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现代生物医学进展 2017年第4期17卷 I0001-I0001页

作者： Yingfei Wang Ran An George K Umanah Hyejin Park Kalyani Nambiar Stephen m Eacker BongWoo Kim Lei Bao maged m Harraz Calvin Chang Rong Chen Jennifer E Wang TaeIn Kam Jun Seop Jeong Zhi Xie Stewart Neifert Jiang Qian Shaida A Andrabi seth Blackshaw Heng Zhu Hongjun Song GuoLi ming Valina L Dawson Ted m Dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. tdawson@jhmi.edu vdawson1@jhmi.edu yingfei.wang@utsouthwestern.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pathology University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX 75390 USA. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology of Huashan Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China. Adrienne Helis malvin medical Research Foundation New Orleans LA 70130-2685 USA. Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pharmacology and molecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Center for High-Throughput Biology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Physiology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋... 详细信息

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。

关键词：细胞死亡脑损伤神经退行性疾病鉴定阿尔茨海默病分子事件研究人员致命性

Nature：研究鉴定出侵袭性胰腺癌细胞及其弱点

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现代生物医学进展 2017年第14期17卷 I0002-I0003页

作者： Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, maria Nezi, Luigi Corti, Denise minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal molin, marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas maitra, Anirban Roberts, Charles W. m. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda Univ Texas mD Anderson Canc Ctr Dept Genom Med Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Inst Appl Canc Sci Houston TX 77030 USA European Inst Oncol I-20141 Milan Italy Sun Yat Sen Univ Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Univ Cattolica Sacro Cuore Ist Patol Gen I-00168 Rome Italy Baylor Coll med Grad Program Struct & Computat Biol & Mol Biophys Houston TX 77030 USA Johns Hopkins Univ Sol Goldman Pancreat Canc Res Ctr Dept Pathol Baltimore MD 21287 USA Univ Texas mD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Translat Mol Pathol Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Off Technol Commercializat Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Canc Biol Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr ORBIT Platform Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Surg Oncol Houston TX 77030 USA Friedrich Alexander Univ Erlangen Nuremberg Univ Hosp Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R D-91054 Erlangen Germany St Jude Childrens Res Hosp Ctr Comprehens Canc Memphis TN 77027 USA St Jude Childrens Res Hosp Dept Oncol Memphis TN 77027 USA C4 Therapeut Cambridge MA 02142 USA Univ Texas Syst Inst Hlth Transformat Austin TX 78701 USA

在一项新的研究中，来自美国德州大学mD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为... 详细信息

在一项新的研究中，来自美国德州大学mD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型，并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。

关键词：胰腺癌癌细胞侵袭性鉴定异种移植研究人员细胞类型细胞转化

结合二维乳腺成像经验,阅片者在使用三维断层成像系统后,诊断能力有否改变?

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国际医学放射学杂志 2017年第4期 460-460页

作者： L.Tucker F.J.Gilbert S.m.Astley A.Dibden A.seth J.morel S.Bundred 马隽 Department of Radiology University of Cambridge Cambridge Biomedical Campus

摘要目的评估具有多年数字钼靶摄影诊断经验及大阅读量的阅片者的诊断能力是否会随着使用数字乳腺三维断层成像系统(DBT)和二维乳腺钼靶成像而发生改变。材料与方法在取得知情同意后,8 869名女性(年龄29～85岁,平均56岁)被招募进行TOmm...

摘要目的评估具有多年数字钼靶摄影诊断经验及大阅读量的阅片者的诊断能力是否会随着使用数字乳腺三维断层成像系统(DBT)和二维乳腺钼靶成像而发生改变。材料与方法在取得知情同意后,8 869名女性(年龄29～85岁,平均56岁)被招募进行TOmmY试验(一项在英国国民健康服务的乳腺癌筛查方案中综合对比乳腺数字摄影的试验),该

关键词：

Critical care practice in India:Results of the intensive care unit need assessment survey(ININ2018)

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World Journal of Critical Care medicine 2020年第2期9卷 31-42页

