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Autologous cord blood vs individualized supplements in autistic spectrum disorder:CORDUS study results

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World Journal of Clinical Pediatrics 2025年第1期14卷 101-112页

作者： Felician A Stancioiu Raluca bogdan bogdan Ivanescu Radu Dumitrescu Department of Clinical Research Bio-Forum FoundationBucharest 040245BucurestiRomania Department of Pediatrics Medicover Hospital BucharestBucharest 013982BucurestiRomania Doctor MiT Clinic Bucharest 013929BucurestiRomania Department of Anesthesiology and Intensive Therapy Medicover HospitalBucharest 013982BucurestiRomania

BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell *** cells have yielded so far mixed results in clinical trials,and at patient level the results varied from impressive to no *** this context we have administered autologous cord blood(ACB)and a non-placebo,material intervention repre-sented by an individualized combination of supplements(ICS)to ASD *** CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children;ACB was infused as an inpatient *** efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist,Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score,after interviewing the children’s parents and *** and after each intervention participants had a set of blood tests including inflammatory,metabolic and oxidative markers,and the neuronal specific *** No serious adverse reactions were noted during and after cord blood or supplement *** improved evaluation scores in 78%of children with age 3–7-years(n=28),but was much less effective in kids older than 8 years or with body weight of more than 35 kg(n=28;only 11%of children improved scores).ICS yielded better results than ACB in 5 cases out of 28,while in 23 kids ACB brought more improvement than ICS(P<0.05);high initial levels of inflammation and ferritin were associated with no *** individual differences were noted in children's progress,and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction,but not on irritability or

关键词： Autistic spectrum disorder Cord blood Stem cells Neuroinflammation Autologous stem cell treatment Neuronal specific enolase

Caregiver burden:A concept analysis

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International Journal of Nursing Sciences 2020年第4期7卷 438-445,I0006页

作者： Zhu Liu catrina Heffernan Jie Tan Department of Hepatobiliary Surgery The People’s Hospital of Deyang CityDeyangSichuanChina Department of Nursing and Healthcare Sciences Institute of Technology TraleeCo.KerryIreland

Objective:Caregiver burden is used frequently within the nursing *** has not yet been clearly defined as there are different opinions regarding this *** purpose of this paper is to provide clarity surrounding the concept caregiver ***:An electronic search of MEDLINE,CINAHL,Health Source Nursing/Academic Edition and Academic Search Complete(ASC)of EBSCO,China National Knowledge Infrastructure(CNKI)and Google Scholar were searched with a limit of 10 years and published in the English or Chinese *** paper adopted the framework by Walker and *** attributes,antecedents,consequences and uses of the concept were ***:At total of 33 articles were *** three attributes of caregiver burden were identified as self-perception,multifaceted strain,and over *** antecedents included insufficient financial resources,multiple responsibility conflict,lack of social *** consequences of caregiver burden resulted in negative change which included decreased care provision,decrease in quality of life,physical and psychological health ***:A definition of caregiver burden was *** to measure caregiver burden were *** findings from this analysis can be used in nursing practice,nursing education,research and administration.

关键词： Burden Caregivers Cost of illness Home nursing Mental health Quality of life

The effect of exosomes in transferring TET signaling alterations

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BIOCELL 2022年第3期46卷 579-581页

作者： sergiu PASCA ANCUTA JURJ Department of Hematology Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca400012Romania Research Center for Functional Genomics Biomedicine and Translational MedicineIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca400337Romania

Ten eleven translocation(TET)enzymes are composed of three representatives:TET1/2/3 which are involved in the hydroxymethylation of methylated *** of the wide array of processes that are governed by these epigenetic marks,there have been a wide range of clinical effects associated with TET *** though many research groups have focused on analyzing the effect of TET alterations within certain cells,few have taken into consideration the effect of TET in the context of intercellular *** important entity through which intercellular communication occurs is represented by ***,in the current viewpoint we discussed the direct transfer of TET by exosomes,its alterations in the cell targeted by exosomes and the effect of TET alterations on exosome secretion.

