检索结果-南通市图书馆

Peripheral Nerve Block is Safely Administered in a Patient with Kearns-Sayre Syndrome

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第10期129卷 1251-1252页

作者： Woo-Jin Kwon seung-uk bang Sae-Cheol Oh Jung-Woo Shim Department of Anesthesiology and Pain Medicine College of Medicine The Catholic University of Korea Seoul Republic of Korea

Kearns-Sayre syndrome （KSS） is an extremely rare form ofmitochondrial myopathy characterized by progressive external ophthalmoplegia, bilateral pigmentary retinopathy, and cardiac conduction abnormalities. In addition, KSS patients might present with proximal muscle weakness, diabetes mellitus, hearing loss, cerebellar ataxia, and elevated cerebrospinal fluid protein levels.

关键词： Anesthesia Kearns-Sayre Syndrome Nerve Block Ultrasonography

MXene-based hybrid materials for electrochemical and photoelectrochemical H_(2) generation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 111-125,I0004页

作者： Jun Young Kim seung Hun Roh Chengkai Xia uk Sim Jung Kyu Kim School of Material Science and Engineering North University of ChinaTaiyuan 030051China School of Chemical Engineering Sungkyunkwan University(SKKU)2066Seobu-roJangan-guSuwon 16419Republic of Korea Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuJeollanamdo 58330Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University(SKKU)2066Seobu-roJangan-guSuwon 16419Republic of Korea

The conversion of solar energy to produce clean hydrogen fuel through water splitting is an emerging strategy for efficiently storing solar energy in the form of solar *** aligns with the increasing global demand for the development of an ideal energy alternative to fossil fuels that does not emit greenhouse ***(EC) and photoelectrochemical(PEC) water splitting technologies have garnered significant attention worldwide for advanced hydrogen solar fuel production in recent *** achieve sustainable green H_(2) production,it is essential to create efficient catalyst materials that are low-cost and can replace expensive noble metal-based *** characteristics make them an ideal catalyst material for the ***-dimensional MXenes with M_(n+1)X_(n) structure have been identified as a promising option for EC and PEC water splitting due to their superior hydrophilicity,metal-like conductivity,large surface area,and adjustable surface ***,we present a summary of recent advancements in the synthesis and performance enhancement methods for MXene hybrid materials in hydrogen production through EC and PEC water ***,we examine the challenges and insights associated with the rational design of MXene-based hybrid materials to facilitate efficient water splitting for sustainable solar fuel production.

关键词： MXene Hybrid materials EC PEC HER OER Water splitting

Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu Lee Bong-Ki Hong Saseong Lee Naeun Lee seung-Whan Kim Donghyun Kim Wan-uk Kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic ***,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong uk Kim Sung Yong Han Suk Kim Nam Kyung Lee seung Baek Hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第3期20卷 219-229页

作者： Min Seo Kim Jae Han Kim Seohyun Ryu seung Won Lee Dong Keon Yon Eunyoung Kim Ai Koyanagi Elena Dragioti Jae Il Shin Lee Smith Samsung Advanced Institute forHealth Sciences&Technology(SAIHST) Samsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea Yonsei University Collegeof Medicine SeoulRepublicof Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulRepublic of Korea Evidence-Based Research Laboratory Department of Clinical Pharmacy and Pharmaceutical CareCollege of PharmacyChung-Ang UniversitySeoulRepublic of Korea Parc Sanitari Sant Joan de Deu/CIBERSAM/ISCIII Universitat de BarcelonaFundacio Sant Joan de Déu.Sant Boi de LlobregatBarcelonaSpain ICREA Pg.Lluis Companys 23BarcelonaSpain Pain and Rehabilitation Centre and Department of Medical and Health SciencesLinkoping University58185 LinkopingSweden Department of Pediatrics Yonsei University College of MedicineYonsei-ro 50Seodaemun-gu8044Seoul 03722Republic of Korea Centre for Health Performanceand WellbeingAnglia Ruskin UniversityCambridge CB11PTUK Research Laboratory Psychology of Patients Families&Health ProfessionalsDepartment of NursingSchool of Health SciencesUniversity of IoanninaIoannina 45500Greece

Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial ***,the effective minimal antibiotic duration for AOM remains ***,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been *** We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October *** meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 *** the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day *** to amoxicillin,a shorter treatment duration was tolerable with *** Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 ***,5-day regimens would be sufficient for a modest treatment *** findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established.

关键词： Amoxicillin-potassium Amoxicillin Antibacterial agents Cephalosporins Duration of therapy

CaCO_3 film synthesis from ladle furnace slag: morphological change, new material properties, and Ca extraction efficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1447-1456页

作者： seung-Woo Lee Yong-Jae Kim Jun-Hwan bang Soochun Chae Center for carbon mineralization Korea Institute of Geosciences and Mineral Resources Frontier in extreme physics Korea Research Institute of Standards and Science

A rapidly air-cooled ladle furnace slag(RA-LFS), which is a type of steelmaking slag discharged from a steel mill, was used to synthesize CaCO_3 film. The CaCO_3 film with 35 cm^2 of surface area was synthesized under atmospheric conditions, and the surface morphology of the CaCO_3 films was changed by using additives(CaCl_2 and ethylene glycol). Especially, the addition of CaCl_2 changed the surface morphology of CaCO_3 film with pore and induced new material properties, such as water adsorption. The(012) face of CaCO_3 film(calcite) was rapidly decreased by the addition of CaCl_2. The major components of RA-LFS were calcium(type of CaO, 53.9 wt%) and aluminum(type of Al_2 O_3, 37.9 wt%), and the major crystal phases of RA-LFS were C_3 S, C_(12) A_7, and C_3 A. The calcium extraction efficiency of RA-LFS was significantly increased after the CaCO_3 film synthesis. The material properties(hardness and elastic modulus) and the thermal characteristics of the CaCO_3 films were analyzed by nano-indentation and thermogravimetry–differential thermal analysis. The synthesized CaCO_3 films from RA-LFS and Ca(OH)_2(reagent) showed similarities in terms of their material properties and the decomposition temperature.

