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Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

Cancer Drug Resistance 2020年第4期3卷 879-911页

作者： serkan yaman Uday Chintapula Edgar Rodriguez Harish Ramachandramoorthy Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010USA Joint Bioengineering Program University of Texas Southwestern Medical CenterDallasTX 75235USA

Nanotechnology-based drug delivery platforms have been developed over the last two decades because of their favorable features in terms of improved drug bioavailability and *** recent advancement in nanotechnology platforms,this approach still falls short to meet the complexity of biological systems and diseases,such as avoiding systemic side effects,manipulating biological interactions and overcoming drug resistance,which hinders the therapeutic outcomes of the NP-based drug delivery *** address these issues,various strategies have been developed including the use of engineered cells and/or cell membrane-coated *** membrane receptor profiles and characteristics are vital in performing therapeutic functions,targeting,and homing of either engineered cells or cell membrane-coated nanocarriers to the sites of *** this context,we comprehensively discuss various cell-and cell membrane-based drug delivery approaches towards cancer therapy,the therapeutic potential of these strategies,and the limitations associated with engineered cells as drug carriers and cell membrane-associated drug ***,we review various cell types and cell membrane receptors for their potential in targeting,immunomodulation and overcoming drug resistance in cancer.

关键词： Cell membrane-based drug delivery cell-mediated drug delivery membrane receptors drug carriers cancer drug resistance nanoparticles

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Targeted chemotherapy via HER2-based chimeric antigen receptor(CAR)engineered T-cell membrane coated polymeric nanoparticles

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Bioactive Materials 2024年第4期34卷 422-435页

作者： serkan yaman Harish Ramachandramoorthy Priyanka Iyer Uday Chintapula Tam Nguyen Manoj Sabnani Tanviben Kotadia Soroush Ghaffari Laurentiu M.Pop Raquibul Hannan Jon A.Weidanz Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonTXUSA Department of Biology University of Texas at ArlingtonTXUSA Joint Bioengineering Program University of Texas Southwestern Medical CenterTXUSA Department of Radiation Oncology University of Texas Southwestern Medical CenterTXUSA Department of Kinesiology University of Texas at ArlingtonArlingtonTXUSA

Cell membrane-derived nanoparticles(NPs)have recently gained popularity due to their desirable features in drug delivery such as mimicking properties of native cells,impeding systemic clearance,and altering foreign body *** NP technology,adoptive immunotherapy has emerged due to its promise in cancer specificity and therapeutic *** this research,we developed a biomimetic drug carrier based on chimeric antigen receptor(CAR)transduced T-cell *** that purpose,anti-HER2 CAR-T cells were engineered via lentiviral transduction of anti-HER2 CAR coding lentiviral ***-HER2 CAR-T cells were characterized by their specific activities against the HER2 antigen and used for cell membrane ***-cancer drug Cisplatin-loaded poly(D,L-lactide-co-glycolic acid)(PLGA)NPs were coated with anti-human epidermal growth factor receptor 2(HER2)-specific CAR engineered T-cell ***-HER2 CAR-T-cell membrane-coated PLGA NPs(CAR-T-MNPs)were characterized and confirmed via fluorescent microscopy and flow ***-coated NPs showed a sustained drug release over the course of 21 days in physiological ***-loaded CAR-T-MNPs also inhibited the growth of multiple HER2+cancer cells in *** addition,in vitro uptake studies revealed that CAR-T-MNPs showed an increased uptake by A549 *** results were also confirmed via in vivo biodistribution and therapeutic studies using a subcutaneous lung cancer model in nude ***-T-MNPs localized preferentially at tumor areas compared to those of other studied groups and consisted of a significant reduction in tumor growth in tumor-bearing *** Conclusion,the new CAR modified cell membrane-coated NP drug-delivery platform has demonstrated its efficacy both in vitro and in ***,CAR engineered membrane-coated NP system could be a promising cell-mimicking drug carrier that could improve therapeutic outcomes of lung cancer treatments.

关键词： Nanoparticles CAR-T cells Membrane-based drug delivery Cancer chemotherapy

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