检索结果-南通市图书馆

High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?

引用

World Journal of Diabetes 2013年第5期4卷 219-226页

作者： Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz servet Altay Department of Cardiology Cerrahpa a Medical FacultyIstanbul University Department of Cardiology Dicle University Medical Faculty Department of Public Health Cerrahpa a Medical FacultyIstanbul University Department of Cardiology Siyami Ersek Center for Cardiovascular Surgery Section of Cardiology Giresun Egitim Hospital

AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic ***:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific *** adiponectin was assayed by an ELISA ***-2 diabetes was identified by criteria of the American Diabetes *** was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive *** were predicted using Cox proportional hazards regression analysis in models that were controlled for potential ***:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum *** regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each *** for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as *** of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying.

关键词： Adiponectin Antioxidative function Coronary heart disease Creatinine Type-2 diabetes Hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：