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Neurons in the hippocampal CA1 region,but not the dentate gyrus,are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes

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Neural Regeneration Research 2015年第3期10卷 451-456页

作者： Sang Gun Lee Dae Young Yoo Hyo Young Jung Sung Min Nam Jong Whi Kim Jung Hoon Choi Sun Shin Yi Moo-Ho Won Yeo Sung Yoon In Koo Hwang seung myung moon Departments of Neurosurgery Dongtan Sacred Heart HospitalCollege of MedicineHallym University Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary MedicineKangwon National University Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang University Department of Neurobiology School of MedicineKangwon National University

In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxi- dant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin （75 mg/kg） was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental pa- rameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment.

关键词： nerve regeneration hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons neural regeneration

Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第6期11卷 924-930页

作者： Dae Young Yoo Ki-Yeon Yoo Joon Ha Park Hyun Jung Kwon Hyo Young Jung Jong Whi Kim Goang-Min Choi seung myung moon Dae Won Kim Yeo Sung Yoon Moo-Ho Won In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Oral Anatomy Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Neurobiology School of Medicine Kangwon National University Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Thoracic and Cardiovascular Surgery Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Dongtan Sacred Heart Hospital College of Medicine Hallym University

In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin（ferritin-H）, and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death.

关键词： ferritin transferrin hippocampal stratum minutes glial Ferritin hippocampus rabbit reactivity

Endoscopic papillary balloon dilation:Revival of the old technique

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World Journal of Gastroenterology 2013年第45期19卷 8258-8268页

作者： seung Uk Jeong Sung-Hoon moon myung-Hwan Kim Department of Internal Medicine Jeju National University School of Medicine Jeju 690-767 South Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang 431-070 South Korea Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea

Radiologists first described the removal of bile duct stones using balloon dilation in the early ***,there has been renewed interest in endoscopic balloon dilation with a small balloon to avoid the complications of endoscopic sphincterotomy(EST)in young patients undergoing laparoscopic ***,there is a disparity in using endoscopic balloon papillary dilation(EPBD)between the East and the West,depending on the origin of the *** the early 2000s,EST followed by endoscopic balloon dilation with a large balloon was introduced to treat large or difficult biliary *** balloon dilation with a large balloon has generally been recognized as an effective and safe method,unlike ***,fatal complications have occurred in patients with endoscopic papillary large balloon dilation(EPLBD).The safety of endoscopic balloon dilation is still a debatable ***,guidelines of indications and techniques have not been established in performing endoscopic balloon dilation with a small balloon or a large *** this article,we discuss the issue of conventional and large balloon endoscopic *** also suggest the indications and optimal techniques of EPBD and EPLBD.

关键词： Endoscopic papillary balloon dilation Endoscopic papillary large balloon dilation Common bile duct stone Endoscopic sphincterotomy Mechanical lithotripsy

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Prophecy about post-endoscopic retrograde cholangiopancreatography pancreatitis:From divination to science

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World Journal of Gastroenterology 2013年第5期19卷 631-637页

作者： Sung-Hoon moon myung-Hwan Kim Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 431-070South Korea Department of Internal Medicine University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

One unresolved issue of endoscopic retrograde cholangiopancreatography(ERCP)is post-ERCP pancreatitis (PEP),which occurs in up to 40%of *** of risk factors for PEP is especially important in the field of ERCP practice because it may assist physicians in taking protective measures in situations with high risk.A decade ago,Freeman et al meticulously evaluated a large number of potentially relevant risk factors for PEP,which can be divided into patient-relat-ed and procedure-related *** this commentary, we summarize this classic article and reevaluate the risk factors for PEP from the current point of *** is followed by assessment of strategies for prevention of PEP that can be divided into mechanical and pharmacologic methods.

关键词： Endoscopic retrograde cholangiopancrea-tography Post-endoscopic retrograde cholangiopancreatography pancreatitis Risk factor Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis Pancreatic stents Nonsteroidal antiinflammatory drugs

Sarcopenia in pancreatic cancer:Effect on patient outcomes

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World Journal of Gastrointestinal Oncology 2022年第12期14卷 2302-2312页

作者： moon Hyung Choi seung Bae Yoon Department of Radiology Eunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea

Pancreatic cancer is a challenging disease with an increasing incidence and extremely poor *** clinical outcomes of pancreatic cancer depend on tumor biology,responses to treatments,and malnutrition or *** represents a severe catabolic condition defined by the age-related loss of muscle mass and strength and affects as much as 70%of malnourished pancreatic cancer *** lumbar skeletal muscle index,defined as the total abdominal muscle area at the L3 vertebral level adjusted by the square of the height,is widely used for assessing sarcopenia in patients with pancreatic *** studies have suggested that sarcopenia may be a risk factor for perioperative complications and decreased recurrence-free or overall survival in patients with pancreatic cancer undergoing *** could also intensify chemotherapyinduced toxicities and worsen the quality of life and survival in the neoadjuvant or palliative chemotherapy ***,not only at the time of diagnosis but also during treatment,decreases survival in patients with pancreatic ***,multimodal interventions may improve sarcopenia and clinical outcomes;however,no study has reported positive *** prospective studies are needed to confirm the prognostic role of sarcopenia and the effects of multimodal interventions in patients with pancreatic cancer.

