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Chalcogenide Ovonic Threshold Switching Selector

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Nano-Micro Letters 2024年第5期16卷 1-40页

作者： Zihao Zhao sergiu Clima Daniele Garbin Robin Degraeve Geoffrey Pourtois Zhitang Song Min Zhu National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China University of Chinese Academy of Sciences Beijing 100029People’s Republic of China IMEC Kapedreef 75LeuvenBelgium

Today’s explosion of data urgently requires memory technologies capable of storing large volumes of data in shorter time frames,a feat unattain-able with Flash or *** Optane,commonly referred to as three-dimensional phase change memory,stands out as one of the most promising *** Optane with cross-point architecture is constructed through layering a storage element and a selector known as the ovonic threshold switch(OTS).The OTS device,which employs chalcogenide film,has thereby gathered increased attention in recent *** this paper,we begin by providing a brief introduction to the discovery process of the OTS ***,we summarize the key elec-trical parameters of OTS devices and delve into recent explorations of OTS materials,which are categorized as Se-based,Te-based,and S-based material ***,we discuss various models for the OTS switching mechanism,including field-induced nucleation model,as well as several carrier injection ***,we review the progress and innovations in OTS mechanism ***,we highlight the successful application of OTS devices in three-dimensional high-density memory and offer insights into their promising performance and extensive prospects in emerging applications,such as self-selecting memory and neuromorphic computing.

关键词： Non-volatile memory Ovonic threshold switch(OTS) Chalcogenide Selector

Translating Pathological Brain Activity Primers in Parkinson’s Disease Research

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Research 2024年第1期2023卷 735-752页

作者： Daniela Mirzac Svenja L.Kreis Heiko J.Luhmann Gabriel Gonzalez-Escamilla sergiu Groppa Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational NeuroscienceRhine Main Neuroscience NetworkUniversity Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany Institute of Physiology University Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany

Translational experimental approaches that help us better trace Parkinson’s disease(PD)pathophysiological mechanisms leading to new therapeutic targets are urgently *** this article,we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations,as well as their underlying mechanisms and *** aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s ***,we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia *** summarize recent achievements extrapolated from available PD animal models,discuss their advantages and limitations,debate on their differential applicability,and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.

关键词： clinical knowledge insight

Modifying the progression of Parkinson's disease through movement interventions:multimodal quantification of underlying mechanisms

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Neural Regeneration Research 2024年第8期19卷 1651-1652页

作者： Manuel Bange Damian Marc Herz Dumitru Ciolac Gabriel Gonzalez-Escamilla sergiu Groppa Section of Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational Neuroscience(FTN)University Medical Center of the Johannes Gutenberg-University MainzMainzGermany

Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement *** pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain *** r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022).

关键词： alterations movement

Kinemaitcs in spatially flat FLRW spacetimes

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Chinese Physics C 2021年第10期45卷 92-101页

作者： Ion I.Cotäescu West University of Timiäoara

The kinematics on spatially flat FLRW spacetimes is presented for the first time in local charts with physical coordinates,i.e.,the cosmic time and proper Cartesian space coordinates of Painlevé-*** is shown that there exists a conserved momentum that determines the form of the covariant four-momentum on geodesics in terms of physical ***,with the help of this conserved momentum,the peculiar momentum can be defined,thus separating the peculiar and recessional motions without *** is shown that the energy and peculiar momentum satisfy the mass-shell condition of special relativity while the recessional momentum does not produce *** this framework,the measurements of the kinetic quantities along geodesics performed by different observers are analyzed,pointing out an energy loss of the massive particles similar to that producing the photon *** examples of the kinematics on the de Sitter expanding universe and a new Milne-type spacetime are extensively analyzed.

关键词： FLRW specetime peculiar momentum recessional momentum conserved quantities energy loss redshift de Sitter expanding universe Milne-type universe

The effect of exosomes in transferring TET signaling alterations

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BIOCELL 2022年第3期46卷 579-581页

作者： sergiu PASCA ANCUTA JURJ Department of Hematology Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca400012Romania Research Center for Functional Genomics Biomedicine and Translational MedicineIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca400337Romania

Ten eleven translocation(TET)enzymes are composed of three representatives:TET1/2/3 which are involved in the hydroxymethylation of methylated *** of the wide array of processes that are governed by these epigenetic marks,there have been a wide range of clinical effects associated with TET *** though many research groups have focused on analyzing the effect of TET alterations within certain cells,few have taken into consideration the effect of TET in the context of intercellular *** important entity through which intercellular communication occurs is represented by ***,in the current viewpoint we discussed the direct transfer of TET by exosomes,its alterations in the cell targeted by exosomes and the effect of TET alterations on exosome secretion.

