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Discrete Evolutionary Genetics: Multiplicative Fitnesses and the Mutation-Fitness Balance

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Applied Mathematics 2011年第1期2卷 11-22页

作者： Thierry Huillet servet Martinez 不详

We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative. Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the fitness-first and mutation-first models, under various schemes of the mutation pattern. We give some stochastic domination relations between the equilibrium states resulting from these models.

关键词： Evolutionary Genetics Fitness Landscape Selection Mutation Stochastic Models Quasi-Stationarity

Improved Artificial Bee Colony Algorithm for Continuous Optimization Problems

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Journal of Computer and Communications 2014年第4期2卷 108-116页

作者： Mustafa servet Kiran Ahmet Babalik Computer Engineering Department Selcuk UniversityKonyaTurkey

The artificial bee colony (ABC) algorithm is a swarm-based metaheuristic optimization technique, developed by inspiring foraging and dance behaviors of honey bee colonies. ABC consists of four phases named as initialization, employed bee, onlooker bee and scout bee. The employed bees try to improve their solution in employed bees phase. If an employed bee cannot improve self-solution in a certain time, it becomes a scout bee. This alteration is done in the scout bee phase. The onlooker bee phase is placed where information sharing is done. Although a candidate solution improved by onlookers is chosen among the employed bee population according to fitness values of the employed bees, neighbor of candidate solution is randomly selected. In this paper, we propose a selection mechanism for neighborhood of the candidate solutions in the onlooker bee phase. The proposed selection mechanism was based on information shared by the employed bees. Average fitness value obtained by the employed bees is calculated and those better than the aver- age fitness value are written to memory board. Therefore, the onlooker bees select a neighbor from the memory board. In this paper, the proposed ABC-based method called as iABC were applied to both five numerical benchmark functions and an estimation of energy demand problem. Obtained results for the problems show that iABC is better than the basic ABC in terms of solution quality.

关键词： Artificial Bee Colony Selection Mechanism Memory Board Numerical Optimization Energy Estimation

Visual outcomes of multifocal intraocular lens implantation in patients with cataract and high hyperopia and patient selection

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1258-1260页

作者： servet Cetinkaya Zeynep Dadaci Nursen Oncel Acir Yasemin Fatma Cetinkaya Halil Ibrahim Yener Muammer Ozcimen Ophthalmology Clinics Turkish Red Crescent Hospital Department of Ophthalmology Faculty of MedicineMevlana University Department of Ophthalmology Ataturk Training and Research Hospital Konya Eye Center Hospital Department of Ophthalmology Konya Training and Research Hospital

Dear Sir,The aim of multifocal intraocular lens(IOL)implantation is to reduce spectacle dependence after the *** optical designs of multifocal IOLs are based on a number of optical concepts that are used to create mul... 详细信息

关键词： IOL LASIK high

Effects of orthodontic experience on the reliability of the GOSLON Yardstick

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Open Journal of Stomatology 2012年第3期2卷 195-199页

作者： Aslihan Uzel servet Dogan Department of Orthodontics Faculty of DentistryCukurova UniversityAdanaTurkey Department of Orthodontics Faculty of DentistryEge UniversityIzmirTurkey

Objective: The aim of this study was to investigate the importance of the clinical experience on the reliability of the GOSLON Yardstick. Design: Comparative-measures study. Material: 3D images of the study models of children with complete unilateral cleft lip and palate (n: 119) at an average age of 9 years were included to the study. All subjects had their cleft lip and palate repaired in many hospitals by different surgeons, but no alveolar graft or any orthodontic treatment was performed. Method: Digital views of the models were used by Orthomodel software program. 3D images of the study models were scored by two groups of raters (Group I: 10 experienced orthodontists, Group II: 10 post-graduate orthodontic stu-dents) after careful perusal of published literature concerning GOSLON scoring and examining dental models samples. Main outcome measures: Statistics of intra- and inter-rater agreement. Results: Intra-rater agreement measurements of the two groups were high and high inter-rater agreement was also found between the two groups. Conclusion: Based on the results of this study clinical orthodontic experience does not affect significantly the reliability of the GOSLON Yardstick when all the raters trained before scoring.

关键词： GOSLON Yardstick Unilateral Cleft Palate Three-Dimensional Images Clinical Experience

Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets:A pilot study

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World Journal of Gastroenterology 2014年第41期20卷 15382-15386页

作者： Erdinc Yenidogan Ismail Okan Huseyin Ayhan Kayaoglu Gokhan Giray Akgul Mufit Sansal servet Tali Zeki Ozsoy Mustafa Sahin Department of General Surgery Faculty of MedicineGaziosmanpasa University

AIM: To evaluate the efficacy of same-day bowel preparation with Senna alkaloids combined with bisacodyl tablets in routine colonoscopy procedures.

关键词： Bisacodyl Bowel preparation Colonoscopy Same-day preparation Senna alkaloid

Effects of glutamine and curcumin on bacterial translocation in jaundiced rats

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World Journal of Gastroenterology 2010年第34期16卷 4313-4320页

作者： Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali servet Karahan Department of Surgery Okmeydani Education and Research Hospital Department of Biochemistry Istanbul Faculty of Medicine Istanbul 34725 Turkey Department of Infectious Disease Istanbul Faculty of Medicine Istanbul 34715 Turkey

AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice.

