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Hepatoma Research 2022年第1期8卷 188-192页

作者： Hye Won Lee seung up.kim Department of Internal Medicine Yonsei University College of MedicineSeoul 03722Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 03722Korea Yonsei Liver Center Severance HospitalSeoul 03722Korea

A paper published several years ago suggested that tenofovir disoproxil fumarate(TDF)was superior to entecavir(ETV)for reducing the risk of hepatocellular carcinoma(HCC).Since then,many observational studies have been conducted comparing TDF and *** studies in Asia demonstrated similar HCC risks between ETV and TDF ***,recent studies involving Caucasian and European did not observe any differences in HCC risk between these *** this article,we briefly review studies that compared the incidence rates of HCC between ETV and TDF and discuss potential reasons for the discrepant results.

关键词： Hepatitis B entecavir tenofovir hepatocellular carcinoma

Understanding secondary phase inclusion and composition variations in the microstructure design of n-type Bi_(2)Te_(3) alloys via selective dissolution of KCl

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Journal of Advanced Ceramics 2023年第12期12卷 2360-2370页

作者： Gwang Min Park seunghyeok Lee Jun-Yun Kang seung-Hyub Baek Heesuk kim Jin-Sang kim Seong Keun kim KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Materials Science and Chemical Engineering Hanyang UniversityAnsan 15588Republic of Korea Ferrous Alloy Department Korea Institute of Materials ScienceChangwon 51508Republic of Korea Soft Hybrid Materials Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju 55324Republic of Korea

This study investigated the effects of KCl treatment on microstructure and thermoelectric properties of n-type Bi_(2)Te_(2.7)Se_(0.3)(BTS)thermoelectric *** innovative KCl treatment was originally intended to introduce nanopores through selective dissolution of KCl from a mixture of thermoelectric materials and ***,it unexpectedly induced substantial variations in material composition and microstructure during the subsequent spark plasma sintering(SPS)*** groups adsorbed on the powder surface during the dissolution resulted in the emergence of a Bi_(2)TeO_(5) secondary phase within the BTS matrix after the SPS process at 450℃.The concentration of Bi_(2)TeO_(5) increased with an increase in the KCl ***,a remarkable grain growth occurred at low KCl concentrations,likely due to the liquid-phase formation in a Te-rich composition during ***,excessive Bi_(2)TeO_(5) at higher KCl concentrations hindered grain *** variations in the microstructure had complex effects on electrical properties:The TeBi antisite defects increased the electron concentration,and Bi_(2)TeO_(5) reduced electron ***,the lattice thermal conductivity decreased due to the presence of Bi_(2)TeO_(5),from 0.8 W·m^(−1)·K^(−1) at 298 K for the pristine BTS to 0.6 W·m^(−1)·K^(−1) at 298 K for BTS treated with 1 wt%*** insights allowed precise adjustments of the electrical and thermal conductivities,leading to an enhancement in the maximum value of figure-of-merit(ZT)from 0.76 to 0.96 through the selective dissolution of KCl *** believe that our observations potentially enable advances in thermoelectric materials by engineering microstructures.

关键词： thermoelectric materials Bi_(2)Te_(3) Bi_(2)TeO_(5) grain growth n-type KCl

Precore/core region mutations of hepatitis B virus related to clinical severity

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World Journal of Gastroenterology 2016年第17期22卷 4287-4296页

作者： Hong kim Seoung-Ae Lee seung Yeon Do Bum-Joon kim Department of Biomedical Sciences Microbiology and Immunology Liver Research Institute and Cancer Research Institute College of Medicine Seoul National University

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due to cirrhosis and liver cancer. HBV mutations are primarily generated due both to a lack of proofreading capacity by HBV polymerase and to host immune pressure, which is a very important factor for predicting disease progression and therapeutic outcomes. Several types of HBV precore/core (preC/C) mutations have been described to date. The host immune response against T cells drives mutation in the preC/C region. Specifically, preC/C mutations in the MHC class II restricted region are more common than in other regions and are significantly related to hepatocellular carcinoma. Certain mutations, including preC G1896A, are also significantly related to HBeAg-negative chronic infection. This review article mainly focuses on the HBV preC/C mutations that are related to disease severity and on the HBeAg serostatus of chronically infected patients.

