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Efficacy and Risk Factors Associated to Resistance to Single-Agent Chemotherapy in Low-Risk Gestational Trophoblastic Neoplasia

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Open Journal of Obstetrics and Gynecology 2016年第1期6卷 50-55页

作者： Mamour gueye Mame Diarra Ndiaye-gueye serigne modou kane-gueye Fatou Niass Dia Aissatou Thiam Sr. Elisabeth Diouf Jean Charles Moreau Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Cheikh Anta Diop University Dakar Senegal

Objectives: This study aimed to assess efficacy of intramuscular methotrexate 8-day protocol in the treatment of low-risk gestational trophoblastic neoplasia and also identify prognostic factors associated with treatment failure, necessitating second line chemotherapy. Methods: This study was performed at Gynaecologic and Obstetric Clinic of Dakar Teaching Hospital, the reference Centre of Gestational Trophoblastic Disease in Senegal. At the beginning of 2011, patients were followed according to FIGO’s recommendations. From 2011 to 2014, we diagnosed 88 low-risk gestational trophoblastic neoplasia (GTN) patients (WHO score < 7). Low-risk patients started their treatment with methotrexate (MTX) based on the 8-day protocol consisting of 1 mg/kg MTX in combination with 0.1 mg/kg folinic acid (FA) every other day. Resistance to treatment was the main outcome. We studied the association of different prognostic factors included in the World Health Organisation (WHO) scoring system and resistance to the initial single agent chemotherapy. Results: Eighty-eight patients were diagnosed for GTN during the study period. Average age was 31 years. The antecedent pregnancy was molar in 98.1% of cases. Seventy-four patients underwent remission after single agent-chemotherapy. Resistance rate to single-agent chemotherapy was 15.9% (14 patients). Nine of them achieved remission after second line chemotherapy. WHO score was significantly associated with the risk of resistance to single-agent chemotherapy. Other variables included in the WHO as age, antecedent pregnancy, pre-treatment hCG, tumour size and FIGO stage were not significantly associated with resistance. We report five fatal cases. Conclusion: The 8-day protocol consisting of 1 mg/kg MTX in combination with 0.1 mg/kg folinic acid (FA) every other day is effective for women with LRGTN. The only significant prognostic factor for failure is pretreatment WHO score. We highly recommend the use of this protocol particularly in de

关键词： Gestational Trophoblastic Neoplasia Chemotherapy International Federation of Gynecology and Obstetrics Resistance

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Abrikossof’s Tumor: Report of a Case

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Open Journal of Obstetrics and Gynecology 2023年第2期13卷 241-246页

作者： Ndama Niang Aissatou Mbodji Mamour gueye Moussa Diallo Yaye Fatou Omar Gaye serigne modou kane gueye Marie Edouard Faye Dieme Principal Hospital Dakar Senegal Cheikh Anta DIOP University Dakar Senegal Philippe Maguilen Senghor Health Center Dakar Senegal Pikine Hospital Dakar Senegal Assane Seck University Ziguinchor Senegal

The granular cell tumor of the breast is a rare tumor and a usually benign disease that appears clinically and radiologically like a malign tumor. We report a case of GCT in a woman of 41 years, who present a clinically and radiologically suspect later. The anatomopathological examination showed the benign tumor proliferation and a large tumorectomy was realized. The immunostaining with PS100 and NSE protein confirm the nature of the tumor.

关键词： Abrikossof Breast Benign

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Sociodemographic Factors Associated with Delays in Breast Cancer

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Open Journal of Obstetrics and Gynecology 2017年第4期7卷 455-463页

作者： Mamour gueye serigne modou kane gueye Moussa Diallo Ousmane Thiam Aissatou Mbodji Aliou Diouf Khalifa Fall Youssou Toure Hadja Maimouna Barro Daff Jean Charles Moreau Gynaecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Dakar Senegal

Objectives: The aim of our study was to investigate the relation of some sociodemographic factors and delays presentation in breast cancer. Patients and method: This was an observational study in Breast Unit of Aristide Le Dantec Teaching Hospital in Dakar. Were included in the study all patients followed for breast cancer from January 2008 to December 2014. The following variables were selected and stratified: age, place of living, educational attainment, menopausal status, socioeconomic status and family history of breast cancer. For each variable, an association with the stage and presentation delay was assessed. Results: Two hundred and fifty nine (259) patients met the inclusion criteria. No correlation was found between the studied socio-demographic factors and delay. Negative history of family breast cancer was associated with presentation delay. The only factor associated with locally advanced breast cancer after adjusting confounding factors was low level of income. Conclusion: A significant percentage of women with breast cancer in Senegal are experiencing presentation delay. Coordinated efforts with public health department are needed to educate the focused groups and mitigate the barriers.

