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Molecular Plant 2016年第12期9卷 1667-1670页

作者： y. Zheng Chen Jiao Honghe Sun Hernan G. Rosli Marina A. Pombo Peifen Zhang Michael Banf Xinbin Dai Gregory.B. Martin James J. Giovannoni Patrick X. Zhao seung y. rhee Zhangjun Fei Boy.e Thompson Institute Ithaca NY 14853 USA Instituto de Fisiología Vegetal (INFIVE CONICET-UNLP) La Plata 1900 Argentina Department of Plant Biology Carnegie Institution for Science Stanford CA 94305 USA Samuel Roberts Noble Foundation Ardmore OK 73401 USA Section of Plant Pathology.and Plant-Microbe Biology School of Integrative Plant Science Cornell University Ithaca NY 14853 USA USDA-ARS Robert W. Holley.Center for Agriculture and Health Ithaca NY 14853 USA

Dear Editor,Transcription factors （TFs） are proteins that regulate the expression of target genes by.binding to specific cis-elements in pro-moter regions. Transcriptional regulators （TRs） a）so regulate the expression of target genes; however, they.operate indirectly.via interaction with the basal transcription apparatus （e.g., TFs）, or by.altering the accessibility.of DNA to TFs via chromatin remodeling. Another ty.e of regulatory.proteins, protein kinases （PKs）,

关键词： My.tery Mendel's Magnesium

Novel N-doped multichannel carbon nanofiber architecture with porous CoS nanoprisms for high-performance potassium-ion batteries

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Rare Metals 2024年第3期43卷 971-983页

作者： Jae Bong Lim seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityGyeonggi-do17546Republic of Korea Department of Intelligence Energy.and Industry Chung-Ang UniversitySeoul06974Republic of Korea Western Seoul Center Korea Basic Science InstituteSeoul03759Republic of Korea

Potassium-ion batteries(PIBs)have gained significant attention as an alternative to lithium-ion batteries(LIBs)due to the abundance of potassium(K)and low ***,the difficulty.in finding appropriate electrode materials that can efficiently.store the larger K ions has hindered their practical ***,we report a novel anode material,N-doped multichannel carbon nanofibers embedded with porous CoS nanoprisms(CSP@NMCNF),for high-performance *** CSP@NMCNF was sy.thesized using a two-step strategy.comprising of the electrospinning of Co acetate hy.roxide nanoprism/binary.poly.er blend and a subsequent heat *** porous CoS nanoprisms with an anisotropic morphology.were well aligned along the length axis of the N-doped multichannel carbon nanofibers,thus ensuring their structural stability.during the repeated charge-discharge *** addition,numerous pores facilitated the transport of electrons and ***,the CSP@NMCNF anode exhibited excellent electrochemical performance,delivering a high specific capacity.of 368 mAh·g^(-1)at 0.5 A·g^(-1)after 200 cy.les and excellent rate capability.232 mAh·g^(-1)at 2.0 A·g^(-1)).

关键词： K-ion batteries Cobalt sulfide Multichannel structured composite Electrospinning Nanoprism Porous structure

Sy.ergistically.coupling of Ni–Fe LDH array. with hollow Co–Mo sulfide nanotriangles for highly.efficient overall water splitting

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Rare Metals 2024年第2期43卷 522-532页

作者： y.n Jae Lee seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityAnseongGyeonggi-do17546Republic of Korea Department of Intelligent Energy.and Industry Chung-Ang University84 Heukseok-ro Dongjak-guSeoul06974Republic of Korea Western Seoul Center Korea Basic Science Institute150 Bugahyeon-roSeodaemun-guSeoul03759Republic of Korea

Developing bifunctional cataly.ts that can cataly.e both oxy.en evolution reaction(OER)and hy.rogen evolution reaction(HER)is pivotal to commercializing large-scale water ***,a novel hollow nanotriangle composed of NiFe LDH-CoMoS_(x) heterojunction(H-CMSx@NiFe LDH)is proposed as a highly.efficient bifunctional electrocataly.t for both OER and *** fabricate a heterojunction sy.tem,ultra-thin nickel–iron lay.red double hy.roxide(NiFe LDH)nanosheets are uniformly.electrodeposited onto a metal–organic framework-derived hollow CoMoS_(x) *** strong coupling of CoMoS_(x) and NiFe LDH cataly.ts forms the intimate heterojunction interfaces to facilitate interfacial charge transfer,which is favorable to enhance the bifunctional cataly.ic ***,the large void of CoMoS_(x) nanotriangles and interconnected ultra-thin NiFe LDH nanosheets result in good electroly.e penetration and gas ***,the as-prepared H-CMSx@NiFe LDH on nickel foam(NF)exhibits an impressive cataly.ic activity.and durability.for OER and HER activities,delivering a current density.of 100 mA·cm^(−2) at the small overpotentials of 214 and 299 mV in OER and HER,***,H-CMSx@NiFe LDH/NF proves to be an effective electrode for an alkaline electroly.er,as a voltage of only.1.99 V is enough to achieve a current density.voltage of only.1.99 V is enough to achieve a current density.of 400 mA·cm^(−2) with no degradation in performance over 50 h.

