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Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant

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Horticulture Research 2020年第1期7卷 1536-1547页

作者： Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo hong Jong Bhak Chang-Kug Kim Personal Genomics Institute Genome Research FoundationOsong 28160Korea Genomics Division National Institute of Agricultural Sciences(NAS)Jeonju 54874Korea Theragen Etex Bio Institute Suwon 16229Korea Department of Plant Science Plant Genomics and Breeding Instituteand Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea Department of Industrial Plant Science&Technology Chungbuk National UniversityCheongju 28644Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal ScienceRural Development Administration(RDA)Eumseong 27709Korea Clinomics Inc Ulsan 44919Korea Green Plant Institute Yongin 16954Korea Korean Genomics Center(KOGIC) Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Biomedical Engineering School of Life SciencesUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea

Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical *** grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East *** oleanane-type TSs,platycosides,are a major component of the *** root *** studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy ***,the evolutionary history of platycoside biosynthesis genes remains *** this study,we sequenced the genome of *** and investigated the genes involved in platycoside *** draft genome of *** is 680.1 Mb long and contains 40,017 protein-coding *** analysis revealed that the CYP716 family genes play a major role in platycoside *** CYP716 gene family of *** was much larger than that of other Asterid *** gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in ***,which was confirmed by tissue-specific gene *** these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside *** addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in ***,suggesting that epigenetic modification of these two gene families affects platycoside *** whole-genome,transcriptome,and methylome data of *** provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families.

关键词： properties insight roots

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Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention

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Journal of Geriatric Cardiology 2019年第8期16卷 639-647页

作者： Yong Hoon Kim Ae-Young Her seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Ju Yeol Baek Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park hong Seog Seo Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Department of Cardiology Soonchunhyang University College of MedicineSeoulSouth Korea Cardiovascular Center Korea University Guro HospitalSeoulSouth Korea Department of Medicine Korea University Graduate SchoolSeoulSouth Korea Cardiovascular Center Seoul St. Mary’s Hospitalthe Catholic University of KoreaSeoulSouth Korea Cardiology Department Konkuk University Chungju HospitalChungjuSouth Korea Department of Internal Medicine Cardiovascular DivisionDankook University HospitalCheonanSouth Korea Department of Cardiology Soonchunhyang University Gumi HospitalGumiSouth Korea Cardiology Department Soonchunhyang University Cheonan HospitalCheonanSouth Korea Division of Cardiology Department of Internal MedicineCardiovascular CenterNowon Eulji Medical CenterEulji UniversitySeoulSouth Korea

Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.

关键词： Chronic total occlusion Drug-eluting stent Outcomes

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Potentiation of antiglioma effect with combined temozolomide and interferon-β

Potentiation of antiglioma effect with combined temozolomide...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Jin-A Park seung-Ho Yang Won-Il Joo Seok-Gu Kang Shin-Soo Jeun Dong-Sup Chung Yong-Kil hong

＜正＞Temozolomide （TMZ） is a DNA methylating agent that has shown promising anti-tumor activity against high grade glioma. Interferon- β （IFN- β） is known to have antiproliferative and antiangiogenic activities. The aim of this study was to elucidate whether an antiglioma effect could be potentiated by the combination of TMZ and IFN-

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An Interesting Case of Cardiac Amyloidosis Initially Misdiagnosed as Syndrome X

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International Journal of Clinical Medicine 2011年第5期2卷 617-620页

作者： Hyung Rae Sohn Bong Gun Song Eun Jin Kim Seong Yeon Jeong Su-Min hong Hyun Gul Jung Hye-Jin Jung wook-Hyun Cho Suk-Koo Choi 不详

Cardiac infiltration of amyloid fibril results in progressive cardiomyopathy with a grave prognosis and results in cardiac diseases such as congestive heart disease, cardiomyopathy, valvular heart disease, and arrhythmias. We present a rare case of cardiac amyloidosis initially misdiagnosed as syndrome X in which recurrent chest pain and progressive heart failure could be managed finally by heart transplantation.

