检索结果-南通市图书馆

Protein-activated atomic layer deposition for robust crude-oil-repellent hierarchical nano-armored membranes

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第2期69卷 218-226页

作者： Xiaobin Yang Pan Sun Yajie wen Anil U.Mane Jeffrey w.Elam Jun Ma Shaomin Liu seth B.Darling Lu Shao MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA Applied Materials Division Argonne National LaboratoryLemont IL 60439USA Advanced Materials for Energy-water Systems Energy Frontier Research Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of Molecular Engineering University of ChicagoChicago IL 60637USA Department of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environment Harbin Institute of TechnologyHarbin 150090China wA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

Atomic layer deposition(ALD)offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water systems.However,current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation sites.Here,we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/sensitization.As a proof of concept,TiO2 ALD-coated membranes activated by bovine serum albumin exhibit remarkable superhydrophilicity,ultralow underwater crude oil adhesion,and robust tolerance to rigorous environments including acid,alkali,saline,and ethanol.Most importantly,excellent cyclable crude oil-in-water emulsion separation performance can be achieved.The mechanism for activation/sensitization is rooted in reactivity for a particular set of amino acids.Furthermore,the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in biomedical engineering,environmental remediation,lowcarbon manufacturing,catalysis,and beyond.

关键词： Membrane separation Atomic layer deposition water treatment Antifouling

Climate-change habitat shifts for the vulnerable endemic oak species(Quercus arkansana Sarg.)

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2024年第1期35卷 117-127页

作者： Suresh Chandra Subedi seth Drake Binaya Adhikari Mark V.Coggeshall Department of Biological Sciences Arkansas Tech UniversityRussellvilleARUSA Department of Biology University of KentuckyLexingtonKYUSA School of Natural Resources University of Missouri203 ABNR BuildingColumbiaMO 65211USA

Quercus arkansana(Arkansas oak)is at risk of becoming endangered,as the total known population size is represented by a few isolated populations.The potential impact of climate change on this species in the near future is high,yet knowledge of its predicted effects is limited.Our study utilized the biomod2 R package to develop habi-tat suitability ensemble models based on bioclimatic and topographic environmental variables and the known loca-tions of current distribution of Q.arkansana.we predicted suitable habitats across three climate change scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5)for 2050,2070,and 2090.Our findings reveal that the current suitable habitat for Q.arkansana is approximately 127,881 km^(2) across seven states(Texas,Arkansas,Alabama,Louisiana,Mississippi,Georgia,and Florida);approximately 9.5%is encompassed within state and federally managed protected areas.Our models predict that all current suitable habitats will disap-pear by 2050 due to climate change,resulting in a northward shift into new regions such as Tennessee and Kentucky.The large extent of suitable habitat outside protected areas sug-gests that a species-specific action plan incorporating pro-tected areas and other areas may be crucial for its conserva-tion.Moreover,protection of Q.arkansana habitat against climate change may require locally and regionally focused conservation policies,adaptive management strategies,and educational outreach among local people.

关键词： Biomod2 Climate change Conservation Habitat loss Habitat shift Species distribution modeling Oak species

两种富含甘氨酸的RNA结合蛋白参与选择性剪接实现对水稻耐热性的昼夜节律调控

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第1期69卷 59-71页

作者：杨闯罗安妮芦海平 seth Jon Davis 刘建祥 State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China Department of Biology University of YorkYork YO105DDUK

Rice(Oryza sativa L.)production is threatened by global warming associated with extreme high temperatures,and rice heat sensitivity is differed when stress occurs between daytime and nighttime.However,the underlying molecular mechanism are largely unknown.we show here that two glycine-rich RNA binding proteins,Os GRP3 and Os GRP162,are required for thermotolerance in rice,especially at nighttime.The rhythmic expression of Os GRP3/Os GRP162 peaks at midnight,and at these coincident times,is increased by heat stress.This is largely dependent on the evening complex component Os ELF3-2.we next found that the double mutant of Os GRP3/Os GRP162 is strikingly more sensitive to heat stress in terms of survival rate and seed setting rate when comparing to the wild-type plants.Interestingly,the defect in thermotolerance is more evident when heat stress occurred in nighttime than that in daytime.Upon heat stress,the double mutant of Os GRP3/Os GRP162 displays globally reduced expression of heat-stress responsive genes,and increases of m RNA alternative splicing dominated by exon-skipping.This study thus reveals the important role of Os GRP3/Os GRP162 in thermotolerance in rice,and unravels the mechanism on how Os GRP3/Os GRP162 regulate thermotolerance in a diurnal manner.

