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Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

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Journal of Geriatric Cardiology 2017年第2期14卷 81-86页

作者： Hoyoun Won Wang Soo lee Sang-Wook Kim Byung Ryul Cho Young Jin Youn Young-Hyo Lim Min-Ho lee jae-Hwan lee seung-Woon Rha Cardiovascular & Arrhythmia Center Chung-Ang University Hospital Chung-Ang University College of Medieine Seoul South Korea Division of Cardiology Kangwon National University Hospital Chuncheon South Korea Division of Cardiology Yonsei University Wonju College of Medicine Wonju South Korea Division of Cardiology College of Medicine Hanyang University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea Department of Cardiology Chungnam National University Hospital Daejeon South Korea Department of Cardiology Korea University Guro Hospital Seoul South Korea

Background Radial artery access for coronary procedures is a safe and beneficial technique. However, elderly patients have been considered as a higher risk group of access site related complications compared to younger patients. This study was conducted to investigate the feasibility and safety oftransradial coronary angiography or intervention in the elderly. Methods A total of 6132 patients from Korean Transradial Intervention Prospective Registry at 20 centers were analyzed. Patients were divided into the non-elderly group （n = 5667） and the elderly （_〉 80 years） group （n = 465）. Using propensity score matching, the elderly group （n = 465） was compared with one-to-one matched the non-elderly group （n = 465）. Results After propensity score matching, mean age was 64.3 ＋ 10.3 years in the non-elderly group and 83.5 -4- 3.3 years in the elderly group. There was no difference of procedural characteristics, procedural and fluoroscopic times. Access site cross-over rate was not different between the non-elderly group and elderly group （7.5% vs. 6.2%, P = 0.074）. Bleeding compli- cations occurred similarly in two groups （2.6% of the non-elderly group vs. 1.9% of the elderly group, P -~ 0.660）. Access site complications were 1.9% of the non-elderly group and 0.9% of the elderly group （P = 0.263）. Both of in hospital death and cardiovascular death for one year were also similar between two groups. Conclusions Transradial angiography or intervention was safe and feasible in elderly patients. Complication rates and clinical outcomes in elderly patients were comparable with those in non-elderly patients.

关键词： The elderly patients Transmdial coronary angiography Transradial coronary intervention

Superelastic metastable Ti-Mo-Sn alloys with high elastic admissible strain for potential bio-implant applications

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Journal of Materials Science & Technology 2023年第32期163卷 45-58页

作者： Shuanglei Li jae H.Kim seung Won Kang jae Ho Kim Tae-Hyun Nam Jong-Taek Yeom Titanium Alloys Department Metal Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Materials Engineering and Convergence Technology&Research Institute for Green Energy Convergence Technology(RIGET) Gyeongsang National University900 GazwadongJinjuGyeongnam 52828Republic of Korea

The demand for titanium alloys simultaneously having high elastic admissible strain and large recovery strain for bio-implant applications is ***-free Ti-based shape memory alloys are promising candidates for obtaining the required multifunctional *** this study,a wide content range of(0-15)wt%of low-cost,toxicity-free,and high-biocompatible Sn element was added to the Ti-8Mo(wt%)alloy to study its effect on the superelastic recovery and mechanical properties of biomedical Ti-Mo-Sn *** tailoring Sn content,desired multifunctional properties of high elastic admissible strain and room temperature superelasticity were achieved in the studied Ti-Mo-Sn *** was found that the increase in Sn content stabilized theβphase and a singleβphase was obtained at room temperature in Ti-8Mo-(13,15)Sn *** addition of Sn modified the lattice parameters of theα″martensite andβphase and affected the lattice deformation stain ofβ→α″.The lattice deformation strain along the[011]βdirection was found to be decreased by-0.26%/wt%*** room temperature superelasticity with a recovery strain of 3.1%and an elastic admissible strain of 1%was obtained in the Ti-8Mo-13Sn *** Sn content increased to 15 wt%,a high elastic admissible strain of 1.56%and a recovery strain of 2.0%were *** Ti-Mo-Sn alloys with excellent multifunctional properties are promising candidates for bio-implant applications.

