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Quantitative assessment of the relevance of organic-aniontransporting-polypeptide 1B1 and 2B1 polymorphisms in fexofenadine pharmacokinetic variants via pharmacometrics

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Journal of Pharmaceutical Analysis 2023年第6期13卷 660-672页

作者： Ji-Hun jang seung-Hyun Jeong Yong-Bok Lee Department of Pharmacy College of PharmacyChonnam National UniversityGwangju61186Republic of Korea Department of Pharmacy College of PharmacySunchon National UniversitySuncheon-si57922Republic of Korea

Fexofenadine is useful in various allergic disease ***,the pharmacokinetic variability information and quantitative factor identification of fexofenadine are very *** study aimed to verify the validity of previously proposed genetic factors through fexofenadine population pharmacokinetic modeling and to explore the quantitative correlations affecting the pharmacokinetic *** of the organic-anion-transporting-polypeptide(OATP)1B1 and 2B1 have been proposed to be closely related to fexofenadine pharmacokinetic ***,modeling was performed using fexofenadine oral exposure data according to the OATP1B1-and ***1B1 and 2B1 were identified as effective covariates of clearance(CL/F)and distribution volume(V/F)-CL/F,respectively,in fexofenadine pharmacokinetic ***/F and average steady-state plasma concentration of fexofenadine differed by up to 2.17-and 2.20-folds,respectively,depending on the OATP1B1 *** the individuals with different OATP2B1 polymorphisms,the CL/F and V/F differed by up to 1.73-and 2.00-folds,*** of the areas under the curves following single-and multiple-administrations,and the cumulative ratio were significantly different between OATP1B1-and 2B1-polymorphism *** on quantitative prediction comparison through a model-based approach,OATP1B1 was confirmed to be relatively more important than 2B1 regarding the degree of effect on fexofenadine pharmacokinetic *** on the established pharmacokineticpharmacodynamic relationship,the difference in fexofenadine efficacy according to genetic polymorphisms of OATP1B1 and 2B1 was 1.25-and 0.87-times,respectively,and genetic consideration of OATP1B1 was expected to be important in the pharmacodynamics area as *** population pharmacometrics study will be a very useful starting point for fexofenadine precision medicine.

关键词： OATP1B1 OATP2B1 Fexofenadine Population pharmacometrics Genetic polymorphism

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High-performance and current crowding-free InGaN-GaN- based LEDs integrated by an electrically-reverse-connected Schottky diode and a Mg-delta doped p-GaN

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Frontiers of Optoelectronics 2012年第2期5卷 127-132页

作者： Sei-Min KIM Seon-Ho jang Ja-soon jang Department of Electronic Engineering LED-IT Fusion Technology Research Center (LIFTRC) Yeungnam University Gyeongbuk 712 749 Korea

This work demonstrates high-performance and current crowding-free InGaN/GaN light-emitting diodes （LEDs） using an electrically-reverse-connected Schottky diode （SD） and an Mg-delta （δ） doped layer. Possible mechanism of carrier transport at the interface between transparent conducting electrode （TCE） and p-GaN with the δ-doped layer is also investigated. Results show that the LED with the SD and Mg delta （δ）-doping layer yields lower series resistance, higher output power, and lower reverse leakage current compared to normal LEDs. In addition, unlike the normal LED, there is no occurrence for the current crowding effect in the proposed LED even at high current density of 380mA/cm2. These remarkable behaviours clearly indicate that the use of the SD and δ- doping in the p-GaN region is very promising to achieve high-brightness and excellent-reliability GaN-based LEDs.

关键词： GaN light-emitting diode (LED) Schottkydiode (SD) integration current crowding

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Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young jang Eun Yee Jie seung Hee Choi Ok-Sun Park soon Hyung Bae Hyun-soon Kim Suk Weon Kim Geum-Sook Hwang Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

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Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

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Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： seung-Hyun Jeong Ji-Hun jang Hea-Young Cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

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Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

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Journal of Pharmaceutical Analysis 2021年第4期11卷 444-457页

作者： seung-Hyun Jeong Ji-Hun jang Guk-Yeo Lee seung-Jung Yang Hea-Young Cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea National Development Institute of Korean Medicine 288 Udeuraendeu-gilAnyang-myeonJangheung-gunJeollanam-do59338Republic of Korea Department of Oriental Rehabilitation Medicine Dongshin University Gwangju Korean Medicine Hospital141 Wolsan-roNam-guGwangju61619Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-do13488Republic of Korea

