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Effectiveness of sensory integration therapy in children,focusing on Korean children:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第7期12卷 1260-1271页

作者： seri oh Jong-Sik Jang A-Ra Jeon Geonwoo Kim Mihwa Kwon Bahoe Cho Narae Lee Department of Occupational Therapy Kangwon National University Graduate SchoolSamcheok 25949South Korea Department of Occupational Therapy Kangwon National UniversitySamcheok 25949South Korea Department of Occupational Therapy Ju-Ju Children Development CenterNonsansi 32985Chungcheongnam-doSouth Korea Department of Occupation Therapy Suwon Women’s UniversityGyeonggi-do 16632South Korea Hijam Center for Development of Children Ochang 28117South Korea Department of Occupational Therapy U1 UniversityChung-cheong bukdo 25949South Korea

BACKGROUND Sensory integration intervention is highly related to the child's effective interaction with the environment and the child's ***,various sensory integration interventions are being applied,but research methodological problems are arising due to unsystematic *** study aims to present the optimal intervention protocol by presenting scientific standards for sensory integration intervention through *** To prove the effectiveness of sensory integration therapy,examine the latest trend of sensory integration studies in Korea,and provide clinical evidence for sensory integration *** The database of Korean search engines,including RISS,KISS,and DBpia,was used to search for related literature published from 2001 to October *** keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this ***,a meta-analysis was conducted on 24 selected studiesRISS,KISS,and DBpia,was used to search for related literature published from 2001 to October *** keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this ***,a meta-analysis was conducted on 24 selected *** Sensory integration intervention has been proven effective in children with cerebral palsy,autism spectrum disorder,attention deficit/hyperactivity disorder,developmental disorder,and intellectual disability in relation to the diagnosis of *** sensory integration therapies,1:1 individual treatment with a therapist or a therapy session lasting for 40 min was most *** terms of dependent variables,sensory integration therapy effectively promoted social skills,adaptive behavior,sensory processing,and gross motor and fine motor *** The results of this study may be used as therapeutic evidence for sensory integration intervention in the clinical field of occupational therapy for

关键词： Children Meta-analysis Occupational therapy Sensory integration Sensory processing Social skills

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Meta-analysis on the effectiveness of parent education for children with disabilities

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World Journal of Clinical Cases 2023年第29期11卷 7082-7090页

作者： JongSik Jang Geonwoo Kim Hyewon Jeong Narae Lee seri oh Department of Occupatioanl Therapy Kangwon National UniversityGangwondoSamcheok 25945South Korea Department of Occupational Therapy Kangwon National University Graduate SchoolGangwon-doSamcheok 25949South Korea

BACKGROUND Parents of children with disabilities often have difficulty understanding their child’s behavior and are unable to do it appropriately because they do not know what to *** more we properly understand children with disabilities,the more positive the importance of parent education becomes in various *** To demonstrate the effectiveness of parent education for children with disabilities in various aspects and present it as evidence that can be used *** For a meta-analysis on the effectiveness of parent education for children with disabilities,literature was collected from 2002 to 2022 using PubMed,Embase,Web of Science,Directory of Open Access Journals,and Europe *** terms were“disabled children,”“disabled children,”“parent education,”“parent training,”and“parent coaching.”The final searched literature included a total of 11 *** calculate the effect size,the mean,standard deviation,and sample size of the experimental and control groups were analyzed,and a meta-analysis was performed using RevMan version *** analyze statistical heterogeneity,a chi-square test was performed to evaluate the significance of Q statistics to indicate statistical *** The final literature totaled 11 articles,and a total of 4 items were *** were 5 studies on parental depression,the heterogeneity was 98%,and the effect size for parental depression was 0.35[confidence interval(CI:0.30-0.40)],indicating a small but statistically significant effect *** were 4 studies on parenting attitude,the heterogeneity was 100%,the effect size on parenting attitude was 0.41(CI:0.37-0.46),which was a medium effect size,and the P value showed a statistically significant ***,face-to-face parent education was found to have a larger effect size than non-face-to-face *** parent education methods,face-to-face parent education had a medium effect size[0.57(CI:0.52-0.61)],while non-face-to-face par

关键词： Children Children with disabilities Education Meta-analysis Parents Parent education

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Analysis of the effectiveness of cognitive rehabilitation for patients with chronic mental illness:A meta-analysis

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World Journal of Clinical Cases 2023年第32期11卷 7822-7832页

作者： Jong-Sik Jang seri oh Geonwoo Kim Narae Lee Hyesu Song Jihye Park Yushin Lee Minji Kim Mihwa Kwon Department of Occupational Therapy Kangwon National UniversitySamcheok 25949South Korea Department of Occupatioanl Therapy Kangwon National University Graduate SchoolSamcheok 25949South Korea Department of Occupational Therapy U1 UniversityChung-Cheong Bukdo 25949South Korea Department of Occupation Therapy Dongnam Health UniversityGyeonggi-do 16328South Korea