关键词： Overall water splitting Metal-organic framework Moly.denum sulfide Lay.red double hy.roxide Heterojunction

Electrochemical biosensors for point-of-care testing

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Bio-Design and Manufacturing 2024年第4期7卷 548-565页

作者： Jinsol Kim Juho Jeong seung Hwan Ko Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Advanced Machinery.and Design(SNU-IAMD) Seoul National UniversitySeoul 08826Republic of Korea

Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely.in a medical laboratory.or other clinical *** has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical ***,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable *** these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity.compact size,and *** are used in various applications,from disease diagnosis to health status *** this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various ty.es of sensing mechanisms that can be ***,we delve into methods for immobilizing specific biorecognition elements,including enzy.es,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings.

关键词： Point-of-care testing(POCT) Electrochemical sensor Enzy.e Antibody Health care

Adverse effects of early.life stress:focus on the rodent neuroendocrine sy.tem

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Neural Regeneration Research 2024年第2期19卷 336-341页

作者： seung Hy.n Lee Eui-Man Jung Department of Molecular Biology College of Natural SciencesPusan National UniversityBusanRepublic of Korea

Early.life stress is associated with a high prevalence of mental illnesses such as post-traumatic stress disorders,attention-deficit/hy.eractivity.disorder,schizophrenia,and anxiety.or depressive behavior,which constitute major public health *** the early.stages of brain development after birth,events such as sy.aptogenesis,neuron maturation,and glial differentiation occur in a highly.orchestrated manner,and external stress can cause adverse long-term effects throughout *** body.utilizes multifaceted mechanisms,including neuroendocrine and neurotransmitter signaling pathway.,to appropriately.process external *** individuals first exposed to early.life stress deploy.neurogenesis as a stress-defense mechanism;however,in adulthood,early.life stress induces apoptosis of mature neurons,activation of immune responses,and reduction of neurotrophic factors,leading to anxiety.depression,and cognitive and memory.*** process involves the hy.othalamus-pituitary.adrenal axis and neurotransmitters secreted by.the central nervous sy.tem,including norepinephrine,dopamine,and *** rodent early.life stress model is generally.used to experimentally.assess the effects of stress during *** paper reviews the use of the early.life stress model and stress response mechanisms of the body.and discusses the experimental results regarding how early.life stress mediates stress-related pathway. at a high vulnerability.of psy.hiatric disorder in adulthood.

关键词： early.life stress hy.othalamic-pituitary.adrenergic axis maternal separation mental illness neurodevelopmental disorder neuroendocrine sy.tem neurotransmitter

NIR emissive Ru(Ⅱ)metallacy.le as a sonosensitizer/sonocataly.t assisting in vivo bacterial diagnosis and eradicating multidrug-resistant biofilms

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Science China Chemistry 2024年第9期67卷 2785-2786页

作者： Chonglu Li Qihang Ding Jong seung Kim School of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea

Microbial biofilm-related infections present a significant global health challenge,posing a major threat to public health sy.tems[1].Biofilms,complex structures formed by.the aggregation of microorganisms,are commonly.found on medical devices,human tissue surfaces,and in natural environments[2].These biofilms exhibit high levels of antibiotic resistance and survival stability.rendering traditional antibiotic treatments ineffective in eradicating infections[3].

关键词： diagnosis dic rendering

Advances in wearable and implantable bioelectronics for precision medicine

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Bio-Design and Manufacturing 2024年第4期7卷 383-387页

作者： Kaichen Xu seung Hwan Ko Jun Chen State Key.Laboratory.of Fluid Power and Mechatronic Sy.tems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoul 08826Republic of Korea Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095-1599USA

The continuous pursuit for a better quality.of life promotes continuous advancements in intelligent *** wearable and implantable bioelectronics have emerged as an innovative complement to rigid material-based electronic devices[1-3].Due to their distinct advantages in terms of ductile,ultrathin,and biocompatible features,these elastic and soft bioelectronic devices can be seamlessly.mounted onto various real or artificial tissues and organs.

