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Distribution of Eye Diseases in Kasungu District, Malawi, Central Africa—A Retrospective Cross-Sectional Study

Advances in Infectious Diseases 2018年第2期8卷 64-69页

作者： Richard Kang Jae Jun Kim Paul Chung Gyuri Hwang Jung Sung Kim seunghan baek Eun Jung Im George Talama The School of Public Health UC Berkeley Berkeley CA USA College of Agriculture and Life Sciences Cornell University Ithaca NY USA The Biology Department Allegheny College Meadville PA USA Korea International School Gyeonggi-do South Korea Henry M. Gunn High School Palo Alto California USA Department of Computer Science Johns Hopkins University Baltimore MD USA Classics College of Letters Arts and Sciences USC LA USA Kasungu District Hospital Kasungu Malawi

Analysis of eye diseases of patients at Kasungu District Hospital in Malawi was made. Malawi is one of the poorest countries in the world and the health system faces a lot challenges in terms of resources. The study was, therefore, done to understand the burden and distribution of eye diseases in this resource-limited setting. A retrospective study was conducted by extracting data from data registers in the outpatient eye department for the period of May 2015 to June 2016. The data of the reported eye diseases analyzed with variables such as patient gender, eye disease type, patient age and times of the year. There was no association between eye diseases and gender nor with times of the year. However, it was noted that the commonest type of eye disease was conjunctivitis. And, there was strong association of some disease type with age, for example, conjunctivitis was common in young age group while cataract was common in the elderly. It was shown in this study that many of the eye diseases endemic in Africa do generally occur in this selected district as well. However, the analysis presents the possibility of reducing the incidences of many diseases by preventive measures and access to health facilities on time.

关键词： Eye Diseases Kasungu District Malawi

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Global Genomic Variations of Pathogenic Bacteria <i>Salmonella</i>Reading

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Computational Molecular Bioscience 2021年第3期11卷 57-68页

作者： Woo Hyung Lee Yein Jeon Jonathan S. Chung Woo Jun Shim Min Jae Shin Seok Gyu Han seunghan baek James Kim Jaewoo Kim Paul S. Chung Biotechnology School of Sciences Hong Kong University of Science of Technology Hong Kong China Fuzbien Technology Institute Rockville USA Ernest Mario School of Pharmacy Rutgers University New Brunswick USA College of Letters & Sciences University of California Los Angeles USA Biology Bachelor of Science California Institute of Technology Pasadena USA School of Arts & Sciences Johns Hopkins University Baltimore USA School of Arts & Sciences University of Michigan Ann Arbor USA Youth with Talents Fairfax USA

US Centers for Disease Control and Prevention (CDC) estimates food-borne pathogenic Salmonella bacteria cause about 1.35 million infections, 26,500 hospitalizations, and 420 deaths in the U.S. every year. Outbreaks of multidrug-resistant Salmonella Reading linked mainly to raw turkey products and alfalfa sprouts have accounted for human illness including mortality. Therefore, we downloaded and compared genome sequences of 897 Salmonella Reading isolated from 27 resources in 11 countries at 21 year-points from the National Center for Biotechnology Information database. Isolates were clustered into 10 clades which consisted of 3 major and 7 minor or single node clades. Although 3 major clades included both Europe and American isolates, one clade consisted of 605 North American isolates out of 614 isolates. Evolutionary distance is more related to the continent than the source of isolation. The host source, continent (North America and Europe) and phylogenetic clade were related to the prevalence of isolates encoding Antimicrobial Resistance Genes (ARGs). Prevalence of prophages was greater in bovine and swine isolates than poultry and human isolates and the least prevalence was found in human isolates. Between continents, the prevalence of phage was greater in North Ame- rican isolates than European. The diversity of virulence factors in swine isolates differed from poultry isolate while no difference was found among continents. In conclusion, evolutionary distance is related to isolation host source rather than the continent, and genome features were distinguished by host and cluster. Our genomic analysis implies that Salmonella Reading evolved independently to environments within its lineages.