关键词： TET Exosomes Immunity Intercellular communication

Conditional disruption of the osterix gene in chondrocytes during early postnatal growth impairs secondary ossification in the mouse tibial epiphysis

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Bone Research 2019年第3期7卷 310-317页

作者： Weirong Xing catrina Godwin Sheila Pourteymoor Subburaman Mohan 1Musculoskeletal Disease Center VA Loma Linda Healthcare System Loma Linda CA 92357 USA Department of Medicine Loma Linda University Loma Linda CA 92357 USA Department of Orthopedics Loma Linda University Loma Linda CA 92357 USA Department of Biochemistry Loma Linda University Loma Linda CA 92357 USA

In our previous studies, we have found that the prepubertal increase in thyroid hormone levels induces osterix(Osx) signaling in hypertrophic chondrocytes to transdifferentiate them into osteoblasts. To test if Osx expressed in chondrocytes directly contributes to transdifferentiation and secondary ossification, we generated Osx^flox/flox;Col2-Cre-ERT2 mice and knocked out Osx with a single injection of tamoxifen at postnatal day(P) 3 prior to evaluation of the epiphyseal bone phenotype by μCT, histology, and immunohistochemistry(IHC) at P21. Vehicle(oil)-treated Osx^flox/flox;Col2-Cre-ERT2 and tamoxifen-treated, Cre-negative Osx^flox/flox mice were used as controls.μCT analysis of tibial epiphyses revealed that trabecular bone mass was reduced by 23% in the Osx conditional knockout(c KO) compared with control mice. Trabecular number and thickness were reduced by 28% and 8%,respectively, while trabecular separation was increased by 24% in the c KO mice. Trichrome staining of longitudinal sections of tibial epiphyses showed that bone area and bone area adjusted for total area were decreased by 22% and 18%, respectively. IHC studies revealed the presence of abundant Osx-expressing prehypertrophic chondrocytes in the epiphyses of control mice at P10, but not in the cKO mice. Furthermore, expression levels of MMP13, COL10, ALP, and BSP were considerably reduced in the epiphyses of cKO mice. We also found that Osx overexpression in ATDC5 chondrocytes increased expression of Col10, Mmp13, Alp, and Bsp. Our data indicate that Osx expressed in chondrocytes plays a significant role in secondary ossification by regulating expression of genes involved in chondrocyte hypertrophy and osteoblast transdifferentiation.

关键词： ossification thyroid hormone Large chondrocyte

Toward future adaptive deep brain stimulation for Parkinson's disease:the novel biomarker--narrowband gamma oscillation

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Neural Regeneration Research 2022年第3期17卷 557-558页

作者： Hao Ding sergiu Groppa Muthuraman Muthuraman Movement Disorders and Neurostimulation Biomedical Statistics and Multimodal Signal ProcessingDepartment of NeurologyJohannes Gutenberg UniversityMainzGermany

Parkinson's disease(PD) is one of the most common neurodegenerative diseases,affecting individuals especially over 60 years of *** the next three decades,more than 12 million people will suffer from PD worldwide(Rocca,2018).The characteristic symptoms of PD begin as a movement disorder including bradykinesia,resting tremor,rigidity,and postural instability.

关键词： stimulation diseases rigidity

Bridging element-free Galerkin and pluri-Gaussian simulation for geological uncertainty estimation in an ensemble smoother data assimilation framework

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Petroleum Science 2024年第3期21卷 1683-1698页

作者： bogdan Sebacher Remus Hanea Department of Applied Informatics Military Technical Academy“Ferdinand I”Bucharest 050141Romania Equinor Sandslivegen 905254 SandsliBergenNorway

The facies distribution of a reservoir is one of the biggest concerns for geologists,geophysicists,reservoir modelers,and reservoir engineers due to its high importance in the setting of any reliable decisionmaking/optimization of field development *** approach for parameterizing the facies distribution as a random variable comes naturally through using the probability *** the prior probability fields of facies come either from a seismic inversion or from other sources of geologic information,they are not conditioned to the data observed from the cores extracted from the *** paper presents a regularized element-free Galerkin(R-EFG)method for conditioning facies probability fields to facies *** conditioned probability fields respect all the conditions of the probability theory(*** the values are between 0 and 1,and the sum of all fields is a uniform field of 1).This property achieves by an optimization procedure under equality and inequality constraints with the gradient projection *** conditioned probability fields are further used as the input in the adaptive pluri-Gaussian simulation(APS)methodology and coupled with the ensemble smoother with multiple data assimilation(ES-MDA)for estimation and uncertainty quantification of the facies *** history-matching of the facies models shows a good estimation and uncertainty quantification of facies distribution,a good data match and prediction capabilities.

