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Efficacy and Risk Factors Associated to Resistance to Single-Agent Chemotherapy in Low-Risk Gestational Trophoblastic Neoplasia

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Open Journal of Obstetrics and Gynecology 2016年第1期6卷 50-55页

作者： Mamour gueye Mame Diarra Ndiaye-gueye serigne modou kane-gueye Fatou Niass Dia Aissatou Thiam Sr. Elisabeth Diouf Jean Charles Moreau Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Cheikh Anta Diop University Dakar Senegal

Objectives: This study aimed to assess efficacy of intramuscular methotrexate 8-day protocol in the treatment of low-risk gestational trophoblastic neoplasia and also identify prognostic factors associated with treatment failure, necessitating second line chemotherapy. Methods: This study was performed at Gynaecologic and Obstetric Clinic of Dakar Teaching Hospital, the reference Centre of Gestational Trophoblastic Disease in Senegal. At the beginning of 2011, patients were followed according to FIGO’s recommendations. From 2011 to 2014, we diagnosed 88 low-risk gestational trophoblastic neoplasia (GTN) patients (WHO score < 7). Low-risk patients started their treatment with methotrexate (MTX) based on the 8-day protocol consisting of 1 mg/kg MTX in combination with 0.1 mg/kg folinic acid (FA) every other day. Resistance to treatment was the main outcome. We studied the association of different prognostic factors included in the World Health Organisation (WHO) scoring system and resistance to the initial single agent chemotherapy. Results: Eighty-eight patients were diagnosed for GTN during the study period. Average age was 31 years. The antecedent pregnancy was molar in 98.1% of cases. Seventy-four patients underwent remission after single agent-chemotherapy. Resistance rate to single-agent chemotherapy was 15.9% (14 patients). Nine of them achieved remission after second line chemotherapy. WHO score was significantly associated with the risk of resistance to single-agent chemotherapy. Other variables included in the WHO as age, antecedent pregnancy, pre-treatment hCG, tumour size and FIGO stage were not significantly associated with resistance. We report five fatal cases. Conclusion: The 8-day protocol consisting of 1 mg/kg MTX in combination with 0.1 mg/kg folinic acid (FA) every other day is effective for women with LRGTN. The only significant prognostic factor for failure is pretreatment WHO score. We highly recommend the use of this protocol particularly in de

关键词： Gestational Trophoblastic Neoplasia Chemotherapy International Federation of Gynecology and Obstetrics Resistance

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Abrikossof’s Tumor: Report of a Case

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Open Journal of Obstetrics and Gynecology 2023年第2期13卷 241-246页

作者： Ndama Niang Aissatou Mbodji Mamour gueye Moussa Diallo Yaye Fatou Omar Gaye serigne modou kane gueye Marie Edouard Faye Dieme Principal Hospital Dakar Senegal Cheikh Anta DIOP University Dakar Senegal Philippe Maguilen Senghor Health Center Dakar Senegal Pikine Hospital Dakar Senegal Assane Seck University Ziguinchor Senegal

The granular cell tumor of the breast is a rare tumor and a usually benign disease that appears clinically and radiologically like a malign tumor. We report a case of GCT in a woman of 41 years, who present a clinically and radiologically suspect later. The anatomopathological examination showed the benign tumor proliferation and a large tumorectomy was realized. The immunostaining with PS100 and NSE protein confirm the nature of the tumor.

关键词： Abrikossof Breast Benign

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Sociodemographic Factors Associated with Delays in Breast Cancer

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Open Journal of Obstetrics and Gynecology 2017年第4期7卷 455-463页

作者： Mamour gueye serigne modou kane gueye Moussa Diallo Ousmane Thiam Aissatou Mbodji Aliou Diouf Khalifa Fall Youssou Toure Hadja Maimouna Barro Daff Jean Charles Moreau Gynaecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Dakar Senegal

Objectives: The aim of our study was to investigate the relation of some sociodemographic factors and delays presentation in breast cancer. Patients and method: This was an observational study in Breast Unit of Aristide Le Dantec Teaching Hospital in Dakar. Were included in the study all patients followed for breast cancer from January 2008 to December 2014. The following variables were selected and stratified: age, place of living, educational attainment, menopausal status, socioeconomic status and family history of breast cancer. For each variable, an association with the stage and presentation delay was assessed. Results: Two hundred and fifty nine (259) patients met the inclusion criteria. No correlation was found between the studied socio-demographic factors and delay. Negative history of family breast cancer was associated with presentation delay. The only factor associated with locally advanced breast cancer after adjusting confounding factors was low level of income. Conclusion: A significant percentage of women with breast cancer in Senegal are experiencing presentation delay. Coordinated efforts with public health department are needed to educate the focused groups and mitigate the barriers.

