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Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2018年第8期15卷 523-533页

作者： Yong Hoon Kim Ae-Young Her seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Ju Yeol Baek Woong Gil Choi Tae Soo Kang Ji Hoon Ahn Sang-Ho Park Ahmed Mashaly Jin Oh Na Cheol Ung Choi hong Euy Lim Eung Ju Kim Chang Gyu Park hong Seog Seo Dong Joo Oh Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuneheon South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Medicine Korea University Graduate School Seoul South Korea Cardiovascular Center Cheong Ju St. Mary hospital Cheong Ju Chung Buk South Korea SCardiology Department Konkuk University Chungju Hospital Chungju South Korea Department of Internal Medicine Cardiovascular Division Dankook University Hospital Cheonan South Korea Department of Cardiology Soonchunhyang University Gumi Hospital G-umi South Korea Cardiology Department Soonchunhyang University Cheonan Hospital Cheonan South Korea

Background There were limited data comparing the major clinical outcomes between first-generation （1G）-drug eluting stentts （DES） and second-generation （2G）-DES in patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI） during very long follow-up periods. We thought to investigate the comparative efficacy and safety of 2G-DES compared with 1G-DES in AMI patients during 5-year follow-up periods. Method A total of 1016 eligible AMI patients who underwent PCI with 1G-DES [paclitaxel-, sirolimus-, 1G-zotarolimus-eluting stent （endeavor~ or endeavor sprintS）, n = 554] or 2G-DES [2G-zotarolimus （endeavor resolute~）- or everolimus-eluting stent, n = 462] were enrolled. The primary endpoint was the occurrence of major adverse cardiac events （MACE） defined as total death, non-fatal myocardial infarction （MI）, target lesion revascularization （TLR）, target vessel revascularization （TVR）, non-target vessel revascularization （Non-TVR） and the secondary endpoint was stem thrombosis （ST） at 5 years. Results Two propensity score-ma- tched （PSM） groups （232 pairs, n = 464, C-statistic = 0.802） were generated. During the 5-year follow-up period, the cumulative incidence of TLR [hazard ratio （HR）： 3.133; 95% confidence interval （CI）： 1.539-6.376; P = 0.002], TVR （HR： 3.144; 95% CI： 1.59645.192; P = 0.001） and total revascularization rate （FIR： 1.874; 95% CI： 1.086-3.140; P = 0.023） were significantly higher in 1G-DES compared with 2G-DES after PSM. However, the incidence of total death, non-fatal MI and ST were similar between the two groups. Conclusion In this single-center and all-comers registry, 2G-DES＇s superiorities for TLR, TVP, and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.

关键词： Acute myocardial infarction Clinical outcomes Drug-eluting stem

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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo hong Cheryn Song Jae Young Park Chang wook Jeong Seok Hwan Choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosine kinase inhibitor Metastatic renal cell carcinoma Overall survival Progression-free survival

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显微CT的锥束重建技术

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CT理论与应用研究（中英文） 2002年第3期11卷 7-11页

作者：王革姜明 seung wook Lee 刘泓 Eric Hoffman Iowa大学放射系和生物医学工程系北京大学数学学院信息科学系 100871 Iowa大学放射系 Oklahoma大学生物医学中心

显微CT技术一直是Iowa大学CT/显微CT实验室研究的焦点。这篇文章报告了我们在锥束显微CT方面最近取得的一些进展。我们利用Feldkamp类算法进行了多X光源和检测器偏置条件下的近似图象重建;解释了Grangeat精确重构框架下的图象伪影。最... 详细信息

显微CT技术一直是Iowa大学CT/显微CT实验室研究的焦点。这篇文章报告了我们在锥束显微CT方面最近取得的一些进展。我们利用Feldkamp类算法进行了多X光源和检测器偏置条件下的近似图象重建;解释了Grangeat精确重构框架下的图象伪影。最后重点介绍了最近有关一般分块迭代Landweber格式的收敛性结果;给出了模拟和实验结果,探讨了进一步的研究方向。

