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Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response

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World Journal of Clinical Cases 2020年第19期8卷 4342-4348页

作者： Young Jun Kim Jeong-Mi lee Jae-hoon lee Department of Internal Medicine Wonkwang University College of MedicineIksan 54538South Korea Department of Public Health Wonkwang University College of MedicineIksan 54538South Korea Department of Internal Medicine and Institute of Wonkwang Medical Science Wonkwang University College of MedicineIksan 54538South Korea

BACKGROUND Urinary tract infection(UTI)is a common *** often requires hospitalization,and severe presentations,including sepsis and other complications,have a mortality rate of 6.7%-8.7%.AIM To evaluate the predictive factors for early clinical response and effects of initial antibiotic therapy on early clinical response in community-onset Escherichia coli(***)urinary tract infections(UTIs).METHODS This retrospective study was conducted at Wonkwang University Hospital in South Korea between January 2011 and December *** patients(aged>18 years)who were diagnosed with community-onset *** UTI were enrolled in this *** A total of 511 hospitalized patients were included.66.1%of the patients had an early clinical *** mean length of hospital stay in patients with an early clinical response were each 4.3 d shorter than in patients without an early clinical *** the multiple regression analysis,initial appropriate antibiotic therapy(OR=2.449,P=0.006),extended-spectrum(3-lactamase(ESBL)-producing ***(OR=2.112,P=0.044),improper use of broad-spectrum antimicrobials(OR=0.411,P=0.006),and a stay in a healthcare facility before admission(OR=0.562,P=0.033)were the factors associated with an early clinical *** broadspectrum antibiotic therapy was not associated with an early clinical *** ESBL producing ***,and the type of residence before hospital admission were the factors associated with an early clinical *** of initial antibiotic therapy was a predictive factor for an early clinical response,but broadspectrum of initial antibiotic therapy did not impact early clinical response.

关键词： Escherichia coli Urinary tract infections Adult Community acquired infections

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Deep-learning-based gas identification by timevariant illumination of a single micro-LEDembedded gas sensor

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Light(Science & Applications) 2023年第5期12卷 826-837页

作者： Incheol Cho Kichul lee Young Chul Sim Jae-Seok Jeong Minkyu Cho Heechan Jung Mingu Kang Yong-hoon Cho seung Chul Ha Kuk-Jin Yoon Inkyu Park Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea SENKO Co. Ltd.485Oesammi-DongOsan-SiGyeonggil-Do 18111Republic of Korea

Electronic nose(e-nose)technology for selectively identifying a target gas through chemoresistive sensors has gained much attention for various applications,such as smart factory and personal health *** overcome the crossreactivity problem of chemoresistive sensors to various gas species,herein,we propose a novel sensing strategy based on a single micro-LED(μLED)-embedded photoactivated(μLP)gas sensor,utilizing the time-variant illumination for identifying the species and concentrations of various target gases.A fast-changing pseudorandom voltage input is applied to the μLED to generate forced transient sensor responses.A deep neural network is employed to analyze the obtained complex transient signals for gas detection and concentration *** proposed sensor system achieves high classification(~96.99%)and quantification(mean absolute percentage error~31.99%)accuracies for various toxic gases(methanol,ethanol,acetone,and nitrogen dioxide)with a single gas sensor consuming 0.53 *** proposed method may significantly improve the efficiency of e-nose technology in terms of cost,space,and power consumption.

关键词： Deep illumination transient

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Highly Flexible Fabrics/Epoxy Composites with Hybrid Carbon Nanofillers for Absorption-Dominated Electromagnetic Interference Shielding

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Nano-Micro Letters 2022年第11期14卷 307-323页

作者： Jong-hoon lee Yoon-Sub Kim Hea-Jin Ru Seul-Yi lee Soo-Jin Park Department of Chemistry Inha University100 InharoIncheon 22212Korea Korea Architecture Safety Testing and Research Institute(KASTI) 88 Gasan Digital 1-roSeoul 08590Korea

Epoxy-based nano-composites can be ideal electromagnetic interference(EMI)-shielding materials owing to their lightness,chemical inertness,and mechanical ***,poor conductivity and brittleness of the epoxy resin are challenges for fast-growing portable and flexible EMI-shielding applications,such as smart wristband,medical cloth,aerospace,and military *** this study,we explored hybrid nanofillers of single-walled carbon nanotubes(SWCNT)/reduced graphene oxide(rGO)as conductive inks and polyester fabrics(PFs)as a substrate for flexible EMI-shielding *** highest electrical conductivity and fracture toughness of the SWCNT/rGO/PF/epoxy composites were 30.2 S m^(−1)and 38.5 MPa m^(1/2),which are~270 and 65%enhancement over those of the composites without SWCNTs,*** mechanical durability was demonstrated by stable electrical conductivity retention during 1000 cycles of bending *** EMI-shielding effectiveness of~41 dB in the X-band frequency of 8.2-12.4 GHz with a thickness of 0.6 mm was obtained with an EM absorption-dominant behavior over a 0.7 absorption *** results are attributed to the hierarchical architecture of the macroscale PF skeleton and nanoscale SWCNT/rGO networks,leading to superior EMI-shielding *** believe that this approach provides highly flexible and robust EMI-shielding composites for next-generation wearable electronic devices.