作者： Rahul Kashyap Kirtivardhan Vashistha Chetan Saini Taru Dutt Dileep Raman Vikas Bansal Harpreet Singh Geeta Bhandari Nagarajan Ramakrishnan Harshit seth Divya Sharma Premkumar Seshadri mradul Kumar Daga mohan Gurjar Yash Javeri Salim Surani Joseph Varon 无 Department of Anesthesiology and Perioperative medicine Mayo ClinicRochesterMN 55905United States Department of Infectious Disease Mayo ClinicRochesterMN 55905United States Department of Internal medicine Allegheny General HospitalPittsburghPA 15212United States Department of Radiology Mayo ClinicRochesterMN 55905United States Department of medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 14061United States Department of Neurology Mayo ClinicRochesterMN 55905United States and Department of PsychiatryHennepin County Medical CenterMinneapolisMN 55415United States Department of medicine Cloud Physician HealthcareBangalore 560038India Department of Critical Care medicine Mayo ClinicRochesterMN 55905United States Department of Internal medicine Maulana Azad Medical College&Associated HospitalsNew DelhiDelhi 110002India Department of Anesthesiology Government Medical CollegeHaldwaniNainital 263129India Department of Critical Care medicine Apollo HospitalsChennai 600006India Department of Hospitalist medicine Allegany ClinicAllegany Health NetworkPittsburghPA 15222United States Premkumar Seshadri Department of MedicineMAAGF HealthcareChennai 600024India Department of Internal medicine and Center for Occupational and Environment Health Maulana Azad Medical CollegeNew DelhiDelhi 110002India Department of Critical Care medicine Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India Department of Critical Care medicine Regency Super Speciality HospitalLucknow 208005India Nayati Healthcare New DelhiDelhi 110065India Department of Pulmonary and Critical Care medicine Texas A&M UniversityCollege StationTX 77843United States Department of Critical Care United Memorial Medical CenterHoustonTX 77091United States ININ-2018 Investigators Team

BACKGROUND A diverse country like India may have variable intensive care units(ICUs)practices at state and city *** To gain insight into clinical services and processes of care in ICUs in India,this would help plan for potential educational and quality improvement *** The Indian ICU needs assessment research group of diverse-skilled individuals was formed.A pan-India survey"Indian National ICU Needs"assessment(ININ 2018-I)was designed on google forms and deployed from July 23rd-August 25th,*** survey was sent to select distribution lists of ICU providers from all 29 states and 7 union territories(UTs).In addition to emails and phone calls,social medial applications-WhatsApp™,Facebook™and LinkedIn™were used to remind and motivate *** completing and submitting the survey,providers gave their consent for research *** study was deemed eligible for category-2 Institutional Review Board exempt *** There were total 134 adult/adult-pediatrics ICU responses from 24(83%out of 29)states,and two(28%out of 7)UTs in 61 *** had median(IQR)16(10-25)beds and most,were mixed medical-surgical,111(83%),with 108(81%)being adult-only *** responders were young,median(IQR),38(32-44)years age and majority,n=108(81%)were *** consultants were,n=101(75%).A total of 77(57%)reported to have 24 h in-house intensivist.A total of 68(51%)ICUs reported to have either 2:1 or 2≥:1 patient:nurse *** than 80%of the ICUs were open,and mixed *** followed regularly by the ICUs included sepsis care,ventilator-associated pneumonia(83%each);nutrition(82%),deep vein thrombosis prophylaxis(87%),stress ulcer prophylaxis(88%)and glycemic control(92%).Digital infrastructure was found to be poor,with only 46%of the ICUs reporting high-speed internet *** In this large,national,semi-structured,need-assessment survey,the need for improved manpower including;in-house intensivists,and decreasing

关键词： Intensive care unit Critical care India Survey Intensive care unit survey Intensive care unit needs

Early Infant Diagnosis (EID) of HIV: An Experience at a Tertiary Care Hospital in India

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World Journal of AIDS 2012年第1期2卷 1-5页

作者： Supriya m. Paranjpe Rajkunwar S. Phakade Nayana A. Ingole Preeti R. mehta Department of microbiology Seth GS Medical College & KEM Hospital Mumbai India

Introduction: Early infant diagnosis (EID) confers substantial benefit to HIV infected and HIV uninfected infants and to programmes providing prevention of mother to child transmission (mTCT), but has been challenging to implement in resource limited settings. Objectives: To find out the rate of perinatal transmission in infants born to HIV positive mothers, to study the effect of various predisposing factors on HIV transmission and to evaluate the utility of dried blood spot (DBS) specimen for EID of HIV. methods: Infants born to HIV positive mothers were tested according to National AIDS Control Organization (NACO) guidelines. Infants of 6 weeks to 6 months of age (n = 84) were diagnosed by DBS PCR;DBS positive results were confirmed by whole blood PCR. Infants 6 - 18 months (n = 47) were subjected to antibody test and if positive were confirmed by DNA PCR. Detailed history including type of delivery, single dose nevirapine (SDN) and breast feeding was taken. Results: The HIV transmission rate was 10.69%. In children ≤ 6 months, who did not receive SDN the positivity was 44.44% (4/9) whereas in those who received SDN it was 6.66% (5/75), (P = 0.0063). In children > 6 months the positivity rate was significantly higher in breast fed 42.85% (3/7) as compared to non breast fed 5% (2/40) children (P = 0.0187). There was 100% concordance between DBS and whole blood PCR. Conclusions: In resource limited settings, though HAART should be considered to further reduce mTCT during pregnancy and to prevent the emergence of resistance, SDN should be kept as an option for mothers coming directly in labour. Also, extended ART should be provided to mothers who want to breast feed their children. Early infant diagnosis using DBS specimens will further reduce the morbidity and mortality in these children.