关键词：显微CT技术锥束重建伪影收敛性近似重建算法精确重建算法迭代重建算法

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Spider-inspired tunable mechanosensor for biomedical applications

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npj Flexible Electronics 2023年第1期7卷 444-452页

作者： Taewi Kim Insic hong Yeonwook Roh Dongjin Kim Sungwook Kim Sunghoon Im Changhwan Kim Kiwon Jang Seongyeon Kim Minho Kim Jieun Park Dohyeon Gong Kihyeon Ahn Jingoo Lee Gunhee Lee Hak-seung Lee Jeehoon Kang Ji Man hong seungchul Lee Sungchul Seo Bon-Kwon Koo Je-sung Koh seungyong Han Daeshik Kang Department of Mechanical Engineering Ajou UniversitySuwonKorea Department of Mechanical Engineering Pohang University of Science and TechnologyPohangKorea Department of Sustainable Environment Research Korea Institute of Machinery&MaterialsDaejeonKorea Department of Internal Medicine and Cardiovascular Center Seoul National University HospitalSeoulKorea Department of Neurology and Neurosurgery Ajou University School of MedicineSuwonKorea Department of Nano-chemical Biological and Environmental EngineeringSeokyeong UniversitySeoulKorea Institute on Aging Seoul National UniversitySeoulKorea

The recent advances of wearable sensors are remarkable but there are still limitations that they need to be refabricated to tune the sensor for target ***,biological sensory systems have the inherent potential to adjust their sensitivity according to the external environment,allowing for a broad and enhanced ***,we developed a Tunable,Ultrasensitive,Nature-inspired,Epidermal Sensor(TUNES)that the strain sensitivity was dramatically increased(GF~30k)and the pressure sensitivity could be tuned(10–254 kPa^(−1))by preset membrane *** sensor adjusts the sensitivity to the pressure regime by preset tension,so it can measure a wide range(0.05 Pa–25 kPa)with the best performance:from very small signals such as minute pulse to relatively large signals such as muscle contraction and *** verified its capabilities as a wearable health monitoring system by clinical trial comparing with pressure wire which is considered the current gold standard of blood pressure(r=0.96)and home health care system by binary classification of Old’s/Young’s pulse waves via machine learning(accuracy 95%).

关键词： Sensor adjust Spider

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Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo In Seob Lee Jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn Jeong Hoon Lee Kee wook Jung Do Hoon Kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

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Ultra-stable and tough bioinspired crack-based tactile sensor for small legged robots

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npj Flexible Electronics 2023年第1期7卷 339-350页

作者： Taewi Kim Insic hong Minho Kim Sunghoon Im Yeonwook Roh Changhwan Kim Jongcheon Lim Dongjin Kim Jieun Park seunggon Lee Daseul Lim Junggwang Cho Seokhaeng Huh seung-Un Jo ChangHwan Kim Je-Sung Koh seungyong Han Daeshik Kang Multiscale Bio-inspired Technology Lab Department of Mechanical EngineeringAjou University206 World cup-roYeongtong-guSuwon-siGyeonggi-do 16499South Korea Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA LIG Nex1 333Pangyo-roBundang-guSeongnam-siGyeonggi-do 13488Republic of Korea Defense Industry Technology Center Agency for Defense Development61Yeouidaebang-roDongjak-guSeoulRepublic of Korea

For legged robots,collecting tactile information is essential for stable posture and efficient ***,mounting sensors on small robots weighing less than 1 kg remain challenges in terms of the sensor’s durability,flexibility,sensitivity,and *** sensors featuring ultra-sensitivity,small-size,and flexibility could be a promising candidate,but performance degradation due to crack growing by repeated use is a stumbling *** paper presents an ultra-stable and tough bio-inspired crack-based sensor by controlling the crack depth using silver nanowire(Ag NW)mesh as a crack stop *** Ag NW mesh inspired by skin collagen structure effectively mitigated crack *** sensor was very thin,lightweight,sensitive,and ultra-durable that maintains its sensitivity during 200,000 cycles of 0.5%*** demonstrate sensor’s feasibility by implementing the tactile sensation to bio-inspired robots,and propose statistical and deep learning-based analysis methods which successfully distinguished terrain type.