关键词： Hepatitis B virus infection Precore/core mutations Hepatocellular carcinoma HBeAg serostatus Disease severity

Prediction models for recurrence in patients with small bowel bleeding

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World Journal of Clinical Cases 2023年第17期11卷 3949-3957页

作者： Ji Hyun kim seung-Joo Nam Division of Gastroenterology and Hepatology Department of Internal MedicineKangwon National University School of MedicineChuncheon 24341South Korea

Obscure gastrointestinal bleeding(OGIB)has traditionally been defined as gastrointestinal bleeding whose source remains unidentified after bidirectional *** can present as overt bleeding or occult bleeding,and small bowel lesions are the most common *** small bowel can be evaluated using capsule endoscopy,device-assisted enteroscopy,computed tomography enterography,or magnetic resonance *** the cause of smallbowel bleeding is identified and targeted therapeutic intervention is completed,the patient can be managed with routine ***,diagnostic tests may produce negative results,and some patients with small bowel bleeding,regardless of diagnostic findings,may experience *** those at risk of rebleeding can help clinicians form individualized surveillance *** studies have identified different factors associated with rebleeding,and a limited number of studies have attempted to create prediction models for *** article describes prediction models developed so far for identifying patients with OGIB who are at greater risk of *** models may aid clinicians in forming tailored patient management and surveillance.

关键词： Obscure gastrointestinal bleeding Prediction model Rebleeding Small bowel bleeding Video capsule endoscopy

Dynamic simulation of universal spacer in Dynesys dynamic stabilization system for human vertebra

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中国有色金属学会会刊：英文版 2009年第B9期19卷 238-242页

作者： Sung-Min kim In-Chul YANG seung-Yeol LEE Sung-Youn CHO Department of Medical Bio Engineering College of BiosystemDongguk University Research Institute of Biotechnology Dongguk University Department of Advanced Technology Fusion Graduate SchoolKonkuk University Research and Development Center U& I Corporation

The aim of this study is to analyze the simulated behavior of universal spacer in Dynesys dynamic stabilization system inserted in human vertebra. Dynesys, so-called "Dynamic neutralization system for the spine", dynamic stabilization system is a new concept in the surgical treatment of lower back pain recently. Universal spacer used as flexible material is to stabilize the spine and the material property of universal spacer is polycarbonate urethane. Universal spacer may apply different kinematic behaviors at implanted level in vertebra. Spinal range of motion(SROM) of inter-vertebra with installed Dynesys dynamic stabilization system was studied using Adams+LifeMOD as simulation software package. The vertebra model was set up to closely resemble the in-vivo conditions. Inter-vertebra rotations were measured by post processor of Adams and compared with the intact values. SROMs of the flexion, extension, lateral bending, and axial rotation of human virtual models were measured, where three spinal fixation systems such as rigid system, Dynesys system, and fused system were installed. As a result, the value of SROM is decreased in flexion-extension and lateral bending when the spinal fixation system is implanted. The movement of Dynesys system is similar to that of intact model by allowing the movement of lumbar. This means that the Dynesys system is proved to be safe and effective in the treatment of unstable spinal condition.