关键词： Breast Cancer Presentation Delay Stage Survival

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Improving Postpartum Haemorrhage Management Using Simulation in Senegal: Midterm Results

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Open Journal of Obstetrics and Gynecology 2017年第13期7卷 1292-1299页

作者： Mamour gueye Moussa Diallo Mame Diarra Ndiaye gueye Omar Gasama Abdoul Aziz Diouf Mouhamadou Mansour Niang Mohamed Diadhiou Astou Coly Niassy serigne modou kane gueye Marie Edouard Faye Dieme Magatte Mbaye Philippe Marc Moreira Alassane Diouf Jean Charles Moreau Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Cheikh Anta Diop University Dakar Senegal

Objective: To assess a training approach in Emergency Obstetric and Neonatal Care (EmONC) to strengthen skills of healthcare providers and reduce maternal mortality. Materials and methods: The approach was based on the skills training using the so-called “humanist” method and “life saving skills”. Simulated practice took place in the classroom through thirteen clinical stations summarizing the clinical skills on EmONC. The evaluation was done in all phases and the results were recorded in a database to document the progress of each learner. Results: We trained 432 providers in 10 months. The increase in technical achievements of each participant was documented through a database. The combination of training based on the model “learning by doing” has ensured learning and mastering all EmONC skills particularly postpartum haemorrhage management and reduced missed learning opportunities. Conclusion: The impact of training on postpartum haemorrhage management and maternal mortality is a major challenge in terms of prospects.

关键词： Emergency Obstetric Care Postpartum Haemorrhage Training Simulation

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Abrikossof’s Tumor: Report of a Case

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2023年第2期

作者： Ndama Niang Aissatou Mbodji Mamour gueye Moussa Diallo Yaye Fatou Omar Gaye serigne modou kane gueye Marie Edouard Faye Dieme

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Comparative Effects of Natural and Synthetic Fungicides on the Pink Root Disease of Onion (<i>Allium cepa </i>L.), in Nursery

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Agricultural Sciences 2017年第8期8卷 743-750页

作者： Mouhameth Camara Elhadji Faye serigne modou Sarr Emile Victor Coly Mamadou gueye Institut Supérieur de Formation Agricole et Rurale (ISFAR) Université de Thiès Thiès Sénégal Centre pour le Développement de l’Horticulture Institut Sénégalais de Recherche Agricole Dakar Sénégal Université du Sine Saloum de Kaolack (USSK) Kaolack Sénégal

Onion is an important vegetable in Senegal horticulture, where it occupies the first place. However in the greatest areas production like the Gandiolais, in the North of Senegal, Pink root disease caused by a soil born fungus Pyrenochaeta terrestris (Hansen) Gorentz, Walker and Larson affects its productivity especially in nursery. On soil sterilized and inoculated by the fungus, we tested 5 natural fungicides and 2 synthetic fungicides, to measure their effectiveness on the Pink root disease on onion, in nursery. The device used is a split plot with 4 repetitions and 8 treatments. The measured variables are the emergence rates, the survival rates and the infestation rates. Our experimentations have shown that, for the emergence rates, there is no significant difference between thiophanate-methyl (Pelt 44), Carbendazim (Bavistine), Azadirachta indica A. Juss and Carica papaya L. It is the same between C. papaya and Moringa oleifera Lam, between M. oleifera and Cassia alata L. It is also the same between C. alata and Crotolaria retusa L. Regarding the survival rates, there is no significant difference between thiophanate-methyl, Azadirachta indica, Carbendazim, C. papaya and M. oleifera. The same is true between M. oleifera and Cassia alata, and between C. alata and C. retusa. Concerning the infestation rates, apart from the control check, all other treatments show no difference.

关键词： Onion Pink Root Pyrenochaeta terrestris Hansen Fungicides

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Characterizations of Drinking Water Quality for Populations of Hann Bel-Air (Dakar, Senegal)

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Journal of Water Resource and Protection 2020年第10期12卷 898-909页

作者： Alassane Thiam Amadou Babacar Sarr serigne modou Sarr UFR Sciences de l’Ingénieur Université de Thiès Thiès Sénégal Institut de Formation et de Recherches Médicales Dakar Sénégal Institut Supérieur de Formation Agricole et Rurale Université Alioune Diop Bambey Sénégal

Populations of Hann Bel-Air municipality are supplied with drinking water from taps water of “Sénégalaise Des Eaux” (SDE) and Jambar pumps which capturie directly the groundwater. This municipality is characterized by a strong environmental pollution which can affect the quality of drinking water. To determine actual quality of that water, 10 samples were taken and analyzed. Physico-chemical results have shown that tap water is more suitable for domestic consumption than Jambar pump water. The results show that physical parameters such as electrical conductivity (maximum value of 2671 μS/cm) exceed World Health Organization standard. The pH of the water from Jambar pumps is between 6.04 and 6.09, which demonstrates the aggressive character of that water. For tap water, pH values of 7.03 to 7.09 demonstrate their alkalinity. For chemical analyses, bicarbonates and sulphates concentrations respectively meet World Health Organization standards. Tap water meets World Health Organization standard for nitrates. With respect to chloride, the threshold of 250 mg/L is exceeded at all levels, but we note that high chloride concentrations are part of the exemptions granted to SDE. Tap water and water from water table have concentrations of calcium, potassium, iron and magnesium irreproachable. For sodium, EP3, EP4 and P5 samples from the web exceed World Health Organization standard with a peak of 310.27 mg/L. Tap water is more drinkable than groundwater but its quality needs to be improved and especially controlled for the well-being and sustainable health of consumers.

