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Chinese Journal of natural Medicines 2024年第5期22卷 441-454页

作者： SHAO Siyuan SUn mohan MA Xianjie JIAnG Jianwei TIAn Jinying ZHAnG Jianjun YE Fei lI Shuai State Key laboratory of Bioactive Substance and Function of natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla *** structures were elucidated through comprehensive analyses of nMR and HRESIMS spectroscopic *** absolute configurations of these compounds were determined by calculating rotational energy barriers and comparison of experimental and calculated ECD *** 5b and 6 exhibited inhibitory effects on lPS-induced nO production in BV-2 cells,with IC_(50) values of 12.59±0.40 and 15.59±0.83μmol·l^(-1),respectively.A mechanistic study suggested that these compounds may attenuate neuroinflammation by reducing the activation of the AKT/IκB/nF-κB signaling ***,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) values of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol·l^(-1),*** investigation revealed that compound 3a might inhibit lPS-induced PTP1B overexpression and nF-κB activation,thereby mitigating the neuroinflammatory response in BV-2 cells.

关键词： Bletilla striata Phenanthrene/bibenzyl trimer nO inhibition AKT/IκB/nF-κB signaling pathway PTP1B inhibitory effect

The in-depth transmission and reception process of the factors influencing review helpfulness from the signaling timeline perspective

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中国科学技术大学学报 2024年

作者： mohan Wang Fei Wan Jiaying Zhang Songyun Xia Key laboratory of Brain–Machine Intelligence for Information Behavior (Ministry of Education and Shanghai) School of Business and Management Shanghai International Studies University Mckelvey School of Engineering Washington University in St.Louis

Many existing studies have considered the factors influencing review helpfulness, mainly focusing on reviewer impact, review informativeness, and managerial response, based on signaling theory. However, previous studies have simply regarded these factors as independent signals, thus ignoring their in-depth transmission and reception *** conclusions about the impact of reviewers on review helpfulness are also inconsistent due to the inaccurate measurement of variables. To fill the above gaps, we followed the signaling timeline theoretical framework used in signaling theory and employed a bootstrapping analysis to examine how reviewer impact, review informativeness, and hotel managerial responses interact to influence review helpfulness. In this study, we used a unique dataset that included official labels from one leading online travel agency. The results show that reviewer impact may affect review helpfulness sequentially through review informativeness and hotel managerial response. Furthermore, by using official labels, both reviewer expertise and reviewer experience significantly affect review helpfulness. Finally, we discuss the theoretical and practical implications of these findings.

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Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

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Microsystems & nanoengineering 2024年第2期10卷 207-218页

作者： Preksha Gupta Ambili mohan Apurv Mishra Atindra nair neeladri Chowdhury Dhanush Balekai Kavyashree Rai Anil Prabhakar Taslimarif Saiyed Discovery Innovation Accelerator Centre for Cellular and Molecular PlatformsBellary RoadBengaluru560065KarnatakaIndia Department of Electrical Engineering Indian Institute of Technology MadrasChennai600036Tamil NaduIndia

Droplet microfluidics has emerged as a critical component of several high-throughput single-cell analysis techniques in biomedical research and *** significant progress in the development of individual assays,multiparametric optical sensing of droplets and their encapsulated contents has been *** current approaches,most commonly involving microscopy-based high-speed imaging of droplets,are technically complex and require expensive instrumentation,limiting their widespread *** address these limitations,we developed the OptiDrop platform;this platform is a novel optofluidic setup that leverages the principles of flow *** platform enables on-chip detection of the scatter and multiple fluorescence signals from the microfluidic droplets and their contents using optical *** highly customizable on-chip optical fiber-based signal detection system enables simplified,miniaturized,low-cost,multiparametric sensing of optical signals with high sensitivity and single-cell resolution within each *** demonstrate the ability of the OptiDrop platform,we conducted a differential expression analysis of the major histocompatibility complex(MHC)protein in response to IFnγ*** results showed the platform’s ability to sensitively detect cell surface biomarkers using fluorescently labeled ***,the OptiDrop platform combines the versatility of flow cytometry with the power of droplet microfluidics to provide wide-ranging,scalable optical sensing solutions for research and diagnostics.

关键词： scatter enable resolution

Management of male obesity-related secondary hypogonadism:A clinical update

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World Journal of Experimental Medicine 2024年第2期14卷 11-28页

作者： mohan T Shenoy Sunetra Mondal Cornelius James Fernandez Joseph M Pappachan Department of Endocrinology Sree Gokulam Medical Collegeand Research FoundationTrivandrum 695607KeralaIndia Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