关键词： carbon dioxide ladle furnace slag carbonation calcium carbonate film calcium efficiency

Gene expression profiling reveals sequential changes in gastric tubular adenoma and carcinoma in situ

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第13期11卷 1937-1945页

作者： Chang-Hee Lee seung-Hyun bang seung-Koo Lee Kyu-Young Song In-Chul Lee Asan Institute for Life Sciences Department of Biochemistry Department of Pathology

AIM: To analyze the expression profiles of premalignant and/or preclinical lesions of gastric ***: We analyzed the expression profiles of normal gastric pit, tubular adenoma and carcinoma in situ using microdissected cells from routine gastric biopsies. For the DNA microarray analysis of formalin-fixed samples,we developed a simple and reproducible RNA extraction and linear amplification procedure applying two polymerasebinding sites. The amplification procedure took only 8 h and yielded comparable DNA microarray data between formalin-fixed tissues and unfixed ***: In comparison with normal pit, adenoma/carcinoma showed 504 up-regulated and 29 down-regulated genes at the expected false significance rate 0.15%. The differential expression between adenoma and carcinoma in situ was subtle: 50 and 22 genes were up-, and down-regulated in carcinomas at the expected false significance rate of 0.61%, respectively. Differentially expressed genes were grouped according to patterns of the sequential changes for the 'tendency analysis' in the gastric mucosaadenoma-carcinoma ***: Groups of genes are shown to reflect the sequential expression changes in the early carcinogenic steps of stomach cancer. It is suggested that molecular carcinogenic pathways could be analyzed using routinely processed biopsies.

关键词： Premalignant lesion Predinical lesion Gastric cancer

Multi-Bandgap Monolithic Metal Nanowire Percolation Network Sensor Integration by Reversible Selective Laser-Induced Redox

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第3期14卷 216-228页

作者： Junhyuk bang Yeongju Jung Hyungjun Kim Dongkwan Kim Maenghyo Cho seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National University1 Gwanak‑roGwanak‑guSeoul 151‑742Republic of Korea Department of Mechanical Engineering Seoul National University1 Gwanak‑roGwanak‑guSeoul 08826Republic of Korea Institute of Advanced Machines and Design Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea

Active electronics are usually composed of semiconductor and metal electrodes which are connected by multiple vacuum deposition steps and photolithography ***,the presence of interface of dissimilar material between semiconductor and metal electrode makes various problems in electrical contacts and mechanical *** ideal electronics should not have defective interfaces of dissimilar *** this study,we developed a novel method to fabricate active electronic components in a monolithic seamless fashion where both metal and semiconductor can be prepared from the same monolith material without creating a semiconductor-metal interface by reversible selective laser-induced redox(rSLIR)***,rSLIR can control the oxidation state of transition metal(Cu)to yield semiconductors with two different bandgap states(Cu_(2)O and CuO with bandgaps of 2.1 and 1.2 eV,respectively),which may allow multifunctional sensors with multiple bandgaps from the same *** novel method enables the seamless integration of single-phase Cu,Cu_(2)O,and CuO,simultaneously while allowing reversible,selec-tive conversion between oxidation states by simply shining laser ***,we fabricated a flexible monolithic metal-semiconduc-tor-metal multispectral photodetector that can detect multiple *** unique monolithic characteristics of rSLIR process can provide next-generation electronics fabrication method overcoming the limitation of conventional photolithography methods.

关键词： Monolithic integration Seamless interface Multi-bandgap nanowire Laser-induced redox Multispectral photodetector

Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第9期14卷 3253-3259页

作者： seung Ji Kang Haeleen Hong Chanho Jeong Ju seung Lee Hyewon Ryu Jae-hun Yang Jong uk Kim Yiel Jae Shin Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Biomedical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The miniaturization and high integration of devices demand significant thermal management *** technologies for the thermal management of electronics show some limitations in the case of multiple chip arrays.A device in multiple chip array is affected by heat from adjacent devices,along with thermal conductive *** address this problem,we present a nano composite of aligned boron nitride(BN)nanosheet islands with porous polydimethylsiloxane(PDMS)foam to have mechanical stability and non-thermal *** islands of tetrahedrally-structured BN in the composite have a high thermal conductivity of 1.219 W·m^(-1)·K^(-1) in the through-plane direction(11.234W·m^(-1)·K^(-1)in the in-plane direction)with 16 wt.%loading of *** the other hand,porous PDMS foam has a low thermal conductivity of 0.0328W·m^(-1)·K^(-1) in the through-plane direction at 70%*** pathways are then formed only in the structured BN islands of the *** porous PDMS foam can be applied as a thermal barrier between structured BN islands to inhibit thermal interference in multiple device ***,this composite can maintain selective thermal dissipation performance with 70%tensile *** beauty of the work is that it could have guided heat dissipation by assembling of multiple layers which have high vertical thermal conductive islands,while inhibiting thermal *** selective heat dissipating composite can be applied as a heatsink for multiple chip arrays electronics.

关键词： selective thermal conduction non-thermal interference thermal conductive composite island stretchable electronics structured boron nitride nanosheet(s-BN) porous polydimethylsiloxane(p-PDMS)