BACKGROUND People suffering from chronic mental illness are sensitive to stressful stimuli,lack coping skills,and have low self-esteem due to problems such as social *** also experience depression,isolation,fear,and *** to cognitive dysfunction,people suffering from chronic mental illness have inadequate cognitive processes that lead to distorted *** To confirm the effectiveness of cognitive rehabilitation therapy in improving cognitive function and alleviating behavioral and psychological symptoms in patients with chronic mental illness,and to identify the cognitive function that had the main *** The quality of the studies was evaluated using the Assessment of Multiple Systematic Reviews criteria,and data published from 2011 to December 2022 were searched using PubMed,Cochrane,RISS,KISS,and *** keywords used in the search were“mental illness,”“cognitive rehabilitation,”“cognition,”and“mental.”A meta-analysis was conducted on the 12 selected *** The level of evidence for the 12 documents was that of a randomized experimental *** types in cognitive rehabilitation can be divided into cognitive behavior,cognitive training,cognitive rehabilitation,and computerized cognitive *** of the studies were on schizophrenia,and the measurement areas were cognitive functions(e.g.,concentration,memory,and executive function)as well as depression,sociability,and quality of *** a result of the meta-analysis of each variable,the effect size for cognitive rehabilitation treatment was in the following order:Sociability,memory,concentration,executive function,quality of life,and ***,sociability and memory exhibited significant *** Cognitive rehabilitation aids cognitive function and sociability in patients with chronic mental illness and can be used as evidence for cognitive rehabilitation in mental health and occupational therapy.

关键词： Cognitive function Mental illness Cognitive rehabilitation Cognitive training Cognitive therapy Schizophrenia Occupational therapy

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Mercury Levels Assessment in the Population of Aby and Frambo Villages in the Vinicity of Aby Lagoon in Côte d’Ivoire (West Africa)

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Journal of Water Resource and Protection 2024年第3期16卷 219-232页

作者： Stéphane Jean Claon Serge Kouakou Kouassi Nina Laurette Ahouéfa Laurent Kipré seri Arsène M’bassidjé Seka Joseph Allico Djaman Luc Kouakou Kouadio Analytical Sciences and Public Health Department University of Félix Houphou&eumlt-Boigny Abidjan C&ocircte d'Ivoire Water Quality Control and Analysis Laboratory (LACQUE) Office National de l’Eau Potable (ONEP) Abidjan C&ocircte d’Ivoire Biology and Health Laboratory University of Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Laboratory of Nutrition and Food Safety Department of Science and Food Technology Nangui Abrogoua University Abidjan C&ocircte d'Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocircte d'Ivoire Abidjan C&ocircte d’Ivoire Laboratory of Environmental Sciences (LSE) University of Nangui Abrogoua Abidjan C&ocircte d’Ivoire

The Minamata Convention in the aim to protect human life and the environment, seeks to reduce mercury (Hg) by monitoring it concentrations in the environment. Artisanal and Small-scale Gold Mining (ASGM) has been identified as the most important anthropogenic source of human exposure to Hg. In this context, the main goal of this study was to assess the level of mercury in hair of two (2) populations living along two lagoons respectively Aby and Tendo, in Ivory Coast. To reach this goal, hair samples of 138 residents were collected and analyzed by using Cold Vapor Atomic Fluorescence Spectrophotometry (CV-AFS) technique for mercury concentration. Results showed that for the entire population the Hg mean was 2.34 μg/g. Also, they were ranged between 0.15 to 8.53 μg/g and presented substantial differences amongst the villages. In Aby village, we observed the highest Hg concentrations (Mean = 2.62 μg/g). Our findings showed that almost the entire sample group (82%) exceed the USEPA recommended limit, furthermore 56% of them exceed the normal level of WHO and 2% of the respondent has the unhealthy levels of mercury (≥6 μg Hg/g) of hair by WHO standards. Gender differences in hair mercury varies greatly among reports. Lower levels in women’s hair compared to men were reported in the both village. Considering age, the lowest concentrations were observed with children. However, when we take in account the age groups, data suggested that the most exposed sub-population of [18-29] years old is from Aby village in opposite at Frambo village, the same case those who were ≥ 40 years old. It’s convenient to note that, the proportion of Mercury levels would not to be neglected among studied population especially with the resident from Aby village. So, some measures need to be taken at the political level to control mercury contamination.

