检索结果-南通市图书馆

Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第18期16卷 2223-2226页

作者： Metin Basaranoglu serra kayacetin Nevin Yilmaz Ertugrul kayacetin Orhan Tarcin Abdullah Sonsuz Division of Gastroenterology Ankara Yüksek Ihtisas Hospital Department of Pathology Konya Education and Teaching Hospital Mugla University School of MedicineGI/Transplant Hepatology Division of Gastroenterology Meram Medical FacultySelcuk University Division of Gastroenterology Yeni Yüzyil University Division of Gastroenterology Cerrahpasa Medical FacultyIstanbul University

A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully *** the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in *** of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed *** these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease.

关键词： Nonalcoholic fatty liver disease Pathogenesis Rat Rodents

Controllable multi-domain semantic artwork synthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2024年第2期10卷 355-373页

作者： Yuantian Huang Satoshi Iizuka Edgar Simo-serra Kazuhiro Fukui Department of Computer Science University of TsukubaTsukuba 305-8577Japan Department of Computer Science and Engineering Waseda UniversityTokyo 169-8050Japan

We present a novel framework for the multidomain synthesis of artworks from semantic *** of the main limitations of this challenging task is the lack of publicly available segmentation datasets for art *** address this problem,we propose a dataset called ArtSem that contains 40,000 images of artwork from four different domains,with their corresponding semantic label *** first extracted semantic maps from landscape photography and used a conditional generative adversarial network(GAN)-based approach for generating high-quality artwork from semantic maps without requiring paired training ***,we propose an artwork-synthesis model using domain-dependent variational encoders for high-quality multi-domain ***,the model was improved and complemented with a simple but effective normalization method based on jointly normalizing semantics and style,which we call spatially style-adaptive normalization(SSTAN).Compared to the previous methods,which only take semantic layout as the input,our model jointly learns style and semantic information representation,improving the generation quality of artistic *** results indicate that our model learned to separate the domains in the latent ***,we can perform fine-grained control of the synthesized artwork by identifying hyperplanes that separate the different ***,by combining the proposed dataset and approach,we generated user-controllable artworks of higher quality than that of existing approaches,as corroborated by quantitative metrics and a user study.

关键词： semantic artwork synthesis generative adversarial network(GAN) datasets non-photorealistic rendering

Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： Marcello serra Nicola Simola Alexia E.Pollack Giulia Costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant Sharma Jenny serra-Vinardell Wendy J.Introne May Christine V.Malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

Ultrasound,contrast-enhanced ultrasound and pyelonephritis:A narrative review

在线全文

学校读者我要写书评

暂无评论

World Journal of Nephrology 2024年第3期13卷 1-8页

作者： Andrea Boccatonda Roberta Stupia Carla serra Department of Medical and Surgical Sciences(DIMEC) University of BolognaBologna 40126Italy Department of General Medicine C Azienda Ospedaliera Universitaria Integrata of VeronaUniversity of VeronaVerona 37134Italy Department of Medical Liver Transplant Care General and University Hospital S.Orsola-MalpighiBologna 40138Italy

Acute pyelonephritis(APN)is a bacterial infection resulting in kidney inflammation,typically arising as a complication of an ascending urinary tract infection that ascends from the bladder to the *** diagnosis is generally based on clinical and laboratory *** guidelines recommend not performing diagnostic imaging unless a complicated APN is suspected or the infection affects high-risk patients such as the elderly,immunocompromised individuals,or ***-enhanced ultrasound(CEUS)is a valuable tool in both the diagnosis and follow-up of *** aids in distinguishing small simple nephritic involvement from abscess complications and monitoring their evolution over time during antibiotic *** its lack of ionizing radiation and nephrotoxicity,CEUS is a valid diagnostic modality for approaching and monitoring pyelonephritis,improving early identification and characterization of inflammatory *** review aims to summarize the main evidence on the use of ultrasound and CEUS in the diagnosis of APN and its follow-up.