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory,analgesic,and antipyretic ***,the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic(PK)study have yet been *** have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma *** conditions were optimized according to the physicochemical properties of the 14 compounds to facilitate efficient separation and eliminate overlap or interference between ***-C18 and Inertsil-C8 columns were used as UPLC stationary phases,and acetonitrile and aqueous formic acid were used as mobile *** the analytes were quantified with a triple quadrupole mass spectrometer using electrospray ionization in multiple reaction monitoring *** chromatograms of 14 bioactive compounds showed excellent elution and sensitivity,and each peak was selectively separated and quantified without interference with each other or *** established analytical method was based on international guidelines and was successfully used to perform PK studies of 14 herbal ingredients in humans after oral administration with Gumiganghwal-tang *** oral absorption of most active components of Gumiganghwal-tang was relatively rapid and remained considerably long in the body to be quantified in plasma up to 48 h after administration.

关键词： Gumiganghwal-tang Fourteen bioactive ingredients Simultaneous analysis UPLC-ESI-MS/MS Pharmacokinetics Clinical study

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Wave prediction in a port using a fully nonlinear Boussinesq wave model

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Acta Oceanologica Sinica 2019年第7期38卷 36-47页

作者： Young-Kwang Choi seung-Nam Seo Jin-Yong Choi Fengyan Shi Kwang-soon Park Civil and Architectural Engineering Department KEPCO Engineering and ConstructionGimcheon-si 39660Republic of Korea Task Force for Construction of RV ISABU Support Facility Korea Institute of Ocean Science and TechnologyBusan Metropolitan City 49111Republic of Korea Operational Oceanography Research Center Korea Institute of Ocean Science and TechnologyBusan Metropolitan City 49111Republic of Korea Center for Applied Coastal Research University of DelawareNewark DE 19716USA

A wave forecasting system using FUNWAVE-TVD which is based on the fully nonlinear Boussinesq equations by Chen(2006)was developed to provide an accurate wave prediction in the Port of Busan,South *** system is linked to the Korea Operational Oceanographic System(KOOS)developed by Park et al.(2015).The computational domain covers a region of 9.6 km×7.0 km with a grid size of 2 m in both directions,which is sufficient to resolve short waves and dominant sea *** total number of grid points exceeds 16 millions,making the model computational *** provide real-time forecasting,an interpolation method,which is based on pre-calculated results of FUNWAVE-TVD and SWAN forecasting results at the FUNWAVE-TVD offshore boundary,was used.A total of 45 cases were pre-calculated,which took 71 days on 924 computational cores of a Linux cluster *** wave generation and propagation from the deep water were computed using the SWAN in *** results provided a boundary condition for the FUNWAVE-TVD forecasting *** verify the model,wave observations were conducted at three locations inside the port in a time period of more than 7 months.A model/model comparison between FUNWAVE-TVD and SWAN was also carried *** is found that,FUNWAVE-TVD improves the forecasting results significantly compared to SWAN which underestimates wave heights in sheltered areas due to incorrect physical mechanism of wave diffraction,as well as large wave heights caused by wave reflections inside the port.

关键词： real-time wave forecasting FUNWAVE-TVD SWAN KOOS wave observations wave diffraction

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Electrochemical characteristics of HVOF spray coated layer with WC-27NiCr and WC-10Co4Cr for Al bronze

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中国有色金属学会会刊：英文版 2012年第S3期22卷 753-759页

作者： Min-su HAN seung-jun LEE Min-sung KIM Seok-ki jang Seong-jong KIM Division of Marine Engineering Mokpo Maritime University

Among the environmentally friendly marine energies,tidal current power plants require low cost because they do not need to construct a large *** power is particularly reliable energy source because the power generation capacity is predictable regardless of weather or *** materials or stainless steel have been used as materials of blades for current power ***,their strength and welding performance generated many problems in field *** alloys with excellent cavitation resistance and corrosion resistance were applied as blade materials to improve the durability of copper *** were coated with WC-27NiCr and WC-10Co4Cr using the high velocity oxy-fuel (HVOF) *** metal spray coating technology has the advantage in terms of the selection of materials for cost effectiveness and environmental effects of corrosion because the properties of the coat layer can be controlled *** with WC-27NiCr and WC-10Co4Cr by HVOF,WC-27NiCr shows better corrosion resistance *** reason for this seems to be that corrosion resistance improves and a stable passive film forms due to the effects of Ni and Cr.