关键词： Conductive polymer composites Fracture toughness Flexible composites Absorption-dominated electromagnetic interference shielding

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Radiologic evaluation of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第23期20卷 7392-7402页

作者： seung Soo lee Seong Ho Park Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

Nonalcoholic fatty liver disease(NAFLD)is a frequent cause of chronic liver diseases,ranging from simple steatosis to nonalcoholic steatohepatitis(NASH)-related liver *** liver biopsy is still the gold standard for the diagnosis of NAFLD,especially for the diagnosis of NASH,imaging methods have been increasingly accepted as noninvasive alternatives to liver *** is a well-established and costeffective imaging technique for the diagnosis of hepatic steatosis,especially for screening a large population at risk of *** has a reasonable accuracy in detecting moderate-to-severe hepatic steatosis although it is less accurate for detecting mild hepatic steatosis,operator-dependent,and rather *** tomography is not appropriate for general population assessment of hepatic steatosis given its inaccuracy in detecting mild hepatic steatosis and potential radiation ***,computed tomography may be effective in specific clinical situations,such as evaluation of donor candidates for hepatic *** resonance spectroscopy and magnetic resonance imaging are now regarded as the most accurate practical methods of measuring liver fat in clinical practice,especially for longitudinal followup of patients with *** elastography and magnetic resonance elastography are increasingly used to evaluate the degree of liver fibrosis in patients with NAFLD and to differentiate NASH from simple *** article will review current imaging methods used to evaluate hepatic steatosis,including the diagnostic accuracy,limitations,and practical applicability of each *** will also briefly describe the potential role of elastography techniques in the evaluation of patients with NAFLD.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Liver steatosis Magnetic resonance spectroscopy Magnetic resonance imaging Ultrasonography Computed tomography Elastography

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Microstructural characteristics of AZ31 alloys rolled at room and cryogenic temperatures and their variation during annealing

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Journal of Magnesium and Alloys 2020年第2期8卷 537-545页

作者： Sang Won lee Sang-hoon Kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

This study investigates the microstructural characteristics of AZ31 Mg alloys rolled at room temperature(RT)and cryogenic temperature(CT)and the variation in their microstructure and hardness during subsequent *** induces the formation of more side cracks than does RT rolling,because of the reduction in the ability of the material to accommodate deformation at ***{10-11}contraction and{10-11}-{10-12}double twins are formed in both the material rolled at RT and that rolled at CT,because the grains of the initial material are favorably oriented for{10-11}twinning under *** RT-rolled material has a higher dislocation density than the cryorolled material,and more twins are uniformly distributed throughout the former *** a result,static recrystallization during subsequent annealing is more pronounced in the RT-rolled material,which results in the formation of a highly recrystallized homogeneous microstructure after *** contrast,the formed twins are predominantly present along the shear bands in the cryorolled material,as a result of which this material has an inhomogeneous bi modal structure containing a large amount of coarse unrecrystallized grains after *** hardness of the annealed RT-rolled material is higher than that of the annealed cryorolled material owing to the finer grain structure of the former.

关键词： Magnesium Rolling Cryogenic temperature Annealing Microstructure

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Journal of Central South University 2013年第4期20卷 982-987页

作者： lee Myeong-ho 魏荷 lee Sang-hyuk lee Sang-min SHIN seung-soo Department of e-Commerce Semyung University Department of Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University Institute for Information and Electronics Research Inha University Department of Information Security Tongmyung University

Similarity measure design for discrete data group was proposed. Similarity measure design for continuous membership function was also carried out. Proposed similarity measures were designed based on fuzzy number and distance measure, and were proved. To calculate the degree of similarity of discrete data, relative degree between data and total distribution was obtained. Discrete data similarity measure was completed with combination of mentioned relative degrees. Power interconnected system with multi characteristics was considered to apply discrete similarity measure. Naturally, similarity measure was extended to multi-dimensional similarity measure case, and applied to bus clustering problem.

关键词： similarity measure multi-dimension discrete data relative degree power interconnected system

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Focal incidental colorectal fluorodeoxyglucose uptake:Should it be spotlighted?