关键词： Pyelonephritis Contrast-enhanced ultrasound Kidney Abscess Urinary infection

Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 99-110页

作者： Marwan Laqdiem Julio García-Fayos Laura Almar Alfonso J.Carrillo Álvaro Represa JoséM.López Nieto Sonia Escolástico David Catalán-Martinez Jose M.serra Instituto de Tecnología Química(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(OTMs)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTMs could provide oxygen from different sources(air,water,CO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,OTMs can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTM material(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the OTM is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.The O_(2)permeation flux reached for the electrified membranes was~3.7 NmL min^(-1)cm^(-2),corresponding to the flux obtained with an OTM non-electrified at 900℃.The influence of depositing a porous Ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(CMR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect Mixed ionic-electronic conductors Catalytic membrane reactors

Aging impairs the osteocytic regulation of collagen integrity and bone quality

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman serra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

Green Hydrogen: Perspectives and Challenges in Using the Natural Gas Network in Ceará/Brazil

在线全文

学校读者我要写书评

暂无评论

Journal of Geoscience and Environment Protection 2024年第3期12卷 70-94页

作者： Francisco Alfredo de Castro Mona Lisa Moura de Oliveira Lutero Carmo de Lima Daniel Silveira serra Science and Technology Center State University of Ceará Ceará Brazil Av. Dr. Silas Munguba 1700 Fortaleza-Ceará Brazil

Climate change, mainly caused by the use of non-renewable fuels, has raised global concerns and led to the search for less polluting energy sources, making hydrogen a promising energy alternative with the potential to contribute to changes in the energy mix of various countries through the use of technologies that enable its production and use with low or zero carbon emissions. In this context, Brazil has aroused great interest from other countries in exploring its renewable resources for the production of hydrogen (green hydrogen). In this sense, the use of natural gas pipelines and the use of hydrogen in mixtures with natural gas have become the subject of studies due to their economically viable alternative for the immediate use of this energy vector. However, there are still technical and regulatory challenges regarding the integration of hydrogen into the existing natural gas pipeline network. In this context, the present study aims to address the effects of hydrogen interaction with the structure of natural gas pipeline steel and the regulatory barriers to the use of this network for the transportation of green hydrogen, particularly in the state of Ceará/Brazil. After extensive analysis of literature and regulatory documents, it was concluded that: 1) Ceará/Brazil has strong potential to meet the demand for green hydrogen through the use of solar and wind energy sources;2) there is feasibility for the adaptation or conversion of natural gas infrastructure for the transportation of green hydrogen;3) discussions regarding the regulatory competence of green hydrogen transportation and distribution through the natural gas network in Brazil are still incipient;4) the current regulation of the natural gas industry can serve as a subsidy for the regulation of green hydrogen and natural gas transportation.

关键词： Decarbonization Natural Gas Green Hydrogen Pipelines

罗马花园巴塞罗那Blow Models总部翻新项目

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

室内设计与装修 2024年第8期 26-29页

作者： [西班牙]Isern serra Aasheen Mittal SALVA LOPEZ(摄影) 麦子(编译) 不详

Blow Models是由哈维·法布雷加斯和纳塔利亚·法布雷加斯两兄弟共同组建的一家顶级模特公司,其总部办公室位于西班牙巴塞罗那。本次设计任务是要在原本的沿街建筑内,将总部办公空间进行一次翻新,创建一处适合公司现状及未来持续性发展... 详细信息

Blow Models是由哈维·法布雷加斯和纳塔利亚·法布雷加斯两兄弟共同组建的一家顶级模特公司,其总部办公室位于西班牙巴塞罗那。本次设计任务是要在原本的沿街建筑内,将总部办公空间进行一次翻新,创建一处适合公司现状及未来持续性发展的办公空间,其中需容纳不同的工作区,以及办公室、会议室、厨房、卫生间等功能空间。

关键词：持续性发展巴塞罗那沿街建筑办公空间功能空间翻新塔利亚总部办公

同方期刊数据库