关键词： Mercury Hair ASGM Population Exposure Côte d’Ivoire

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尿酸盐转运蛋白-1抑制剂治疗痛风临床研发审评考虑

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中国新药杂志 2024年第8期33卷 768-773页

作者：色日格楞艾星赵伯媛李远红赵田张杰国家药品监督管理局药品审评中心北京100076

痛风是一种单钠尿酸盐(monosodium urate,MSU)沉积在关节所致的晶体相关性关节病,其与嘌呤代谢紊乱和/或尿酸排泄减少所致的高尿酸血症直接相关。随着人们物质生活水平的不断提高以及越来越多的含嘌呤类食物的摄入,痛风的患病率呈逐年... 详细信息

痛风是一种单钠尿酸盐(monosodium urate,MSU)沉积在关节所致的晶体相关性关节病,其与嘌呤代谢紊乱和/或尿酸排泄减少所致的高尿酸血症直接相关。随着人们物质生活水平的不断提高以及越来越多的含嘌呤类食物的摄入,痛风的患病率呈逐年上升的趋势。目前国内常用的降尿酸药物包括抑制尿酸合成(别嘌醇和非布司他)和促进尿酸排泄(苯溴马隆)2类,虽然现有的药物可以减轻痛风发作和痛风的负担,但其仍然有一定的局限性,需要研发新的有效、安全痛风治疗药物。目前以尿酸盐转运蛋白-1(urate transporter 1,URAT1)为靶向的药物设计是抗痛风药物研发的热点。本文综述了URAT1抑制剂的临床应用现状以及URAT1品种临床试验申报日益增多的情况,结合审评中遇到的相关问题,阐述目前URAT1抑制剂药物治疗痛风临床试验的一般性设计与审评考虑,期望为企业研发人员在痛风临床试验设计方面提供参考,从而提高研发效率,使患者早日获益。

关键词：痛风尿酸盐转运蛋白-1抑制剂临床研发审评考虑

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Mortality and Long-Term Outcome of Neonates with Congenital Heart Disease and Acute Perinatal Stroke:A Population-Based Case-Control Study

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Congenital Heart Disease 2022年第4期17卷 447-461页

作者： Eszter Vojcek VAnna Gyarmathy Rozsa Graf Anna M.Laszlo Laszlo Ablonczy Zsolt Prodan Istvan seri First Department of Pediatrics Semmelweis UniversityMTA Centre of ExcellenceBudapestHungary Department of Pediatrics Saint John Hospital and North-Buda Unified HospitalsBudapestHungary Epiconsult BioMedical Consulting and Medical Communications Agency DoverUSA Department of Epidemiology Johns Hopkins UniversityBaltimoreUSA Department of Rehabilitation Saint John Hospital and North-Buda Unified HospitalsBudapestHungary Institute of Mathematics and Base Sciences Hungarian University of Agriculture and Life SciencesGödöllőHungary Gottsegen National Cardiovascular Center BudapestHungary Children’s Hospital Los Angeles University of Southern CaliforniaLos AngelesUSA

Objective:Neonates with congenital heart disease(CHD)and perinatal stroke have high mortality and survivors are at risk for poor long-term neurodevelopmental *** aim of this study was to assess the risk factors and outcome of neonates with both CHD and MRI-confirmed perinatal stroke(Study Group)and compare those to the risk factors and outcome of infants matched for CHD without stroke(Control-1)and of infants matched for MRI-confirmed stroke without CHD(Control-2).Methods:We conducted a population-based case-control study enrolling 28 term neonates with CHD and MRI-confirmed acute perinatal stroke born between 2007–2017 in the Central-Hungarian *** of the control groups included 56 *** Bayley Scales of Infant Development-II,the Brunet-Lézine test and the Binet Intelligence scales-V were used for neurodevelopmental follow-up at a median age of 61 ***:Mortality was highest in the Study Group(25%compared to 5%and 2%,respectively,p=0.001).Adverse neurodevelopmental outcome was prevalent in the Study(53%)and Control-2 Groups(52%,p=0.03).Significantly different parameters among the three groups included Apgar scores,mode of delivery,gestational age at birth,cardiac interventions and twin *** a multivariable regression analysis adjusted for clinically relevant parameters,patients in the Study Group had significantly higher odds for mortality compared to patients in the Control-1 Group(OR:6.595%CI:1.1–39.4).Conclusions:Neonates with perinatal stroke and CHD are at a higher risk for dying compared to neonates with CHD without *** addition,the stroke-associated direct insult to the brain likely plays an important role in the development of neurodevelopmental morbidity in these patients.