关键词： Salmonella Serovar Reading Genome Antimicrobial Resistance Genes Virulence Factors Phylogenomic Tree

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Renewable Biofuel Production Using Red Ginseng Marc in Microbial Fuel Cells

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Journal of Sustainable Bioenergy Systems 2022年第1期12卷 1-11页

作者： Sung Jun Jang Immanuel H. Anaborne Jacqueline E. Chang Seohyun Shim Sue Min Shin Justin Kong seunghan baek Kunmin Kim Abraham Ha Paul S. Chung The Village School Houston USA Oakton High School Vienna USA Redondo Union High School Redondo Beach USA Branksome Hall Asia International School Jeju-do Korea School of Arts & Sciences Emory University Atlanta USA School of Arts & Sciences Washington University St. Louis USA School of Arts & Sciences Johns Hopkins University Baltimore USA Fuzbien Technology Institute Rockville USA

Microbial fuel cell (MFC) is one of the clean and sustainable energy technologies, often referred to as renewable energy, and directly chemical energy contained in organic matter into electrical energy by using the catalytic activity of microorganisms. Cellulosic biomass is a particularly attractive renewable resource for its abundant supply at low cost and its neutral carbon balance. However, methanogenesis had been negatively linked to anaerobic cellulosic power generation in MFCs. Ginseng root is a saponin-rich plant material and red ginseng marc (RGM) has not been reused as a high-value resource for industry although its residue contained both electron donors and saponin, the potential power generation enhancers for MFC. In this study, RGM was supplemented into MFC to evaluate its effects on methanogenesis and power generation. Two-chamber H-type MFCs were established using rumen fluid as anolyte to ferment cellulose at 2% (w/v). RGM, the residue from the steam and press process for red ginseng beverage preparation, was freeze-dried and ground to pass 0.5 mm sieve and added to the anode of MFC at 1% (w/v;Exp. 1) or 0.1% (Exp. 2) dose for treatment. Open circuit voltage, voltage and current across an external resistor were measured daily for 10d. On d10 of operation, collected biogases were measured for total gas production and analyzed for its components. In Exp. 1, power density was between 44.0 and 97.2 with an average of 83.8 mW/m2 in 1% RGM MFCs and was between 45.2 and 76.3 with an average of 61.5 mW/m2 in control. In Exp. 2, power density was between 44.8 and 75.6 with an average of 60.9 mW/m2 in 0.1% RGM MFCs and was between 45.1 and 54.1 with an average of 49.7 mW/m2 in control. Total gas production for 10d was 563 and 523 mL for RGM and control, respectively, in Exp 1, and was 546 and 477 mL for RGM and control, respectively, in Exp 2. Methane took up 58.6 and 67.9% of total gas for RGM and control, respective

关键词： Microbial Fuel Cell Red Ginseng Marc Cellulose Methanogenesis Electricity

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Analysis of Shear and Firiction Behaviors in End Milling Process

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Journal of Materials Science & Technology 2003年第Z1期19卷 237-238页

作者： seunghan YANG Seungil CHANG Youngmoon LEE Heesool KIM Taejo KO School of Mechanical Engineering Kyungpook National University1370Sankyuk-DongPuk-kuTaegu702-701Korea School of Mechanical Engineering Yeungnam UniversityDaedongGyoungsan712-749Korea

As a new approach to analyze shear behaviors in the shear plane and chip-tool friction behaviors in the chip-toolcontact region during an end milling process,this paper introduces a method to transform an up-end milling processto an equivalent oblique cutting *** this approach,varying undeformed chip thicknesses and cutting forcesin the up-end milling process are replaced with the equivalent of oblique cutting *** investigationsfor Inconel 718 were performed to verify the presented model.

关键词： Up-end milling Equivalent oblique cutting Specific cutting energy

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Laser-assisted Grinding Wheel Dressing (Ⅱ)-Experimental Researches

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Journal of Materials Science & Technology 2003年第Z1期19卷 167-168页

作者： Ming CHEN Fanghong SUN Youngmoon LEE seunghan YANG Jongchan LEE School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200030 China School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200030 China School of Mechanical Engineering Kyungpook National University Daegu 702-701 Korea School of Mechanical Engineering Kyungpook National University Daegu 702-701 Korea School of Mechanical Engineering Kumoh National University of Technology Kumi Kyungpook 730-701 Korea

