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Surgical management of colonic diverticular disease:Discrepancy between right- and left-sided diseases

World Journal of Gastroenterology 2014年第29期20卷 10115-10120页

作者： Heung-Kwon Oh Eon Chul Han heon-Kyun Ha Eun Kyung Choe Sang Hui Moon seung-Bum Ryoo seung-Yong Jeong Kyu Joo Park Division of Colorectal Surgery Department of SurgerySeoul National University College of Medicine

AIM:To compare the outcome of the surgical management of left-sided and right-sided diverticular ***:The medical records of 77 patients who were surgically treated for diverticular disease between 1999 and 2010 in a tertiary referral hospital were retrospectively *** study population was limited to cases wherein the surgical specimen was confirmed as diverticulosis by *** diverticula were classified as those arising from the cecum,ascending colon,and transverse colon,and those from the descending colon,sigmoid colon,and rectum were classified as left-sided *** assess the changing trend of occurrence of diverticulosis,data were compared with two previous studies of 51 ***:The proportion of left-sided disease cases was significantly increased compared to the results of our previous studies in 1994 and 2001,(27.5%vs48.1%,P<0.05).Moreover,no differences in gender,body mass index,multiplicity of the diverticula,fever,or leukocytosis were noted between patients with rightsided and left-sided ***,patients with right-sided disease were significantly younger(50.9year vs 64.0 year,P<0.01).Furthermore,left-sided disease was significantly associated with a higher incidence of complicated diverticulitis(89.2%vs 57.5%,P<0.01),combined resection due to extensive inflammation(21.6%vs 5.0%,P<0.05),operative complications(51.4%vs 27.5%,P<0.05),and in-hospital mortality(10.8%vs 0%,P<0.05),along with longer post-operative hospitalization duration(21.3±10.2 d vs 10.6±8.1 d,P<0.05).CONCLUSION:Compared with right-sided diverticular disease,the incidence of left-sided disease in Korea has increased since 2001 and is associated with worse surgical outcomes.

关键词： Colonic diverticulosis Diverticular bleeding Diverticulitis Poor surgical outcome Left-sided diverticulitis

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Pediatric appendicitis with appendicolith often presents with prolonged abdominal pain and a high risk of perforation

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World Journal of Pediatrics 2018年第2期14卷 184-190页

作者： Hee Mang Yoon Jung heon Kim Jong seung Lee Jeong-Min Ryu Dae Yeon Kim Jeong-Yong Lee Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pediatric Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of Medicine88Olympic-ro 43-gilSongpa-guSeoul 05505South Korea

Background Appendicolith can cause appendiceal obstruction and acute *** high prevalence may be related to the high perforation rate in pediatric *** study assessed the characteristics of appendicolith and its clinical significance in pediatric *** A retrospective study was performed among children and adolescents younger than 17 years who were preopera-tively diagnosed with appendicitis in the pediatric emergency department(ED).A total of 269 patients with a mean age of 9.98±3.37 years were *** features and contrast-enhanced computed tomography findings were *** Among the 269 patients,147(54.6%)had appendicoliths,with a mean maximal diameter of 5.21±2.34 ***-pared to the no appendicolith group,the appendicolith group demonstrated more prolonged abdominal pain(≥48 hours)before the ED visit(23.1%vs.11.5%;P=0.013),clinical features of severe appendicitis(presence of fever,vomiting,posi-tive urine ketone,and increased C-reactive protein),and higher rate of perforation(43.5%vs.9.8%;P<0.001).Multivariate risk factor analysis for perforated appendicitis in the appendicolith group revealed that maximal diameter of 5 mm or more in the appendicolith(adjusted odds ratio[aOR]2.919;95%CI 1.325-6.428,P=0.008)and proximal collapse adjacent to the appendicolith(aOR 2.943;95%CI 1.344-6.443,P=0.007)were *** Pediatric appendicitis with appendicolith often presents with prolonged abdominal pain and severe clinical conditions with a high risk of perforation.