关键词：稳定系统动态模拟间隔人类脊椎聚碳酸酯聚氨酯运动行为旋转模型

Inhibition behavior of Tragia involucrata L. phenolic compounds against acidic medium corrosion in low carbon steel surface

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Chinese Journal of Chemical Engineering 2019年第3期27卷 717-725页

作者： Ill-Min Chung seung-Hyun kim Venkatesan Hemapriya Kathirvel Kalaiselvi Mayakrishnan Prabakaran Department of Crop Science College of sanghr Life Science Konkuk University Department of Chemistry PSGR Krishnammal College for Women

The antioxidant and anticorrosive effect of Tragia involucrate L.(T. involucrate L.) was evaluated to aid in finding new compounds which can be used for various purposes. The total phenolic(TPC) and flavonoid content(TFC),antioxidant activity(DPPH, reducing potential and phosphomolybdenum), and electrochemical measurements,Fourier transform infrared(FT-IR), UV–visible(UV–vis) spectral analysis, scanning electron microscopy/energydispersive X-ray spectroscopy(SEM–EDX) and atomic force microscopy(AFM) were done to analyze the potency and also the inhibition efficiency of T. involucrate L. against 1 mol·L^(-1) HCl on low carbon steel. The TPC(145.21 mg GAE·g^(-1)), TFC(52.32 mg QCE·g^(-1)) and antioxidant activities were found to be significant. The electrochemical studies performed by AC impedance measurements showed significant changes in impedance spectra without causing any change in Nyquist plots. An increase in charge transfer resistance(Rct) values, a blockage in active sites exhibiting cathodic and anodic inhibition shows the action of inhibitor on low carbon steel. This was later confirmed by FT-IR and UV–vis which showed variation in absorption band at 270 nm and273 nm(before immersion) and 208 and 281 nm(after immersion). The same was tested again by SEM–EDX through altered strength of iron and oxygen bands and using AFM by analyzing the change in average roughness values of low carbon steel before(61.65 nm) and after(97.87 nm) exposure to blank acid without inhibitor, while it was shifted to 81.58 nm in acid with inhibitor. All these results showed strong evidence adding values to T. involucrate L. plant extract in inhibiting corrosion on low carbon steel and by promoting antioxidant importance of the extract which helps in scavenging free radicals.

关键词： Tragia involucrate L Antioxidant Corrosion Adsorption Electrochemistry SEM–EDX–AFM

MicroRNAs in pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2011年第7期17卷 817-827页

作者： Jong Y Park James Helm Domenico Coppola Donghwa kim Mokenge Malafa seung Joon kim Division of Cancer Prevention and Control Moffitt Cancer Center FL 33612 United States Gastrointestinal Tumor Program Moffitt Cancer Center FL 33612 United States Department of Anatomic Pathology Moffitt Cancer Center FL 33612 United States Department of Molecular Oncology MoffittCancer Center FL 33612 United States Department of Internal Medicine Collegeof Medicine the Catholic University of Korea Seoul 137-040South Korea

Ductal adenocarcinoma of the pancreas is a lethal cancer for which the only chance of long-term survival belongs to the patient with localized disease in whom a potentially curative resection can be done. Therefore, biomarkers for early detection and new therapeutic strategies are urgently needed. miRNAs are a recently discovered class of small endogenous non-coding RNAs of about 22 nucleotides that have gained attention for their role in downregulation of mRNA expression at the post-transcriptional level. miRNAs regulate proteins involved in critical cellular processes such as differentiation, proliferation, and apoptosis. Evidence suggests that deregulated miRNA expression is involved in carcinogenesis at many sites, including the pancreas. Aberrant expression of miRNAs may upregulate the expression of oncogenes or downregulate the expression of tumor suppressor genes, as well as play a role in other mechanisms of carcinogenesis. The purpose of this review is to summarize our knowledge of deregulated miRNA expression in pancreatic cancer and discuss the implication for potential translation of this knowledge into clinical practice.

