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Effect of the herbal medicine Danggui Sini plus Wuzhuyu Shengjiang Tang on erythrocyte deformability in normal subjects: a cross-over trial

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Journal of Traditional Chinese Medicine 2018年第5期38卷 769-772页

作者： JiEun Lee seung-Yeon Cho Seong-uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ki-Ho Cho seungwon Kwon Department of Cardiology and Neurology College of Korean Medicine Kyung Hee University

OBJECTIVE: To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang(DSWST) has any transient effect on erythrocyte deformability in normal ***: A total of 25 subjects [mean age(27.8± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte ***: The elongation index increased significantly after 2 h(P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant differenceobserved. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration,DSWST improved erythrocyte deformability significantly compared to water(P < 0.001).CONCLUSION: DSWST has a transient effect on erythrocyte deformability in normal subjects.

关键词： Erythrocyte deformability Peptide elongation factors Raynaud disease Coldness of hands and feet Cross-over studies Danggui Sini plus Wuzhuyu Shengjiang Tang

Brain Activity Associated with Memory and Cognitive Function During Jaw-Tapping Movement in Healthy Subjects Using Functional Magnetic Resonance Imaging*

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Chinese Journal of Integrative Medicine 2013年第6期19卷 409-417页

作者： seung-Yeon Cho Ae-Sook Shin Byung-Jo Na Geon-Ho Jahng Seong-uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Department of Cardiovascular and Neurological Diseases College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Internal Medicine Kang-Nam Korean HospitalKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongSchool of MedicineKyuna Hee UniversitySeoulKorea

Objective： TO determine whether jaw-tapping movement, a classically described as an indication of personal well-being and mental health, stimulates the memory and the cognitive regions of the brain and is associated with improved brain performance. Methods： Twelve healthy right-handed female subjects completed the study. Each patient performed a jaw-tapping task and an n-back task during functional magnetic resonance imaging （fMRI）. The subjects were trained to carry out the jaw-tapping movement at home twice a day for 4 weeks. The fMRI was repeated when they returned. Results： During the first and second jaw-tapping session, both sides of precentral gyrus and the right middle frontal gyrus （BA 6） were activated. And during the second session of the jaw-tapping task, parts of frontal lobe and temporal lobe related to memory function were more activated. In addition, the total percent task accuracy in n-beck task significantly increased after 4 weeks of jaw- tapping movement. After jaw-tapping training for 4 weeks, brain areas related to memory showed significantly increased blood oxygen level dependent signals. Conclusion： Jaw-tapping movement might be a useful exercise for stimulating the memory and cognitive regions of the brain.

关键词： Jaw-tapping movement functional magnetic resonance imaging memory cognitive function dementia

Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-Min Kim Seyeong Lee Dongyoon Kim Dong-Hee Kang Kisuk Yang seung-Woo Cho Jin Seok Lee Insung S. Choi Kyungtae Kang Myung-Han yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures metal-assisted chemical etching primary hippocampal neurons neurite outgrowth cytoskeletal dynamics

Formation of unidirectional nanoporous structures in thickly anodized aluminum oxide layer

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中国有色金属学会会刊：英文版 2009年第4期19卷 1013-1017页

作者： Hyun-Chae NA Taek-Jin SUNG Seok-Heon yoon seung-Kyoun HYUN Mok-Soon KIM Young-Gi LEE Sang-Hyun SHIN Seok-Moon CHOI Sung YI Division of Materials Science and Engineering Inha University Samsung Electro-Mechanics Co. Ltd.