关键词： Appendicitis Appendicolith Computed tomography Pediatrics Risk factors

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Microbiota-based treatments in alcoholic liver disease

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World Journal of Gastroenterology 2016年第29期22卷 6673-6682页

作者： Hotaik Sung seung Woo Kim Meegun hong Ki Tae Suk Department of Molecular and Cell Physiology University of Cincinnati College of Medicine Department of Biomedical Science Hallym University College of Medicine Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Hallym University College of Medicine

Gut microbiota plays a key role in the pathogenesis of alcoholic liver disease(ALD). Consumption of alcohol leads to increased gut permeability, small intestinal bacterial overgrowth, and enteric dysbiosis. These factors contribute to the increased translocation of microbial products to the liver via the portal tract. Subsequently, bacterial endotoxins such as lipopolysaccharide, in association with the Toll-like receptor 4 signaling pathway, induce a gamut of damaging immune responses in the hepatic milieu. Because of the close association between deleterious inflammation and ALD-induced microbiota imbalance, therapeutic approaches that seek to reestablish gut homeostasis should be considered in the treatment of alcoholic patients. To this end, a number of preliminary studies on probiotics have confirmed their effectiveness in suppressing proinflammatory cytokines and improving liver function in the context of ALD. In addition, there have been few studies linking the administration of prebiotics and antibiotics with reduction of alcoholinduced liver damage. Because these preliminary results are promising, large-scale randomized studies are warranted to elucidate the impact of these microbiotabased treatments on the gut flora and associated immune responses, in addition to exploring questions about optimal delivery. Finally, fecal microbiota transplant has been shown to be an effective method of modulating gut microbiota and deserve further investigation as a potential therapeutic option for ALD.

关键词： Alcoholic liver disease Gut Microbiota Probiotics Treatment

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Characteristics of gastric cancer recurrence five or more years after curative gastrectomy

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Chinese Journal of Cancer Research 2016年第5期28卷 503-510页

作者： Chang-Hyun Shin Woo-Yong Lee seung-Woo hong Yeo-Goo Chang Department of Surgery Ilsan Paik HospitalInje University College of Medicine Department of Surgery Seoul Paik HospitalInje University College of Medicine

Objective： To investigate the characteristics of recurrences that occurred 5 or more years after curative resection for gastric ***： We analyzed recurrences among 1,299 patients with gastric cancer who underwent curative operations at the Department of Surgery, Inje University Seoul Paik Hospital between September 1998 and December 2002. Recurrences were classified as within 2 years （early）, 2-5 years （intermediate）, and more than 5 years （late） after gastrectomy. The clinicopathologic findings of the patients with late recurrence were compared with those of patients in the other two recurrence groups, with special reference to the patterns of recurrence. Both univariate and multivariate analyses were performed, incorporating factors such as operation type, T-stage, N-stage, stage, lymphatic invasion, neural invasion, histology, tumor size, and recurrence ***： At the time of last follow-up, recurrence occurred in 266 （20.5%） patients. Recurrence times were classified as 〈2 years （182 patients）, 2-5 years （61 patients）, or 〉5 years （23 patients）. The late recurrence rate was 8.6%. The occurrence of recurrence 〉5 years after gastrectomy was significantly correlated with age, operation type, T-stage, N-stage, stage, lymphatic invasion, neural invasion, histology, tumor size, location and recurrence site （P〈0.05）. The main recurrence patterns in the 23 patients with late recurrence were locoregional metastasis （10 patients, 43.5%）, peritoneal seeding （8 patients, 34.8%）, hematogenous metastasis （2 patients, 8.7%）, and multiple metastasis （3 patients, 13.0%）. A multivariate analysis showed that larger tumor size and younger age were independent prognostic factors for late recurrence. Additionally, locoregional and peritoneal recurrences were significantly more common than hematogenous recurrences. Conclusions： Although late recurrence was uncommon, younger age and larger tumor size were associated with high risk. Follow-up surveillance is recommended

关键词： Curative surgery gastric cancer gastrectomy late recurrence recurrence

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Intermittent, low-dose, antiandrogen monotherapy as an alternative therapeutic option for patients with positive surgical margins after radical prostatectomy

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Asian Journal of Andrology 2018年第3期20卷 270-275页

作者： Kyung Hwa Choi seung Ryeol Lee Young Kwon hong Dong Soo Park Department Urology CHA Bundang Medical Center CHA University Seongnam Korea.

The aim of the present study was to determine whether oncologic outcomes and adverse events associated with active on/off intermittent antiandrogen monotherapy （daily bicalutamide, 50 mg per day） are comparable with those of standard external beam radiation therapy （EBRT） or combined androgen blockade （CAB） therapy in prostate cancers with positive surgical margins after radical prostatectomy. Two hundred twenty-three patients with positive surgical margins post-radical prostatectomy who underwent active surveillance （AS, n = 32）, EBRT without hormone therapy （n = 55）, intermittent antiandrogen monotherapy without EBRT （IAAM, n= 50）, or CAB without EBRT （n = 86）, between 2007 and 2014, were reviewed retrospectively. Pathologic outcomes, biochemical recurrence rates, radiological disease progression, and adverse events were collected from medical records. Biochemical recurrence rates, biochemical recurrence-free survival rates, and radiological recurrence were not different between the groups （P = 0.225, 0.896, and 0.284, respectively）. Adverse event rates and severities were lower for IAAM compared with EBRT or CAB （both P 〈 0.05）, but were comparable to those for AS （P = 0.591 and 0.990, respectively）. Grade ：〉3 adverse events were not reported in the IAAM or AS groups. Erectile dysfunction and loss of libido rates were lower in the IAAM group compared with the EBRT and CAB groups （P = 0.032）. Gastrointestinal complications were more frequently reported in the EBRT group （P = 0.008）. Active on/off IAAM treatment might be an appropriate treatment option for patients with positive surgical margins after radical prostatectomy. Furthermore, regarding oncologic outcomes, IAAM was comparable to standard EBRT but had a milder adverse event profile.

关键词： androgen receptor antagonists disease progression margins of excision prostatectomy prostatic neoplasms

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Effects of dietary intake and genetic factors on hypermethyiation of the hMLH1 gene promoter in gastric cancer

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World Journal of Gastroenterology 2005年第25期11卷 3834-3841页

作者： Young-Jin Song Hyo-Yung Yun Joo-seung Park heon Kim Departments of Surgery Department of Surgery Department of Preventive Medicine

AIM: Hypermethylation of the promoter of the hMLH1gene, which plays an important role in mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer tissues. The purpose of this study was to investigate the effects of environmental factors, genetic polymorphisms of major metabolic enzymes, and microsatellite instability on hypermethylation of the promoter of the hMLH1 gene in gastric ***: Data were obtained from a hospital-based,case-control study of gastric cancer. One hundred and ten gastric cancer patients and 220 age- and sex-matched control patients completed a structured questionnaire regarding their exposure to environmental risk *** of the hMLH1 gene promoter,polymorphisms of the GSTM1, GSTT1, CYP1A1, CYP2E1,ALDH2 and L-myc genes, microsatellite instability and mutations of p53 and Ki-ras genes were ***: Both smoking and alcohol consumption were associated with a higher risk of gastric cancer with hypermethylation of the hMLH1 gene promoter. High intake of vegetables and low intake of potato were associated with increased likelihood of gastric cancer with hypermethylation of the hMLH1 gene promoter. Genetic polymorphisms of the GSTM1, GSTT1, CYP1A1, CYP2E1,ALDH2, and L-mycgenes were not significantly associated with the risk of gastric cancer either with or without hypermethylation in the promoter of the hMLH1 *** of the hMLH1 promoter was significantly associated with microsatellite instability (MSI): 10 of the 14 (71.4%) MSI-positive tumors showed hypermethylation,whereas 28 of 94 (29.8%) the MSI-negative tumors were hypermethylated at the hMLH1 promoter *** of the hMLH1 gene promoter was significantly inversely correlated with mutation of the ***: These results suggest that cigarette smoking and alcohol consumption may influence the development of hMLH1-positive gastric cancer. Most dietary factors and polymorphisms of GSTM1, G