关键词： MicroRNAs Pancreatic cancer

Evaluation of properties of concrete using fluosilicate salts and metal (Ni,W) compounds

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中国有色金属学会会刊：英文版 2009年第B9期19卷 134-142页

作者： Gyu-Yong kim Eui-Bae LEE Bae-Su KHIL seung-Hun LEE Division of Architecture Engineering Chungnam National University Research Institute of Technology Tripod Co. Research Institute of Technology Samsung Construction and Engineering

To improve watertightness and antibiosis of sewage structure concrete, the antimicrobial watertight admixture was made with fluosilicate salts and antimicrobial compounds. And fresh properties, watertightness, harmlessness and antibiosis of concrete were investigated experimentally. As a result, the fresh properties of concrete were similar to those of an ordinary concrete, without setting time delay. Compressive strength and carbonation resistance of concrete were better than those of an ordinary concrete. Finally it was confirmed that the antimicrobial watertight admixture of concrete had an antibiosis inhibiting SOB growth.

关键词：抗菌化合物混凝土性能混凝土外加剂普通混凝土金属评价盐硅

Evaluating the effects of granular and membrane filtrations on chlorine demand in drinking water

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Journal of Environmental Sciences 2009年第1期21卷 23-29页

作者： Veeriah Jegatheesan seung Hyun kim C. K. Joo GAO Baoyu School of Engineering James Cook University Townsville QLD 4811 Australia. Department of Civil Engineering Kyungnam University 631-701 Masan Korea Chilseo Water Treatment Plant Haman 637-940 Korea School of Environmental Science and Engineering Shandong University Jinan 250100 China

In this study, chlorine decay experiments were conducted for the raw water from Nakdong River that is treated by Chllseo Water Treatment Plant （CWTP） situated in Haman, Korea as well as the effluents from sand and granular activated carbon （GAC） filters of CWTP and fitted using a chlorine decay model. The model estimated the fast and slow reacting nitrogenous as well as organic/inorganic compounds that were present in the water. It was found that the chlorine demand due to fast and slow reacting （FRA and SRA） organic/inorganic substances was not reduced significantly by sand as well as GAC filters. However, the treated effluents from those filters contained FRA and SRA that are less reactive and had small reaction rate constants. For the effluents from microfiltration, ultrafiltration, and nanofiltration the chlorine demand because FRA and SRA were further reduced but the reaction rate constants were larger compared to those of sand and GAC filter effluents. This has implications in the formation of disinfection by products （DBPs）. If DBPs are assumed to form due to the interactions between chlorine and SRA, then it is possible that the DBP formation potential in the effluents from membrane filtrations could be higher than that in the effluents from granular media filters.

关键词： chlorine decay model initial concentration nitrogenous compounds organic and inorganic compounds reaction rate constants

Map-based control method for vehicle stability enhancement

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Journal of Central South University 2015年第1期22卷 114-120页

作者： Moon-Young Yoon seung-Hwan Baek Kwang-Suk Boo Heung-Seob kim Graduate school of Mechanical Engineering Inje University 607 High Safety Vehicle Core Technology Research Center Inje University 607

This work proposes a map-based control method to improve a vehicle's lateral stability, and the performance of the proposed method is compared with that of the conventional model-referenced control method. Model-referenced control uses the sliding mode method to determine the compensated yaw moment; in contrast, the proposed map-based control uses the compensated yaw moment map acquired by vehicle stability analysis. The vehicle stability region is calculated by a topological method based on the trajectory reversal method. A 2-DOF vehicle model and Pacejka's tire model are used to evaluate the proposed map-based control method. The properties of model-referenced control and map-based control are compared under various road conditions and driving inputs. Model-referenced control uses a control input to satisfy the linear reference model, and it generates unnecessary tire lateral forces that may lead to worse performance than an uncontrolled vehicle with step steering input on a road with a low friction coefficient. However, map-based control determines a compensated yaw moment to maintain the vehicle within the stability region,so the typical responses of vehicle enable to converge rapidly. The simulation results with sine and step steering show that map-based control provides better the tracking responsibility and control performance than model-referenced control.

关键词： model-referenced control map-based control vehicle stability yaw moment