关键词： Cardiac Amyloidosis Syndrome X Heart Transplantation

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Large-scale and high-quality III-nitride membranes through microcavity-assisted crack propagation by engineering tensile-stressed Ni layers

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Opto-Electronic Science 2022年第10期1卷 51-61,42-50页

作者： Jung-hong Min Kwangjae Lee Tae-Hoon Chung Jung-wook Min Kuang-Hui Li Chun hong Kang Hoe-Min Kwak Tae-Hyeon Kim Youyou Yuan Kyoung-Kook Kim Dong-Seon Lee Tien Khee Ng Boon S.Ooi Photonics Laboratory ComputerElectrical and Mathematical Sciences and Engineering Division(CEMSE)King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Light Source Research Division Korea Photonics Technology Institute(KOPTI)Gwangju 61007Republic of Korea School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Advanced Convergence Technology Research Institute of Advanced Convergence TechnologyKorea Polytechnic University237 Sangidaehak-roSiheung-si 15073Republic of Korea King Abdullah University of Science and Technology(KAUST) Thuwal 23955-6900Saudi Arabia

Epitaxially grown III-nitride alloys are tightly bonded materials with mixed covalent-ionic *** tight bonding presents tremendous challenges in developing III-nitride membranes,even though semiconductor membranes can provide numerous advantages by removing thick,inflexible,and costly ***,cavities with various sizes were introduced by overgrowing target layers,such as undoped GaN and green LEDs,on nanoporous templates prepared by electrochemical etching of n-type *** large primary interfacial toughness was effectively reduced according to the design of the cavity density,and the overgrown target layers were then conveniently exfoliated by engineering tensile-stressed Ni *** resulting III-nitride membranes maintained high crystal quality even after exfoliation due to the use of GaN-based nanoporous templates with the same lattice *** microcavity-assisted crack propagation process developed for the current III-nitride membranes forms a universal process for developing various kinds of large-scale and high-quality semiconductor membranes.

关键词： III-nitride alloys membranes nanoporous Ni stressor light-emitting diodes ultraviolet photodetectors

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Intraductalpapillarymucinousneoplasmofthebileductwithgastricand duodenalfistulas

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World Journal of Gastrointestinal Endoscopy 2014年第7期6卷 70-76,78+337-338页

作者： hong MY Yu DW hong SG Man Yong hong Dong Wook Yu Seung Goun Hong Department of Internal Medicine SAM Anyang Hospital Gyeonggi 430-733 South Korea

Intraductal papillary mucinous neoplasm (IPMN) of the bile duct is still rare and not yet understood despite of its increased incidence and similar clinicopathologic characteristics compared with IPMN of the pancreas. The fistula formation into other organs can occur in IPMN, especially the pancreatic type. To our knowl-edge, only two cases of IPMN of the bile duct with a choledochoduodenal fistula were reported and we have recently experienced a case of IPMN of the bile duct penetrating into two neighboring organs of the stom-ach and duodenum presenting with abdominal pain and jaundice. Endoscopy showed thick mucin extruding from two openings of the fistulas. Endoscopic suction of thick mucin using direct peroral cholangioscopy with ultra-slim endoscope through choledochoduodenal fis-tula was very difficult and ineffective because of very thick mucin and next endoscopic suction through the stent after prior insertion of biliary metal stent into cho-ledochogastric fistula also failed. Pathologic specimen obtained from the proximal portion of the choledocho-gastric fistula near left intrahepatic bile duct through the metal stent showed a low grade adenoma. The pa-tient declined the surgical treatment due to her old age and her abdominal pain with jaundice was improved af-ter percutaneous transhepatic biliary drainage with the irrigation of N-acetylcysteine three times daily for 10 d.

关键词： Intraductal papillary mucinous neoplasm Bile duct Fistula Acetylcysteine

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东亚思想对建立人类新闲暇观的启示

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太原师范学院学报（社会科学版） 2008年第5期7卷 1-5页

作者：洪胜杓韩国启明大学校社会科学大学社会学系

现代社会中,闲暇普遍地被误解为单纯的娱乐和消费活动,从而出现了闲暇观念深刻的异化,观念的错位带来个人生活的不幸和人类文明的瓦解。闲暇观的异化根源于近代以来西方的世界观、人生观。东亚传统的世界观能够为现代人创造性的闲暇生... 详细信息

现代社会中,闲暇普遍地被误解为单纯的娱乐和消费活动,从而出现了闲暇观念深刻的异化,观念的错位带来个人生活的不幸和人类文明的瓦解。闲暇观的异化根源于近代以来西方的世界观、人生观。东亚传统的世界观能够为现代人创造性的闲暇生活提供人生视角。人是内在于"真我"的存在,人生的终极目的在于领悟和喜欢这个"真我",创造性的闲暇生活也就意味着以"修行"和"乐道"来充实个人的闲暇时光。人类应该实现从劳动的世界到修行的世界、从消费的世界到乐道的世界的转换。在近代文明成就和在东亚传统思想的基础上,当人类学会享受创造性的闲暇生活时,才能获得真正的幸福,真正协调各文明的发展。