关键词： Sarcopenia Pancreatic cancer Skeletal muscle Computed tomography Outcomes Survival

Carbon Dioxide Concentration and Flux in an Urban Residential Area in Seoul,Korea

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Advances in Atmospheric Sciences 2014年第5期31卷 1101-1112页

作者： moon-Soo PARK seung Jin JOO Soon-Ung PARK Weather Information Service Engine Center for Atmospheric Science & Earthquake ResearchSeoul 121-835 Korea Center for Atmospheric and Environmental Modeling Seoul 152-775 Korea

The carbon dioxide （CO2） concentrations and fluxes measured at a height of 17.5 m above the ground by a sonic anemometer and an open-path gas analyzer at an urban residential site in Seoul, Korea from February 2011 to January 2012 were analyzed. The annual mean CO2 concentration was found to be 750 mg m-3, with a maximum monthly mean concentration of 827 mg m-3 in January and a minimum value of 679 mg m-3 in August. Meanwhile, the annual mean CO2 flux was found to be 0.45 mg m-2 s-1, with a maximum monthly mean flux of 0.91 mg m-2 s-1 in January and a minimum value of 0.19 mg m-2 s-1 in June. The hourly mean CO2 concentration was found to show a significant diurnal variation; a maximum at 0700-0900 LST and a minimum at 1400-1600 LST, with a large diurnal range in winter and a small one in summer, mainly caused by diurnal changes in mixing height, CO2 flux, and surface complexity. The hourly mean CO2 flux was also found to show a significant diurnal variation, but it showed two maxima at 0700-0900 LST and 2100-2400 LST, and two minima at 1100-1500 LST and 0300-0500 LST, mainly caused by a diurnal pattern in CO2 emissions and sinks from road traffic, domestic heating and cooking by liquefied natural gas use, and the different horizontal distribution of CO2 sources and sinks near the site. Differential advection with respect to wind direction was also found to be a cause of diurnal variations in both the CO2 concentration and flux.

关键词： CO2 concentration CO2 flux liquefied natural gas (LNG) Seoul urban residential area

Effect of W/C ratio and cover thickness on polarization characteristics of embedded steel in mortar

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中国有色金属学会会刊：英文版 2009年第4期19卷 909-912页

作者： Kyung-Man moon Sung-Yul LEE myung-Hoon LEE Yun-Hae KIM Department of Mechanical and Material Engineering Korea Maritime University Department of Marine System Engineering Korea Maritime University

The effects of cover thickness and W/C(water-to-cement) ratio on polarization properties of embedded steel bar were investigated with electrochemical *** potentials shift to the noble direction with increasing the cover *** addition,when the cover thickness increasingly becomes thinner and thinner,effect of the W/C ratio on variation of corrosion potential increases as *** value at 100 kHz indicating the resistance of cover thickness increases with the decrement of W/C ratio as well as the increment of cover ***,in the case of W/C ratio at 0.6,impedance at 10 mHz shows the relatively larger value than that at W/C ratio of 0.4 or 0.5 in the range of cover thickness from 4 to 8 cm,which is probably expected that oxide film built up on the surface of steel bar due to strong alkali environment by hydration reaction with increasing W/C ratio is performed as the resistance *** is also observed that liquid junction potential tends to increase with decreasing W/C ratio.

关键词：保护层厚度嵌入式偏振特性钢筋砂浆覆盖厚度极化性能电化学方法

Effects of an Urban Park and Residential Area on the Atmospheric CO_2 Concentration and Flux in Seoul,Korea

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Advances in Atmospheric Sciences 2013年第2期30卷 503-514页

作者： moon-Soo PARK seung Jin JOO Chang Seok LEE Center for Atmospheric and Environmental Modeling Seoul 151 919Korea Life and Environmental Engineering Seoul Women's UniversitySeoul 139 774Korea

The CO2 concentrations and fluxes over an urban forest site （Namsan） and an urban residential region （Boramae） in Seoul, Korea, during the non-growing season （2 4 March 2011）, the growing season （10-12 June 2011）, and the late-growing season （22-24 September 2011） were analyzed. The CO2 concentrations of two sites showed nearly the same diurnal variation, with a maximum value occurring during the night and a minimum value occurring during daytime, as well as the same seasonal variation, with a maximum value during the non-growing season （early spring） and a minimum value during the growing season （summer）. The CO2 flux over the urban forest did not show any typical diurnal variation during the non-growing season, but did show diurnal variation with a small positive value during the night and a large negative value during daytime in the growing and late-growing seasons due to photosynthesis in the urban forest. The CO2 flux over the urban residential region showed a positive daily mean value for all periods, with large values during the non-growing season and small values during the growing season, and it also showed diurnal variation with two maxima at 0600-1000 LST and 1800-2400 LST, and two minima at 0300-0600 LST and 1100-1500 LST, and was strongly correlated with the use of liquefied natural gas for cooking and heating by surrounding houses.

关键词： C02 concentration C02 flux Seoul urban forest urban residential region