关键词： Ti-Mo-Sn alloy Shape memory alloy Elastic admissible strain Elastic modulus Superelasticity

Two-Terminal Lithium-Mediated Artificial Synapses with Enhanced Weight Modulation for Feasible Hardware Neural Networks

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Nano-Micro Letters 2023年第5期15卷 236-253页

作者： Ji Hyun Baek Kyung Ju Kwak seung Ju Kim jaehyun Kim jae Young Kim In Hyuk Im Sunyoung lee Kisuk Kang Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Recently,artificial synapses involving an electrochemical reaction of Li-ion have been attributed to have remarkable synaptic ***-terminal synaptic transistors utilizing Li-ion intercalation exhibits reliable synaptic characteristics by exploiting the advantage of nondistributed weight updates owing to stable ion ***,the three-terminal configurations with large and complex structures impede the crossbar array implementation required for hardware neuromorphic ***,achieving adequate synaptic performances through effective Li-ion intercalation in vertical two-terminal synaptic devices for array integration remains ***,two-terminal Au/LixCoO_(2)/Pt artificial synapses are proposed with the potential for practical implementation of hardware neural *** Au/LixCoO_(2)/Pt devices demonstrated extraordinary neuromorphic behaviors based on a progressive dearth of Li in LixCoO_(2)*** intercalation and deintercalation of Li-ion inside the films are precisely controlled over the weight control spike,resulting in improved weight control *** types of synaptic plasticity were imitated and assessed in terms of key factors such as nonlinearity,symmetricity,and dynamic ***,the LixCoO_(2)-based neuromorphic system outperformed three-terminal synaptic transistors in simulations of convolutional neural networks and multilayer perceptrons due to the high linearity and low programming *** impressive performances suggest the vertical two-terminal Au/LixCoO_(2)/Pt artificial synapses as promising candidates for hardware neural networks.

关键词： Artificial synapse Neuromorphic Li-based Two-terminal Synaptic plasticity

Pancreatic tuberculosis masquerading as pancreatic serous cystadenoma

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World Journal of Gastroenterology 2009年第8期15卷 1010-1013页

作者： seung Goun Hong jae Seon Kim Moon Kyung Joo Kwang Gyun lee Key Hyeon Kim Cho Rong Oh Jong-jae Park Young-Tae Bak Department of Internal Medicine Korea University College of Medicine Seoul South Korea

Solitary pancreatic involvement of tuberculosis is rare, especially in an immunocompetent individual, and it may be misdiagnosed as pancreatic cystic neoplasms. Pancreatic cystic neoplasms are being identified in increasing numbers, probably because of the frequent use of radiology and advances in endoscopic techniques. However, they are composed of a variety of neoplasms with a wide range of malignant potential, and it is often difficult to differentiate pancreatic tuberculosis mimicking cystic neoplasms from benign or malignant pancreatic cystic neoplasms. Non-surgical diagnosis of pancreatic tuberculosis is inconclusive and continues to be a challenge in many cases. If so, then laparotomy should be employed to establish the diagnosis. Therefore, pancreatic tuberculosis should be kept in mind during the differential diagnosis of solitary cystic masses in the pancreas. We report a patient who had solitary pancreatic tuberculosis masquerading as pancreatic serous cystadenoma.

关键词： Tuberculosis Pancreas Cystadenoma Serous neoplasm

Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma

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World Journal of Gastroenterology 2017年第18期23卷 3301-3308页

作者： Jang Han Jung Hyun Jik lee Hee seung lee Jung Hyun Jo In Rae Cho Moon jae Chung Jeong Youp Park seung Woo Park Si Young Song seungmin Bang Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Division of Gastroenterology Department of Internal Medicine and Yonsei Institute of Gastroenterology Yonsei University College of Medicine

To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA).METHODSWe retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative *** median disease-free survival (DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 26.0 and 15.1 mo, respectively (P = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively (P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis (P = 0.01).CONCLUSIONNACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability.