关键词： Early Infant Diagnosis (EID) Dried Blood Spot (DBS) Single Dose Nevirapine (SDN) mother to Child Transmission of HIV (mTCT)

Regional Copper Deficiency in White-Tailed Deer

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标准蛋白和高蛋白小麦的农艺品质与其营养体中氮磷含量的关系

Open Journal of Ecology（生态学期刊） 2023年第1期

作者： seth T. Rankins Randy W. DeYoung Aaron m. Foley J. Alfonso Ortega-S. Timothy E. Fulbright David G. Hewitt Clayton D. Hilton Landon R. Schofield Tyler A. Campbell

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新疆农业科学 1986年第6期 46-47页

作者： D.L.Fjell,G.m.Paulsen,T.L.Walter,J.R.Lawless,赵广才美美美美

人们对小麦籽粒蛋白质的含量及其营养价值愈来愈重视,很多人还试图增加小麦籽粒中的蛋白质含量.seth等人报道,高蛋白和标准蛋白小麦营养体的全氮含量在抽穗前无甚差别,抽穗后高蛋白品种穗中氮的增加比标准蛋白品种更多.meneal等人在5个... 详细信息

人们对小麦籽粒蛋白质的含量及其营养价值愈来愈重视,很多人还试图增加小麦籽粒中的蛋白质含量.seth等人报道,高蛋白和标准蛋白小麦营养体的全氮含量在抽穗前无甚差别,抽穗后高蛋白品种穗中氮的增加比标准蛋白品种更多.meneal等人在5个春小麦品种中发现,它们营养体中的含氮量没有不同,但籽粒中蛋白质含量却有差别,只是变化范围很小.Johnson等人报道,Warrior小麦植株含氮量最高,但其籽粒含氮量最低;Warrior比其它品种能吸收更多的土壤有效氮,但却不能将吸收的土壤有效氮全部转移到籽粒中去.高蛋白品种与标准

关键词：营养体含磷量植株体标准蛋白含P量高蛋白小麦籽粒产量开花期拔节期

Sleep Paralysis - Cultural Significance and Its management

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Psychosomatic medicine Research 2019年第2期1卷 19-25页

作者： Javed Ather Siddiqui Shazia Farheen Qureshi Abdul Khaliq Alghamdi Waseem m marei Department of Psychiatry Mental Health HospitalTaifSaudi Arabia seth GS medical College and KEm Hospital MumbaiIndia Government medical College Aurangabad (Maharashtra) India Consultant Psychiatrist Department of PsychiatristMental Health HospitalTaifSaudi Arabia Arab board of Psychiatry Saudi Arabia Jordanian board Psychiatry Jordan

Sleep paralysis (SP) is a benign,transient episode of immobility and it lasts a few seconds to a few *** can occur while falling asleep or on *** is a condition of unknown etiology and all the skeletal muscles are almost ‘paralyzed’.It leads to an inability to speak or move but individual remains *** review summarizes the existential clinical literature on sleep paralysis most relevant to practitioners;also summarizes the many historical and artistic manifestations of SP in different *** also throws light on the available Arabic literature and others as per the aim of the *** this review,literature search using engines was carried out,and review papers and original research articles were *** start with a review which summarizes the collection of symptoms,prevalence rate,risk factors and etiological theories,characteristics and classification of the SP over the past years up to the present time,also the management in the form of psychotherapy and pharmacotherapy as well as the cultural significances in different *** plays an important role in the genesis and maintenance of many supernatural beliefs such as nocturnal alien abductions,demonic and ghost attacks in individuals with intact reality testing.

关键词： Sleep paralysis meditation muscle relaxation therapy Rapid eye movement sleep Sleep hygiene

Early Infant Diagnosis (EID) of HIV: An Experience at a Tertiary Care Hospital in India

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