关键词： Alternative splicing Diurnal regulation Glycine-rich protein Oryza sativa L. Thermotolerance

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

在线全文

学校读者我要写书评

暂无评论

Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka weissferdt Neda Kalhor Jia wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio Iwistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like components.The molecular and immune landscape of PSC has not been well defined.Methods:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA sequencing.we describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical outcomes.Results:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by KRAS.Interestingly,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC tumors.we identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and signaling.The Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized PSCs.Conclusions:we provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with prognosis.IM-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

Concordance between bio-impedance analysis and clinical score in fluid-status assessment of maintenance haemodialysis patients: A single centre experience

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

world Journal of Nephrology 2022年第4期11卷 127-138页

作者： Kamiti Muchiri Joshua K Kayima Elijah N Ogola seth McLigeyo Sally w Ndung’u Samuel K Kabinga Clinical Medicine and Therapeutics University of NairobiNairobi+254Kenya Department of Clinical Medicine and Therapeutics University of NairobiNairobi+254Kenya Department of Public Health University of NairobiNairobi+254Kenya East African Kidney Institute University of NairobiNairobi+254Kenya

BACKGROUND The burden of chronic kidney disease(CKD)is rising rapidly globally.Fluid overload(FO),an independent predictor of mortality in CKD,should be accurately assessed to guide estimation of the volume of fluid to be removed during haemodialysis(HD).Clinical score(CS)and bio-impedance analysis(BIA)have been utilized in assessment of FO and BIA has demonstrated reproducibility and accuracy in determination of fluid status in patients on HD.There is need to determine the performance of locally-developed CSs in fluid status assessment when evaluated against BIA.AIM To assess the hydration status of patients on maintenance HD using BIA and a CS,as well as to evaluate the performance of that CS against BIA in fluid status assessment.METHODS This was a single-centre,hospital-based cross-sectional study which recruited adult patients with CKD who were on maintenance HD at Kenyatta National Hospital.The patients were aged 18 years and above and had been on maintenance HD for at least 3 mo.Those with pacemakers,metallic implants,or bilateral limbs amputations were excluded.Data on the patients’clinical history,physical examination,and chest radiograph findings were collected.BIA was performed on each of the study participants using the Quantum®II bio-impedance analyser manufactured by RJL Systems together with the BC 4®software.In evaluating the performance of the CS,BIA was considered as the gold standard test.A 2-by-2 table of the participants’fluid status at each of the CS values obtained compared to their paired BIA results was constructed(either++,+-,--or-+for FO using the CS and BIA,respectively).The results from this 2-by-2 table were used to compute the sensitivity and specificity of the CS at the various reference points and subsequently plot a receiver operating characteristic(ROC)curve that was used to determine the best cut-off point.Those above and below the best CS cut-off point as determined by the ROC were classified as being positive and negative for FO,respectively.The proportions of participants di

关键词： Bio-impedance analysis Clinical score Chronic kidney disease Maintenance haemodialysis Fluid overload Concordance

A perspective on recent findings and future strategies for reactive aldehyde removal in spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第10期18卷 2190-2191页

作者： seth A.Herr Anna J.Prall Riyi Shi Center for Paralysis Research Purdue UniversityWest LafayetteINUSA Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteINUSA weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA

Acrolein in spinal cord injury:The propensity of reactive aldehydes such as acrolein to both initiate and perpetuate tissue damage after spinal cord injury (SCI) is well established.Formed primarily from lipid peroxidation,acrolein is known to be one of the most reactive aldehydes.Acrolein will quickly overwhelm endogenous clearance mechanisms and antioxidants,and form adductswith lipids,proteins,and DNA.

关键词： aldehydes finding primarily

Concise review on short bowel syndrome: Etiology, pathophysiology, and management

在线全文

学校读者我要写书评

暂无评论

world Journal of Clinical Cases 2022年第31期10卷 11273-11282页

作者： Saraswathi Lakkasani Deeksha seth Imran Khokhar Masara Touza Theodore Jr Dacosta Gastroenterology and Hepatology Saint Michael’s Medical Center in Affiliation with New York Medical CollegeNewarkNJ 07102United States Gastroenterology Chandan Institute of Liver and Biliary SciencesLucknow 226001India Medicine Suburban Medical CenterNorristownPA 19401United States Medicine Saint Michael’s Medical Center in Affiliation with New York Medical CollegeNewarkNJ 07102United States

Adults have approximately 20 feet of small intestine,which is the primary site for absorbing essential nutrients and water.Resection of the intestine for any medical reason may result in short bowel syndrome(SBS),leading to loss of major absorptive surface area and resulting in various malabsorption and motility disorders.The mainstay of treatment is personalized close dietary management.Here we present SBS with its pathophysiology and different nutritional management options available.The central perspective of this paper is to provide a concise review of SBS and the treatment options available,along with how proper nutrition can solve major dietary issues in SBS and help patients recover faster.