A series of anodic aluminum oxide(AAO) was grown on the commercially pure 1050 aluminum sheet by controlling electrolyte temperature(2-15 ℃) and anodizing time(0.5-6 h),using a fixed applied current density of 3 A/dm2 in diluted sulfuric acid electrolyte.A crack-free thick AAO with the thickness of 105-120 μm and containing unidirectional nano sized pores(average pore diameter of 5-7 nm) is successfully achieved in the specimens anodized for 2 h,irrespective of electrolyte *** anodizing time reaches 6 h,very thick AAO with the thickness of 230-284 μm is grown,and average diameter of unidirectional pores is in the range of 6-24 *** higher values in both the AAO thickness and pore diameter are attained for the specimens anodized at higher temperatures of 10-15 ℃.A crack is observed to exist in the AAO after anodizing up to 4 h and more.A higher fraction(more than 9%) of the crack is shown in the specimens anodized at higher temperatures of 10-15 ℃ for 6 h and a considerable amount of giant cracks are contained.

关键词：阳极氧化铝纳米孔单向结构层电解液温度平均直径氧化时间硫酸电解液

The association of stromal antigen 3(STAG3) sequence variations with spermatogenic impairment in the male Korean population

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Asian Journal of Andrology 2020年第1期22卷 106-111页

作者： Yeojung Nam Kyung Min Kang Se Ra Sung Ji Eun Park Yun-Jeong Shin seung Hun Song Ju Tae Seo Tae Ki yoon Sung Han Shim Department of Biomedical Science College of Life ScienceCHA UniversitySeongnam 13488Korea Genetics Laboratory Fertility Center of CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology Cheil General HospitalSeoul 04619Korea Department of Obstetrics and Gynecology CHA Gangnam Medical CenterSeoul 04637Korea

The stromal antigen 3(STAG3)gene,encoding a meiosis-specific cohesin component,is a strong candidate for causing male infertility,but little is known about this gene so *** identified STAG3 in patients with nonobstructive azoospermia(NOA)and normozoospermia in the Korean *** coding regions and their intron boundaries of STAG3 were identified in 120 Korean men with spermatogenic impairments and 245 normal controls by using direct sequencing and haplotype analysis.A total of 30 sequence variations were identified in this *** the total,seven were exonic variants,18 were intronic variants,one was in the 5’-UTR,and four were in the 3'-*** variations that directly caused NOA were not ***,two variants,c.3669+35C>G(rs1727130)and+198A>T(rs1052482),showed significant differences in the frequency between the patient and control groups(P=0.021,odds ratio[OR]:1.79,95%confidence interval[Cl]:1.098-2.918)and were tightly linked in the linkage disequilibrium(LD)*** pmir-rs1052482A was cotransfected with miR-3162-5p,there was a substantial decrease in luciferase activity,compared with *** result suggests that rsl052482 was located within a binding site of miR-3162-5p in the STAG33'-UTR,and the minor allele,the rs1052482T polymorphism,might offset inhibition by *** are the first to identify a total of 30 single-nucleotide variations(SNVs)of STAG3 gene in the Korean *** found that two SNVs(rs1727130 and rsl052482)located in the 3'-UTR region may be associated with the NOA *** findings contribute to understanding male infertility with spermatogenic impairment.

关键词： linkage disequilibrium meiotic-specific gene single-nucleotide variations spermatogenic impairment stromal antigen 3 gene

Computational design of Mg alloys with minimal galvanic corrosion

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Journal of Magnesium and Alloys 2022年第7期10卷 1972-1980页

作者： Krishnamohan Thekkepat Hyung-Seop Han Ji-Won Choi seung-Cheol Lee Eul Sik yoon Guangzhe Li Hyun-Kwang Seok Yu-Chan Kim Jae-Hun Kim Pil-Ryung Cha Indo-Korea Science and Technology Center JakkurBangalore 560065India Division of Nano&Information Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Plastic and Reconstructive Surgery Korea University College of MedicineSeoul 02841Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea School of Advanced Materials Engineering Kookmin UniversitySeoul 02707Republic of Korea

Formation of galvanic cells between constituent phases is largely responsible for corrosion in Mg-based *** develop a methodology to calculate the electrochemical potentials of intermetallic compounds and alloys using a simple model based on the Born-Haber *** electrochemical potentials are used to predict and control the formation of galvanic cells and minimize *** demonstrate the applicability of our model by minimizing galvanic corrosion in Mg-3wt%Sr-x Zn alloy by tailoring the Zn *** methodology proposed in this work is applicable for any general alloy system and will facilitate efficient design of corrosion resistant alloys.