关键词： Gastric cancer Environmental carcinogens Genetic polymorphisms hMTLH1 Microsatellite instability p53 Ki-ras

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Favorable surgical treatment outcomes for chronic constipation with features of colonic pseudo-obstruction

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World Journal of Gastroenterology 2012年第32期18卷 4441-4446页

作者： Eon Chul Han Heung-Kwon Oh heon-Kyun Ha Eun Kyung Choe Sang Hui Moon seung-Bum Ryoo Kyu Joo Park Department of Surgery Seoul National University College of MedicineSeoul 110-744South Korea Seoul National University Hospital Gangnam Center Seoul 110-744South Korea

AIM:To determine long-term outcomes of surgical treatments for patients with constipation and features of colonic ***:Consecutive 42 patients who underwent surgery for chronic constipation within the last 13 years were prospectively *** identified a subgroup with colonic pseudo-obstruction(CPO) features,with dilatation of the colon proximal to the narrowed transitional zone,in contrast to typical slowtransit constipation(STC),without any dilated colonic *** outcomes of surgical treatments for chronic constipation with features of CPO were analyzed and compared with outcomes for ***:Of the 42 patients who underwent surgery for constipation,33 patients had CPO with dilatation of the colon proximal to the narrowed transitional *** were 16 males and 17 females with a mean age of 51.2 ± 16.1 *** had symptoms of chronic intestinal obstruction,including abdominal distension,pain,nausea,or vomiting,and the mean duration of symptoms was 67 mo(range:6-252 mo).Preoperative defecation frequency was 1.5 ± 0.6 times/wk(range:1-2 times/wk).Thirty-two patients underwent total colectomy,and one patient underwent diverting transverse *** was no surgery-related *** histologic examination showed hypoganglionosis or agangliosis in 23 patients and hypoganglionosis combined with visceral neuropathy or myopathy in 10 *** contrast,histology of STC group revealed intestinal neuronal dysplasia type B(n = 6) and visceral myopathy(n = 3).Early postoperative complications developed in six patients with CPO;wound infection(n = 3),paralytic ileus(n = 2),and intraabdominal abscess(n = 1).Defecation frequencies 3 mo after surgery improved to 4.2 ± 3.2 times/d(range:1-15 times/d).Long-term follow-up(median:39.7 mo) was available in 32 patients;all patients had improvements in constipation symptoms,but two patients needed intermittent medication for management of *** 32 patients had distinct

关键词： Constipation Total colectomy Pseudoobstruction Surgical outcome Hypoganglionosis

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Factor analysis of recent major heatwaves in East Asia

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Geoscience Frontiers 2024年第1期15卷 374-383页

作者： Arim Yoon Jeongwon Kim Jooyeop Lee Hyun Min Sung Je-Woo hong seung-Ki Min Junhong Lee Jinkyu hong Ecosystem-Atmosphere Process Laboratory Department of Atmospheric SciencesYonsei UniversitySeoul 03722Republic of Korea National Institute of Meteorological Sciences Jeju 63568Republic of Korea Korea Adaptation Center for Climate Korea Environment InstituteSejong 30121Republic of Korea Division of Environmental Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Max Planck Institute for Meteorology Hamburg 20146Germany Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoulRepublic of Korea

Heatwaves(HWs)present a major hazard to our society and more extreme heatwaves are expected with future climatic ***,it is important to improve our understanding of the underlying processes that drive HWs,in order to boost our socioeconomic-ecological *** this study,we quantified the influences of key driving factors(large-scale atmospheric circulation,soil moisture,and sea surface temperature)and their synergies on recent heatwaves in East *** conducted a factor separation analysis for three recent HW events by constraining the key factors in the regional Weather Research and Forecasting model with their climatologies or pseudo-observations in different *** study showed distinct spatial variations in the HW-controlling factors in East *** synergistic interaction of large-scale circulation and soil moisture was the most important factors in the 2013 Chinese *** the 2018 HWs in Korea and Japan,the same stagnant large-scale atmospheric circulation played a dominant role in driving the HW *** land-atmosphere coupling via soil moisture,its interaction with circulation,and SST exhibited stronger influences during the Korean HW than the Japanese *** analysis also revealed temporal variations in the factors driving Korean and Chinese HWs due to typhoon passage and other multiple processes over heterogeneous surfaces(i.e.,topographically induced Foehn winds,large-scale warm advection from the warm ocean,spatial differences in soil moisture).Our findings suggest that future heatwave-related studies should consider interactive contributions of key factors,their interplay with surface heterogeneities of complex terrain.