关键词： Congenital heart disease perinatal stroke neurodevelopmental outcome mortality

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Discovery of an unknown conduction mechanism in insulating polymers

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High Voltage 2020年第4期5卷 403-408页

作者： Gian Carlo Montanari Paolo seri Leonard A.Dissado Center for Advanced Power Systems Florida State University2000 Levy AvenueFL 32310USA DEI University of BolognaViale del Risorgimento2–40136BolognaItaly Department of Engineering University of LeicesterUniversity RoadLeicesterLE17RHUK

Polymer dielectrics are widely used in electrical and electronic apparatus and devices because of their capability to insulate conductors,withstand high fields and suffer negligible conductive *** near-to-zero conductivity has been explained in terms of long-accepted theories of electronic and ionic transport that lead to the accumulation of local net charge regions at high electric *** the authors describe a previously unknown conduction mechanism consisting of small bipolar ultra-fast charge pulses crossing the polymer with the mobility,as large as,4 to 5 orders of magnitude greater than that of the previously *** authors show that this motion is a consequence of molecular relaxation processes triggered by the electric field locally enhanced by the pulses *** accumulation at the electrodes increases interface field and thus contributes substantially towards premature failure in insulating dielectrics in DC fields.

关键词： conduction mechanism negligible

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Ageing and reliability of electrical insulation: the risk of hybrid AC/DC grids

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High Voltage 2020年第5期5卷 620-627页

作者： Gian Carlo Montanari Peter Morshuis Paolo seri Riddhi Ghosh CAPS Florida State UniversityTallahasseeUSA School of Electrical Engineering Xi'an Jiaotong UniversityXi'anPeople's Republic of China University of Bologna BolognaItaly

With an impetuous growth of DC links and future grids that will be often hybrid,providing AC and DC supply to nearby or the same customer,an important element is often neglected,that is,electrical *** are no doubts that overhead lines will step back compared to insulated cables,for known reasons of environmental impact,right of way and reliability,especially in an urban or harsh *** the other hand,while AC insulation systems have been investigated and used for decades,there is no analogue experience for DC polymeric insulation,nor for insulation systems subjected to power electronics *** study aims at enhancing the attention on this topic,focusing on insulation ageing mechanisms and models of relevance for hybrid AC/DC assets and *** and life models for AC,DC and power electronics supply are discussed and compared to experimental data,focusing on partial discharge and space *** is shown how these two phenomena affect lifetime for different AC,DC and transient operating *** main drivers for insulation design and material selection are discussed,showing that insulation reliability can be achieved only if operating stresses,ageing mechanisms and life models are known and accounted for properly by insulation designers.

关键词： insulation electrical properly

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Phytochemical Constituents of the Stem Barks of Uvaria tortilis, an Endemic Annonaceae from Côte d’Ivoire

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Open Journal of Applied Sciences 2023年第6期13卷 888-895页

作者： Aboua Timothée Okpekon seri Chardin seri Maxime Eric Joel Dade Akpa Salemon Agnes Yao San Yao Landry Kouakou UFR Sciences des Structures de la Matière et Technologie Laboratoire de Constitution et Réaction de la Matière (LCRM) Université Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire

Uvaria tortilis is a lianescent annonaceous species endemic to the Côte d’Ivoire where it is used to treat amenorrhea and as uterotonic. Thus, the Meoh crude extract of its stem barks was investigated in order to determine the chemical composition. A new C-benzyl hydroxlated, uvriatortilisin (1), together with six known compounds, dichamanetin (2), β-sitosterol (3), stigmasterol (4), chamanetin (5), uvaretin (6) and (-)-epicatechin (7), were isolated. Structure of these compounds was elucidated using spectroscopic techniques, including IR, UV, MS and NMR (1D and 2D). Certain compounds could be considered to have chemotaxonomic value.

关键词： Uvaria tortilis Annonaceae C-Benzyl Uvriatortilisin

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New C-13 Norisoprenoids and Flavonoids from Lannea kerstingii

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Journal of Materials Science and Chemical Engineering 2022年第10期10卷 10-19页

作者： Jean-Michel Kouamé Koffi Philomène Akoua Yao-Kouassi Chardin seri seri Abdulmagid Alabdul Magid Zachée Louis Evariste Akissi Laurence Voutquenne-Nazabadioko Université Félix Houphouë t-Boigny Laboratoire de Constitution et Réaction de la Matière UFR Sciences des Structures de la Matière et de Technologie Abidjan C&#244 te d’Ivoire Université de San Pedro San Pedro C&#244 te d’Ivoire Université de Reims Champagne-Ardenne CNRS Reims France

Lannea kerstingii is known for its multiple therapeutic and biological activities. Despite of many traditional uses of this plant, scientific research on the content of its chemical compounds is still limited. This study aims to isolate the chemical compounds contained in the n-butanol fraction of Lannea kerstingii leaves. The chemical investigation of the leaves of Lannea kerstingii led to isolation of three undescribed C-13 norisoprenoids, lankerstinol A-C (1-3), together with six (4-9) known flavonoid glycosides. The structures of these compounds were established by spectroscopic analyses.

关键词： Lannea kerstingii Anacardiaceae Flavonoids C-13 Norisoprenoids Structure Elucidation

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