关键词： Breast Cancer Presentation Delay Stage Survival

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Improving Postpartum Haemorrhage Management Using Simulation in Senegal: Midterm Results

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Open Journal of Obstetrics and Gynecology 2017年第13期7卷 1292-1299页

作者： Mamour gueye Moussa Diallo Mame Diarra Ndiaye gueye Omar Gasama Abdoul Aziz Diouf Mouhamadou Mansour Niang Mohamed Diadhiou Astou Coly Niassy serigne modou kane gueye Marie Edouard Faye Dieme Magatte Mbaye Philippe Marc Moreira Alassane Diouf Jean Charles Moreau Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Cheikh Anta Diop University Dakar Senegal

Objective: To assess a training approach in Emergency Obstetric and Neonatal Care (EmONC) to strengthen skills of healthcare providers and reduce maternal mortality. Materials and methods: The approach was based on the skills training using the so-called “humanist” method and “life saving skills”. Simulated practice took place in the classroom through thirteen clinical stations summarizing the clinical skills on EmONC. The evaluation was done in all phases and the results were recorded in a database to document the progress of each learner. Results: We trained 432 providers in 10 months. The increase in technical achievements of each participant was documented through a database. The combination of training based on the model “learning by doing” has ensured learning and mastering all EmONC skills particularly postpartum haemorrhage management and reduced missed learning opportunities. Conclusion: The impact of training on postpartum haemorrhage management and maternal mortality is a major challenge in terms of prospects.

关键词： Emergency Obstetric Care Postpartum Haemorrhage Training Simulation

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Abrikossof’s Tumor: Report of a Case

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Open Journal of Obstetrics and Gynecology 2023年第2期

作者： Ndama Niang Aissatou Mbodji Mamour gueye Moussa Diallo Yaye Fatou Omar Gaye serigne modou kane gueye Marie Edouard Faye Dieme

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Comparative Effects of Natural and Synthetic Fungicides on the Pink Root Disease of Onion (<i>Allium cepa </i>L.), in Nursery

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Agricultural Sciences 2017年第8期8卷 743-750页

作者： Mouhameth Camara Elhadji Faye serigne modou Sarr Emile Victor Coly Mamadou gueye Institut Supérieur de Formation Agricole et Rurale (ISFAR) Université de Thiès Thiès Sénégal Centre pour le Développement de l’Horticulture Institut Sénégalais de Recherche Agricole Dakar Sénégal Université du Sine Saloum de Kaolack (USSK) Kaolack Sénégal

Onion is an important vegetable in Senegal horticulture, where it occupies the first place. However in the greatest areas production like the Gandiolais, in the North of Senegal, Pink root disease caused by a soil born fungus Pyrenochaeta terrestris (Hansen) Gorentz, Walker and Larson affects its productivity especially in nursery. On soil sterilized and inoculated by the fungus, we tested 5 natural fungicides and 2 synthetic fungicides, to measure their effectiveness on the Pink root disease on onion, in nursery. The device used is a split plot with 4 repetitions and 8 treatments. The measured variables are the emergence rates, the survival rates and the infestation rates. Our experimentations have shown that, for the emergence rates, there is no significant difference between thiophanate-methyl (Pelt 44), Carbendazim (Bavistine), Azadirachta indica A. Juss and Carica papaya L. It is the same between C. papaya and Moringa oleifera Lam, between M. oleifera and Cassia alata L. It is also the same between C. alata and Crotolaria retusa L. Regarding the survival rates, there is no significant difference between thiophanate-methyl, Azadirachta indica, Carbendazim, C. papaya and M. oleifera. The same is true between M. oleifera and Cassia alata, and between C. alata and C. retusa. Concerning the infestation rates, apart from the control check, all other treatments show no difference.

