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Chinese Journal of Polymer Science 2020年第2期38卷 109-117,I0004页

作者： serife o.hacioglu Iskenderun Technical University Department of Engineering Science

In this study,novel electrochromic copolymers of 3,4-ethylenedioxythiophene(EDoT)and(E)-1,2-bis(2-fluoro-4-(4-hexylthiophen-2-yl)phenyl)diazene(M1)with different monomer feed ratios were designed and synthesized *** and spectroelectrochemical characterizations were performed using voltammetry and UV-Vis-NIR spectrophotometry techniques to test the applicability of copolymers for electrochromic *** terms of electrochemical behaviors,addition of an electron-rich EDoT unit into the azobenzenecontaining copolymer increased the electron density on the polymer chain and afforded copolymers with very low oxidation potentials at around0.30 *** the homopolymers(P1 and PEDoT)exhibited neutral state absorptions centered at 510 and 583 nm,EDoT-bearing copolymers showed red shifted absorptions compared to those of P1 with narrower optical band *** addition,the poor optical contrast and switching times of azobenzene-bearing homopolymer were significantly improved with EDoT addition into the copolymer *** a result of the promising electrochromic and kinetic preperties,Co P1.5-bearing single layer electrochromic device that works between purple and light greenish blue colors was constructed and characterized.

关键词： Azobenzene EDoT Copolymerization Electrochromic device

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Idiopathic hirsutism:Is it really idiopathic or is it misnomer?

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World Journal of Clinical Cases 2023年第2期11卷 292-298页

作者： Kursad Unluhizarci Aysa hacioglu Serpil Taheri Zuleyha Karaca Fahrettin Kelestimur Department of Endocrinology Erciyes University Medical SchoolKayseri 38039Turkey Department of Medical Biology Erciyes University Medical SchoolKayseri 38039Turkey Department of Endocrinology Yeditepe University Medical SchoolIstanbul 34755Turkey

Hirsutism,which is characterized by excessive growth of terminal hair in a male pattern,may result from various causes including polycystic ovary syndrome(PCoS),non-classic congenital adrenal hyperplasia,adrenal or ovarian tumors or it may be *** hirsutism is currently defined as hirsutism associated with normal ovulatory function,normal serum androgen levels and normal ovarian morphology,however,the pathogenesis of idiopathic hirsutism is not *** androgens are the main hormones to stimulate growth of body hair,therefore,there should be any form of increased androgen effect irrespective of normal serum androgen levels in any patient with *** accordance to this scientific truth,we have previously shown that,although within normal limits,patients with idiopathic hirsutism have relatively higher serum androgen levels(relative hyperandrogenemia)in comparison to healthy subjects which let as to think that is idiopathic hirsutism really idiopathic?In addition to relative hyperandrogenemia,we have previously shown that,in comparison to healthy subjects,women with idiopathic hirsutism demonstrated higher expression of steroid sulphatase and 17-beta hydroxysteroid dehydrogenase mRNA both in the subumbilical region and arm skin,which contributes to local androgen *** results support the idea that,in some patients,although the adrenals or ovaries do not secrete increased amount of androgens leading to hyperandrogenemia,pilocebaceous unit locally produce increased amount of androgens leading to hirsutism without ovulatory *** the demonstration of relative hyperandrogenemia and possible increase in local androgen synthesis in patients with idiopathic hirsutism,we think that idiopathic hirsutism is not idiopathic and it may be named as“normoandrogenic hirsutism”.Furthermore,it may not be a different entity but may be an early stage of hyperandrogenic disorders such as ***,this can be find out by following-up p

关键词： Idiopathic hirsutism Normoandrogenic hirsutism Hyperandrogenemia Androgen excess disorders

Comparison of numbers of interneurons in three thalamic nuclei of normal and epileptic rats

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Neuroscience Bulletin 2014年第3期30卷 451-460页

作者： Safiye avdar Hüsniye hacioglu Bay Sercan D.Yildiz Dilek Akakin Serap Sirvanci Filiz onat Department of Anatomy School of Medicine Ko University Department of Anatomy School of Medicine Marmara University Department of Histology and Embryology School of Medicine Marmara University Department of Pharmacology and Clinical Pharmacology School of Medicine Marmara University