关键词： crack tough durability

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High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction mode

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Asian Journal of Andrology 2010年第2期12卷 164-170页

作者： Young Hwii Ko Yu Jeong Woo Jin wook Kim Hoon Choi Seok Ho Kang Jeong Gu Lee Je Jong Kim hong Seok Park Jun Cheon Department of Urology Korea University School of MedicineSeoul 136-705Korea

To evaluate the role of high-dose dietary zinc in the process of prostate malignancy,60 Sprague-Dawley rats were randomly divided into four groups：tumor induction with carcinogen and hormone （group 1）,oral zinc administration without tumor induction （group 2）,oral zinc administration with tumor induction （group 3） and a control without zinc administration or tumor induction （group 4）. Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group （P = 0.082）,intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 μg g^-1,respectively. However,in group 3,zinc levels increased in both lobes to 59.3 and 12.1 μg g^-1,respectively,comparable with that of group 4 （54.5±14.6 and 14.1±2.4 μg g^-1）. In spite of these increases in zinc concentration,the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 （53.3% and 46.7%） compared with group 1 （33.3% and 33.3%） in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4,zinc administration did induce prostate intraepithelial neoplasm in group 2 （46.7% and 40.0%）. Thus,although high dietary zinc increased intraprostatic zinc concentrations,it promoted,instead of preventing,prostate intraepithelial neoplasm in a murine prostate malignancy induction model.

关键词： experimental animal model prostatic cancer prostatic intraepithelial neoplasia zinc

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Multi-directionally wrinkle-able textile OLEDs for clothing-type displays

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npj Flexible Electronics 2020年第1期4卷 288-296页

作者： seungyeop Choi Woosung Jo Yongmin Jeon Seonil Kwon Jeong Hyun Kwon Young Hyun Son Junmo Kim Jun hong Park Hyuncheol Kim Ho seung Lee Minwoo Nam Eun Gyo Jeong Jeong Bin Shin Taek-Soo Kim Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

A clothing-type wearable display can be utilized in fashion,bio-healthcare,and safety industries as well as smart textiles for the internet of things(IoTs)and wearable *** response to this trend,we demonstrate a textile display that can endure the active movements of a human *** can be applied to any kind of textile,and is durable against conditions such as rain,sweat,and *** a key technology for realizing the multi-directional wrinkle-able textile display,we fabricated a stress-lowering textile platform with an ultrathin planarization layer replicated from the flat surface of *** elastomeric strain buffer for reducing mechanical stress is also inserted into the textile ***,organic light-emitting diodes(OLEDs)with red,green and blue color,thin film transistors(TFTs)fabricated at a low temperature below 150℃,and a washable encapsulation layer blocking both gas and liquid were demonstrated on the textile platform.

关键词： OLEDs IoT directional

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Monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia

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Neural Regeneration Research 2015年第10期10卷 1604-1611页

作者： Seongkweon hong Ji Yun Ahn Geum-Sil Cho In Hye Kim Jeong Hwi Cho Ji Hyeon Ahn Joon Ha Park Moo-Ho Won Bai Hui Chen Bich-Na Shin Hyun-Jin Tae seung Min Park Jun Hwi Cho Soo Young Choi Jae-Chul Lee Department of Surgery School of Medicine Kangwon National University Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Neuroscience College of Medicine Korea University Department of Neurobiology School of Medicine Kangwon National University Department of Physiology College of Medicine Hallym University Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University

Monocarboxylate transporters（MCTs）, which carry monocarboxylates such as lactate across biological membranes, have been associated with cerebral ischemia/reperfusion process. In this study, we studied the effect of ischemic preconditioning（IPC） on MCT4 immunoreactivity after 5 minutes of transient cerebral ischemia in the gerbil. Animals were randomly designated to four groups（sham-operated group, ischemia only group, IPC ＋ sham-operated group and IPC ＋ ischemia group）. A serious loss of neuron was found in the stratum pyramidale of the hippocampal CA1 region（CA1）, not CA2/3, of the ischemia-only group at 5 days post-ischemia; however, in the IPC ＋ ischemia groups, neurons in the stratum pyramidale of the CA1 were well protected. Weak MCT4 immunoreactivity was found in the stratum pyramidale of the CA1 in the sham-operated group. MCT4 immunoreactivity in the stratum pyramidale began to decrease at 2 days post-ischemia and was hardly detected at 5 days post-ischemia; at this time point, MCT4 immunoreactivity was newly expressed in astrocytes. In the IPC ＋ sham-operated group, MCT4 immunoreactivity in the stratum pyramidale of the CA1 was increased compared with the sham-operated group, and, in the IPC ＋ ischemia group, MCT4 immunoreactivity was also increased in the stratum pyramidale compared with the ischemia only group. Briefly, present findings show that IPC apparently protected CA1 pyramidal neurons and increased or maintained MCT4 expression in the stratum pyramidale of the CA1 after transient cerebral ischemia. Our findings suggest that MCT4 appears to play a significant role in the neuroprotective mechanism of IPC in the gerbil with transient cerebral ischemia.

关键词： nerve regeneration monocarboxylate transporters ischemic preconditioning ischemia/ reperfusion injury hippocampus CA1 pyramidal neurons neural regeneration

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Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1499-1505页

作者： Sungbae Moon Hyun wook Ryoo Jae Yun Ahn Jung Bae Park Kang Suk Seo Sang Do Shin Kyoung Jun Song Kang Hyun Lee In Sool Yoo Jin Seong Cho Hyun Ho Ryu Tae Oh Jeong Seok Ran Yeom Young Taek Kim Sung Ok hong Department of Emergency Medicine School of MedicineKyungpook National University Daegu 700-721 Korea Department of Emergency Medicine College of MedicineSeoul National University Seoul 110-799 Korea Department of Emergency Medicine Wonju College of Medicine Yonsei University Wonju Gangwon-do 220-701Korea Department of Emergency Medicine School of MedicineChungnam National University Daejeon 301-747 Korea Department of Emergency Medicine Gachon University Gil Medical Center Incheon 406-799 Korea Department of Emergency Medicine School of MedicineChonnam National University Gwangju 501-746 Korea Department of Emergency Medicine School of MedicineChonbuk National University Jeonju Jeollabuk-do 561-180Korea Department of Emergency Medicine School of MedicinePusan National University Busan 602-739 Korea Korean Centers for Disease Control & Prevention Cheongiu Chungcheongbuk-do 361-951 Korea

AIM：To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS： A cross-sectional,multi-center,observational *** with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were *** data were prospectively collected between March and September 2010 using a *** injuries that occurred during risky sports were examined by gender and ***,the rate of open globe injuries that occurred with and without protective eyewear was examined for each *** variables were compared using Student＇s t-test and categorical variables were compared using Chi-square ***： A total of 446 patients had sports-related eye ***（10-19 years old） and young adults（20-29 years old） had the most eye *** injuries accounted for 0.2% of Emergency Department *** was the most common cause of sports-related eye injuries,followed by soccer and *** gear was worn by 9.4% of all *** that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of *** proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and ***： Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear *** in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was *** athletes should be educated on and provided with protective eyewear and policies protective gear use should be *** older adults,eye protection should be encouraged,especially during hiking.

关键词： athletic injuries eye injuries protective devices sports.

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