关键词： Klatskin tumor Locally advanced Survival rate Neoadjuvant therapy Chemoradiotherapy

Changes of the intestinal endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma (3LL): An immunohistochemical quantitative study

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World Journal of Gastroenterology 2005年第35期11卷 5460-5467页

作者： Sae-Kwang Ku seung-Kyoo Seong Dae-Young Kim Hyeung-Sik lee Jong-Dae Kim Hae-Yun Choi Bu-Il Seo jae-Hyun lee Pharmacology and Toxicology Laboratory Central Research Laboratories Dong-Wha Pharmaceutical Industrial Co Ltd Anyang 430-017 Republic of Korea Developmental Biology/Embryology Division of Biological Science Gachon Medical School Kanghwha 417-840 Republic of Korea Department of Herbal Biotechnology Daegu Haany University Gyeongsan 712-715 Republic of Korea College of Oriental Medicine Daegu Haany University Gyeongsan 712-715 Republic of Korea Laboratory of Histology College of Veterinary Medicine Kyungpook National University Taegu 702-701 Republic of Korea

AIM: To study the distributions and frequencies of intestinal endocrine cells in the C57BL/6 mouse with immunohistochemical method using seven types of specific antisera against chromogranin A (CGA), serotonin,somatostatin, glucagons, gastrin, cholecystokinin (CCK)-8 and human pancreatic polypeptide (hPP) after abdominal subcutaneous implantation of murine lung carcinoma (3LL).METHODS: The experimental animals were divided into two groups, one is non-implanted Sham and the other is 3LL-implanted group. Samples were collected from six regions of intestinal tract at 28th d after implantation of 3LL cells (1×105 cell/mouse).RESULTS: In this study, five types of immunoreactive (IR) cells were identified except for gastrin and hPP. The regional distributions of the intestinal endocrine cells in the 3LL-implanted group were similar to those of the non-implanted Sham. However, significant decreases of IR cells were detected in 3LL-implanted group compared to those of non-implanted Sham. CGA- and serotonin-IR cells significantly decreased in 3LL-implanted groups compared to that of non-implanted Sham. Somatostatin-IR cells in the jejunum and ileum and CCK-8-IR cells in the jejunum of 3LL-implanted groups significantly decreased compared to that of non-implanted Sham. In addition,glucagon-IR cells were restricted to the ileum and colon of non-implanted ***: Implantation of tumor cell mass (3LL)induced severe quantifiable changes of intestinal endocrine cell density and the abnormality in density of intestinal endocrine cells may contribute to the development of gastrointestinal symptoms such as anorexia and indigestion, frequently encountered in patients with cancer.

关键词： Intestinal endocrine cell Immunohistochemistry C57BL/6 mouse 3LL Tumor

3-Dimensional liver volume assessment in patients with hepatitis B virus-related liver cirrhosis during long-term oral nucleos(t)ide analogues therapy

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World Journal of Gastroenterology 2017年第2期23卷 297-305页

作者： Chang Hun lee In Hee Kim Jin Chang Moon seung Young Seo Seong Hun Kim Sang Wook Kim seung Ok lee Soo Teik lee Dae Ghon Kim jae Do Yang Hee Chul Yu Division of Gastroenterology Department of Internal MedicineChonbuk National University Medical School and Hospital Department of Surgery Chonbuk National University Medical School and Hospital