关键词： Galvanic corrosion First-principles Cluster expansion Thermodynamics Modeling Magnesium alloys

Efficient solar fuel production enabled by an iodide oxidation reaction on atomic layer deposited MoS_(2)

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Carbon Energy 2023年第12期5卷 200-214页

作者： Young Sun Park Gyumin Jang Inkyu Sohn Hyungsoo Lee Jeiwan Tan Juwon Yun Sunihl Ma Jeongyoub Lee Chan uk Lee Subin Moon Hayoung Im seung-Min Chung seungho Yu Hyungjun Kim Jooho Moon Department of Materials Science and Engineering Yonsei UniversitySeoulRepublic of Korea School of Electrical and Electronic Engineering Yonsei UniversitySeoulRepublic of Korea Energy Storage Research Center Korea Institute of Science and TechnologySeoulRepublic of Korea

Oxygen evolution reaction(OER)as a half-anodic reaction of water splitting hinders the overall reaction efficiency owing to its thermodynamic and kinetic *** oxidation reaction(IOR)with low thermodynamic barrier and rapid reaction kinetics is a promising alternative to the ***,we present a molybdenum disulfide(MoS_(2))electrocatalyst for a high-efficiency and remarkably durable anode enabling ***_(2)nanosheets deposited on a porous carbon paper via atomic layer deposition show an IOR current density of 10 mA cm^(–2)at an anodic potential of 0.63 V with respect to the reversible hydrogen electrode owing to the porous substrate as well as the intrinsic iodide oxidation capability of MoS_(2)as confirmed by theoretical *** lower positive potential applied to the MoS_(2)-based heterostructure during IOR electrocatalysis prevents deterioration of the active sites on MoS_(2),resulting in exceptional durability of 200 ***,we fabricate a two-electrode system comprising a MoS_(2)anode for IOR combined with a commercial Pt@C catalyst cathode for hydrogen evolution ***,the photovoltaic–electrochemical hydrogen production device comprising this electrolyzer and a single perovskite photovoltaic cell shows a record-high current density of 21 mA cm^(–2)at 1 sun under unbiased conditions.

关键词： iodide oxidation reaction molybdenum sulfide photovoltaic-electrochemical hydrogen production solar hydrogen

ntestinal Duplication Cyst Misdiagnosed as Meckel＇s Diverticulum

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Chinese Medical Journal 2016年第2期129卷 235-236页

作者： Yee-Suk Kim Donn-Ju Kim seung-uk Bang Jun-Jae Park Department of Anesthesiology and Pain Medicine College of Medicine The Catholic University of Korea Seoul Republic of Korea Department of Surgery College of Medicine and Medical Research Institute The Chungbuk National University Chungbuk Republic of Korea

An intestinal duplication cyst is a very rare congenital anomaly, with symptoms including abdominal pain, abdominal distention, intestinal bleeding, and hematochezia. Hematochezia can be caused by ectopic gastric mucosa, although there are other causes of infantile hematochezia; hence, an intestinal duplication cyst can be misdiagnosed as bowel intussusception or Meckel＇s diverticulum. Here, a case of an intestinal duplication cyst that was misdiagnosed as Meckel＇s diverticulum is reported.

关键词： Duplication Cyst Gastrointestinal Hemorrhage Meckel's Diverticulum

Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages

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Journal of Integrative Medicine 2017年第4期15卷 326-336页

作者： Byung Hyuk Han Yun Jung Lee Jung Joo yoon Eun Sik Choi seung Namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. METHODS： The effects of HHT were evaluated by confirming nitric oxide （NO） production and expression of inducible NO synthase （iNOS） and mitogen-activated protein kinases （MAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （NF-κB）. The secretion and expression of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined via enzyme-linked immunosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced NO production and expression of iNOS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. CONCLUSION： HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation