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Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve

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Acta Pharmacologica Sinica 2006年第1期27卷 50-58页

作者： Tae-beom SEO In-sun HAN Jin-hwan YOON In-chan SEOL Yun-sik RIM Hyun-kyung JO Joung-jo AN Kwon-eui hong Young-bae SEO Dong-hee KIM seung-kiel PARK Deok-chun YANG Uk NAMGUNG Korea Department of Oriental Medicine.Daejeon University Daejeon 300-716Korea Korea Department of Biochemistry College of Medicine Chungnam National University.Daejeon 301-130Korea Korea

Aim:Extract of Hominis Placenta (HP) has been used in oriental medicine as anagent for improving physiological *** present study was conducted toinvestigate whether HP treatment in an experimental sciatic nerve injury animalmodel produces growth-promoting effects on regenerating peripheral nerve fibersafter ***:After HP was injected into a sciatic nerve injury site,changesin protein levels were analyzed in the regenerating nerve area by Western blottingand immunofluorescence staining *** quantitative assessment of ax-onal regeneration,a retrograde tracing technique was used to identify the neu-ronal cell bodies corresponding to regenerating axons,and the extent of neuriteoutgrowth in cultured dorsal root ganglia (DRG) sensory neurons prepared fromanimals that had experienced a sciatic nerve crush injury 7d before neuron collec-tion was ***:Induction levels of axonal growth-associated protein(GAP-43) in the injured sciatic nerves were elevated by HP *** treat-ment also upregulated cell division cycle 2 (Cdc2) protein levels in the distalstump of the injured sciatic *** Cdc2 protein was detected in Schwanncells,suggesting that Cdc2 kinase activity may be involved in the growth-promot-ing activity of regenerating axons via Schwann cell *** body mea-surement by retrograde tracing indicated that HP treatment produced significantincreases in regenerating motor ***,HP treatment of cultured DRGsensory neurons significantly increased neurite arborization and ***:HP promotes the regeneration of injured sciatic axons by upregulatingthe synthesis of regeneration-related protein factors such as GAP-43 and Cdc2.

关键词： hominis placenta axonal regeneration sciatic nerve GAP-43 protein Cyclindepend kinase 2

Fire risk of green building technical components

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Journal of Chongqing University 2012年第1期11卷 12-18页

作者： SON Jone-Yeong NA wook-Jung JEON Gyu-Yeob hong Won-Hwa KIM In-Han Kyungpook National University Daegu 702-701Republic of Korea Daegu Technical University Daegu 704-721Republic of Korea Jeju National University Jeju 690-756Republic of Korea KyungHee University Daegu 130-701Republic of Korea

The concept of the green building as sustainable construction has continuously been studied,developed and *** to realize the green building to use less energy,while protecting the environment and improving the quality of residences have increasingly been used in not only new buildings in the design phase,but also in existing ones to reduce the energy and environment ***,the number of green buildings is ***,there are some cases that green building technologies for low energy use,low carbon emissions and pleasant indoor environment violate fire safety standards;so it is imminent to address the ***,unlike continuous studies on development and distribution of green buildings,there are few studies on the issue because of the lack of fire safety awareness of green ***,this study intends to raise the awareness of fire safety awareness of green buildings through theoretical consideration and analysis of cases about green building technologies.

关键词： green building fire safety sustainable construction

Clinical validation of scoring systems of postoperative pancreatic fistula after pancreatoduodenectomy: applicability to Eastern cohorts?

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 211-218页

作者： Jae seung Kang Taesung Park Youngmin Han seungyeon Lee Jae Ri Kim hongbeom Kim Wooil Kwon Sun-Whe Kim Jin Seok Heo Seong Ho Choi Dong wook Choi Song Cheol Kim Tae Ho hong Dong Sup Yoon Joon Seong Park Sang Jae Park Sung-Sik Han Sae-Byeol Choi Joo Seop Kim Chang-Sup Lim Jin-Young Jang Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Statistics and Interdisciplinary Program in Biostatistics Seoul National UniversitySeoulRepublic of Korea Department of Mathematics and Statistics Sejung UniversitySeoulRepublic of Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryUlsan University College of Medicine and Asan Medical CenterSeoulRepublic of Korea Department of Surgery Seoul St.Mary’s HospitalThe Catholic University of KoreaCollege of MedicineSeoulRepublic of Korea Pancreatobiliary Cancer Clinic Department of SurgeryGangnam Severance HospitalYonsei University College of MedicineSeoulRepublic of Korea Center for Liver Cancer National Cancer CenterGyeonggidoRepublic of Korea Department of Surgery Korea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Department of Surgery Kangdong Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Surgery Seoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoul National University College of MedicineSeoulRepublic of Korea

Background:Although several prediction models for the occurrence of postoperative pancreatic fistula(POPF)after pancreatoduodenectomy(PD)exist,all were established using Western ***-scale external validation studies in Eastern cohorts that consider demographic variables including lower body mass index(BMI)are *** purpose of this study was to externally validate POPF prediction models using nationwide large-scale Korean ***:Nine tertiary university hospitals in the Republic of Korea ***'preoperative characteristics,intraoperative factors,and pathologic findings were *** grades were determined according to the 2016 International Study Group on Pancreatic Surgery *** POPF risk models(Callery,Roberts,and Mungroop)were selected for external ***:A total of 1,898 PD patients were enrolled.A non-pancreatic disease diagnosis[hazard ratio(HR),1.856;95%confidence interval(CI),1.223–2.817;P=0.004),higher preoperative BMI(HR,1.069;95%CI,1.019–1.121;P=0.006),and soft pancreatic texture(HR,1.859;95%CI,1.264–2.735;P=0.002)were independent risk factors for clinically relevant POPF(CR-POPF).The area under the receiver operating characteristic curve(AUC)values were 0.61,0.64,and 0.63 on the Callery,Roberts,and Mungroop models,respectively;all were lower than those published in each external validation ***:Western POPF prediction models performed less well when applied to Korean ***,a large-scale Eastern-specific and externally validated POPF prediction model is needed.

关键词： Pancreatic fistula pancreatoduodenectomy(PD) predictive score

Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee seung Baek hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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采用轻压下技术减少板坯中心偏析

钢铁 2004年第Z1期39卷 286-288页

作者： Jemin Park hong-gu Ryu seung-kwan Baek Shin-Eon Kang Steel Making Department Gwangyang Works POSCO Steel Making Department Gwangyang Works POSCO Steel Making Department Gwangyang Works POSCO POSCO Research Laboratory

近来,为提高竞争力,提高API钢市场占有率,必须增加高质量API钢的产量,尽最大努力去满足消费者对产品质量的严格要求,尤其是生产耐酸钢.不仅要最大限度地控制钢中残留元素和夹杂物的含量,而且还要避免中心偏析.因此,POSCO正致力于开发生... 详细信息

近来,为提高竞争力,提高API钢市场占有率,必须增加高质量API钢的产量,尽最大努力去满足消费者对产品质量的严格要求,尤其是生产耐酸钢.不仅要最大限度地控制钢中残留元素和夹杂物的含量,而且还要避免中心偏析.因此,POSCO正致力于开发生产工艺,更新基础设备,以满足消费者的要求.在POSCO的Gwangyang工厂,由于受铸机条件限制,控制板坯中心偏析有一定难度.为了克服这一困难,Gwangyang工厂在1-3铸机上安装了动态轻压下设备.动态轻压下系统的操作条件处于优化阶段.轻压下设备上采用了动态二次冷却系统和热示踪模型,板坯中心偏析系数有了明显降低.

关键词：连铸轻压下二次冷却中心偏析

Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn's disease

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World Journal of Gastroenterology 2017年第8期23卷 1489-1496页

作者： Eun Hye Oh Dae-Hyun Ko Hyungil Seo Kiju Chang Gwang-Un Kim Eun Mi Song Myeongsook Seo Ho-Su Lee Sung wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center Department of Laboratory Medicine Hallym University College of MedicineDongtan Sacred Heart Hospital Department of Gastroenterology University of Ulsan College of MedicineAsan Medical Center Health Screening and Promotion Center University of Ulsan College of MedicineAsan Medical Center

To investigate the clinical implications of infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATI) levels in Crohn’s disease (CD) patients in Asian ***-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD (quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician’s judgment of patients’ clinical status at enrollment. The impact of concomitant immunomodulators was also *** study enrolled 138 patients with CD (84 with quiescent and 54 with active disease). In patients with quiescent and active diseases, the median IFX-TLs were 1.423 μg/mL and 0.163 μg/mL, respectively (P < 0.001) and the median ATI levels were 8.064 AU/mL and 11.209 AU/mL, respectively (P < 0.001). In the ATI-negative and -positive groups, the median IFX-TLs were 1.415 μg/mL and 0.141 μg/mL, respectively (P < 0.001). In patients with and without concomitant immunomodulator use, there were no differences in IFX-TLs (0.632 μg/mL and 1.150 μg/mL, respectively; P = 0.274) or ATI levels (8.655 AU/mL and 9.017 AU/mL, respectively; P = 0.083).CONCLUSIONIFX-TL/ATI levels were well correlated with the clinical activity in South Korean CD patients. Our findings support the usefulness of IFX-TLs/ATI levels in treating CD patients receiving IFX in clinical practice.

关键词： Infliximab Drug effect Antibody Crohn’s disease Drug monitoring

Analyses of oligodontia phenotypes and genetic etiologies

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International Journal of Oral Science 2021年第3期13卷 323-332页

作者： Mengqi Zhou hong Zhang Heather Camhi Figen Seymen Mine Koruyucu Yelda Kasimoglu Jung-wook Kim Hera Kim-Berman Ninna M.R.Yuson Paul J.Benke Yiqun Wu Feng Wang Yaqin Zhu James P.Simmer Jan C-C.Hu Dental Research Laboratory University of Michigan School of DentistryAnn ArborMIUSA Department of Second Dental Center Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Department of General Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Orthodontic and Pediatric Dentistry University of Michigan School of Dentistry1011N.University AveAnn ArborMIUSA Mott Children’s Health Center 806 Tuuri Place FlintMIUSA Department of Pedodontics Faculty of DentistryIstanbul UniversityIstanbulTurkey Department of Molecular Genetics&Dental Research Institute School of Dentistry Seoul National UniversitySeoulKorea Department of Pediatric Dentistry&Dental Research Institute School of Dentistry Seoul National UniversitySeoulKorea Department of Paediatric Dentistry Women’s and Children’s HospitalNorth AdelaideSAAustralia Department of Medical Genetics Joe DiMaggio Children’s HospitalHollywoodFLUSA Department of Oral Implantology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina

Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth *** genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical *** purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia *** online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic ***,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence *** identified a novel mutation in WNT10A(c.99_105dup)and eight previously reported mutations in WNT10A(c.433 G>A;c.682 T>A;c.318 C>G;c.511.C>T;c.321 C>A),EDAR(c.581 C>T),and LRP6(c.1003 C>T,c.2747 G>T).Collectively,20 different causative genes were implicated among those 393 cases with *** each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were ***–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations,mandibular first premolar agenesis is least associated with PAX9 mutations.

关键词： clinical congenital likely

Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients

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World Journal of Gastroenterology 2022年第9期28卷 933-947页

作者： Yonghoon Choi Nayoung Kim Ki wook Kim Hyeong Ho Jo Jaehyung Park Hyuk Yoon Cheol Min Shin Young Soo Park Dong Ho Lee Hyeon Jeong Oh Hye seung Lee Young Suk Park Sang-Hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-Ho Kim Ji-Won Kim Jin Won Kim Keun-wook Lee Won Chang Ji HoonPark Yoon Jin Lee Kyoung Ho Lee Young Hoon Kim Department ofInternal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Nayoung Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Radiology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Radiology Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for *** A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were *** clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were *** Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, *** average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P < 0.001).Cancer of the gastric body(P < 0.001) and diffuse-type histology(P < 0.001) were more common in females than in *** trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male *** of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with *** overall survival rate was significantly higher in females(P < 0.001).However, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type *** terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in *** Sex-based differences in GC were

关键词： Gastric cancer Histology Prognosis Sex difference Survival

Effect of music on colonoscopy performance: A propensity scorematched analysis

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 397-406页

作者： Eun Jeong Choi Sam Ryong Jee Sang Heon Lee Jun Sik Yoon seung Jung Yu Jong Hyun Lee Han Byul Lee Sang wook Yi Myeong Pyo Kim Byung Cheol Chung hong Sub Lee Department of Internal Medicine Inje University College of MedicineBusan Paik HospitalBusan 47392South Korea Department of Public Health Ajou University Graduate School of Public HealthSuwon 16499South Korea Department of Preventive Medicine and Public Health Catholic Kwandong University College of MedicineGangneung 25601South Korea

BACKGROUND Music has been used to reduce stress and improve task performance during medical *** To assess the effects of music on colonoscopy performance *** We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular *** performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music *** reduce selection bias,propensity score matching was *** After one-to-one propensity score matching,169 colonoscopies were selected from each *** significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two *** analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in ***,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic *** The current study found that listening to music during colonoscopy did not affect procedure ***,it suggested that music may distract trainees from appropriately detecting adenomas and polyps.

关键词： Music Colonoscopy Performance Adenoma Colonic polyps Cecal insertion time