The global obesity pandemic has resulted in a rise in the prevalence of male obesity-related secondary hypogonadism(MOSH)with emerging evidence on the role of testosterone *** aim to provide an updated and practical approach towards its *** did a comprehensive literature search across MEDlInE(via PubMed),Scopus,and Google Scholar databases using the keywords“MOSH”OR“Obesity-related hypogonadism”OR“Testosterone replacement therapy”OR“Selective estrogen receptor modulator”OR“SERM”OR“Guidelines on male hypogonadism”as well as a manual search of references within the articles.A narrative review based on available evidence,recommendations and their practical implications was *** weight loss is the ideal therapeutic strategy for patients with MOSH,achievement of significant weight reduction is usually difficult with lifestyle changes alone in real-world ***,androgen administration is often necessary in the management of hypogonadism in patients with MOSH which also improves many other comorbidities related to ***,there is conflicting evidence for the appropriate use of testosterone replacement therapy(TRT),and it can also be associated with *** evidence-based review updates the available evidence including the very recently published results of the TRAVERSE trial and provides comprehensive clinical practice pearls for the management of patients with *** starting testosterone replacement in functional hypogonadism of obesity,it would be desirable to initiate lifestyle modification to ensure weight *** should be coupled with the management of other comorbidities related to obesity in MOSH *** the risks and benefits of TRT should be considered in every patient before and during longterm management.

关键词： Male obesity-related secondary hypogonadism Androgen therapy Testosterone replacement therapy Obesity Cardiovascular benefits

A Journey Along the Frontier:My Attempts to Bring Accountability to Shadow Education in Australia and Beyond

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ECnU Review of Education 2024年第1期7卷 111-130页

作者： mohan Dhall University of Technology Sydney

●This article provides insights into stakeholders'challenges while bringing educational accountability to private tutoring providers through a self-regulation *** is no participant involved in this narrative inquiry study.●Policymakers may be ambivalent about bringing accountability as their families may benefit from private tutoring.●This account is written from the perspective of a teacher-trained tutor who has worked with policymakers to address some of the challenges.●This first-person narrative describes the experience of establishing a national peak body to bring greater accountability to private tutoring *** peak body is unique because it positions the educational interests of students as at least equal to providers'commercial interests.●The author believes that greater accountability for tutoring businesses is required in all markets and that issues will not resolve through self-regulation alone.

关键词： Coaching coaching colleges shadow education tuition tutoring

An Intelligent Big Data Security Framework Based on AEFS-KEnn Algorithms for the Detection of Cyber-Attacks from Smart Grid Systems

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Big Data Mining and Analytics 2024年第2期7卷 399-418页

作者： Sankaramoorthy Muthubalaji naresh Kumar Muniyaraj Sarvade Pedda Venkata Subba Rao Kavitha Thandapani Pasupuleti Rama mohan Thangam Somasundaram Yousef Farhaoui Department of Electrical and Electronics Engineering CMR College of Engineering&TechnologyHyderabad 501401India Department of Electronics and Communication Engineering Vardhaman College of Engineering KacharamShamshabad 501218India Department of Electronics and Communication Engineering Sreenidhi Institute of Science and TechnologyHyderabad 501301India Department of Electronics and Communication Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Electrical and Electronics Engineering Bharat Institute of Engineering and TechnologyHyderabad 501510India Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidhyapeethamBengaluru 560035India T-IDMS Department of Computer ScienceFaculty of Sciences and TechniquesMoulay Ismail UniversityErrachidia 52000Morocco

Big data has the ability to open up innovative and ground-breaking prospects for the electrical grid,which also supports to obtain a variety of technological,social,and financial *** is an unprecedented amount of heterogeneous big data as a consequence of the growth of power grid technologies,along with data processing and advanced *** main obstacles in turning the heterogeneous large dataset into useful results are computational burden and information *** original contribution of this paper is to develop a new big data framework for detecting various intrusions from the smart grid systems with the use of AI ***,an AdaBelief Exponential Feature Selection(AEFS)technique is used to efficiently handle the input huge datasets from the smart grid for boosting ***,a Kernel based Extreme neural network(KEnn)technique is used to anticipate security vulnerabilities more *** Polar Bear Optimization(PBO)algorithm is used to efficiently determine the parameters for the estimate of radial basis ***,several types of smart grid network datasets are employed during analysis in order to examine the outcomes and efficiency of the proposed AdaBelief Exponential Feature Selection-Kernel based Extreme neural network(AEFS-KEnn)big data security *** results reveal that the accuracy of proposed AEFS-KEnn is increased up to 99.5%with precision and AUC of 99%for all smart grid big datasets used in this study.

关键词： smart grid Machine learning(Ml) big data analytics AdaBelief Exponential Feature Selection(AEFS) Polar Bear Optimization(PBO) Kernel Extreme neural network(KEnn)

Combining stochastic density functional theory with deep potential molecular dynamics to study warm dense matter

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Matter and Radiation at Extremes 2024年第1期9卷 44-57页

作者： Tao Chen Qianrui liu Yu liu liang Sun mohan Chen HEDPS CAPTCollege of Engineering and School of PhysicsPeking UniversityBeijing 100871People’s Republic of China

In traditional finite-temperature Kohn–Sham density functional theory(KSDFT),the partial occupation of a large number of high-energy KS eigenstates restricts the use of first-principles molecular dynamics methods at extremely high ***,stochastic density functional theory(SDFT)can overcome this ***,SDFT and the related mixed stochastic–deterministic density functional theory,based on a plane-wave basis set,have been implemented in the first-principles electronic structure software ABACUS[*** and ***,***.B 106,125132(2022)].In this study,we combine SDFT with the Born–Oppenheimer molecular dynamics method to investigate systems with temperatures ranging from a few tens of eV to 1000 ***,we train machine-learning-based interatomic models using the SDFT data and employ these deep potential models to simulate large-scale systems with long ***,we compute and analyze the structural properties,dynamic properties,and transport coefficients of warm dense matter.