Most of the mechanical dressing technologies for resin bonded superabrasive grinding wheels are time consumingand costly. Based on the outcomes of the simulations in the previous study, this paper demonstrates the comprehensive researches on the laser-assisted dressing process control, grinding wheel topography reconfiguration by 3Dlaser scanning technology and analyses of grinding temperature. The synthesized parameter incorporates the laserdressing process parameters and can be used to the process control. In order to evaluate the laser-assisted dressingeffectiveness, the newly developed non-contact laser measuring system based on the principle of the triangulationwas used. Grain protrusion height and intergrain spacing can characterize the grinding wheel surface. A series ofgrinding tests with the laser-assisted dressed grinding wheel and mechanically dressed grinding wheel were conductedfor comparison. The results proved the feasibility of laser-assisted dressing for resin bonded superabrasive grindingwheels and revealed the importance of choosing appropriate laser dressing parameters.

关键词： Grinding wheel topography, Laser, Dressing, Grinding

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Global Genomic Variations of Pathogenic Bacteria Salmonella Reading

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Computational Molecular Bioscience（计算分子生物学） 2021年第3期

作者： Woo Hyung Lee Yein Jeon Jonathan S. Chung Woo Jun Shim Min Jae Shin Seok Gyu Han seunghan baek James Kim Jaewoo Kim Paul S. Chung

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Characteristics and biological control functions of Bacillus ***8313 as a host-associated probiotic in red sea bream(Pagrus major)aquaculture

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Animal Nutrition 2023年第1期12卷 20-31页

作者： Won Je Jang Kyung-Bon Lee Mi-Hyeon Jeon Su-Jeong Lee Sang Woo Hur seunghan Lee Bong-Joo Lee Jong Min Lee Kang-Woong Kim Eun-Woo Lee Department of Biotechnology Pukyong National UniversityBusan48513South Korea Department of Biology Education College of Education Chonnam National UniversityGwangju61186South Korea Biopharmaceutical Engineering Major Division of Applied BioengineeringDong-Eui UniversityBusan47340South Korea Aquafeed Research Center National Institute of Fisheries SciencePohang37517South Korea Department of Smart Fisheries Resources College of Industrial SciencesKongju National UniversityYesan32439South Korea

Host-associated probiotics(HAPs)are bacteria originally isolated from rearing water or the host's gastrointestinal tract in order to enhance the host's growth and *** study investigated the HAP potential of Bacillus ***8313,isolated from wild red sea bream(Pagrus major),through characterization and feeding *** based on in vitro tests showed that PM8313 is safe,confirming its hemolytic,cytotoxic,and antibiotic *** addition,PM8313 showed advantages as a probiotic with high viability in the gastrointestinal model and a high cell adhesion ***-genome sequencing demonstrated that PM8313 has a 4,615,871 bp single circular chromosome and a guaninecytosine content of 45.25%.It also showed the absence of genes encoding virulence factors,such as cytotoxin,enterotoxin,hemolysin,sphingomyelinase,and *** the feeding trial,a supplemental diet of 1×10^(8)CFU/g PM8313 positively altered the weight gain,digestive enzyme activity,and intestinal microbiota composition of red sea *** of nonspecific immune parameters and immune-related gene expression,and a challenge test showed that PM8313 supplementation increases immunity and pathogenic bacteria *** findings suggest that PM8313 should be considered for application as a novel HAP to red sea bream aquaculture.

关键词： Host-associated probiotics Immunity Microbiota Probiotics Red sea bream

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长脉冲超声条件下脂质体微泡协同rt-PA溶解微血栓

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中国医学影像技术 2014年第12期30卷 1769-1772页

作者：陈向辉 seunghan Ha 崔凯查道刚宾建平李自成刘伊丽暨南大学附属第一医院心内科广东广州510630 韩国忠北卫生科学大学居勤学院南方医科大学附属南方医院心内科广东广州510515

目的观察长脉冲超声（US）条件下脂质体微泡造影剂协同重组组织型纤溶酶原激活剂（rt-PA）溶解微血栓的疗效。方法采集6名健康受试者全血制备200～300μm的微血栓,根据不同干预方式分为单纯rt-PA组、rt-PA＋低占空比US组（5000个循环）... 详细信息