关键词： TET Exosomes Immunity Intercellular communication

Toward future adaptive deep brain stimulation for Parkinson's disease:the novel biomarker--narrowband gamma oscillation

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Neural Regeneration Research 2022年第3期17卷 557-558页

作者： Hao Ding sergiu Groppa Muthuraman Muthuraman Movement Disorders and Neurostimulation Biomedical Statistics and Multimodal Signal ProcessingDepartment of NeurologyJohannes Gutenberg UniversityMainzGermany

Parkinson's disease(PD) is one of the most common neurodegenerative diseases,affecting individuals especially over 60 years of *** the next three decades,more than 12 million people will suffer from PD worldwide(Rocca,2018).The characteristic symptoms of PD begin as a movement disorder including bradykinesia,resting tremor,rigidity,and postural instability.

关键词： stimulation diseases rigidity

Highly luminescent europium and terbium complexes based on succinimide and N-hydroxysuccinimide

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Journal of Rare Earths 2012年第5期30卷 401-407页

作者： Corneliu sergiu Stan Ioan Rosca Daniel Sutiman Marius Sebastian Secula Faculty of Chemical Engineering and Environmental Protection Gheorghe Asachi Technical University of Iasi73 D.Mangeron700050IasiRomania

The preparation of two highly luminescent europium（Ill） and terbium（Ill） complexes with succinimide （SI） and N-hydroxysuccinimide （NHSI） were reported, which were further investigated through elemental chemical analysis, thermal analysis, FT-IR, powder X-ray diffraction, SEM and fluorescence spectroscopy. Data collected through these analysis revealed the formation of the Eu（III） and Th（III） complexes with the above mentioned ligands at a metal to ligand （M：L） molar ratio of 1：3. Interesting conclusions regarding the effi- cient sensitization through the coordination site of the lanthanide luminescent centers were retained from the photoluminescent spectra inves- tigation. Strong luminescence emission was observed in case of Eu（III）-SI and Tb（III）-NHSI complexes while the corresponding Eu（III）-NHSI and Tb（III）-SI complexes exhibited no photo luminescent properties. Newly obtained luminescent lanthanide complexes may be of particular interest for various applications in optoelectronics.

关键词： lanthanide complex succinimide N-hydroxysuccinimide luminescence rare earths

Flat limit of the de Sitter QFT in the rest frame vacuum

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Chinese Physics C 2021年第1期45卷 101-112页

作者： Ion I.Cot?escu West University of Timi?oara

The problem of the flat limits of the scalar and spinor fields on the de Sitter expanding universe is considered in the traditional adiabatic vacuum and in the new rest frame vacuum we proposed recently, in which the frequencies are separated in the rest frames as in special relativity. It is shown that only in the rest frame vacuum can the Minkowskian flat limit be reached naturally for any momentum, whereas in the adiabatic vacuum, this limit remains undefined in rest frames in which the momentum vanishes. An important role is played by the phases of the fundamental solutions in the rest frame vacuum, which must be regularized to obtain the desired Minkowskian flat limits. This procedure fixes the phases of the scalar mode functions and Dirac spinors, resulting in their definitive expressions derived here. The physical consequence is that, in the rest frame vacuum, the flat limits of the oneparticle operators are simply the corresponding operators of special relativity.

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Kinemaitcs in spatially flat FLRW spacetimes

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Chinese Physics C 2021年第10期 96-105页

作者： Ion I.Cot?escu West University of Timi?oara

The kinematics on spatially flat FLRW spacetimes is presented for the first time in local charts with physical coordinates, i.e., the cosmic time and proper Cartesian space coordinates of Painlevé-type. It is shown that there exists a conserved momentum that determines the form of the covariant four-momentum on geodesics in terms of physical coordinates. Moreover, with the help of this conserved momentum, the peculiar momentum can be defined, thus separating the peculiar and recessional motions without ambiguity. It is shown that the energy and peculiar momentum satisfy the mass-shell condition of special relativity while the recessional momentum does not produce energy. In this framework, the measurements of the kinetic quantities along geodesics performed by different observers are analyzed, pointing out an energy loss of the massive particles similar to that producing the photon redshift. The examples of the kinematics on the de Sitter expanding universe and a new Milne-type spacetime are extensively analyzed.

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