty with activities of daily living or hearing impairment before the onset of *** tone audiometry showed bilateral severe hearing *** magnetic resonance imaging(MRI)and laboratory tests were within normal *** his diagnosis of sudden sensory hearing loss,the patient received corticosteroid treatment but it was *** weeks later,he complained of aggravated gait impairment,disorientation,and cognitive *** brain MRI showed diffuse cortical high signal intensities on diffusion-weighted *** cerebrospinal fluid analysis,the real-time quaking-induced conversion assay was positive,and 14-3-3 protein was detected in the by western *** all the data,we diagnosed probable s CJD,and the patient’s symptoms rapidly progressed into akinetic *** For patients with abrupt bilateral hearing impairment,especially in the elderly,various differential diagnoses,including s CJD,should be considered.

关键词： Case report Creutzfeldt-Jakob disease Bilateral hearing loss Diffusion-weighted imaging Real-time quaking-induced conversion assay

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In Vitro Assessment of Irritation Potential of an Anti-Melanogenic Agent, PF3758309, in a Reconstructed Human Epidermis Model

In Vitro Assessment of Irritation Potential of an Anti-Melan...

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Purpose: This study was designed to determine whether a novel anti-melanogenic agent, PF3758309, has the potential to cause acute cutaneous irritation using a human skin equivalent model(HSEM). Methods: Human skin equivalent was constructed through incubation of normal human derived epidermal keratinocytes(HEKs) on collagen matrix insert with proliferation media. Using constructed human skin equivalent, the irritation potential of PF3758309 were investigated whether the viability of this agent-treated HESM is under 50%(irritant) or not(non-irritant) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay after applying the agent to the epidermal surface of the HSEM. Also, the PF3758309-mediated anti-pigmentation effects were analyzed using Fontana-Masson staining in the HSEM. Results: The integrity of the constructed HSEM was confirmed using immunohistochemical staining with differentiation markers of epidermis, and observed that Keratin 5, Keratin 1 and Involucrin were stained in basal, supra-basal and granular layers, respectively. In vitro irritation assay showed that the mean viabilities of the PF3758309 was 83.6%, 78.8% and 77.8% at the treatment doses of 0.2, 0.5 and 1 mg, respectively;however, the mean viability of the positive control(5% sodium dodecyl sulfate)-treated HESM was 2.8%. Also, in vitro corrosion assay showed that the mean viabilities of the PF3758309 was 95.3%, 95.0% and 94.2% at the treatment doses of 0.2, 0.5 and 1 mg, respectively. Furthermore, using a Fontana-Masson staining assay, the melanin levels in the PF3758309-treated HSEM was significantly decreased compared with the levels in control HSEM. Conclusion: The anti-melanogenic agent, PF3758309, has no skin irritation potential under the conditions used in this study.

关键词： Human skin equivalent PF3758309 Irritation Skin Anti-melanogenesis

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Comparative Analysis of Pathogenicity Assays and PCR for <i>Listeria monocytogenes</i>Isolated from Animal, Raw Food and Environmental Sources in Korea

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Advances in Microbiology 2013年第2期3卷 191-199页

作者： Sanghun Park Jihun Jung Younghee Oh Jibho lee seunghee Ryu Hyowon Jung Sunhee Park Miok Song Gunyong Park Sungmin Choi Sangmi lee Junghun Kim YoungZoo Chae Byungyeol Jung Myunghun lee Hyunsoo Kim Seoul Metropolitan Government Research Institute of Public Health and Environment Yangjae-Dong Seocho-Gu Seoul Korea

Results of PCR with oligonucleotide primers were designed from the assembled panel of four potential virulence genes (two of internalin gene and two of transcriptional regulator gene). Most of the isolates including reference strains were reactive by PCR, whereas the other strains (No.80, 81, and 83) isolated from pork, were non-reactive by PCR. In particular, all pork isolates were PCR-negative for two primers (lmo2672 and 2821) sets tested. However, No.82 was positive for lmo1134 primer, and No.84 was positive for lmo2470 of pork isolates. It was observed that all Listeria monocytogenes (L. monocytogenes) penetrate Vero cells, although the invasion efficiency of each strain varied (between 0.5 and 18.9%). When compared in cell assay with PFGE, the results were shown that the mean invasion efficiency for lineage II isolate (2.6%) was significantly lower (ANOVA-test,

关键词： PFGE Vero Cell Listeria monocytogenes in Vitro Assay

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Molecular Characterization of <i>Listeria monocytogenes</i>Based on the PFGE and RAPD in Korea