关键词： Obstructive jaundice Bacterial translocation Oxidative damage Glutamine Curcumin

Stacking transition in rhombohedral graphite

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Frontiers of physics 2019年第1期14卷 67-73页

作者： Tataiana Latychevskaia Seok-Kyun Son Yaping Yang Dale Chancellor Michael Brown servet Ozdemir Ivan Madan Gabriele Berruto Fabrizio Carbone Artem Mishchenko Kostya S. Novoselov Institute of Physics Laboratory for Ultrafast Microscopy and Electron Scattering (LUMES)école Polytechnique Fédérale de Lausanne (EPFL) CH-1015 Lausanne Switzerland National Graphene Institute University of Manchester Oxford Road Manchester M13 9PL UK School of Physics and Astronomy University of Manchester Oxford Road Manchester M13 9PL UK

Few-layer graphene (FLG) has recently been intensively investigated for its variable electronic properties, which are defined by a local atomic arrangement. While the most natural arrangement of layers in FLG is ABA (Bernal) stacking, a metastable ABC (rhombohedral) stacking, characterized by a relatively high-energy barrier, can also occur. When both types of stacking occur in one FLG device, the arrangement results in an in-plane heterostructure with a domain wall (DW). In this paper, we present two approaches to demonstrate that the ABC stacking in FLG can be controllably and locally turned into the ABA stacking. In the first approach, we introduced Joule heating, and the transition was characterized by 2D peak Raman spectra at a submicron spatial resolution. The transition was initiated in a small region, and then the DW was controllably shifted until the entire device became ABA stacked. In the second approach, the transition was achieved by illuminating the ABC region with a train of 790-nm-wavelength laser pulses, and the transition was visualized by transmission electron microscopy in both diffraction and dark-field imaging modes. Further, using this approach, the DW was visualized at a nanoscale spatial resolution in the dark-field imaging mode.

关键词： graphene graphite van der Waals heterostructures domain wall Raman spectroscopy transmission electron microscopy electron diffraction structural transition

Ocular penetration of topically applied 1% tigecycline in a rabbit model

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 679-683页

作者： Yasar Sakarya Rabia Sakarya Muammer Ozcimen Sertan Goktas Serap Ozcimen Ismail Alpfidan Ismail Senol Ivacik Erkan Erdogan servet Cetinkaya Abdulkadir Bukus Department of Ophthalmology Konya Training and Research Hospital Konya 42090 Turkey Department of Infectious Diseases and Clinical Microbiology Konya State Hospital Konya 42060 Turkey Department of Ophthalmology Konya Kizilay HospitalKonya 42200 Turkey

AIM：To evaluate ocular penetration of topically applied 1% ***：Forty-two New Zealand White rabbits were divided into 3 groups. A 50 μL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered every 15 min for 60min（keratitis protocol）. Aqueous humor samples in groups 1 and 2 were collected under general anesthesia at 15, 30, 45, 60, 120, and 180 min after the last drop. All animals in group 3 were euthanatized. Cornea, vitreous and blood samples were collected 60 and 120 min after the last drop. Tigecycline concentrations were measured using high performance liquid chromatography-mass spectrometry（LC-MS/MS）.RESULTS：The peak aqueous humor tigecycline concentration [mean 0.73±0.14 mg/L（SD） and 2.41±0.14 mg/L, respectively] occurred 45 min after topical drug application in groups 1 and 2. Group 3 mean values in the cornea, and vitreous, were 3.27±0.50 μg/g, and 0.17±0.10 mg/L at 60 min and 3.17±0.77 μg/g and 0.20±0.07 mg/L at 120 min, respectively. Tigecycline serum concentrations were ***：Tigecycline levels in the aqueous humor in groups 1 and 2, and in the cornea in group 3 exceeded the minimum inhibitory concentrations of most grampositive organisms that cause bacterial keratitis and endophthalmitis.

关键词： antibiotic cornea pharmacokinetics aqueoushumor rabbit eyes

Vernacular Building Heritage in the Eastern Black Sea Region in Turkey

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Journal of Civil Engineering and Architecture 2012年第7期6卷 867-875页

作者： Hamiyet Oezen servet Kele Emre Engin Department of Architecture Karadeniz Technical University Trabzon 61080 Turkey

The eastern Black Sea Region, in Turkey, has a significantly authentic characteristic as regards to its rural architecture. The climate, geography, and local living culture in the region have developed an invaluable rural built environment in terms of cultural heritage, Thus, the architectural heritage of the region shows the perfect balance between the nature and human life, there is a need to understand the value of the vernacular architecture heritage in the region, The architecture is a response to functional requirements as well as environmental factors. Indeed, rural architectural of this region is a reflection of the cultural values of the society, behavioural patterns of the people and environmental factors from the past. In this study, the aim is understand and appreciate this heritage through systematic surveying and documentation in eastern Black Sea Region composed from Trabzon, Rize and Artvin Cities. Further aims are the establishment of an architectural typology based on the plan, faqade and site plan, and materials use, with the goal to develop guidelines for new buildings in the region.

关键词： Rural architecture vernacular architecture black sea region cultural heritage.