关键词： Element free Galerkin(EFG) Adaptive pluri-Gaussian simulation(APS) Facies distribution estimation Ensemble smoother with multipledata assimilation(ESMDA)

Miniature Detonating Cord (MDC) for Breaking Organic Glass Plates

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含能材料 2008年第5期16卷 618-620页

作者： bogdan ZYGMUNT Military University of Technology Mechatronics Faculty2 Kaliski Str.00-908 WarsawPoland

In order to develop a method to break the aircrafts canopy,a miniature detonating cords (MDC) of 1 mm in diameter were manufactured and its detonation properties were *** in a heavy lead confinement were also manufactured and were examined for breaking of organic glass *** showthat MDC in lead confinement with 1g plastic explosive per metre,cuts organic glass plate 10 mm thick.

关键词：有机玻璃爆炸性能物理性能功能材料塑胶炸弹

Highly luminescent europium and terbium complexes based on succinimide and N-hydroxysuccinimide

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Journal of Rare Earths 2012年第5期30卷 401-407页

作者： Corneliu sergiu Stan Ioan Rosca Daniel Sutiman Marius Sebastian Secula Faculty of Chemical Engineering and Environmental Protection Gheorghe Asachi Technical University of Iasi73 D.Mangeron700050IasiRomania

The preparation of two highly luminescent europium（Ill） and terbium（Ill） complexes with succinimide （SI） and N-hydroxysuccinimide （NHSI） were reported, which were further investigated through elemental chemical analysis, thermal analysis, FT-IR, powder X-ray diffraction, SEM and fluorescence spectroscopy. Data collected through these analysis revealed the formation of the Eu（III） and Th（III） complexes with the above mentioned ligands at a metal to ligand （M：L） molar ratio of 1：3. Interesting conclusions regarding the effi- cient sensitization through the coordination site of the lanthanide luminescent centers were retained from the photoluminescent spectra inves- tigation. Strong luminescence emission was observed in case of Eu（III）-SI and Tb（III）-NHSI complexes while the corresponding Eu（III）-NHSI and Tb（III）-SI complexes exhibited no photo luminescent properties. Newly obtained luminescent lanthanide complexes may be of particular interest for various applications in optoelectronics.

关键词： lanthanide complex succinimide N-hydroxysuccinimide luminescence rare earths

Response of photosynthesis,growth,and acorn mass of pedunculate oak to diff erent levels of nitrogen in wet and dry growing seasons

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Journal of Forestry Research 2023年第1期34卷 167-176页

作者： Krunoslav Sever Saša bogdan ŽeljkoŠkvorc Faculty of Forestry and Wood Technology University of ZagrebSvetošimunska 2510000 ZagrebCroatia

The objective was to examine the effects of optimal leaf nitrogen levels>2.0%and suboptimal levels<2.0%,nitrogen nutrition on net photo synthetic rate,stem diameter increment,height growth increment and acorn mass of pedunculate oak during 2010 in the absence of drought stress and during 2011 under the impact of moderate drought *** to the results,moderate drought stress significantly reduced net photo synthetic rate,stem diameter increment and height growth increment,while acorn mass was not *** nitrogen nutrition significantly reduced the net photo synthetic rate and stem diameter increment only in the wet year,acorn mass in both wet and dry years,while height growth increment was not significantly reduced by suboptimal nitrogen nutrition in either *** results indicate that optimal nitrogen levels can stimulate photo synthetic rate and stem diameter increment of pedunculate oak only in the absence of moderate drought ***,the results show that moderate drought stress is a more dominant stressor for photosynthesis and growth of pedunculate oak than suboptimal nitrogen nutrition,while for acorn development,it is the more dominant stressor.

关键词： Quercus robur L. Drought stress Net photosynthic rate Stem diameter increment Height growth increment Acorn mass