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Advances in Microbiology 2012年第4期2卷 605-616页

作者： Sanghun Park Jihun Jung Sungsun Choi Younghee Oh Jibho lee Heesun Chae seunghee Ryu Hyowon Jung Gunyong Park Sungmin Choi Bogsoon Kim Junghun Kim Young Zoo Chae Byungyeol Jung Myunghun lee Hyunsoo Kim Animal Disease Diagonsis Division National Veterinary Research and Quarantine Service Anyang City Korea College of Veterinary Medcine Chungnam National University Daejeon Korea Seoul Metropolitan Government Research Institute of Public Health and Environment Seoul Korea Veterinary Pharmacology Division National Veterinary Research and Quarantine Service Anyang City Korea

This study was performed to characterize 35 L. monocytogenes isolates from animals, foods, environmental samples collected between 1997 and 2007 with no apparent epidemiological relations, and five reference isolates using serotypic, genotypic and molecular typing methods to understand the pattern of strain distribution in Korea. For this study, we used serotyping and detected 6 different virulence-associated genes (inlA, inlB, plcA, plcB, hlyA, and actA) and 16s rRNA using multiplex-PCR. We also compared RAPD and PFGE to determine genetic characterization of L. monocytogenes strains to define the genetic diversity. Serotype patterns of the 30 L. monocytogenes strains was as follows;9 isolates (30.0%) belonged to serotype, 7 isolates (23.3%) belonged to serotype 4b, 4 isolates (13.3%) belonged to serotype 1/2b, 3 isolates (10.0%) belonged to serotype 1/2c, 2 (6.7%) isolates belonged to4c, 2 (6.7%) isolates belonged to NT (Non Type), one isolate (3.2%) belonged to3aand 3b, and4a, respectively. Although, a limited number of isolates were analyzed in this study, molecular typing with RAPD and PFGE indicated that PFGE is more discriminatory for the subtyping L. monocytogenes than RAPD. Some L. monocytogenes isolates by RAPD and PFGE types are associated with specific sources. And, combining data obtained by these methods will increases the likelihood of strain discrimination.

关键词： Listeria monocytogenes PFGE RAPD

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In Vitro Assessment of Irritation Potential of an Anti-Melanogenic Agent,PF3758309,in a Reconstructed Human Epidermis Model

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北京日化 2018年第4期 33-40页

作者： Ayeong lee Yu Rim lee Ji Yea Kim Jin Hyuk Jung Young Kum Park Yu-Jung Kim Sung-Nae lee Sungkwan An seunghee Bae Research Institute for Molecular-Targeted Drugs Department of Cosmetics EngineeringKonkuk UniversitySeoulKorea Korea Institute of Dermatological Sciences SeoulKorea Gragem Corporation Cheongju-siChuncheongbuk-doKorea Department of Beauty Yakson Care Yeoju Institute of TechnologyYeoju-siGyeongi-doKorea Department of Cosmetology Kyung-In Women's UniversityIncheonKorea

Purpose:This study was designed to determine whether a novel anti-melanogenic agent,PF3758309,has the potential to cause acute cutaneous irritation using a human skin equivalent model (HSEM).Methods:Human skin equivalent was constructed through incubation of normal human derived epidermal keratinocytes (HEKs)on collagen matrix insert with proliferation *** constructed human skin equivalent,the irritation potential of PF3758309 were investigated whether the viability of this agent-treated HESM is under 50%(irritant)or not (non-irritant)using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)assay after applying the agent to the epidermal surface of the ***,the PF3758309-mediated anti-pigmentation effects were analyzed using Fontana-Masson staining in the ***:The integrity of the constructed HSEM was confirmed using immunohistochemical staining with differentiation markers of epidermis,and observed that Keratin 5,Keratin I and Involucrin were stained in basal,supra-basal and granular layers,*** vitro irritation assay showed that the mean viabilities of the PF3758309 was 83.6%,78.8%and 77.8%at the treatment doses of 0.2,0.5 and I mg,respectively;however,the mean viability of the positive control (5%sodium dodecyl sulfate)-treated HESM was 2.8%.Also,in vitro corrosion assay showed that the mean viabilities of the PF3758309 was 95.3%,95.0%and 94.2% at the treatment doses of 0.2,0.5 and 1 mg,***,using a Fontana-Masson staining assay,the melanin levels in the PF3758309-treated HSEM was significantly decreased compared with the levels in control ***: The anti-melanogenic agent,PF3758309,has no skin irritation potential under the conditions used in this study.

关键词： Human skin equivalent PF3758309 Irritation,Skin Anti-melanogenesis

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