关键词： Short bowel Small bowel resection Malabsorption Nutrition Intestinal transplantation

REVEILLE 7 inhibits the expression of the circadian clock gene EARLY FLOwERING 4 to fine-tune hypocotyl growth in response to warm temperatures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2022年第7期64卷 1310-1324页

作者： Ying-Ying Tian wei Li Mei-Jing wang Jin-Yu Li seth Jon Davis Jian-Xiang Liu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310027China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Department of Biology University of YorkHeslingtonYorkYO105DDUK

The circadian clock maintains the daily rhythms of plant growth and anticipates predictable ambient temperature cycles.The evening complex(EC),comprising EARLY FLOwERING 3(ELF3),ELF4,and LUX ARRHYTHMO,plays an essential role in suppressing thermoresponsive hypocotyl growth by negatively regulating PHYTOCHROME INTERACTING FACTOR 4(PIF4)activity and its downstream targets in Arabidopsis thaliana.However,how EC activity is attenuated by warm temperatures remains unclear.Here,we demonstrate that warm temperature-induced REVEILLE7(RVE7)fine-tunes thermoresponsive growth in Arabidopsis by repressing ELF4 expression.RVE7 transcript and RVE7 protein levels increased in response to warm temperatures.Under warm temperature conditions,an rve7 loss-of-function mutant had shorter hypocotyls,while overexpressing RVE7 promoted hypocotyl elongation.PIF4 accumulation and downstream transcriptional effects were reduced in the rve7 mutant but enhanced in RVE7 overexpression plants under warm conditions.RVE7 associates with the Evening Element in the ELF4 promoter and directly represses its transcription.ELF4 is epistatic to RVE7,and overexpressing ELF4 suppressed the phenotype of the RVE7 overexpression line under warm temperature conditions.Together,our results identify RVE7 as an important regulator of thermoresponsive growth that functions(in part)by controlling ELF4 transcription,highlighting the importance of ELF4 for thermomorphogenesis in plants.

关键词： Arabidopsis thaliana ELF4 hypocotyl growth RVE7 warm temperature

Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1505-1511页

作者： seth A.Herr Liangqin Shi Thomas Gianaris Yucheng Jiao Siyuan Sun Nick Race Scott Shapiro Riyi Shi Center for Paralysis Research&Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteINUSA Department of Orthopedics Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityInstitute of Trauma and OrthopedicsShanghaiChina Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA

Lipid peroxidation-derived aldehydes,such as acrolein,the most reactive aldehyde,have emerged as key culprits in sustaining post-spinal cord injury(SCI)secondary pathologies leading to functional loss.Strong evidence suggests that mitochondrial aldehyde dehydrogenase-2(ALDH2),a key oxidoreductase and powerful endogenous anti-aldehyde machinery,is likely important for protecting neurons from aldehydesmediated degeneration.Using a rat model of spinal cord contusion injury and recently discovered ALDH2 activator(Alda-1),we planned to validate the aldehyde-clearing and neuroprotective role of ALDH2.Over an acute 2 day period post injury,we found that ALDH2 expression was significantly lowered post-SCI,but not so in rats given Alda-1.This lower enzymatic expression may be linked to heightened acrolein-ALDH2 adduction,which was revealed in co-immunoprecipitation experiments.we have also found that administration of Alda-1 to SCI rats significantly lowered acrolein in the spinal cord,and reduced cyst pathology.In addition,Alda-1 treatment also resulted in significant improvement of motor function and attenuated post-SCI mechanical hypersensitivity up to 28 days post-SCI.Finally,ALDH2 was found to play a critical role in in vitro protection of PC12 cells from acrolein exposure.It is expected that the outcome of this study will broaden and enhance anti-aldehyde strategies in combating post-SCI neurodegeneration and potentially bring treatment to millions of SCI victims.All animal work was approved by Purdue Animal Care and Use Committee(approval No.1111000095)on January 1,2021.

关键词： acrolein acrolein-lysine adduct alda-1 enzymatic catalyst lipid peroxidation mitochondrial aldehyde dehydrogenase-2 neurotrauma oxidative stress reactive aldehydes spinal cord contusion