关键词： tidal power copper alloys HVOF coating corrosion resistance

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A newly developed subcutaneous nodule 15 years after liver transplantation

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 430-432页

作者： soon Kyu Lee Pil Soo Sung seung Kew Yoon Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

A 79-year-old man,who had undergone liver transplantation(LT)15 years ago due to hepatocellular carcinoma(HCC)related to chronic hepatitis B,was referred for a newly developed 2 cm-sized mass on his left cheek(Figure 1A).Alpha-fetoprotein had been within normal range since LT,and the patient had been on 1 mg/day *** emission tomography-computed tomography documented a focal 18F-fluorodeoxyglucose uptake in skin lesion(Figure 1B).

关键词： liver Figure fetoprotein

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ST-segment elevation myocardial infarction in Kawasaki disease:A case report and review of literature

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World Journal of Clinical Cases 2022年第26期10卷 9368-9377页

作者： Joonpyo Lee Jeongduk Seo Yong Hoon Shin Albert Youngwoo jang soon Yong Suh Division of Cardiology Department of Internal MedicineGachon UniversityGil Medical CenterIncheon 21565South Korea

BACKGROUND Kawasaki disease(KD)is an acute self-limiting febrile vasculitis that occurs during childhood and can cause coronary artery aneurysm(CAA).CAAs are associated with a high rate of adverse cardiovascular *** SUMMARY A Korean 35-year-old man with a 30-year history of KD presented to the emergency room with chest *** coronary angiography was performed as ST-segment elevation in the inferior leads was observed on the *** aneurysm of the left circumflex(LCX)coronary artery was found with massive thrombi within.A drug-eluting 4.5 mm 23 mm-sized stent was inserted into the occluded area without *** maximal diameter of the LCX was 6.0 mm with a Z score of 4.7,suggestive of a small aneurysm considering his age,sex,and body surface *** further present a case series of 19 patients with KD,including the current patient,presenting with acute coronary syndrome(ACS).Notably,none of the cases showed Z scores;only five patients(26%)had been regularly followed up by a physician,and only one patient(5.3%)was being treated with antithrombotic therapy before ACS *** For KD presenting with ACS,regular follow up and medical therapy may be crucial for improved outcomes.

关键词： Kawasaki disease Acute coronary syndrome ST elevation myocardial infarction Coronary angiography Percutaneous coronary intervention Case report

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Long-term performance of fiber-grid-reinforced asphalt overlay pavements: A case study of Korean national highways

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 366-382页

作者： Jong-Hoon Lee seung-Beom Baek Kang-Hoon Lee Jo-soon Kim Jin-Hoon Jeong Department of Civil Engineering Inha UniversityIncheon 22212South Korea Civil&Environmental BG Doosan Engineering&ConstructionSeoul 06057South Korea Department of Infrastructure Safety Research Korea Institute of Civil Engineering and Building TechnologyGoyang-si 10223South Korea SN Construction Co. LtdDaejeon 34573South Korea

The objective of this study was to verify the effect of fiber grid reinforcement on the longterm performance of asphalt overlay pavements by performing field investigation, laboratory test, and finite element analysis. Crack, rutting, roughness, and other miscellaneous distresses of fiber-grid-reinforced overlay sections and ordinary overlay sections were compared. Pavement conditions of fiber grid overlay sections before and after the overlay were also compared. Cores were obtained from the fiber-grid-reinforced and ordinary sections to measure bonding shear strength between the intermediate and overlay *** energy, displacement after yield, and shear stiffness of the cores were also obtained by analyzing the test results. Finite element analysis was performed by using the test results to validate the effect of the fiber grid reinforcement on the long-term performance of asphalt overlay pavements. Rutting and fatigue cracking were predicted for three cases: 1) fiber grid was not used;2) glass fiber grid was used;and 3) carbon fiber grid was used. The cracking ratio of fiber-grid-reinforced sections was much smaller than that of ordinary sections. The results of field investigation, laboratory test, and finite element analysis showed that the fiber grid reinforcement improved the long-term performance of asphalt overlay pavements.

关键词： Asphalt pavement Fiber grid reinforcement Overlay pavement Finite element analysis Bonding shear strength

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