关键词： wear mounted pursuit

A ly.osomal-targeted Pt(Ⅱ) metallacy.le for NIR-Ⅱ fluorescence imaging guided highly.efficient tumor immunogenic cell death

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Science China Chemistry 2024年第11期67卷 3508-3509页

作者： Qihang Ding Shuai Zhang Jong seung Kim Department of Chemistry Korea University Department of Medical Oncology Harbin Medical University Cancer Hospital

Cisplatin, carboplatin, and oxaliplatin are well-known firstline antineoplastic drugs that have been approved worldwide. Recently. the successful integration of chemotherapy.and immunotherapy.in clinical trials has hi...

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Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

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Neural Regeneration Research 2024年第2期19卷 331-335页

作者： seung-Woo Han Jinhee Choi Kwon-y.l Ry. Department of Life Science University of SeoulSeoulSouth Korea School of Environmental Engineering University of SeoulSeoulSouth Korea

Many.ty.es of plastic products,including poly.ty.ene,have long been used in commercial and industrial *** and nanoplastics,plastic particles derived from these plastic products,are emerging as environmental pollutants that can pose health risks to a wide variety.of living organisms,including ***,it is not well understood how microplastics and nanoplastics affect cellular functions and induce stress *** can be exposed to poly.ty.ene-microplastics and poly.ty.ene-nanoplastics through ingestion,inhalation,or skin *** ingested plastics are excreted from the body.but inhaled plastics may.accumulate in the lungs and can even reach the brain via the nose-to-brain ***-sized poly.ty.ene-nanoplastics can enter cells by.endocy.osis,accumulate in the cy.oplasm,and cause various cellular stresses,such as inflammation with increased pro-inflammatory.cy.okine production,oxidative stress with generation of reactive oxy.en species,and mitochondrial *** induce autophagy.activation and autophagosome formation,but autophagic flux may.be impaired due to ly.osomal *** permanently.exposed to poly.ty.ene-nanoplastics,they.can be removed from cells by.exocy.osis and subsequently.restore cellular ***,neurons are very.susceptible to this ty.e of stress,thus even acute exposure can lead to neurodegeneration without *** review focuses specifically.on recent advances in research on poly.ty.ene-nanoplastic-induced cy.otoxicity.and ***,in this review,based on mechanistic studies of poly.ty.ene-nanoplastics at the cellular level other than neurons,future directions for overcoming the negative effects of poly.ty.ene-nanoplastics on neurons were suggested.

关键词： autophagy cellular stress cy.otoxicity endocy.osis exocy.osis inflammation microplastics nanoplastics neurotoxicity oxidative stress poly.ty.ene

Engineering punching shear strength of flat slabs predicted by.nature-inspired metaheuristic optimized regression sy.tem

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 551-567页

作者： Dinh-Nhat TRUONG Van-Lan TO Gia Toai TRUONG Hy.un-seung JANG Department of Civil Engineering University of Architecture Ho Chi Minh CityHo Chi Minh City 700000Vietnam Faculty.of Civil Engineering and Technology Dong A UniversityDa Nang City 550000Vietnam School of Architecture Seoul National University of Science and TechnologySeoul 01811Republic of Korea

Reinforced concrete(RC)flat slabs,a popular choice in construction due to their flexibility.are susceptible to sudden and brittle punching shear *** design methods often exhibit significant bias and *** estimation of punching shear strength in RC flat slabs is crucial for effective concrete structure design and *** study.introduces a novel computation method,the jelly.ish-least square support vector machine(JS-LSSVR)hy.rid model,to predict punching shear *** combining machine learning(LSSVR)with jelly.ish swarm(JS)intelligence,this hy.rid model ensures precise and reliable *** model’s development utilizes a real-world experimental data *** with seven established optimizers,including artificial bee colony.ABC),differential evolution(DE),genetic algorithm(GA),and others,as well as existing machine learning(ML)-based models and design codes,validates the superiority.of the JS-LSSVR hy.rid *** innovative approach significantly.enhances prediction accuracy.providing valuable support for civil engineers in estimating RC flat slab punching shear strength.

关键词： punching shear strength reinforced concrete flat slabs machine learning jelly.ish search support vector machine