关键词： Heatwave East Asia Large-scale circulation Soil moisture Sea surface temperature Synergistic impacts

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Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands

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Nano Research 2021年第9期14卷 3253-3259页

作者： seung Ji Kang Haeleen hong Chanho Jeong Ju seung Lee Hyewon Ryu Jae-hun Yang Jong Uk Kim Yiel Jae Shin Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Biomedical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The miniaturization and high integration of devices demand significant thermal management *** technologies for the thermal management of electronics show some limitations in the case of multiple chip arrays.A device in multiple chip array is affected by heat from adjacent devices,along with thermal conductive *** address this problem,we present a nano composite of aligned boron nitride(BN)nanosheet islands with porous polydimethylsiloxane(PDMS)foam to have mechanical stability and non-thermal *** islands of tetrahedrally-structured BN in the composite have a high thermal conductivity of 1.219 W·m^(-1)·K^(-1) in the through-plane direction(11.234W·m^(-1)·K^(-1)in the in-plane direction)with 16 wt.%loading of *** the other hand,porous PDMS foam has a low thermal conductivity of 0.0328W·m^(-1)·K^(-1) in the through-plane direction at 70%*** pathways are then formed only in the structured BN islands of the *** porous PDMS foam can be applied as a thermal barrier between structured BN islands to inhibit thermal interference in multiple device ***,this composite can maintain selective thermal dissipation performance with 70%tensile *** beauty of the work is that it could have guided heat dissipation by assembling of multiple layers which have high vertical thermal conductive islands,while inhibiting thermal *** selective heat dissipating composite can be applied as a heatsink for multiple chip arrays electronics.

关键词： selective thermal conduction non-thermal interference thermal conductive composite island stretchable electronics structured boron nitride nanosheet(s-BN) porous polydimethylsiloxane(p-PDMS)

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Development of a Powder Extruder System for Dual-pore Tissue-engineering Scaffold Fabrication

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Journal of Bionic Engineering 2019年第4期16卷 686-695页

作者： Nae-Un Kang Myoung Wha hong Young Yul Kim Young-Sam Cho seung-Jae Lee Department of Mechanical Design Engineering College of EngineeringWonkwang University460 Iksandae-roIks an Jeonbuk570-749Republic of Korea Department of Orthopedics Daejeon StMary's HospitalCatholic University of Korea64Daeheung-i Jung-guDaejeon301-723Republic of Korea

In this study,we developed a powder extruder system that can extrude and deposit powder mixtures to overcome the reported limitations of conventional dualpore scaffold manufacturing *** evaluate the extrusion and deposition capability of the powder extruder system,3D tissue-engineering scaffolds with dual-pore characteristics were fabricated with a PCL/PEO/NaCl(polycaprolactone/polyethylene oxide/sodium chloride)powder *** addition,to evaluate the fabricated scaffolds,their compressive modulus,morphology,and in-vitro cell activity were ***,it was confirmed that the proposed powder extruder system can fabricate dual-pore scaffolds with well-interconnected pores as well as arbitrary 3D shapes shown by the fabrication of a 3D femur-shape scaffold similar to the femur *** results of the cell proliferation and Cell Counting Kit-8(CCK-8)assays,DNA content analysis and viability assays confirm that the dual-pore scaffold fabricated by the powder extruder system improves cell attachment,proliferation,and viability.

关键词： dual-pore scaffold powder extruder system polycaprolactone 3D tissue-engineering scaffold

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