The inhibitory sources in the thalamic nuclei are local interneurons and neurons of the thalamic reticular nucleus. Studies of models of absence epilepsy have shown that the seizures are associated with an excess of inhibitory neurotransmission in the thalamus. In the present study, we used light- microscopic gamma-aminobutyric acid （GABA） immunocytochemistry to quantify the interneurons in the lateral geniculate （LGN）, ventral posteromedial （VPM）, and ventral posterolateral （VPL） thalamic nuclei, and compared the values from normal Wistar rats and genetic absence epilepsy rats from Strasbourg （GAERS）. We found that in both Wistar rats and GAERS, the proportion of interneurons was significantly higher in the LGN than in the VPM and VPL. In the LGN of Wistar rats, 16.4% of the neurons were interneurons and in the GAERS, the value was 15.1%. In the VPM, the proportion of interneurons was 4.2% in Wistar and 14.9% in GAERS; in the VPL the values were 3.7% for Wistar and 11.1% for the GAERS. There was no significant difference between Wistar rats and the GAERS regarding the counts of interneurons in the LGN, whereas the VPM and VPL showed significantly higher counts in GAERS. Comparison of the mean areas of both relay cells and interneuronal profiles showed no significant differences between Wistar rats and GAERS. These findings show that in the VPL and the VPM there are relatively more GABAergic interneurons in GAERS than in Wistar rats. This may represent a compensatory response of the thalamocortical circuitry to the absence seizures or may be related to the production of absence seizures.

关键词： immunohistochemistry interneuron relay neuron thalamus GABA

Hepatitis B reactivation related to everolimus

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World Journal of Hepatology 2013年第1期5卷 43-45页

作者： Sema Sezgin Gksu serife Bilal Hasan Senol Coskun Faculty of Medicine Department of Medical OncologyAkdeniz Univercity07058 AntalyaTurkey

Reactivation of hepatitis B virus (HBV) during chemotherapy is a well known complication in patients with chronic hepatitis B and *** clinical manifestations range from subclinical elevation of liver enzymes to severe,potentially fatal fulminant *** can occur in a patient with previous inactive HBV infection;either an inactive carrier or a patient with resolved *** is a mammalian target of rapamycin (mToR) inhibitor approved in renal cell carcinoma,neuroendocrine tumours and breast *** inhibitors are a new generation of drugs for targeted treatment;therefore,little about their side effects is ***,we report a patient with renal cell carcinoma who experienced a flare of hepatitis B infection during treatment with *** should be aware of HBV reactivation in patients who are undergoing treatment with everolimus,and screening for hepatitis B infection and prophylactic antiviral treatment should be considered.

关键词： Hepatitis B Virus reactivation Everolimus Mammalian target of rapamycin inhibitors Immunosuppressive treatment Renal cell carcinoma

Portopulmonary hypertension in liver transplant candidates

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World Journal of Gastroenterology 2016年第6期22卷 2024-2029页

作者： serife Savas Bozbas Huseyin Bozbas Department of Pulmonary Disease Baskent University Faculty of Medicine06490 AnkaraTurkey Cardiology Clinic Guven Hospital06540 AnkaraTurkey

Pulmonary vascular disorders including portopulmonary hypertension(PoPHT) are among the common complications of liver disease and are prognostically significant. Survival is very low without medical treatment and liver transplantation. With advances in medical therapy for elevated pulmonary artery pressure(PAP) and liver transplant surgery, survival of patients with Po PHT and advanced liver disease is significantly improved. Because of the prognostic significance of Po PHT and the limited donor pool, a comprehensive preoperative cardio-pulmonary assessment is of great importance in cirrhotic patients prior to transplant surgery. Therefore, a detailed transthoracic Doppler echocardiographic examination must be an essential component of this evaluation. Patients with mild Po PHT can safely undergo liver transplant surgery. In cases of moderate to severe Po PHT, right heart catheterization(RHC) should be performed. In patients with moderate to severe Po PHT on RHC(mean PAP 35-45 mm Hg), vasodilator therapy should be attempted. Liver transplantation should be encouraged in cases that demonstrate a positive response. Bridging therapy with specific pulmonary arterial hypertension treatment agents should be considered until the transplant surgery and should be continued during the peri- and post-operative periods as needed.

关键词： portopulmonary hypertension pulmonaryarterial hypertension liver disease liver transplantation portal hypertension