关键词： stochastic theory functional

Impact Acceleration Signals in Pavement Engineering for Assessing load-Bearing Capacity and fracturing Degree

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： mohan Zhao Yu liu Xinnan Xu Yuhao Pei Chengmiao Zhang Chaofan Wu Key laboratory of Special Area Highway Engineering of Ministry of Education， Chang'an University Xi'an Changda Highway Maintenance Technology Go.，lTD

Efficient and targeted evaluation of pavement bearing capacity， especially for specific layers， is critical for pavement construction and maintenance. This study introduces a novel falling weight impact method that establishes a direct relationship between material modulus and impact acceleration signals based on Hertz elastic theory. Through a combination of laboratory experiments and field tests， the method demonstrates that the modulus of the impacted structure can be accurately correlated with the impact acceleration signal. Additionally， the depth of the impact can be effectively controlled by adjusting the falling weight parameters. Key findings from field tests show that the falling weight impact signals are highly correlated with dynamic modulus testing results， allowing for reliable assessment of subgrade bearing capacity. At locations with anomalous deflection， the falling weight device can be used to evaluate the shallow-layer bearing capacity， helping to identify the layer responsible for the deflection anomaly. The falling weight impact signals can also assess the degree of bearing capacity degradation in asphalt pavements with varying levels of cracking. Furthermore， during pavement recycling projects， this method can replace deflection testing， allowing for real-time evaluation of the degree of pavement fracturing. This method is operationally efficient， requires no bearing plate， and enables effective shallow-layer bearing capacity testing. Its characteristics offer a new approach to pavement bearing capacity evaluation and serve as a valuable complement or enhancement to existing testing methods.

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Enhancing Security in QR Code Technology Using AI: Exploration and Mitigation Strategies

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International Journal of Intelligence Science 2024年第2期14卷 49-57页

作者： Saranya Vaithilingam Santhosh Aradhya mohan Shankar Department of Information Technology University of the Cumberlands Williamsburg KY USA

The widespread adoption of QR codes has revolutionized various industries, streamlined transactions and improved inventory management. However, this increased reliance on QR code technology also exposes it to potential security risks that malicious actors can exploit. QR code Phishing, or “Quishing”, is a type of phishing attack that leverages QR codes to deceive individuals into visiting malicious websites or downloading harmful software. These attacks can be particularly effective due to the growing popularity and trust in QR codes. This paper examines the importance of enhancing the security of QR codes through the utilization of artificial intelligence (AI). The abstract investigates the integration of AI methods for identifying and mitigating security threats associated with QR code usage. By assessing the current state of QR code security and evaluating the effectiveness of AI-driven solutions, this research aims to propose comprehensive strategies for strengthening QR code technology’s resilience. The study contributes to discussions on secure data encoding and retrieval, providing valuable insights into the evolving synergy between QR codes and AI for the advancement of secure digital communication.

关键词： Artificial Intelligence Cyber Security QR Codes Quishing AI Framework Machine learning AI-Enhanced Security

Comparison of the Anatomy and Adaptability of Reconstructed Teeth with natural Teeth:An Innovative Approach in Forensic Dentistry

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Journal of Forensic Science and Medicine 2024年第1期10卷 47-54页

作者： Supraja S P M Tejaswi Ravikanth Manyam mohan Kumar Pasupuleti Swetha P Ramesh Kumar Budumuru Department of Oral and Maxillofacial Pathology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Vishnu Dental College BhimavaramAndhra PradeshIndia Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Oral Medicine and Radiology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Background:Forensic tooth reconstruction is the technique of reconstructing the morphology of a missing tooth from the intra-alveolar morphology of dental sockets from skeletal *** and Objectives:The aim and objective of the study are to compare and investigate whether the anatomy and adaptability of reconstructed teeth simulate with the natural tooth and to investigate whether the dental materials have potential in reconstruction of *** and Methods:An in vitro experimental study was undertaken on a human *** to the Fédération Dentaire Internationale,charting will be done based on the number of teeth *** entire study will be conducted in three phases using dental *** 1 comprised preparation for negative replica,where an impression will be taken,Phase 2 comprised preparation of a positive replica or cast,and Phase 3 comprised tooth reconstruction using the flowable ***:The specimen tooth(which had been taken from its socket)and the newly constructed tooth were compared,and when the length of the newly constructed root was measured using digital vernier calipers,there was a disparity of 0.5-1 *** cone-beam computed tomography radiographs demonstrated the necessary ***:The present study demonstrated that dental information can be obtained even when teeth are absent postmortem by making an attempt to recreate the teeth using dental materials while documenting the intra-alveolar anatomy of the dental root socket.

关键词： Adaptability anatomy reconstruction teeth