关键词： Hann Bel-Air Water Resources Physico-Chemical Analyses Quality

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Study of Efficiencies CdTe/CdS Photovoltaic Solar Cell According to Electrical Properties by Scaps Simulation

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Natural Resources 2020年第4期11卷 147-155页

作者： serigne Massamba Seck Elhadji Ndiouga Ndiaye modou Fall Stephane Charvet Laboratoire de Physique de la Matiere Condensee(LPMC) Universite de Picardie Jules VerneAmiensFrance Laboratoire de Chimie Physique Organique et d’Analyses Environnementales(LCPOAE) Universite Cheikh Anta DiopDakarSenegal Departement de Physique UFR SATICUniversite Alioune Diop de BambeyBambeySenegal

The photovoltaic performance (efficiency η) of an ITO/CdS/CdTe structure cell is studied in this article according to its electrical properties. The study is carried out by simulation with SCAPS (Solar Cell Capacitance Simulator) whose mathematical model is based on solving the equations of Poisson and continuity of electrons and holes. An electrical conversion efficiency of 23.58% is obtained by optimizing the mobility of the electrons (100 cm2/Vs), that of the holes (25 cm2/Vs), the density of electrons (1015 cm-3), the density of the effective states in the conduction band (7.9 × 1017 cm-3) and the electronic affinity (3.85 eV) of the CdTe absorbent layer.

关键词： Solar Cells Photovoltaic Thin Films CdTe Electron Mobility Charge Carrier Density Simulation SCAPS

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Neonatal Mortality in Rural Area in Senegal

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Open Journal of Pediatrics 2022年第2期12卷 325-331页

作者： Aliou Mar Coundoul Amadou Sow modou gueye Djibril Boiro Fatou Ndiaye Guilaye Diagne Aminata Mbaye Awa kane Mohameth Mbodj Khadim Bop serigne Tawa Ndiaye Papa Souleye Sow Ndeye Fatou Sow Mame Aita Seck Mohamed Fattah Papa Moctar Faye Amadou Lamine Fall Ousmane Ndiaye Albert Royer National Hospital Center Dakar Senegal Abass Ndao Hospital Center Dakar Senegal

Most newborn deaths occur in two regions of the world, South Asia and sub-Saharan Africa. In Senegal, much progress has been made over the past two decades with a reduction in overall infant mortality by 38%. However, the decline in neonatal mortality has been slower during the same period. The objective of this study is to assess neonatal mortality, to determine the different causes and to make recommendations for improving care in rural areas. This is a retrospective study with a descriptive and analytical aim carried out in the pediatrics department of the Diourbel regional hospital, 130 km from Dakar, the Senegalese capital, over a 12-month period from January 1 to January 31, December 2018. All newborns hospitalized in the pediatric ward during the study period were included. Overall mortality was 30.6%, newborns between 0 and 7 days accounted for 90.6% of deaths, INBORNs accounted for 62.3% of deaths. Newborns whose mother’s age was between 20 and 35 years of age accounted for 69.3% of deaths. Newborns of first-time mothers accounted for 40.2% of deaths and those of multiparous mothers 31%. Newborns who did not reach term accounted for 58.9% of deaths. Newborns admitted for respiratory distress represented the majority of deaths 45.5% (n = 93) followed by those with low birth weight 32.5 (n = 65) followed by those with neurological manifestations 30.5 (n = 62). Conclusion: Neonatal mortality is very high in the Diourbel region and the main cause is the lack of human resources and a very insufficient technical platform. The fight against this mortality involves improving the technical platform and recruiting sufficient and well-trained staff.

关键词： Mortality Neonatal Rural Area Senegal

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E_Breast: A Computerized Database Management System for Breast Diseases Patients in a Low Income Country

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Open Journal of Obstetrics and Gynecology 2016年第12期6卷 754-760页

作者： Mamour Guèye Mame Diarra Ndiaye-Guèye serigne modou kane-Guèye Moussa Diallo Mor Cissé Khalifa Fall Hadja Maimouna Barro Daff Mihimit Abdoulaye Sylvestre Gahungu Sidy Ka Jean Charles Moreau Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Dakar Senegal Oncology Clinic Aristide Le Dantec Teaching Hospital Dakar Senegal

Objectives: To report our experience in using an electronic database for management of breast diseases in a developing country. Materials and methods: E-Breast is a database developed on FileMaker Pro Advanced to serve as patient file and breast diseases registry. The development of the platform, its usage and advantages on a manual filing system are described. Results: For 6 years, we use this database, which accounts more than 2000 patients and includes data from more than 10 years. An overview of the activity is easily generated by E-Breast. The generated reports are used to the routine care of patients, statistics and clinical research. Data entered are immediately useful in addition to simultaneously implement the database for clinical research. Many custom features are integrated. For research purposes, the system has the ability to perform detailed analyses on subsets defined by the user as breast cancer, breast benign diseases, etc. Conclusion: E-Breast has proven to be a useful way of documentation that has become an integral and essential part of the daily activity and also a valuable research tool.

关键词： E_Breast Breast Electronic Medical Record Senegal

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