关键词：人类闲暇观东亚思想自我乐道

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International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s Disease

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Phenomics 2023年第4期3卷 375-389页

作者： Mei Tian Chuantao Zuo Ali Cahid Civelek Ignasi Carrio Yasuyoshi Watanabe Keon wook Kang Koji Murakami Valentina Garibotto John OPrior Henryk Barthel Yihui Guan Jiaying Lu Rui Zhou Chentao Jin Shuang Wu Xiaohui Zhang Yan Zhong hong Zhang Molecular Imaging-Based Precision Medicine Task Group of A3(China-Japan-Korea)Foresight Program PET Center Huashan HospitalFudan UniversityShanghai 200235China Human Phenome Institute Fudan UniversityShanghai 201203China Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China National Center for Neurological Disorders and National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Radiology and Radiological Science Division of Nuclear Medicine and Molecular ImagingJohns Hopkins MedicineBaltimore 21287USA Department of Nuclear Medicine Hospital Sant PauAutonomous University of BarcelonaBarcelona 08025Spain Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobeHyogo 650‑0047Japan Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Korea Department of Radiology Juntendo University HospitalTokyo 113‑8431Japan Diagnostic Department University Hospitals of Geneva and NIMTlabUniversity of GenevaGeneva 1205Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University HospitalLausanne 1011Switzerland Department of Nuclear Medicine Leipzig University Medical CenterLeipzig 04103Germany Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang University Hangzhou 310007China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310007China 不详

Alzheimer’s disease(AD)is the main cause of dementia,with its diagnosis and management remaining *** positron emission tomography(PET)has become increasingly important in medical practice for patients with *** integrate and update previous guidelines in the field,a task group of experts of several disciplines from multiple countries was assembled,and they revised and approved the content related to the application of amyloid PET in the medical settings of cognitively impaired individuals,focusing on clinical scenarios,patient preparation,administered activities,as well as image acquisition,processing,interpretation and *** addition,expert opinions,practices,and protocols of prominent research institutions performing research on amyloid PET of dementia are *** the increasing availability of amyloid PET imaging,a complete and standard pipeline for the entire examination process is essential for clinical *** international consensus and practice guideline will help to promote proper clinical use of amyloid PET imaging in patients with AD.

关键词： Positron emission tomography(PET) Alzheimer’s disease Amyloid Brain imaging Expert consensus

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中国古文献中所看到的古代建筑结构力学认识研究

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中国文物科学研究 2014年第3期 59-61页

作者：金德文玄胜旭韩国国立文化财研究所建筑文化财研究室

考察古代人的结构力学认识,是对古建筑结构的分析及解释必不可少的研究之一。因为与现代建筑结构不同,古代建筑结构主要取决于当时工匠们的经验与直观判断。古代人对结构力学的认识概念,我们从中国古文献中可以看到。通过本研究发现,古... 详细信息

考察古代人的结构力学认识,是对古建筑结构的分析及解释必不可少的研究之一。因为与现代建筑结构不同,古代建筑结构主要取决于当时工匠们的经验与直观判断。古代人对结构力学的认识概念,我们从中国古文献中可以看到。通过本研究发现,古代人已经有对力与荷重的力学认识以及古建筑的对称结构就是从古代力学的平衡概念出发而发展的。

关键词：建筑结构力量荷重力的平衡力学认识

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异常钙钛矿氧化物结构规律研究

异常钙钛矿氧化物结构规律研究

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中国化学会第七届全国结构化学学术会议

作者： Man-Rong Li seung-Tae hong David Walker Martha Greenblatt MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen University CR&D LG Chem Research Park Lamont Doherty Earth Observatory Columbia University

多功能钙钛矿氧化物因其多样性的结构和优异的物化性能,日益成为结构化学和材料科学领域的研究热点。常见的材料是ABO3型简单钙钛矿和ABB’O6型双钙钛矿,其结构和成相规律已广为研究,理想情况下A位为12配位的较大离子而B/B’位为6(八面...

多功能钙钛矿氧化物因其多样性的结构和优异的物化性能,日益成为结构化学和材料科学领域的研究热点。常见的材料是ABO3型简单钙钛矿和ABB’O6型双钙钛矿,其结构和成相规律已广为研究,理想情况下A位为12配位的较大离子而B/B’位为6(八面体)配位的小离子。随着A位离子变小,其结构随容忍因子(Tolerance factor,t)降低而发生畸变,对称性依次从六角变为立方、四方、菱方、单斜等。当A位和

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