AIMTo assess the effect of long-term oral nucleos(t)ide analogues (NUCs) therapy on liver volume change in patients with suppress hepatitis B virus (HBV)-related liver *** reviewed the data of naïve patients with HBV-related liver cirrhosis, who had taken oral NUCs therapy, between 2003 and 2007 at Chonbuk University Hospital. We analyzed two consecutive sets of abdominal computerized tomography scans-one at the time of treatment initiation and another at the second-year follow-up. Liver volume was calculated by 3-dimensional liver extraction volumetry *** total of 55 patients (34 males) were included. There was 114.3 mL ± 167.8 mL (12.9% ± 17.9%) of increase in liver volume during the two years of NUCs therapy (993.8 mL ± 242.8 mL at baseline vs 1108.1 mL ± 263.3 mL at two-year follow-up, P < 0.001). The ratio of the measured baseline liver volume to the estimated standard liver volume was improved from 70.8% to 78.0%. An increase in liver volume was shown not only in patients with compensated cirrhosis (P = 0.046) but also in those with decompensated cirrhosis (P < 0.001). Significant factors for volume increases were Child-Turcotte-Pugh grade and model for end-stage liver disease score improvement without virological breakthrough. In multiple linear regression analysis, delta albumin and delta alanine aminotransferase levels showed a significant association with the increase in liver volume (P = 0.002 and 0.005, respectively).CONCLUSIONLong-term oral NUCs therapy in patients with HBV-related liver cirrhosis lead to significant increase in liver volume assessed with 3-dimensional liver extraction volumetry program.

关键词： Antiviral agents Liver cirrhosis Liver regeneration Image processing Computer-assisted

The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction

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Asian Journal of Andrology 2019年第5期21卷 493-500页

作者： Min Chui Cho Junghoon lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son jae-seung Paick Soo Woong Kim Department of Urology Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea Department of Urology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080Korea Department of Biostatistics Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea

We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous apoptosis in a rat model of cavernous nerve crush injury(CNCI).Seventy 12-week-old Sprague-Dawley rats were equally distributed into five groups as follows:(1)sham surgery(Group S),(2)CNCI(Group I),(3)CNCI treated with daily intraperitoneal administration of 10.0 mg kg^-1 LIMK2i(Group I+L),(4)daily oral administration of 20.0 mg kg-1 udenafil,PDE5i(Group I+U),and(5)combined administration of 10.0 mg kg^-1 LIMK2i and 20.0 mg kg^-1 udenafil(Group I+L+U).Rats in Groups I+L,I+U,and I+L+U were treated with respective regimens for 2 weeks after *** 2 weeks after surgery,erectile response was assessed using *** tissues were processed for histological studies and western *** I showed lower intracavernous pressure(ICP)/mean arterial pressure(MAP),lower area under the curve(AUC)/MAP,decreased immunohistochemical staining for alpha-smooth muscle(SM)actin,higher apoptotic index,lower SM/collagen ratio,increased phospho-LIMK2-positive fibroblasts,decreased protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)phosphorylation,increased LIMK2/cofilin phosphorylation,and increased protein expression of fibronectin,compared to Group *** all three treatment groups,erectile responses,protein expression of fibronectin,and SM/collagen ratio were *** I+L+U showed greater improvement in erectile response than Group I+*** content and apoptotic index in Groups I+U and I+L+U were improved compared to those in Group ***,Group I+L did not show a significant improvement in SM content or apoptotic *** number of phospho-LIMK2-positive fibroblasts was normalized in Groups I+L and I+L+U,but not in Group I+***/eNOS phosphorylation was improved in Groups I+U and I+L+U,but not in Group I+***2/cofilin phosphorylation was i

关键词： apoptosis erectile dysfunction fibrosis LIM kinase phosphodiesterase

Comparative Study of Visual and Instrumental Analyses of Shade Selection

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Journal of Wuhan University of Technology(Materials Science) 2010年第1期25卷 62-67页

作者： Jee-Ha Choi Ju-Mi Park seung-Geun Ahn Kwang-Yeob Song Min-Ho lee jae-Youn Jung Xinyu Wang Department of Prosthodontics and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University Jeonju Republic of Korea Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

The difference between visual and instrumental analyses of a shade selection on natural teeth was investigated. With visual analysis, five prosthodontist examined the middle third of the unrestored maxillary right central incisor of a patient using VITAPEN classical and Vita Toothguide 3D-MASTER tooth shade guide. In instrumental analysis, one prosthodontist examined the same teeth using a spectrophotometer （ShadepilotTM, Degudent, Hanau-Wolfgang, Germany, software 2.40）. Overall, instrumental analysis is more accurate and reproducible than a visual assessment. However, the difference is clinically acceptable.

关键词： shade selection visual analysis instrumental analysis spectrophotometer