目的观察长脉冲超声（US）条件下脂质体微泡造影剂协同重组组织型纤溶酶原激活剂（rt-PA）溶解微血栓的疗效。方法采集6名健康受试者全血制备200～300μm的微血栓,根据不同干预方式分为单纯rt-PA组、rt-PA＋低占空比US组（5000个循环）、rt-PA＋高占空比US组（600 000个循环）,另将仅US（600 000个循环）照射但无声学微泡协同作为单纯US组。根据辐照系统内压力减低程度评价溶栓的疗效。结果单纯rt-PA组溶栓率与rt-PA＋低占空比US组比较,差异无统计学意义（P〉0.05）,rt-PA＋高占空比US组溶栓率高于单纯rt-PA组和rt-PA＋低占空比US组（P均〈0.01）。结论长脉冲US声学微泡辅助rt-PA溶栓效果良好,但此协同作用需在低声压条件下依赖一定比例的占空比才能实现。

关键词：超声检查微泡纤溶酶原激活剂溶栓治疗

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长脉冲超声联合脂质体微泡溶解微血栓的体外实验研究

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中国超声医学杂志 2015年第3期31卷 253-256页

作者：陈向辉 seunghan Ha 余健宾建平查道刚李自成刘伊丽暨南大学附属第一医院心内科韩国忠北健康科学大学 3. 南方医科大学附属南方医院心内科

目的评价长脉冲超声联合脂质体微泡造影剂溶解微血栓的疗效。方法构建评价溶栓效能的体外循环系统,通过造成200;00μm的微血栓阻塞于滤网来模仿体内的微循环栓塞。然后治疗组给予脂质体微泡加超声治疗15min,超声频率1MHz、声压1.5MPa、... 详细信息

目的评价长脉冲超声联合脂质体微泡造影剂溶解微血栓的疗效。方法构建评价溶栓效能的体外循环系统,通过造成200;00μm的微血栓阻塞于滤网来模仿体内的微循环栓塞。然后治疗组给予脂质体微泡加超声治疗15min,超声频率1MHz、声压1.5MPa、脉冲间隔3s,包括100、1 000、5 000 3种周期,对照组给予超声照射但无声学微泡。结果治疗组溶栓的效果随着脉冲的延长而增加,且对应的惯性空化效应强度也随之增加。1 000和5 000周期组的溶栓率显著高于单纯超声组（P均<0.01）。结论长脉冲超声联合脂质体微泡能实现良好的溶栓效果,且在一定范围内溶栓的效果随着脉冲的延长而增加。惯性空化可能是长脉冲超声介导微泡溶栓的重要机制之一。

关键词：长脉冲超声微泡造影剂溶栓

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钛合金假体,偏离和视域大小对骨密度的定量CT测定的影响(英文)

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医用生物力学 1998年第2期13卷 72-79页

作者：冯祖德 JaeRho seunghan 厦门大学材料科学系美国孟菲斯大学生物医学工程系美国纽约州立大学布法罗分校骨科系

为了评价用定量CT测定假体植入后周围骨密度变化这一方法的可行比性，本文用人皮质育和松质骨试样研究了钛合金假体，偏离和视域大小对骨密度的定量CT测定精度的影响、取自新鲜人尸体胫骨的14个皮质骨和14个松质骨试样（分别组成两列）... 详细信息

为了评价用定量CT测定假体植入后周围骨密度变化这一方法的可行比性，本文用人皮质育和松质骨试样研究了钛合金假体，偏离和视域大小对骨密度的定量CT测定精度的影响、取自新鲜人尸体胫骨的14个皮质骨和14个松质骨试样（分别组成两列）用于本研究。骨试样分别在含有或不含有钛合金假体、同轴（骨试样列的纵轴线与CT扫描平面的轴线平行且重合）或偏离（骨试样列的纵轴线与CT扫描平面的轴线平行但偏离14厘米）、10厘米或30厘米视域条件下进行CT扫描和图象重构。实验结果表明：当骨试样列的纵轴线与CT扫描平面的轴线同轴时，由于钛合金假作的存在对皮质骨和松质骨BMD测量值的平均影响都小于1％，视域大小对骨密度测量的影响也很小。然而，当骨试样列中插入钛合金假体时，偏离会引起BMD测量值的显著不同（P＜0．0001）。因此，在临床中用定量CT测定假体植入后周围骨密度变化时必须考虑到这一因素。

关键词：定量CT 骨密度钛合金假体偏离视域大小

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