关键词： Onion Pink Root Pyrenochaeta terrestris Hansen Fungicides

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Radio Frequency Quadrupole for Bunching Electron Beam: Electromagnetic Field, Particle Velocity Range, and Accuracy at 10 GHz

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Journal of Electromagnetic Analysis and Applications 2023年第1期15卷 1-11页

作者： serigne Bira gueye Department of Physics Faculty of Sciences and Techniques Cheikh Anta Diop University Dakar Senegal

The Radio Frequency Quadrupole (RFQ) accelerator invented by Kapchinskii and Tepliakov can focus, bunch, and accelerate charged-particle beams simultaneously. Typically, it operates at frequencies up to 500 MHz, for low particle velocities ( β ). The first attempt to design cylindrical RFQ for electrons in the GHz region was done using 3 GHz at Frascati in 1990. In this paper, an analytical approximation of the electromagnetic field is given, and linearized in the beam region for a rectangular Electron Radio Frequency Quadrupole (ERFQ). The differences between the proton-RFQ and the electron-RFQ are discussed. Then, it will be shown that contrary to the quadrupoles for protons or heavy-ions, the ERFQ is suited for electron velocities in the range 0.5 - 0.7 c, and possible applications are given. Finally, it is illustrated, with numerical field computations that this approach gives sufficient accuracy at 10 GHz.

关键词： Electron RF Quadrupole Buncher Linear Accelerator Linac Beam Injector

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Semi-Analytical Solution of the 1D Helmholtz Equation, Obtained from Inversion of Symmetric Tridiagonal Matrix

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Journal of Electromagnetic Analysis and Applications 2014年第14期6卷 425-438页

作者： serigne Bira gueye Département de Physique Faculté des Sciences et Techniques Université Cheikh Anta Diop Dakar-Fann Sénégal

An interesting semi-analytic solution is given for the Helmholtz equation. This solution is obtained from a rigorous discussion of the regularity and the inversion of the tridiagonal symmetric matrix. Then, applications are given, showing very good accuracy. This work provides also the analytical inverse of the skew-symmetric tridiagonal matrix.

关键词： Helmholtz Equation Tridiagonal Matrix Linear Homogeneous Recurrence Relation

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The Exact Formulation of the Inverse of the Tridiagonal Matrix for Solving the 1D Poisson Equation with the Finite Difference Method

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Journal of Electromagnetic Analysis and Applications 2014年第10期6卷 303-308页

作者： serigne Bira gueye Département de Physique Faculté des Sciences et Techniques Université Cheikh Anta Diop Dakar-Fann Sénégal

A new method for solving the 1D Poisson equation is presented using the finite difference method. This method is based on the exact formulation of the inverse of the tridiagonal matrix associated with the Laplacian. This is the first time that the inverse of this remarkable matrix is determined directly and exactly. Thus, solving 1D Poisson equation becomes very accurate and extremely fast. This method is a very important tool for physics and engineering where the Poisson equation appears very often in the description of certain phenomena.

关键词： 1D Poisson Equation Finite Difference Method Tridiagonal Matrix Inversion Thomas Algorithm Gaussian Elimination Potential Problem

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Exact Inversion of Pentadiagonal Matrix for Semi-Analytic Solution of 2D Poisson Equation

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Journal of Modern Physics 2022年第12期13卷 1525-1529页

作者： serigne Bira gueye Department of Physics Faculty of Sciences and Techniques Cheikh Anta Diop University Dakar-Fann Senegal

This work essentially consists in inverting in an exact, explicit, and original way the pentadiagonal Toeplitz matrix or tridiagonal block matrix resulting from the discretization of the two-dimensional Laplace operator. This method is an algorithm facilitating the resolution of a large number of problems governed by PDEs involving the Laplacian in two dimensions. It guarantees high precision and high efficiency in solving various differential equations.

关键词： Block Matrix Pentadiagonal Matrix 2D Laplacian Toeplitz Matrix Inversion

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