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World Journal of Clinical Cases 2024年第15期12卷 2466-2474页

作者： Haejun lee Kyung-hoon Hwang Department of Nuclear Medicine Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea

Fluorine-18 fluorodeoxyglucose(F-18 FDG)positron emission tomography/computed tomography(PET/CT)has emerged as a cornerstone in cancer evaluation imaging,with a well-established history spanning several *** imaging modality,encompassing the examination of the body from the base of the skull to the upper thighs,comprehensively covers the chest and abdominopelvic regions in a singular scan,allowing for a holistic assessment of nearly the entire body,including areas of marginal *** inherent advantage of this expansive scan range lies in its potential to unveil unexpected incidental abnormal hypermetabolic *** identification of incidental focal FDG uptake within colorectal regions during PET/CT scans is not an uncommon occurrence,albeit fraught with challenges associated with non-specific FDG *** presence of benign colorectal lesions or physiological uptake poses a particular obstacle,as these may manifest with FDG uptake levels that mimic ***,physicians are confronted with a diagnostic dilemma when encountering abnormal FDG uptake in unexpected colorectal *** studies have presented divergent results concerning these *** uptake value and its derivatives have served as pivotal metrics in quantifying FDG uptake in PET *** this article,we aim to succinctly explore the distinctive characteristics of FDG,delve into imaging findings,and elucidate the clinical significance of incidental focal colorectal *** discussion aims to contribute valuable insights into the nuanced interpretation of such findings,fostering a comprehensive understanding.

关键词： Focal Incidental Colorectal Fluorodeoxyglucose Positron emission tomography Hypermetabolism

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Self-assembly of tau fragments as a key pathologic event in tauopathies

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Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： Ly Thi Huong Luu Le Jung hoon lee Min Jae lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

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Unexpected focal fluorodeoxyglucose uptake in main organs;pass through or pass by?

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World Journal of Clinical Cases 2024年第11期12卷 1885-1899页

作者： Haejun lee Kyung-hoon Hwang Department of Nuclear Medicine Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea

Since the inception of fluorine-18 fluorodeoxyglucose(F-18 FDG),positron emission tomography/computed tomography(PET/CT)utilizing F-18 FDG has become widely accepted as a valuable imaging modality in the field of oncology,with global prevalence in clinical *** that a single Torso PET/CT scan encompasses the anatomical region from the skull base to the upper thigh,the detection of incidental abnormal focal hypermetabolism in areas of limited clinical interest is both feasible and not *** investigations have been undertaken to delineate the distinctive features of these findings,yet the outcomes have proven *** incongruent results of these studies present a challenge for physicians,leaving them uncertain about the appropriate course of *** article provides a succinct overview of the characteristics of fluorodeoxyglucose,followed by a comprehensive discussion of the imaging findings and clinical significance associated with incidental focal abnormal F-18 FDG activity in several representative *** conclusion,while the prevalence of unrecognized malignancy varies across organs,malignancies account for a substantial proportion,ranging from approximately one-third to over half,of incidental focal *** light of these rates,physicians are urged to exercise vigilance in not disregarding unexpected uptake,facilitating more assured clinical decisions,and advocating for further active evaluation.

关键词： Incidental Focal Incidentaloma Fluorodeoxyglucose Positron emission tomography Hypermetabolism

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Chromosomal assembly of the Antarctic toothfish(Dissostichus mawsoni)genome using third-generation DNA sequencing and Hi-C technology

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Zoological Research 2021年第1期42卷 124-129页

作者： seung Jae lee Jeong-hoon Kim Euna Jo Eunkyung Choi Jinmu Kim Seok-Gwan Choi Sangdeok Chung Hyun-Woo Kim Hyun Park College of Life Sciences and Biotechnology Korea UniversitySeoul 02841Republic of Korea Division of Polar Life Science Korea Polar Research InstituteIncheon 21990Republic of Korea Unit of Research for Practical Application Korea Polar Research InstituteIncheon 21990Republic of Korea National Institute of Fisheries Science(NIFS) Busan 46083Republic of Korea Department of Marine Biology Pukyong National UniversityBusan 48513Republic of Korea

DEAR EDITOR,The Antarctic toothfish,Dissostichus mawsoni,belongs to the Nototheniidae family and is distributed in sub-zero temperatures below S60°latitude in the Southern ***,it is an attractive model species to study the stenothermal cold-adapted character *** this study,we successfully generated highly contiguous genome sequences of ***,which contained 1062 scaffolds with a N50 length of 36.98 Mb and longest scaffold length of 46.82 *** elements accounted for 40.87%of the *** also inferred 32914 protein-coding genes using in silico gene prediction and transcriptome sequencing and detected splicing variants using Isoform-Sequencing(Iso-Seq),which will be invaluable resource for further exploration of the adaptation mechanisms of Antarctic *** new high-quality reference genome of *** provides a fundamental resource for a deeper understanding of cold adaptation and conservation of species.

关键词： Antarctic latitude fish

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